quetiapine-fumarate and Cholestasis--Intrahepatic

A case of intrahepatic cholestasis secondary to treatment with quetiapine in combination with lamotrigine and zopiclone, resulting in severe hypercholesterolaemia without overt lactescence of the plasma, is presented. Abundant lipoprotein-X was seen on lipoprotein electrophoresis. The patient was diagnosed and treated for hyponatraemia which was likely factitious and caused by hypercholesterolaemia. Cholestasis and hypercholesterolaemia resolved over a period of several months after the discontinuation of quetiapine.

Topics: Adult; Antipsychotic Agents; Cholestasis, Intrahepatic; Dibenzothiazepines; Humans; Hypercholesterolemia; Hyponatremia; Lipoprotein-X; Male; Quetiapine Fumarate

Drug hepatotoxicity is the most common cause of fulminant hepatic failure in the USA. We describe a rare case of a patient who developed an acute liver injury after initiation of therapy with quetiapine, but after conservative management and a trial of steroids, has fully recovered. This is the second reported case of quetiapine-induced liver injury in the published literature.

Topics: Acute Disease; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dibenzothiazepines; Humans; Male; Quetiapine Fumarate; Young Adult