quercetin-3-o-methyl-ether and Disease-Models--Animal

quercetin-3-o-methyl-ether has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for quercetin-3-o-methyl-ether and Disease-Models--Animal

Article	Year
Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects. Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15 Reactive oxygen species have been implicated in several diseases, particularly in ischemia-reperfusion injury. Quercetin 3-O-methyl ether has been reported to show potent antioxidant and neuroprotective activity against neuronal damage induced by reactive oxygen species. Several aminoethyl-substituted derivatives of quercetin 3-O-methyl ether have been synthesized to increase water solubility while retaining antioxidant and neuroprotective activity. Among such derivatives, compound 3a shows potent and well-balanced antioxidant activity in three types of cell-free assay systems and has in vivo neuroprotective effects on transient focal ischemic injury induced by the occlusion of the middle cerebral artery in rats. Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Neuroprotective Agents; Quercetin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Structure-Activity Relationship	2015

Article

Year

Synthesis of (2-amino)ethyl derivatives of quercetin 3-O-methyl ether and their antioxidant and neuroprotective effects.

Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

Reactive oxygen species have been implicated in several diseases, particularly in ischemia-reperfusion injury. Quercetin 3-O-methyl ether has been reported to show potent antioxidant and neuroprotective activity against neuronal damage induced by reactive oxygen species. Several aminoethyl-substituted derivatives of quercetin 3-O-methyl ether have been synthesized to increase water solubility while retaining antioxidant and neuroprotective activity. Among such derivatives, compound 3a shows potent and well-balanced antioxidant activity in three types of cell-free assay systems and has in vivo neuroprotective effects on transient focal ischemic injury induced by the occlusion of the middle cerebral artery in rats.

Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Neuroprotective Agents; Quercetin; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Structure-Activity Relationship

2015