pyruvic acid has been researched along with Triple Negative Breast Neoplasms in 3 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Triple Negative Breast Neoplasms: Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| " CB-839 is a potent, selective, orally bioavailable inhibitor of glutaminase that has activity in Triple receptor-Negative Breast Cancer (TNBC) cell lines and evidence of efficacy in advanced TNBC patients." | 1.56 | Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer. ( Baguley, BC; Dechaume, AL; Katt, WP; Leung, EY; Murray, PM; Singleton, DC, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Singleton, DC | 1 |
| Dechaume, AL | 1 |
| Murray, PM | 1 |
| Katt, WP | 1 |
| Baguley, BC | 1 |
| Leung, EY | 1 |
| Vande Voorde, J | 1 |
| Ackermann, T | 1 |
| Pfetzer, N | 1 |
| Sumpton, D | 1 |
| Mackay, G | 1 |
| Kalna, G | 1 |
| Nixon, C | 1 |
| Blyth, K | 1 |
| Gottlieb, E | 1 |
| Tardito, S | 1 |
| Bizjak, M | 1 |
| Malavašič, P | 1 |
| Pirkmajer, S | 1 |
| Pavlin, M | 1 |
3 other studies available for pyruvic acid and Triple Negative Breast Neoplasms
| Article | Year |
|---|---|
Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer.
Topics: Benzeneacetamides; Cell Proliferation; Drug Resistance, Neoplasm; Female; Glutaminase; Glutamine; Hu | 2020 |
Improving the metabolic fidelity of cancer models with a physiological cell culture medium.
Topics: Arginine; Argininosuccinate Lyase; Cell Line, Tumor; Cell Proliferation; Culture Media; Female; Ferr | 2019 |
Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations.
Topics: AMP-Activated Protein Kinases; Cell Culture Techniques; Cell Survival; Enzyme Activation; Female; Gl | 2019 |