quinacrine has been researched along with Angiogenesis, Pathologic in 10 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combined cediranib/quinacrine treatment synergistically increased antivascular/antitumor efficacy in intracranial 4C8 mouse glioma, suggesting a promising and facile treatment strategy for malignant glioma." | 7.79 | Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma. ( Gillespie, GY; Green, SC; Lobo, MR; Pike, MM; Schabel, MC; Woltjer, RL, 2013) |
| "Combined cediranib/quinacrine treatment synergistically increased antivascular/antitumor efficacy in intracranial 4C8 mouse glioma, suggesting a promising and facile treatment strategy for malignant glioma." | 3.79 | Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma. ( Gillespie, GY; Green, SC; Lobo, MR; Pike, MM; Schabel, MC; Woltjer, RL, 2013) |
| "Quinacrine (QC) is a tricyclic compound and a derivative of 9-aminoacridine." | 2.72 | Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle. ( Das, B; Kundu, CN, 2021) |
| "Using 5-Fluouracil-resistant cervical cancer stem cells (PEMT-5FU-R-MC) and different NECTIN-4 domain-specific constructs, different domains of NECTIN-4 were over-expressed in PEMT-5FU-R-MC cells." | 1.56 | Nanoformulated quinacrine regulates NECTIN-4 domain specific functions in cervical cancer stem cells. ( Chatterjee, S; Kundu, CN, 2020) |
| "Complete eradication of aggressive oral cancer remains a challenge due to the presence of CSCs." | 1.48 | Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner. ( Das, S; Kundu, CN; Nayak, A; Nayak, D; Satapathy, SR; Siddharth, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 5 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, X | 1 |
| Xiong, B | 1 |
| Zhao, M | 1 |
| Wan, W | 1 |
| Zhang, S | 1 |
| Wu, X | 1 |
| Xu, J | 1 |
| Das, B | 2 |
| Dash, SR | 1 |
| Patel, H | 1 |
| Sinha, S | 1 |
| Bhal, S | 1 |
| Paul, S | 1 |
| Das, C | 1 |
| Pradhan, R | 1 |
| Ahmed, I | 1 |
| Goutam, K | 1 |
| Kundu, CN | 5 |
| Chatterjee, S | 1 |
| Kulkarni, NS | 1 |
| Vaidya, B | 1 |
| Parvathaneni, V | 1 |
| Bhanja, D | 1 |
| Gupta, V | 1 |
| Satapathy, SR | 2 |
| Nayak, A | 2 |
| Siddharth, S | 2 |
| Das, S | 1 |
| Nayak, D | 1 |
| Yan, H | 1 |
| Bian, A | 1 |
| Gao, X | 1 |
| Li, H | 1 |
| Chen, Z | 1 |
| Liu, X | 1 |
| Lobo, MR | 1 |
| Green, SC | 1 |
| Schabel, MC | 1 |
| Gillespie, GY | 1 |
| Woltjer, RL | 1 |
| Pike, MM | 1 |
| Das, D | 1 |
| Illanes, J | 1 |
| Dabancens, A | 1 |
| Acuña, O | 1 |
| Fuenzalida, M | 1 |
| Guerrero, A | 1 |
| Lopez, C | 1 |
| Lemus, D | 1 |
1 review available for quinacrine and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle.
Topics: Antimalarials; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; DNA, Neoplasm; Dru | 2021 |
9 other studies available for quinacrine and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Quinacrine is active in preclinical models of glioblastoma through suppressing angiogenesis, inducing oxidative stress and activating AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glioblastom | 2022 |
Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Cell Line, Tumor | 2023 |
Nanoformulated quinacrine regulates NECTIN-4 domain specific functions in cervical cancer stem cells.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Antineoplastic Agents; Cell Adhesion Molecules; | 2020 |
Repurposing Quinacrine for Treatment of Malignant Mesothelioma: In-Vitro Therapeutic and Mechanistic Evaluation.
Topics: Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Drug Repositioning; Humans; In | 2020 |
Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Cytokines; Gene Ex | 2018 |
Novel applications for an established antimalarial drug: tumoricidal activity of quinacrine.
Topics: Animals; Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell C | 2018 |
Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Blotting, Western; Capil | 2013 |
Enhancement of Cytotoxicity and Inhibition of Angiogenesis in Oral Cancer Stem Cells by a Hybrid Nanoparticle of Bioactive Quinacrine and Silver: Implication of Base Excision Repair Cascade.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Chick Embryo; Chorioallantoic Membran | 2015 |
Effects of betamethasone, sulindac and quinacrine drugs on the inflammatory neoangiogenesis response induced by polyurethane sponge implanted in mouse.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Betamethasone; Cyclooxygenase 1; Cycloo | 2002 |