quinacrine has been researched along with Arterial Obstructive Diseases in 2 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine treated rats showed significantly reduced infarct areas in the caudoputamen compared to saline treated rats (P < 0." | 1.30 | The phospholipase A2 inhibitor, quinacrine, reduces infarct size in rats after transient middle cerebral artery occlusion. ( Estevez, AY; Phillis, JW, 1997) |
| "In quinacrine-treated animals phospholipids and CK also fell initially; however, 24 and 48 hr after occlusion they were higher than in controls (phospholipids: 0." | 1.27 | Inhibition of ischemia-induced phospholipase activation by quinacrine protects jeopardized myocardium in rats with coronary artery occlusion. ( Ambrosio, G; Cappelli-Bigazzi, M; Chiariello, M; Condorelli, M; Marone, G; Nevola, E; Perrone-Filardi, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Estevez, AY | 1 |
| Phillis, JW | 1 |
| Chiariello, M | 1 |
| Ambrosio, G | 1 |
| Cappelli-Bigazzi, M | 1 |
| Nevola, E | 1 |
| Perrone-Filardi, P | 1 |
| Marone, G | 1 |
| Condorelli, M | 1 |
2 other studies available for quinacrine and Arterial Obstructive Diseases
| Article | Year |
|---|---|
The phospholipase A2 inhibitor, quinacrine, reduces infarct size in rats after transient middle cerebral artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Cerebral Arteries; Cerebral Infarction; Enzyme Inhibitors; Mal | 1997 |
Inhibition of ischemia-induced phospholipase activation by quinacrine protects jeopardized myocardium in rats with coronary artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Creatine Kinase; Hemodynamics; Isoenzymes; Male; Mathematics; | 1987 |