quinacrine has been researched along with Acute Myelogenous Leukemia in 8 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 16 treated patients with acute myelogenous leukemia and a normal karyotype, 11 (69 per cent) had a complete remission and a median survival of 13 months." | 1.26 | Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia: an eight-year study (1970-1977). ( Golomb, HM; Mintz, U; Rowley, JD; Testa, JR; Vardiman, JW, 1978) |
| "Macrothrombocytosis was observed in most of the cases of AML, was rare in AGL and was never found in ALL." | 1.26 | Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia. ( Boneu, B; Capdeville, J; Caranobe, C; Nouvel, C; Pris, J; Sie, P, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eriksson, A | 2 |
| Chantzi, E | 1 |
| Fryknäs, M | 2 |
| Gullbo, J | 2 |
| Nygren, P | 2 |
| Gustafsson, M | 1 |
| Höglund, M | 2 |
| Larsson, R | 2 |
| Österroos, A | 1 |
| Hassan, S | 1 |
| Rickardson, L | 1 |
| Jarvius, M | 1 |
| Testa, U | 1 |
| Pelicci, PG | 1 |
| Thomopoulos, P | 1 |
| Titeux, M | 1 |
| Rochant, H | 1 |
| Ferrante, A | 1 |
| Goh, DH | 1 |
| Golomb, HM | 1 |
| Vardiman, JW | 1 |
| Rowley, JD | 2 |
| Testa, JR | 1 |
| Mintz, U | 1 |
| Nouvel, C | 1 |
| Caranobe, C | 1 |
| Sie, P | 1 |
| Capdeville, J | 1 |
| Pris, J | 1 |
| Boneu, B | 1 |
| Hellriegel, KP | 1 |
| Borberg, H | 1 |
| Reitz, H | 1 |
| Gross, R | 1 |
8 other studies available for quinacrine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Cytarabine; | 2017 |
Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia, Myeloid, Acu | 2015 |
The number of the Trf receptors on human hematopoietic cell lines is influenced by membrane phospholipids.
Topics: Acetophenones; Cell Line; Cell Membrane; Humans; Kinetics; Leukemia, Myeloid, Acute; Membrane Lipids | 1983 |
The effect of anti-malarial drugs on human natural killer cells in vitro.
Topics: Antimalarials; Cell Line; Chloroquine; Cytotoxicity, Immunologic; Humans; Killer Cells, Natural; Leu | 1984 |
Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia: an eight-year study (1970-1977).
Topics: Adolescent; Adult; Aged; Chromosome Aberrations; Female; Humans; Leukemia, Monocytic, Acute; Leukemi | 1978 |
Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia.
Topics: Blood Cell Count; Blood Platelets; Cytoplasmic Granules; Humans; Leukemia; Leukemia, Lymphoid; Leuke | 1978 |
Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.
Topics: Adult; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 6-12 and X; Fema | 1973 |
Evaluation of the efficiency of leukocyte transfers by Y-chromatin studies.
Topics: ABO Blood-Group System; Adult; Agranulocytosis; Female; Histocompatibility Testing; Humans; Leukemia | 1974 |