quinacrine has been researched along with Acute Respiratory Distress Syndrome in 2 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A good model of the adult respiratory distress syndrome (ARDS) is intravenously injected phorbol myristate acetate (PMA), which causes pulmonary sequestration of neutrophils and a neutrophil-dependent acute edematous lung injury in rabbits." | 1.27 | Mepacrine but not methylprednisolone decreases acute edematous lung injury after injection of phorbol myristate acetate in rabbits. ( Canham, EM; Harada, RN; McMurtry, IF; Repine, JE; Shoemaker, SA; Tate, RM, 1983) |
| "Peritonitis has been produced in rabbits by the spreading of 5 ml of caecal contents throughout the peritoneal cavity." | 1.27 | A phospholipase inhibitor modifies the pulmonary damage associated with peritonitis in rabbits. ( Bennett, ED; Hynd, J; Moss, R; Parker-Williams, J; Tighe, D, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Canham, EM | 1 |
| Shoemaker, SA | 1 |
| Tate, RM | 1 |
| Harada, RN | 1 |
| McMurtry, IF | 1 |
| Repine, JE | 1 |
| Tighe, D | 1 |
| Moss, R | 1 |
| Parker-Williams, J | 1 |
| Hynd, J | 1 |
| Bennett, ED | 1 |
2 other studies available for quinacrine and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
Mepacrine but not methylprednisolone decreases acute edematous lung injury after injection of phorbol myristate acetate in rabbits.
Topics: Animals; Lung; Methylprednisolone; Neutrophils; Phorbols; Premedication; Pulmonary Edema; Quinacrine | 1983 |
A phospholipase inhibitor modifies the pulmonary damage associated with peritonitis in rabbits.
Topics: Animals; Disease Models, Animal; Lung; Microscopy, Electron; Peritonitis; Phospholipases; Quinacrine | 1987 |