quinacrine has been researched along with Asthma, Bronchial in 5 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For this, extended subacute ovalbumin mice model of asthma was developed; these mice showed an increased expression of profibrotic mediators, subepithelial fibrosis, and goblet cell metaplasia along with airway inflammation, increased Th(2) cytokines, allergen-specific IgE, IgG(1), increased cytosolic PLA(2) (cPLA(2)), and airway hyperresponsiveness." | 3.75 | Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma. ( Agrawal, A; Aich, J; Ghosh, B; Mabalirajan, U, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mabalirajan, U | 3 |
| Aich, J | 1 |
| Agrawal, A | 2 |
| Ghosh, B | 3 |
| Ahmad, T | 1 |
| Hasija, K | 1 |
| ENGESET, A | 1 |
| Ram, A | 1 |
| Singh, SK | 1 |
| Singh, VP | 1 |
| Voog, R | 1 |
| Chouteau, J | 1 |
| Marchal, A | 1 |
| Cabanel, G | 1 |
5 other studies available for quinacrine and Asthma, Bronchial
| Article | Year |
|---|---|
Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.
Topics: Animals; Arginase; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Epithelial Cells; Fibr | 2009 |
Mepacrine treatment attenuates allergic airway remodeling segregated from airway inflammation in mice.
Topics: Airway Remodeling; Animals; Anti-Asthmatic Agents; Arginase; Asthma; Blotting, Western; Collagen; Cy | 2011 |
[Quinacrine & chloroquine in asthma therapy].
Topics: Asthma; Chloroquine; Disease; Peritoneal Diseases; Peritoneum; Quinacrine | 1957 |
Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bro | 2008 |
[Asthma therapy with a combination of synthetic antimalarials (83 cases)].
Topics: Adolescent; Adult; Aged; Asthma; Chloroquine; Drug Synergism; Electrocardiography; Eosinophilia; Eye | 1969 |