quercetin-3-o-glucopyranoside and Leukemia

The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O-β-glucopyranosyl-β-sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6ꞌꞌ-O-galloyl)-β-d-glucopyranoside (8) and quercetin-3-O-β-d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC

Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Eugenia; Flavonoids; Galactosides; Humans; Inhibitory Concentration 50; Leukemia; Magnetic Resonance Spectroscopy; Oleanolic Acid; Plant Bark; Plant Extracts; Plant Leaves; Quercetin