quercetin-3-o-glucuronide and Gastritis

The mechanism of the protective effect of quercetin-3-O-β-D-glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.

Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Gastric Mucosa; Gastritis; Indomethacin; Intercellular Adhesion Molecule-1; Interleukin-1beta; Male; Mucus; Peroxidase; Plant Leaves; Quercetin; Rats; Rats, Sprague-Dawley; Rumex; Stomach Ulcer; Tumor Necrosis Factor-alpha