quetiapine-fumarate and Hyperventilation

Quetiapine is an atypical antipsychotic with favorable properties in the treatment of bipolar disorder, but it has recently been associated with respiratory dysfunction.. In this case report, we describe a patient who developed quetiapine-induced hyperventilation and dyspnea after being treated with quetiapine.. To our knowledge, this is the first case presented with quetiapine-induced hyperventilation in a patient with bipolar disorder.. We recommend a quick reduction of the quetiapine dosage and a change to an alternative antipsychotic for patients treated with quetiapine, who report such respiratory symptoms without a somatic cause for the symptoms.

Topics: Aged; Antipsychotic Agents; Bipolar Disorder; Dibenzothiazepines; Dyspnea; Humans; Hyperventilation; Male; Quetiapine Fumarate; Respiratory Rate

To describe a case of hyperventilation associated with the administration of quetiapine.. A 69-year-old African-American woman admitted to a psychiatric hospital for treatment of major depression with psychotic features was treated and successfully discharged with quetiapine, along with metronidazole and miconazole to treat bacterial/monilial vaginitis. Three days after discharge, the patient presented to a community hospital with shortness of breath and hyperventilation. The patient was admitted and treated for tachypnea and acute respiratory alkalosis. During this hospitalization, the patient was noted to have increased respiratory rate following the administration of quetiapine.. Hyperventilation was reported during the clinical trials of quetiapine; however, this is the first published report to date. Serotonin is involved both centrally and peripherally in the regulation of respiration. A contributing factor in this case may have been the concomitant administration of metronidazole, which inhibits the cytochrome P450 enzyme (CYP3A4) also responsible for the metabolism of quetiapine.. The development of hyperventilation and respiratory alkalosis was associated with the administration of quetiapine.

Topics: Aged; Alkalosis, Respiratory; Antipsychotic Agents; Antitrichomonal Agents; Depressive Disorder; Dibenzothiazepines; Drug Interactions; Female; Humans; Hyperventilation; Metronidazole; Quetiapine Fumarate