quercetin-3-o-glucuronide and Arteriosclerosis

quercetin-3-o-glucuronide has been researched along with Arteriosclerosis* in 2 studies

Reviews

1 review(s) available for quercetin-3-o-glucuronide and Arteriosclerosis

ArticleYear
Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis.
    Journal of pharmacological sciences, 2011, Volume: 115, Issue:4

    Quercetin, a member of the bioflavonoids family, has been proposed to have anti-atherogenic, anti-inflammatory, and anti-hypertensive properties leading to the beneficial effects against cardiovascular diseases. It was recently demonstrated that quercetin 3-O-β-D-glucuronide (Q3GA) is one of the major quercetin conjugates in human plasma, in which the aglycone could not be detected. Although most of the in vitro pharmacological studies have been carried out using only the quercetin aglycone form, experiments using Q3GA would be important to discover the preventive mechanisms of cardiovascular diseases by quercetin in vivo. Therefore we examined the effects of the chemically synthesized Q3GA, as an in vivo form, on vascular smooth muscle cell (VSMC) disorders related to the progression of arteriosclerosis. Platelet-derived growth factor-induced cell migration and proliferation were inhibited by Q3GA in VSMCs. Q3GA attenuated angiotensin II-induced VSMC hypertrophy via its inhibitory effect on JNK and the AP-1 signaling pathway. Q3GA scavenged 1,1-diphenyl-2-picrylhydrazyl radical measured by the electron paramagnetic resonance method. In addition, immunohistochemical studies with monoclonal antibody 14A2 targeting the Q3GA demonstrated that the positive staining specifically accumulates in human atherosclerotic lesions, but not in the normal aorta. These findings suggest Q3GA would be an active metabolite of quercetin in plasma and may have preventative effects on arteriosclerosis relevant to VSMC disorders.

    Topics: Animals; Antioxidants; Arteriosclerosis; Cell Movement; Cell Proliferation; Drug Evaluation, Preclinical; Food, Organic; Free Radicals; Humans; Hypertrophy; Muscle, Smooth, Vascular; Quercetin; Signal Transduction

2011

Other Studies

1 other study(ies) available for quercetin-3-o-glucuronide and Arteriosclerosis

ArticleYear
Quercetin-3-O-glucuronide induces ABCA1 expression by LXRα activation in murine macrophages.
    Biochemical and biophysical research communications, 2013, Nov-29, Volume: 441, Issue:4

    Reverse cholesterol transport (RCT) removes excess cholesterol from macrophages to prevent atherosclerosis. ATP-binding cassette, subfamily A, member 1 (ABCA1) is a crucial cholesterol transporter involved in RCT to produce high density lipoprotein-cholesterol (HDLC), and is transcriptionally regulated by liver X receptor alpha (LXRα), a nuclear receptor. Quercetin is a widely distributed flavonoid in edible plants which prevented atherosclerosis in an animal model. We found that quercetin-3-O-glucuronide (Q3GA), a major quercetin metabolite after absorption from the digestive tract, enhanced ABCA1 expression, in vitro, via LXRα in macrophages. In addition, leaf extracts of a traditional Asian edible plant, Nelumbo nucifera (NNE), which contained abundant amounts of quercetin glycosides, significantly elevated plasma HDLC in mice. We are the first to present experimental evidence that Q3GA induced ABCA1 in macrophages, and to provide an alternative explanation to previous studies on arteriosclerosis prevention by quercetin.

    Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; ATP Binding Cassette Transporter 1; Biological Transport; Cholesterol; Flavonoids; Ligands; Liver X Receptors; Macrophages; Mice; Nelumbo; Orphan Nuclear Receptors; Plant Extracts; Quercetin

2013