quinacrine has been researched along with Alzheimer Disease in 4 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinacrine was then administered to adult 5XFAD transgenic mice via weekly intravenous injections for 6 weeks, and we found a significant reduction of Aβ plaques and astrocytosis in their cortex and hippocampus." | 1.62 | Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer's disease. ( Kim, HY; Kim, Y; Oh, HA; Park, IW; Park, S; Shin, J; Woo, DH; Yoon, S, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tasso, B | 1 |
| Catto, M | 1 |
| Nicolotti, O | 1 |
| Novelli, F | 1 |
| Tonelli, M | 1 |
| Giangreco, I | 1 |
| Pisani, L | 1 |
| Sparatore, A | 1 |
| Boido, V | 1 |
| Carotti, A | 1 |
| Sparatore, F | 1 |
| Park, S | 1 |
| Kim, HY | 1 |
| Oh, HA | 1 |
| Shin, J | 1 |
| Park, IW | 1 |
| Yoon, S | 1 |
| Woo, DH | 1 |
| Kim, Y | 1 |
| Dolphin, GT | 1 |
| Chierici, S | 1 |
| Ouberai, M | 1 |
| Dumy, P | 1 |
| Garcia, J | 1 |
| Lockhart, BP | 1 |
| Benicourt, C | 1 |
| Junien, JL | 1 |
| Privat, A | 1 |
4 other studies available for quinacrine and Alzheimer Disease
| Article | Year |
|---|---|
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cattle; Cholinesterase Inhi | 2011 |
Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Humans; Mice; Mice, Trans | 2021 |
A multimeric quinacrine conjugate as a potential inhibitor of Alzheimer's beta-amyloid fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Drug Des | 2008 |
Inhibitors of free radical formation fail to attenuate direct beta-amyloid25-35 peptide-mediated neurotoxicity in rat hippocampal cultures.
Topics: Allopurinol; Alzheimer Disease; Amino Acid Oxidoreductases; Amyloid beta-Peptides; Animals; Arginine | 1994 |