quinacrine has been researched along with Anoxemia in 15 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment." | 7.91 | Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer. ( Kim, CW; Kim, HG; Lee, DH; Lee, JS; Oh, ET; Park, HJ, 2019) |
| "Quinacrine was found to exert a concentration-dependent negative inotropic effect (1." | 5.28 | Functional and electrophysiological effects of quinacrine on the response of ventricular tissues to hypoxia and reoxygenation. ( Moffat, MP; Tsushima, RG, 1989) |
| "5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment." | 3.91 | Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer. ( Kim, CW; Kim, HG; Lee, DH; Lee, JS; Oh, ET; Park, HJ, 2019) |
| "Quinacrine was found to exert a concentration-dependent negative inotropic effect (1." | 1.28 | Functional and electrophysiological effects of quinacrine on the response of ventricular tissues to hypoxia and reoxygenation. ( Moffat, MP; Tsushima, RG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, HG | 1 |
| Kim, CW | 1 |
| Lee, DH | 1 |
| Lee, JS | 1 |
| Oh, ET | 1 |
| Park, HJ | 1 |
| JAILER, JW | 1 |
| ZUBROD, CG | 1 |
| Furchgott, RF | 1 |
| Miyahara, M | 1 |
| Okimasu, E | 1 |
| Mikasa, H | 1 |
| Terada, S | 1 |
| Kodama, H | 1 |
| Utsumi, K | 1 |
| Araki, H | 1 |
| Peck, RC | 1 |
| Lefer, AM | 1 |
| Shen, CY | 1 |
| Wang, D | 1 |
| Chang, ML | 1 |
| Hsu, K | 1 |
| Salińska, E | 1 |
| Lazarewicz, JW | 1 |
| Bunnachak, D | 1 |
| Almeida, AR | 1 |
| Wetzels, JF | 1 |
| Gengaro, P | 1 |
| Nemenoff, RA | 1 |
| Burke, TJ | 1 |
| Schrier, RW | 1 |
| Sheridan, AM | 1 |
| Schwartz, JH | 1 |
| Kroshian, VM | 1 |
| Tercyak, AM | 1 |
| Laraia, J | 1 |
| Masino, S | 1 |
| Lieberthal, W | 1 |
| Bugge, E | 1 |
| Gamst, TM | 1 |
| Hegstad, AC | 1 |
| Andreasen, T | 1 |
| Ytrehus, K | 1 |
| Modig, HG | 1 |
| Edgren, M | 1 |
| Révész, L | 1 |
| Gu, M | 1 |
| Elliott, DA | 1 |
| Ong, BY | 1 |
| Bose, D | 1 |
| Klaas, M | 1 |
| Wadsworth, R | 1 |
| Moffat, MP | 1 |
| Tsushima, RG | 1 |
| Bowman, A | 1 |
| McGrath, JC | 1 |
1 review available for quinacrine and Anoxemia
| Article | Year |
|---|---|
The role of endothelium in the responses of vascular smooth muscle to drugs.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Acetylcholine; Adenosine Diphosphate; Adenosine Trip | 1984 |
14 other studies available for quinacrine and Anoxemia
| Article | Year |
|---|---|
Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; | 2019 |
Effect of acidosis and anoxia on the concentration of quinacrine and chloroquine in blood.
Topics: Acidosis; Chloroquine; Hypoxia; Quinacrine | 1948 |
Improvement of the anoxia-induced mitochondrial dysfunction by membrane modulation.
Topics: Acetophenones; Adenine Nucleotides; Alkaloids; Animals; Benzylisoquinolines; Chlorpromazine; Egtazic | 1984 |
Biphasic actions of chlorpromazine and mepacrine on modulation of hepatic cell injury in the perfused cat liver.
Topics: Amines; Animals; Cathepsin D; Cathepsins; Cats; Chemical and Drug Induced Liver Injury; Chlorpromazi | 1981 |
Protective effect of mepacrine on hypoxia-reoxygenation-induced acute lung injury in rats.
Topics: Animals; Capillary Permeability; Dexamethasone; Granulocytes; Hypoxia; In Vitro Techniques; Leukocyt | 1995 |
NMDA receptors mediate anoxia/aglycemia-induced release of eicosanoids in immature rat hippocampal slices: utility of an in vitro "ischemic" superfusion model with temporary arrest of medium flow.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Brain Ischemia; Calcium; Culture Techniques | 1994 |
Ca2+ uptake, fatty acid, and LDH release during proximal tubule hypoxia: effects of mepacrine and dibucaine.
Topics: Animals; Biological Transport; Calcium; Dibucaine; Dose-Response Relationship, Drug; Fatty Acids, No | 1994 |
Renal mouse proximal tubular cells are more susceptible than MDCK cells to chemical anoxia.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Cyanides; Deoxyglucose; Disease Sus | 1993 |
Mepacrine protects the isolated rat heart during hypoxia and reoxygenation--but not by inhibition of phospholipase A2.
Topics: Animals; Enzyme Inhibitors; Fatty Acids, Nonesterified; Heart; Hemodynamics; Hypoxia; In Vitro Techn | 1997 |
Effect of radioprotective aminothiols on the induction and repair of single-strand breaks in the DNA of irradiated mammalian cells.
Topics: Amino Acids, Sulfur; Animals; Cell Line; Cricetinae; Cysteamine; DNA; DNA Repair; Hypoxia; Oxygen; Q | 1977 |
Possible role of leukotrienes in hypoxic contraction of canine isolated basilar artery.
Topics: Animals; Arachidonic Acid; Basilar Artery; Dogs; Female; Hypoxia; In Vitro Techniques; Leukotriene A | 1991 |
Contraction followed by relaxation in response to hypoxia in the sheep isolated middle cerebral artery.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cerebral Arteries; Endotheliu | 1989 |
Functional and electrophysiological effects of quinacrine on the response of ventricular tissues to hypoxia and reoxygenation.
Topics: Acidosis, Lactic; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiolo | 1989 |
The effect of hypoxia on neuroeffector transmission in the bovine retractor penis and rat anococcygeus muscles.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alprostadil; Animals; Cattle; Electric Stimulation; Guanethidine; G | 1985 |