pyruvic acid has been researched along with Stroke in 15 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The long-term effects of the sodium salt of dichloroacetic acid (DCA) were evaluated in four patients with mitochondrial encephalomyelopathy with lactic acidosis and stroke-like episodes (MELAS) carrying A3243G mutation." | 5.11 | Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. ( Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T, 2004) |
| " The authors' goal was to characterize patterns of markers of energy metabolism (glucose, pyruvate, and lactate) and neuronal injury (glutamate and glycerol) in patients with subarachnoid hemorrhage (SAH), in whom ischemia was or was not suspected." | 5.09 | Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Schulz, MK; Tange, M; Wang, LP, 2000) |
| "Increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population." | 4.12 | Related factors based on non-targeted metabolomics methods in minor ischaemic stroke. ( Chen, C; Ding, L; Guo, J; Liu, H; Ma, Y; Qiao, X; Wang, J; Wang, M; Yang, T; Zhao, S, 2022) |
| "Both stroke and depression have independently been associated with pathologically elevated glutamate levels in the brain's extra-cerebral fluid (ECF)." | 1.51 | The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach. ( Boyko, M; Brotfain, E; Frank, D; Grinshpun, Y; Gruenbaum, BF; Kuts, R; Natanel, D; Shelef, I; Tsenter, P; Zlotnik, A; Zvenigorodsky, V, 2019) |
| "Children with MELAS had various clinical manifestations." | 1.39 | [Clinical, pathological and molecular biological characteristics of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episode in children]. ( Bao, XH; Chang, XZ; Liu, XL; Ma, YN; Qin, J; Wu, XR, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, C | 1 |
| Qiao, X | 1 |
| Guo, J | 1 |
| Yang, T | 1 |
| Wang, M | 1 |
| Ma, Y | 1 |
| Zhao, S | 1 |
| Ding, L | 1 |
| Liu, H | 1 |
| Wang, J | 1 |
| Li, F | 3 |
| Geng, X | 3 |
| Ilagan, R | 3 |
| Bai, S | 3 |
| Chen, Y | 4 |
| Ding, Y | 3 |
| Hyacinthe, JN | 1 |
| Buscemi, L | 1 |
| Lê, TP | 1 |
| Lepore, M | 1 |
| Hirt, L | 1 |
| Mishkovsky, M | 1 |
| Pinczolits, A | 2 |
| Zdunczyk, A | 1 |
| Dengler, NF | 1 |
| Hecht, N | 2 |
| Kowoll, CM | 1 |
| Dohmen, C | 1 |
| Graf, R | 1 |
| Winkler, MK | 1 |
| Major, S | 1 |
| Hartings, JA | 1 |
| Dreier, JP | 2 |
| Vajkoczy, P | 2 |
| Woitzik, J | 2 |
| Frank, D | 1 |
| Kuts, R | 1 |
| Tsenter, P | 1 |
| Gruenbaum, BF | 1 |
| Grinshpun, Y | 1 |
| Zvenigorodsky, V | 1 |
| Shelef, I | 1 |
| Natanel, D | 1 |
| Brotfain, E | 1 |
| Zlotnik, A | 1 |
| Boyko, M | 1 |
| Liu, XL | 1 |
| Bao, XH | 1 |
| Ma, YN | 1 |
| Chang, XZ | 1 |
| Qin, J | 1 |
| Wu, XR | 1 |
| Baxter, P | 1 |
| Xu, Y | 1 |
| Swanson, RA | 1 |
| Sandow, N | 1 |
| Scheel, M | 1 |
| Drenckhahn, C | 1 |
| Wang, P | 1 |
| Li, L | 1 |
| Zhang, Z | 1 |
| Kan, Q | 1 |
| Chen, S | 1 |
| Gao, F | 1 |
| Helbok, R | 1 |
| Kurtz, P | 1 |
| Schmidt, JM | 1 |
| Stuart, RM | 1 |
| Fernandez, L | 1 |
| Malhotra, R | 1 |
| Presciutti, M | 1 |
| Ostapkovich, ND | 1 |
| Connolly, ES | 1 |
| Lee, K | 1 |
| Badjatia, N | 1 |
| Mayer, SA | 1 |
| Claassen, J | 1 |
| Ryou, MG | 1 |
| Liu, R | 1 |
| Ren, M | 1 |
| Sun, J | 1 |
| Mallet, RT | 1 |
| Yang, SH | 1 |
| Tu, J | 1 |
| A, J | 1 |
| Wang, G | 1 |
| Wen, H | 1 |
| Wang, A | 1 |
| Di, L | 1 |
| Cao, B | 1 |
| Liu, L | 1 |
| Mori, M | 1 |
| Yamagata, T | 1 |
| Goto, T | 1 |
| Saito, S | 1 |
| Momoi, MY | 1 |
| Chen, CJ | 1 |
| Cheng, FC | 1 |
| Liao, SL | 1 |
| Chen, WY | 1 |
| Lin, NN | 1 |
| Kuo, JS | 1 |
| Schulz, MK | 1 |
| Wang, LP | 1 |
| Tange, M | 1 |
| Bjerre, P | 1 |
1 review available for pyruvic acid and Stroke
| Article | Year |
|---|---|
Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke.
Topics: Animals; Apoptosis; Disease Models, Animal; Humans; Mice; Mitochondria; Neuroprotective Agents; Poly | 2014 |
2 trials available for pyruvic acid and Stroke
| Article | Year |
|---|---|
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dic | 2004 |
Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Brain Death; Brain Ischemia; Cerebral Angiography; Extracellular Space; Glucose; | 2000 |
12 other studies available for pyruvic acid and Stroke
| Article | Year |
|---|---|
Related factors based on non-targeted metabolomics methods in minor ischaemic stroke.
Topics: Biomarkers; Blood Glucose; Brain Ischemia; C-Reactive Protein; Homocysteine; Humans; Hypertension; I | 2022 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
Standard-sampling microdialysis and spreading depolarizations in patients with malignant hemispheric stroke.
Topics: Cerebral Cortex; Cerebral Infarction; Cortical Spreading Depression; Electrocorticography; Female; G | 2017 |
The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach.
Topics: Animals; Depression; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Pyruvic Acid; Random A | 2019 |
[Clinical, pathological and molecular biological characteristics of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episode in children].
Topics: Acidosis, Lactic; Adolescent; Brain; Child; Child, Preschool; DNA Mutational Analysis; DNA, Mitochon | 2013 |
Excitotoxicity and metabolic changes in association with infarct progression.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Infarction; Disease Progression; Female; Glucose; Gl | 2014 |
Time-dependent homeostasis between glucose uptake and consumption in astrocytes exposed to CoCl₂ treatment.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; G | 2016 |
Effect of mannitol on brain metabolism and tissue oxygenation in severe haemorrhagic stroke.
Topics: Adult; Blood Pressure; Brain; Diuretics, Osmotic; Female; Glasgow Coma Scale; Glucose; Humans; Intra | 2011 |
Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway.
Topics: Animals; Brain; Cell Line, Tumor; Disease Models, Animal; Erythropoietin; Gene Expression Regulation | 2012 |
[Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets].
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Fructose; Glyceric Acids; Hydroxyproline; Lactic Aci | 2012 |
Effects of naloxone on lactate, pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain; Catalase; Energy Metabolism; Free Radicals; Glutathione Peroxidase; Is | 2000 |