quinacrine has been researched along with Amyloid Deposits in 2 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine was then administered to adult 5XFAD transgenic mice via weekly intravenous injections for 6 weeks, and we found a significant reduction of Aβ plaques and astrocytosis in their cortex and hippocampus." | 1.62 | Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer's disease. ( Kim, HY; Kim, Y; Oh, HA; Park, IW; Park, S; Shin, J; Woo, DH; Yoon, S, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, S | 1 |
| Kim, HY | 1 |
| Oh, HA | 1 |
| Shin, J | 1 |
| Park, IW | 1 |
| Yoon, S | 1 |
| Woo, DH | 1 |
| Kim, Y | 1 |
| Kumar, M | 1 |
| Sarkar, N | 1 |
| Dubey, VK | 1 |
2 other studies available for quinacrine and Amyloid Deposits
| Article | Year |
|---|---|
Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Humans; Mice; Mice, Trans | 2021 |
Evaluating quinacrine as a potential amyloid imaging compound: studies on hen egg white lysozyme as model system.
Topics: Amyloidogenic Proteins; Animals; Chickens; Contrast Media; Humans; Microscopy, Atomic Force; Muramid | 2012 |