quetiapine-fumarate and Cerebral-Infarction

We investigated the change of antipsychotic treatment of elderly persons with dementia after several publications indicated an association between use of antipsychotics and cerebrovascular events in this population.. Twice a year, the complete medication, age, diagnosis and gender of all inpatients in 30 German psychiatric sites is collected anonymously in a data base for statistical analysis.. The treatment changed for the benefit of Quetiapine and Haloperidol. The use of both Risperidone and Olanzapine decreased markedly.. The antipsychotic treatment changed due to critical publication. But, the evidence for the risk profile is still a matter of debate.

Topics: Adverse Drug Reaction Reporting Systems; Aged; Alzheimer Disease; Antipsychotic Agents; Cerebral Infarction; Dibenzothiazepines; Drug Therapy, Combination; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; Evidence-Based Medicine; Female; Germany; Humans; Male; Practice Patterns, Physicians'; Publication Bias; Quetiapine Fumarate; Risk; Risperidone