pyruvic acid has been researched along with Ventricular Dysfunction, Left in 6 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of L-propionylcarnitine on patients with left ventricular dysfunction (EF < 45%) NYHA class II, symptomatic despite therapy with digitalis and diuretics was evaluated in a phase II parallel, double-blind, randomized, placebo-controlled study." | 9.07 | Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. ( Brunelli, C; Canale, C; Caponnetto, S; Masperone, MA; Terracchini, V; Valentini, G, 1994) |
| "The effect of L-propionylcarnitine on patients with left ventricular dysfunction (EF < 45%) NYHA class II, symptomatic despite therapy with digitalis and diuretics was evaluated in a phase II parallel, double-blind, randomized, placebo-controlled study." | 5.07 | Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. ( Brunelli, C; Canale, C; Caponnetto, S; Masperone, MA; Terracchini, V; Valentini, G, 1994) |
| " The results suggested that metabolic products of fatty acid oxidation and glucose oxidation pathways such as oleic acid, stearic acid, palmitic acid, linoleic acid, galactose, pyruvic and lactic acids are predominantly up regulated in patients with coronary artery disease and severity of diastolic dysfunction appears to be linked to increase in fatty acid oxidation and inflammation." | 3.91 | Untargeted metabolomic analysis of coronary artery disease patients with diastolic dysfunction show disturbed oxidative pathway. ( Basir, N; Bokhari, SS; Fatima, T; Hashmi, S; Iqbal, A; Musharraf, SG; Sami, SA; Sharif, H; Siddiqui, AJ, 2019) |
| "Mouse models of sepsis have likewise demonstrated that the absence of PPARα is associated with decreased survival and organ injury, specifically of the heart." | 1.46 | PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis. ( Bennion, BG; Knowles, TO; Ledee, DR; Liles, WC; McGuire, JK; Olson, AK; Portman, MA; Standage, SW, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hiraki, N | 1 |
| Tanaka, TD | 1 |
| Yoshimura, M | 1 |
| Fatima, T | 1 |
| Hashmi, S | 1 |
| Iqbal, A | 1 |
| Siddiqui, AJ | 1 |
| Sami, SA | 1 |
| Basir, N | 1 |
| Bokhari, SS | 1 |
| Sharif, H | 1 |
| Musharraf, SG | 1 |
| Standage, SW | 1 |
| Bennion, BG | 1 |
| Knowles, TO | 1 |
| Ledee, DR | 1 |
| Portman, MA | 1 |
| McGuire, JK | 1 |
| Liles, WC | 1 |
| Olson, AK | 1 |
| Nakajima, J | 1 |
| Bessho, M | 1 |
| Adachi, T | 1 |
| Yamagishi, T | 1 |
| Tokuno, S | 1 |
| Horinouchi, H | 1 |
| Ohsuzu, F | 1 |
| Schroeder, MA | 1 |
| Lau, AZ | 1 |
| Chen, AP | 1 |
| Gu, Y | 1 |
| Nagendran, J | 1 |
| Barry, J | 1 |
| Hu, X | 1 |
| Dyck, JR | 1 |
| Tyler, DJ | 1 |
| Clarke, K | 1 |
| Connelly, KA | 1 |
| Wright, GA | 1 |
| Cunningham, CH | 1 |
| Caponnetto, S | 1 |
| Canale, C | 1 |
| Masperone, MA | 1 |
| Terracchini, V | 1 |
| Valentini, G | 1 |
| Brunelli, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hyperpolarized MRSI in Ischemic Heart Disease: Metabolic Profiling of the Myocardium[NCT06054516] | 15 participants (Anticipated) | Observational | 2023-10-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pyruvic acid and Ventricular Dysfunction, Left
| Article | Year |
|---|---|
Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction.
Topics: Adult; Aged; Cardiotonic Agents; Carnitine; Double-Blind Method; Echocardiography, Doppler; Exercise | 1994 |
5 other studies available for pyruvic acid and Ventricular Dysfunction, Left
| Article | Year |
|---|---|
A Man With Left Ventricular Hypertrophy.
Topics: Adult; Atrophy; Cardiomyopathies; Cerebellar Diseases; Cognitive Dysfunction; Echocardiography; Gluc | 2022 |
Untargeted metabolomic analysis of coronary artery disease patients with diastolic dysfunction show disturbed oxidative pathway.
Topics: Adult; Biomarkers; Case-Control Studies; Coronary Artery Disease; Discriminant Analysis; Fatty Acids | 2019 |
PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis.
Topics: Animals; Blotting, Western; Carbon Isotopes; Cecum; Citric Acid Cycle; Echocardiography; Fatty Acids | 2017 |
Hemoglobin vesicle improves recovery of cardiac function after ischemia-reperfusion by attenuating oxidative stress in isolated rat hearts.
Topics: Animals; Blood Substitutes; Catalase; Coronary Circulation; Glutathione; Glutathione Disulfide; Glut | 2011 |
Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.
Topics: Adenosine Triphosphate; Animals; Bicarbonates; Carbon Isotopes; Cardiac Pacing, Artificial; Cardiac | 2013 |