quinacrine has been researched along with African Sleeping Sickness in 3 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compound was orally bioavailable and displayed good plasma and brain exposure in mice." | 1.40 | Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis. ( Brun, R; Buckner, FS; Chatterjee, AK; Creason, SA; Duster, NA; Gelb, MH; Gillespie, JR; Glynne, R; Hulverson, MA; McQueen, J; Molteni, V; Nagendar, P; Nagle, A; Norcross, NR; Ranade, RM; Supek, F; Tatipaka, HB; Wenzler, T, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tatipaka, HB | 1 |
| Gillespie, JR | 2 |
| Chatterjee, AK | 1 |
| Norcross, NR | 1 |
| Hulverson, MA | 2 |
| Ranade, RM | 2 |
| Nagendar, P | 1 |
| Creason, SA | 2 |
| McQueen, J | 2 |
| Duster, NA | 1 |
| Nagle, A | 1 |
| Supek, F | 1 |
| Molteni, V | 1 |
| Wenzler, T | 1 |
| Brun, R | 1 |
| Glynne, R | 1 |
| Buckner, FS | 2 |
| Gelb, MH | 2 |
| Patrick, DA | 1 |
| Herbst, ZM | 1 |
| Tidwell, RR | 1 |
| Klein, P | 1 |
3 other studies available for quinacrine and African Sleeping Sickness
| Article | Year |
|---|---|
Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.
Topics: Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Cell Membrane Permeability | 2014 |
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.
Topics: Benzothiazoles; Humans; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Ur | 2017 |
[On the ideological history of the early period of chemotherapy].
Topics: Animals; Arsphenamine; Birds; Drug Therapy; History, 20th Century; Humans; Malaria; Malaria, Avian; | 1966 |