quetiapine-fumarate and Granuloma

Lesion-based investigations of psychopathology have preceded contemporary network-neuroscience initiatives. However, brain-lesions detected in routine psychiatric practice are often considered incidental and therefore ignored. Here, we illustrate a strategy to combine individual subject-level lesion information with open-source normative functional-connectomics data to make putative, neuroscience-informed symptom interpretation. Specifically, we report a patient with left precuneus granulomatous lesion and seizures followed by two distinct symptoms - kinetopsia and delusions of nihilism and guilt - which had a differential treatment response. The lesion-based brain-mapping approach could identify correlated (default-mode) and anti-correlated (temporo-parieto-occipital) networks, which enabled a neurobiological formulation of these diverse clinical manifestations.

Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Brain Mapping; Brain Neoplasms; Depressive Disorder, Major; Diagnosis, Differential; Electroconvulsive Therapy; Female; Fluoxetine; Granuloma; Humans; Magnetic Resonance Imaging; Middle Aged; Parietal Lobe; Phenytoin; Quetiapine Fumarate; Schizophrenia, Paranoid; Seizures

Topics: Antipsychotic Agents; Drug Eruptions; Granuloma; Humans; Male; Middle Aged; Quetiapine Fumarate; Torso