quetiapine-fumarate and Rhabdomyolysis

Topics: Acute Disease; Acute Kidney Injury; Adult; Antipsychotic Agents; Brachial Plexus Neuropathies; Compartment Syndromes; Creatine Kinase; Deltoid Muscle; Fasciotomy; Humans; Male; Myositis; Pectoralis Muscles; Quetiapine Fumarate; Rhabdomyolysis; Tomography Scanners, X-Ray Computed; Treatment Outcome

Rhabdomyolysis is a potential complication of psychotropic drugs use and may potentially lead to life-threatening complications, such as an acute renal failure. We describe the case of a 40-year-old military soldier suffering from post-traumatic stress disorder was admitted for an adaptation of his treatment. Mirtazapine was introduced and quetiapine increased. Two days later, the patient presented with severe rhabdomyolysis syndrome. Mirtazapine administration was paused and intravenous hydration commenced. Shortly after the creatine kinase levels decreased enabling mirtazapine to be reintroduced without complication. It is our opinion that 5-hydroxytryptamine 2a serotonergic receptors inhibition (related to mirtazapine and quetiapine) associated with muscle training was responsible for inducing rhabdomyolysis. This must be kept in mind when psychotropic medications are adjusted, especially in an athletic population such as military.

Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; France; Humans; Male; Mianserin; Military Personnel; Mirtazapine; Quetiapine Fumarate; Rhabdomyolysis; Stress Disorders, Post-Traumatic

Topics: Antipsychotic Agents; Dibenzothiazepines; Humans; Male; Middle Aged; Quetiapine Fumarate; Rhabdomyolysis

Topics: Aged; Antipsychotic Agents; Dibenzothiazepines; Humans; Male; Parkinson Disease; Psychoses, Substance-Induced; Quetiapine Fumarate; Rhabdomyolysis

Topics: Adult; Antipsychotic Agents; Dibenzothiazepines; Drug Overdose; Humans; Male; Quetiapine Fumarate; Rhabdomyolysis; Suicide, Attempted

Topics: Adult; Antipsychotic Agents; Creatine Kinase; Dibenzothiazepines; Drug Overdose; Humans; Male; Quetiapine Fumarate; Rhabdomyolysis; Schizophrenia

Topics: Adult; Alanine Transaminase; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Aspartate Aminotransferases; Creatine Kinase; Depression; Dibenzothiazepines; Drug Therapy, Combination; Female; Fluoxetine; Humans; Quetiapine Fumarate; Rhabdomyolysis

Topics: Adult; Dibenzothiazepines; Drug Overdose; Humans; Male; Quetiapine Fumarate; Rhabdomyolysis

Young onset Parkinson's disease (YOPD) is defined as idiopathic Parkinson's disease (IPPD) occurring in people between 21 and 40 years of age; it strikes approximately 5% of Parkinson's patients. YOPD has earlier onset of motor complications than later onset Parkinson's disease. Motor complications and disease progression are responsible for devastating morbidity. Current medical and surgical treatments can dramatically ameliorate motor complications and help maintain function and employment. Patient education, support, and advocacy provided by nursing staff can influence the treatment options for these patients, having a significant effect on the future course of the disease. This case history documents the course of a YOPD patient with unusually severe motor complications. He is the only patient at Puget Sound Neurology ever to develop rhabdomyolysis due to dyskinesias. Following bilateral subthalamic nucleus deep brain stimulation, his Parkinson's symptoms have improved dramatically, and his motor complications are significantly improved.

Topics: Activities of Daily Living; Adult; Age of Onset; Amantadine; Antiparkinson Agents; Carbidopa; Combined Modality Therapy; Deep Brain Stimulation; Dibenzothiazepines; Disease Progression; Dyskinesias; Humans; Levodopa; Male; Motor Skills; Nurse's Role; Parkinson Disease; Patient Advocacy; Patient Education as Topic; Quality of Life; Quetiapine Fumarate; Rhabdomyolysis; Severity of Illness Index; Social Support; Treatment Outcome