pyruvic acid has been researched along with Sensitivity and Specificity in 85 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 7.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 3.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| "Thirteen subarachnoid hemorrhage patients (age, 48." | 2.71 | Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study. ( Amthauer, H; Haux, D; Küchler, I; Lüdemann, L; Plotkin, M; Sarrafzadeh, AS; Unterberg, AW, 2004) |
| "In severe aneurysmal subarachnoid hemorrhage (aSAH), pathological changes in cerebral energy metabolism can be detected either by local measurements using cerebral microdialysis (cMD) together with brain tissue oxygen probe or by global measurements of arterio-jugular difference performed with retrograde jugular vein catheter." | 1.42 | Biochemical neuromonitoring of poor-grade aneurysmal subarachnoid hemorrhage: comparative analysis of metabolic events detected by cerebral microdialysis and by retrograde jugular vein catheterization. ( Barcelos, GK; Dailler, F; Marinesco, S; Perret-Liaudet, A; Renaud, B; Tholance, Y, 2015) |
| "IP glycerol was only moderately indicative for ischemia after 91-120 minutes with 0,791 ROC AUCs (threshold 122 μmol/l)." | 1.39 | Validation of intraluminal and intraperitoneal microdialysis in ischemic small intestine. ( Minkkinen, M; Nordback, I; Perner, A; Pynnönen, L; Räty, S; Sand, J; Tenhunen, J, 2013) |
| "In the treatment of patients with aneurysmal subarachnoid hemorrhage (SAH), early occlusion of the aneurysm is necessary as well as monitoring and treatment of complications following the primary bleeding episode." | 1.32 | Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Kristensen, SR; Schulz, M; Skjøth-Rasmussen, J, 2004) |
| "Glycerol was progressively released during prolonged ischemia." | 1.31 | Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis. ( Bäckström, T; Franco-Cereceda, A; Liska, J; Lockowandt, U; Sylven, C, 2002) |
| " The method is rapid, precise, and lacks any toxic byproduct." | 1.30 | In vitro correlation between two colorimetric assays and the pyruvic acid consumption by fibroblasts cultured to determine the sodium laurylsulfate cytotoxicity. ( Coiffard, C; Coiffard, LJ; De Roeck-Holtzhauer, Y; Rivalland, P; Verhulst, C, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (9.41) | 18.2507 |
| 2000's | 27 (31.76) | 29.6817 |
| 2010's | 50 (58.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cameli, N | 1 |
| Mariano, M | 1 |
| Ardigò, M | 1 |
| Corato, C | 1 |
| De Paoli, G | 1 |
| Berardesca, E | 1 |
| Swisher, CL | 1 |
| Larson, PE | 8 |
| Kruttwig, K | 1 |
| Kerr, AB | 3 |
| Hu, S | 4 |
| Bok, RA | 3 |
| Goga, A | 1 |
| Pauly, JM | 4 |
| Nelson, SJ | 8 |
| Kurhanewicz, J | 8 |
| Vigneron, DB | 10 |
| Harzstark, AL | 1 |
| Ferrone, M | 1 |
| van Criekinge, M | 1 |
| Chang, JW | 1 |
| Bok, R | 5 |
| Park, I | 4 |
| Reed, G | 3 |
| Carvajal, L | 2 |
| Small, EJ | 1 |
| Munster, P | 1 |
| Weinberg, VK | 1 |
| Ardenkjaer-Larsen, JH | 3 |
| Chen, AP | 8 |
| Hurd, RE | 6 |
| Odegardstuen, LI | 1 |
| Robb, FJ | 1 |
| Tropp, J | 2 |
| Murray, JA | 1 |
| Ramirez, MS | 1 |
| Lee, J | 2 |
| Walker, CM | 1 |
| Sandulache, VC | 1 |
| Hennel, F | 1 |
| Lai, SY | 1 |
| Bankson, JA | 1 |
| Pynnönen, L | 1 |
| Minkkinen, M | 1 |
| Perner, A | 1 |
| Räty, S | 1 |
| Nordback, I | 1 |
| Sand, J | 1 |
| Tenhunen, J | 1 |
| Tropp, JL | 1 |
| Robb, F | 1 |
| Bringas, J | 1 |
| Kells, A | 1 |
| Pivirotto, P | 1 |
| Bankiewicz, K | 1 |
| Cunningham, CH | 5 |
| Dominguez Viqueira, W | 1 |
| Asghar Butt, S | 1 |
| Søgaard, LV | 1 |
| Lauritzen, MH | 1 |
| Engelholm, LH | 1 |
| Paulson, OB | 1 |
| Mirza, O | 1 |
| Holck, S | 1 |
| Magnusson, P | 1 |
| Åkeson, P | 1 |
| Xu, HN | 1 |
| Kadlececk, S | 1 |
| Profka, H | 1 |
| Glickson, JD | 1 |
| Rizi, R | 1 |
| Li, LZ | 1 |
| Durst, M | 3 |
| Koellisch, U | 3 |
| Gringeri, C | 1 |
| Janich, MA | 1 |
| Rancan, G | 2 |
| Frank, A | 2 |
| Wiesinger, F | 2 |
| Menzel, MI | 3 |
| Haase, A | 3 |
| Schulte, RF | 3 |
| Chen, K | 1 |
| Zhu, C | 1 |
| Cai, M | 1 |
| Fu, D | 1 |
| Cheng, B | 1 |
| Cai, Z | 1 |
| Li, G | 1 |
| Liu, J | 1 |
| Mallett, CL | 1 |
| Lim, H | 1 |
| Thind, K | 1 |
| Chen, Y | 1 |
| Ribot, EJ | 1 |
| Martinez, F | 1 |
| Scholl, TJ | 1 |
| Foster, PJ | 1 |
| Tang, S | 1 |
| Jiang, W | 1 |
| Chen, HY | 1 |
| Khemtong, C | 1 |
| Carpenter, NR | 1 |
| Lumata, LL | 1 |
| Merritt, ME | 2 |
| Moreno, KX | 1 |
| Kovacs, Z | 1 |
| Malloy, CR | 2 |
| Sherry, AD | 2 |
| Tholance, Y | 1 |
| Barcelos, GK | 1 |
| Dailler, F | 1 |
| Renaud, B | 1 |
| Marinesco, S | 1 |
| Perret-Liaudet, A | 1 |
| Gordon, JW | 1 |
| Fain, SB | 1 |
| Niles, DJ | 1 |
| Ludwig, KD | 1 |
| Johnson, KM | 1 |
| Peterson, ET | 1 |
| Yoo, KS | 1 |
| Lee, EJ | 1 |
| Hamilton, BK | 1 |
| Patil, BS | 1 |
| Gringeri, CV | 1 |
| Karas, V | 1 |
| Schwaiger, M | 2 |
| Laustsen, C | 1 |
| Hansen, ES | 1 |
| Kjaergaard, U | 1 |
| Bertelsen, LB | 1 |
| Ringgaard, S | 1 |
| Stødkilde-Jørgensen, H | 1 |
| Chen, WC | 1 |
| Teo, XQ | 1 |
| Lee, MY | 1 |
| Radda, GK | 1 |
| Lee, P | 1 |
| Breukels, V | 1 |
| Jansen, KC | 1 |
| van Heijster, FH | 1 |
| Capozzi, A | 1 |
| van Bentum, PJ | 1 |
| Schalken, JA | 1 |
| Comment, A | 1 |
| Scheenen, TW | 1 |
| Dzien, P | 1 |
| Tee, SS | 1 |
| Kettunen, MI | 2 |
| Lyons, SK | 1 |
| Larkin, TJ | 1 |
| Timm, KN | 1 |
| Hu, DE | 1 |
| Wright, A | 1 |
| Rodrigues, TB | 2 |
| Serrao, EM | 2 |
| Marco-Rius, I | 2 |
| Mannion, E | 1 |
| D'Santos, P | 1 |
| Kennedy, BW | 2 |
| Brindle, KM | 2 |
| Varma, G | 1 |
| Wang, X | 1 |
| Vinogradov, E | 1 |
| Bhatt, RS | 1 |
| Sukhatme, VP | 1 |
| Seth, P | 1 |
| Lenkinski, RE | 1 |
| Alsop, DC | 1 |
| Grant, AK | 1 |
| Geraghty, BJ | 1 |
| Lau, JY | 1 |
| DeVience, SJ | 1 |
| Mayer, D | 2 |
| von Morze, C | 2 |
| Chang, GY | 1 |
| Shang, H | 1 |
| Allu, PK | 1 |
| Crane, JC | 1 |
| Olson, MP | 1 |
| Tan, CT | 1 |
| Pearce, D | 1 |
| Kumar, D | 1 |
| Gupta, A | 1 |
| Mandhani, A | 1 |
| Sankhwar, SN | 1 |
| Gallagher, FA | 1 |
| Vowler, SL | 1 |
| Burling, KA | 1 |
| Daniele, V | 1 |
| Steiger, K | 1 |
| Aime, S | 1 |
| Reineri, F | 1 |
| Wang, JX | 1 |
| Sun, L | 1 |
| Li, JQ | 1 |
| Ren, N | 1 |
| Qi, H | 1 |
| Dong, F | 1 |
| Xiao, J | 1 |
| Xu, F | 1 |
| Jiao, WW | 1 |
| Shen, C | 1 |
| Song, WQ | 1 |
| Shen, AD | 1 |
| Dienel, GA | 1 |
| Rothman, DL | 1 |
| Nordström, CH | 1 |
| Datta, K | 1 |
| Spielman, DM | 1 |
| Joe, E | 1 |
| Lee, H | 1 |
| Yang, S | 1 |
| Choi, YS | 1 |
| Wang, E | 1 |
| Song, HT | 1 |
| Kim, DH | 1 |
| Marcoux, J | 1 |
| McArthur, DA | 1 |
| Miller, C | 1 |
| Glenn, TC | 1 |
| Villablanca, P | 1 |
| Martin, NA | 1 |
| Hovda, DA | 1 |
| Alger, JR | 1 |
| Vespa, PM | 1 |
| Hillered, L | 1 |
| Enblad, P | 1 |
| Liu, L | 1 |
| Arnold, MA | 1 |
| Yen, YF | 3 |
| Kohler, SJ | 1 |
| Wolber, J | 1 |
| Albers, MJ | 2 |
| Gram, KA | 1 |
| Zierhut, ML | 1 |
| Zhang, V | 1 |
| Dirven, HA | 1 |
| Feron, O | 1 |
| Harada, M | 1 |
| Kubo, H | 1 |
| Abe, T | 1 |
| Maezawa, H | 1 |
| Otsuka, H | 1 |
| Lustig, M | 1 |
| Zhu, A | 1 |
| Romero, R | 1 |
| Petty, HR | 1 |
| Lau, AZ | 2 |
| Fonouni, H | 1 |
| Tahmasbi Rad, M | 1 |
| Golriz, M | 1 |
| Faridar, A | 1 |
| Esmaeilzadeh, M | 1 |
| Jarahian, P | 1 |
| Hafezi, M | 1 |
| Jafarieh, S | 1 |
| Macher-Goeppinger, S | 1 |
| Longerich, T | 1 |
| Orakcioglu, B | 1 |
| Sakowitz, O | 1 |
| Schmidt, J | 1 |
| Mehrabi, A | 1 |
| Reed, GD | 1 |
| Essa, MM | 1 |
| Guillemin, GJ | 1 |
| Waly, MI | 1 |
| Al-Sharbati, MM | 1 |
| Al-Farsi, YM | 1 |
| Hakkim, FL | 1 |
| Ali, A | 1 |
| Al-Shafaee, MS | 1 |
| Biagi, S | 1 |
| Ghimenti, S | 1 |
| Onor, M | 1 |
| Bramanti, E | 1 |
| Kristensen, DL | 1 |
| Ladefoged, SA | 1 |
| Sloth, E | 1 |
| Aagaard, R | 1 |
| Birke-Sørensen, H | 1 |
| Matsumoto, S | 1 |
| Saito, K | 1 |
| Yasui, H | 1 |
| Morris, HD | 1 |
| Munasinghe, JP | 1 |
| Lizak, M | 1 |
| Merkle, H | 1 |
| Choudhuri, R | 1 |
| Devasahayam, N | 1 |
| Subramanian, S | 1 |
| Koretsky, AP | 1 |
| Mitchell, JB | 1 |
| Krishna, MC | 1 |
| Barry, J | 1 |
| Graham, JJ | 1 |
| Dominguez-Viqueira, W | 1 |
| Ghugre, NR | 1 |
| Wright, GA | 1 |
| Vancriekinge, M | 1 |
| Leach, AM | 1 |
| Leon, C | 1 |
| Zhou, J | 1 |
| Shin, PJ | 1 |
| Keselman, P | 1 |
| Yoshihara, H | 1 |
| Spielman, D | 1 |
| Josan, S | 1 |
| Pfefferbaum, A | 1 |
| Haugaa, H | 1 |
| Almaas, R | 1 |
| Thorgersen, EB | 1 |
| Foss, A | 1 |
| Line, PD | 1 |
| Sanengen, T | 1 |
| Bergmann, GB | 1 |
| Ohlin, P | 1 |
| Waelgaard, L | 1 |
| Grindheim, G | 1 |
| Pischke, SE | 1 |
| Mollnes, TE | 1 |
| Tønnessen, TI | 1 |
| Collins, SB | 1 |
| Reznik, E | 1 |
| Segrè, D | 1 |
| Barb, AW | 1 |
| Hekmatyar, SK | 1 |
| Glushka, JN | 1 |
| Prestegard, JH | 1 |
| Buziol, S | 1 |
| Bashir, I | 1 |
| Baumeister, A | 1 |
| Claassen, W | 1 |
| Noisommit-Rizzi, N | 1 |
| Mailinger, W | 1 |
| Reuss, M | 1 |
| Chong, BF | 1 |
| Nielsen, LK | 1 |
| Inaba, Y | 1 |
| Hamada-Sato, N | 1 |
| Kobayashi, T | 1 |
| Imada, C | 1 |
| Watanabe, E | 1 |
| Carragher, FM | 1 |
| Bonham, JR | 1 |
| Smith, JM | 1 |
| Mengual, R | 1 |
| El Abida, K | 1 |
| Mouaffak, N | 1 |
| Rieu, M | 1 |
| Beaudry, M | 1 |
| Heilmann, A | 1 |
| Teuscher, N | 1 |
| Kiesow, A | 1 |
| Janasek, D | 1 |
| Spohn, U | 1 |
| Skjøth-Rasmussen, J | 1 |
| Schulz, M | 1 |
| Kristensen, SR | 1 |
| Bjerre, P | 1 |
| Payne, B | 1 |
| Sarrafzadeh, AS | 1 |
| Haux, D | 1 |
| Lüdemann, L | 1 |
| Amthauer, H | 1 |
| Plotkin, M | 1 |
| Küchler, I | 1 |
| Unterberg, AW | 1 |
| Ewaschuk, JB | 1 |
| Naylor, JM | 1 |
| Barabash, WA | 1 |
| Zello, GA | 1 |
| Jansson, K | 1 |
| Redler, B | 1 |
| Truedsson, L | 1 |
| Magnuson, A | 1 |
| Ungerstedt, U | 1 |
| Norgren, L | 1 |
| Shabalina, IG | 1 |
| Jacobsson, A | 1 |
| Cannon, B | 1 |
| Nedergaard, J | 1 |
| Hlatky, R | 1 |
| Valadka, AB | 1 |
| Goodman, JC | 1 |
| Contant, CF | 1 |
| Robertson, CS | 1 |
| Weinberg, GL | 1 |
| Massad, MG | 1 |
| Debray, FG | 1 |
| Mitchell, GA | 1 |
| Allard, P | 1 |
| Robinson, BH | 1 |
| Hanley, JA | 1 |
| Lambert, M | 1 |
| Li, SJ | 1 |
| Umena, Y | 1 |
| Yorita, K | 1 |
| Matsuoka, T | 1 |
| Kita, A | 1 |
| Fukui, K | 1 |
| Morimoto, Y | 1 |
| Haouz, A | 1 |
| Geloso-Meyer, A | 1 |
| Burstein, C | 1 |
| Sperl, W | 1 |
| Trijbels, JM | 1 |
| Ruitenbeek, W | 1 |
| van Laack, HL | 1 |
| Janssen, AJ | 1 |
| Kerkhof, CM | 1 |
| Sengers, RC | 1 |
| Chen, P | 1 |
| Nie, LH | 1 |
| Yao, SZ | 1 |
| Valero, E | 1 |
| García-Carmona, F | 1 |
| Chan, A | 1 |
| Gold, R | 1 |
| Arp, S | 1 |
| Pflughaupt, KW | 1 |
| Toyka, KV | 1 |
| Reichmann, H | 1 |
| Chang, AK | 1 |
| Duggleby, RG | 1 |
| Chou, YH | 1 |
| Tsou Yau, KI | 1 |
| Wang, PJ | 1 |
| Verhulst, C | 1 |
| Coiffard, C | 1 |
| Coiffard, LJ | 1 |
| Rivalland, P | 1 |
| De Roeck-Holtzhauer, Y | 1 |
| Maeda-Nakai, E | 1 |
| Ichiyama, A | 1 |
| Yang, YT | 1 |
| Bennett, GN | 1 |
| San, KY | 1 |
| Wulkan, RW | 1 |
| Verwers, R | 1 |
| Neele, M | 1 |
| Mantel, MJ | 1 |
| Izco, JM | 1 |
| Tormo, M | 1 |
| Jiménez-Flores, R | 1 |
| Bäckström, T | 1 |
| Lockowandt, U | 1 |
| Liska, J | 1 |
| Sylven, C | 1 |
| Franco-Cereceda, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779] | 12 participants (Actual) | Observational | 2017-08-28 | Completed | |||
| Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage[NCT03987139] | 45 participants (Anticipated) | Interventional | 2019-06-15 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells.
Topics: Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Energy Metabolism; Glycolysis; Humans; La | 2009 |
2 trials available for pyruvic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study.
Topics: Adult; Aged; Biomarkers; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Ex | 2004 |
Postoperative on-line monitoring with intraperitoneal microdialysis is a sensitive clinical method for measuring increased anaerobic metabolism that correlates to the cytokine response.
Topics: Adult; Aged; Aged, 80 and over; Digestive System Surgical Procedures; Female; Humans; Interleukin-10 | 2004 |
82 other studies available for pyruvic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Comparative instrumental evaluation of efficacy and safety between a binary and a ternary system in chemexfoliation.
Topics: Adult; Chemexfoliation; Female; Humans; Keratolytic Agents; Male; Microscopy, Confocal; Middle Aged; | 2018 |
Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.
Topics: Alanine; Algorithms; Animals; Biomarkers, Tumor; Carbon Isotopes; Computer Simulation; Lactic Acid; | 2014 |
Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate.
Topics: Aged; Carbon Isotopes; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Prostatic Neoplasms; P | 2013 |
Radial spectroscopic MRI of hyperpolarized [1-(13) C] pyruvate at 7 tesla.
Topics: Algorithms; Animals; Biomarkers, Tumor; Carbon Isotopes; Electron Spin Resonance Spectroscopy; Feasi | 2014 |
Validation of intraluminal and intraperitoneal microdialysis in ischemic small intestine.
Topics: Aged; Carcinoma; Female; Glucose; Glycerol; Humans; Intestine, Small; Ischemia; Lactic Acid; Male; M | 2013 |
Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain.
Topics: Animals; Brain; Carbon Isotopes; Equipment Design; Equipment Failure Analysis; Feasibility Studies; | 2014 |
Frequency correction method for improved spatial correlation of hyperpolarized 13C metabolites and anatomy.
Topics: Algorithms; Animals; Artifacts; Carbon Isotopes; Echo-Planar Imaging; Kidney; Lactic Acid; Magnetic | 2014 |
Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-13C]pyruvate.
Topics: Animals; Antineoplastic Agents, Hormonal; Carbon-13 Magnetic Resonance Spectroscopy; Disease Progres | 2015 |
Is higher lactate an indicator of tumor metastatic risk? A pilot MRS study using hyperpolarized (13)C-pyruvate.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Humans; Lactic | 2014 |
Bolus tracking for improved metabolic imaging of hyperpolarised compounds.
Topics: Animals; Carbon Isotopes; Computer Simulation; Isotope Labeling; Kidney; Magnetic Resonance Spectros | 2014 |
Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells.
Topics: Biomarkers, Tumor; Case-Control Studies; Cyclic GMP-Dependent Protein Kinase Type I; Down-Regulation | 2014 |
Longitudinal anatomical and metabolic MRI characterization of orthotopic xenograft prostate tumors in nude mice.
Topics: Animals; Carbon Isotopes; Cell Line, Tumor; Computer Simulation; Contrast Media; Humans; Image Inter | 2014 |
A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging.
Topics: Algorithms; Animals; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Feasibility Studies | 2015 |
Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.
Topics: Adrenergic beta-Agonists; Animals; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Glyco | 2015 |
Biochemical neuromonitoring of poor-grade aneurysmal subarachnoid hemorrhage: comparative analysis of metabolic events detected by cerebral microdialysis and by retrograde jugular vein catheterization.
Topics: Adolescent; Adult; Biomarkers; Brain; Catheterization; Female; Glasgow Outcome Scale; Humans; Intrac | 2015 |
Simultaneous imaging of 13C metabolism and 1H structure: technical considerations and potential applications.
Topics: Animals; Carbon Isotopes; Image Interpretation, Computer-Assisted; Kidney; Lactic Acid; Magnetic Res | 2015 |
A comparison of juice extraction methods in the pungency measurement of onion bulbs.
Topics: Food Handling; Odorants; Onions; Plant Roots; Pyruvic Acid; Sensitivity and Specificity; Water | 2016 |
Comparison of acquisition schemes for hyperpolarised ¹³C imaging.
Topics: Algorithms; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Humans; Informatio | 2015 |
Acute porcine renal metabolic effect of endogastric soft drink administration assessed with hyperpolarized [1-(13)C]pyruvate.
Topics: Administration, Oral; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Carbonated Beverages; Diet | 2015 |
Robust hyperpolarized (13)C metabolic imaging with selective non-excitation of pyruvate (SNEP).
Topics: Algorithms; Carbon-13 Magnetic Resonance Spectroscopy; Molecular Imaging; Phantoms, Imaging; Pyruvic | 2015 |
Direct dynamic measurement of intracellular and extracellular lactate in small-volume cell suspensions with (13)C hyperpolarised NMR.
Topics: Biological Transport; Carbon-13 Magnetic Resonance Spectroscopy; Cell Count; Cell Line, Tumor; Extra | 2015 |
(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Enzyme Activation; Female; Genes, Reporter; HEK2 | 2016 |
Selective spectroscopic imaging of hyperpolarized pyruvate and its metabolites using a single-echo variable phase advance method in balanced SSFP.
Topics: A549 Cells; Alanine; Algorithms; Animals; Biomarkers, Tumor; Carbon Isotopes; Carbon-13 Magnetic Res | 2016 |
Accelerated 3D echo-planar imaging with compressed sensing for time-resolved hyperpolarized
Topics: Algorithms; Animals; Artifacts; Carbon-13 Magnetic Resonance Spectroscopy; Data Compression; Echo-Pl | 2017 |
Speeding up dynamic spiral chemical shift imaging with incoherent sampling and low-rank matrix completion.
Topics: Algorithms; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Image Enhancement; Image Interpretat | 2017 |
Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Gluconeogenesis; Glucose; Kidney; Lactic Acid; L | 2017 |
NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics.
Topics: Aged; Biomarkers, Tumor; Biopsy; Citric Acid; Diagnosis, Differential; Digital Rectal Examination; G | 2016 |
Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.
Topics: Algorithms; Animals; Biomarkers, Tumor; Carbon-13 Magnetic Resonance Spectroscopy; Fasting; Female; | 2016 |
Probing lactate secretion in tumours with hyperpolarised NMR.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Lactic Acid; Magnetic Resonance Imaging; Male; Molecul | 2016 |
Accelerated chemical shift imaging of hyperpolarized (13) C metabolites.
Topics: Algorithms; Animals; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Kidney; Lactic Acid | 2016 |
Utility of Novel Plasma Metabolic Markers in the Diagnosis of Pediatric Tuberculosis: A Classification and Regression Tree Analysis Approach.
Topics: Betaine; Biomarkers; Case-Control Studies; Child; Discriminant Analysis; Humans; Magnetic Resonance | 2016 |
Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients.
Topics: Brain; Brain Injuries, Traumatic; Critical Care; Energy Metabolism; Glucose; Humans; Lactic Acid; Mi | 2016 |
Doublet asymmetry for estimating polarization in hyperpolarized
Topics: Algorithms; Carbon-13 Magnetic Resonance Spectroscopy; Computer Simulation; Models, Chemical; Molecu | 2017 |
An indirect method for in vivo T
Topics: Algorithms; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; | 2017 |
Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury.
Topics: Adolescent; Adult; Atrophy; Biomarkers; Brain Diseases; Brain Injuries; Chronic Disease; Cohort Stud | 2008 |
Nonischemic energy metabolic crisis in acute brain injury.
Topics: Biomarkers; Brain Injuries; Critical Care; Critical Illness; Energy Metabolism; Female; Glasgow Coma | 2008 |
Selectivity for glucose, glucose-6-phosphate, and pyruvate in ternary mixtures from the multivariate analysis of near-infrared spectra.
Topics: Algorithms; Calibration; Glucose; Glucose-6-Phosphate; Least-Squares Analysis; Models, Theoretical; | 2009 |
Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate.
Topics: Algorithms; Animals; Carbon Isotopes; Image Enhancement; Kidney; Magnetic Resonance Imaging; Magneti | 2009 |
Selection of endogenous 13C substrates for observation of intracellular metabolism using the dynamic nuclear polarization technique.
Topics: Acetates; Animals; Biomarkers, Tumor; Carbon Isotopes; Cell Line, Tumor; Cells, Cultured; Female; Gl | 2010 |
Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI.
Topics: Animals; Carbon Isotopes; Echo-Planar Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Tr | 2010 |
Amplex UltraRed enhances the sensitivity of fluorimetric pyruvate detection.
Topics: Fluorescent Dyes; Fluorometry; Oxazines; Pyruvic Acid; Sensitivity and Specificity | 2010 |
Integrated Bloch-Siegert B₁ mapping and multislice imaging of hyperpolarized ¹³C pyruvate and bicarbonate in the heart.
Topics: Algorithms; Animals; Bicarbonates; Heart; Image Interpretation, Computer-Assisted; Magnetic Resonanc | 2012 |
Using microdialysis for early detection of vascular thrombosis after kidney transplantation in an experimental porcine model.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Blood Glucose; Disease Models, Animal; Ea | 2012 |
Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging.
Topics: Algorithms; Brain; Carbon Radioisotopes; Echo-Planar Imaging; Humans; Image Enhancement; Image Inter | 2012 |
Increased markers of oxidative stress in autistic children of the Sultanate of Oman.
Topics: Biomarkers; Child; Child Development Disorders, Pervasive; Female; Humans; Lactic Acid; Male; Malond | 2012 |
Simultaneous determination of lactate and pyruvate in human sweat using reversed-phase high-performance liquid chromatography: a noninvasive approach.
Topics: Adult; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Exercise; Female; Humans | 2012 |
Microdialysis: characterisation of haematomas in myocutaneous flaps by use of biochemical agents.
Topics: Animals; Biomarkers; Catheters, Indwelling; Central Venous Catheters; Female; Glucose; Glycerol; Hem | 2013 |
EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carbon Radioisotopes; Carcinoma, Squamous Cell; C | 2013 |
Reproducibility study for free-breathing measurements of pyruvate metabolism using hyperpolarized (13) C in the heart.
Topics: Animals; Carbon Isotopes; L-Lactate Dehydrogenase; Magnetic Resonance Imaging; Myocardial Ischemia; | 2013 |
Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer.
Topics: Animals; Carbon Isotopes; Dichloroacetic Acid; Image Enhancement; Magnetic Resonance Imaging; Magnet | 2013 |
Exchange-linked dissolution agents in dissolution-DNP (13)C metabolic imaging.
Topics: Animals; Blood Vessels; Carbon Isotopes; Kidney; Liver; Magnetic Resonance Imaging; Male; Molecular | 2013 |
Clinical experience with microdialysis catheters in pediatric liver transplants.
Topics: Adolescent; Age Factors; Biomarkers; Blood Glucose; Catheters, Indwelling; Child; Child, Preschool; | 2013 |
Temporal expression-based analysis of metabolism.
Topics: Acetates; Algorithms; Kinetics; Metabolism; Models, Biological; Pyruvic Acid; Reproducibility of Res | 2012 |
Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate.
Topics: Alanine Transaminase; Carbon Isotopes; Catalysis; Deuterium; Nuclear Magnetic Resonance, Biomolecula | 2013 |
New bioreactor-coupled rapid stopped-flow sampling technique for measurements of metabolite dynamics on a subsecond time scale.
Topics: Adenine Nucleotides; Bioreactors; Cells, Cultured; Culture Media; Equipment Design; Escherichia coli | 2002 |
Amplifying the cellular reduction potential of Streptococcus zooepidemicus.
Topics: Acetates; Adenosine Triphosphate; Catalysis; Cells, Cultured; Cloning, Molecular; Gene Expression Re | 2003 |
Determination of D- and L-alanine concentrations using a pyruvic acid sensor.
Topics: Alanine; Animals; Biosensing Techniques; Bivalvia; Electrochemistry; Environmental Pollutants; Equip | 2003 |
Pitfalls in the measurement of some intermediary metabolites.
Topics: 3-Hydroxybutyric Acid; Artifacts; Biomarkers; Diagnostic Techniques and Procedures; Fatty Acids, Non | 2003 |
Pyruvate shuttle in muscle cells: high-affinity pyruvate transport sites insensitive to trans-lactate efflux.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Biological Transport, Active; Cell Line; Dose-Response Rel | 2003 |
Nanoporous aluminum oxide as a novel support material for enzyme biosensors.
Topics: Aluminum Oxide; Biosensing Techniques; Crystallization; Electrochemistry; Enzymes, Immobilized; Equi | 2003 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Pitfalls in the measurement of some intermediary metabolites: stabilization of lactate and pyruvate.
Topics: Artifacts; Diagnostic Techniques and Procedures; Humans; Lactic Acid; Pyruvic Acid; Sensitivity and | 2004 |
High-performance liquid chromatographic assay of lactic, pyruvic and acetic acids and lactic acid stereoisomers in calf feces, rumen fluid and urine.
Topics: Acetic Acid; Animals; Body Fluids; Cattle; Chromatography, High Pressure Liquid; Feces; Lactic Acid; | 2004 |
Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.
Topics: Adipose Tissue, Brown; Animals; Blotting, Southern; Carrier Proteins; Dose-Response Relationship, Dr | 2004 |
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H | 2004 |
Metabolic modulation for cardiac protection.
Topics: Animals; Cardiac Surgical Procedures; Cardioplegic Solutions; Female; Glucose; Heart Arrest, Induced | 2007 |
Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis.
Topics: Acidosis, Lactic; Child; Diagnosis, Differential; Female; Hospitals, Pediatric; Humans; Lactic Acid; | 2007 |
Crystallographic study on the interaction of L-lactate oxidase with pyruvate at 1.9 Angstrom resolution.
Topics: Binding Sites; Computer Simulation; Crystallography; Enzyme Activation; Mixed Function Oxygenases; M | 2007 |
Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C.
Topics: Animals; Calibration; Carbon Isotopes; Magnetic Resonance Spectroscopy; Phantoms, Imaging; Pyruvic A | 2007 |
Assay of dehydrogenases with an O2-consuming biosensor.
Topics: Animals; Bacterial Proteins; Biosensing Techniques; Cell Survival; Chloromercuribenzoates; Electrode | 1994 |
Measurement of totally activated pyruvate dehydrogenase complex activity in human muscle: evaluation of a useful assay.
Topics: Adolescent; Adult; Biopsy; Carbon Radioisotopes; Child; Child, Preschool; Female; Humans; Infant, Ne | 1993 |
Determination of lactic acid and pyruvic acid in serum and cerebrospinal fluid by ion-exclusion chromatography with a bulk acoustic wave detector.
Topics: Acoustics; Chromatography; Humans; Lactates; Lactic Acid; Phosphoric Acids; Pyruvates; Pyruvic Acid; | 1995 |
Optimizing enzymatic cycling assays: spectrophotometric determination of low levels of pyruvate and L-lactate.
Topics: Animals; Biological Assay; Evaluation Studies as Topic; Kinetics; L-Lactate Dehydrogenase; Lactates; | 1996 |
[Standardized bicycle ergometry test in mitochondrial myopathies. Indications, interferences and clinical parameters].
Topics: Adult; Energy Metabolism; Exercise Test; Female; Humans; Isometric Contraction; Lactic Acid; Male; M | 1998 |
Herbicide-resistant forms of Arabidopsis thaliana acetohydroxyacid synthase: characterization of the catalytic properties and sensitivity to inhibitors of four defined mutants.
Topics: Acetolactate Synthase; Arabidopsis; Catalysis; Enzyme Activation; Enzyme Inhibitors; Enzyme Stabilit | 1998 |
Clinical application of the measurement of cord plasma lactate and pyruvate in the assessment of high-risk neonates.
Topics: Female; Fetal Blood; Humans; Infant, Newborn; Infant, Premature; Lactic Acid; Male; Pyruvic Acid; Ri | 1998 |
In vitro correlation between two colorimetric assays and the pyruvic acid consumption by fibroblasts cultured to determine the sodium laurylsulfate cytotoxicity.
Topics: Cells, Cultured; Colorimetry; Fibroblasts; Humans; NAD; Neutral Red; Pyruvic Acid; Sensitivity and S | 1998 |
A spectrophotometric method for the determination of glycolate in urine and plasma with glycolate oxidase.
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Formazans; Glycolates; Glyoxylates; Humans; Pyruvic A | 2000 |
The effects of feed and intracellular pyruvate levels on the redistribution of metabolic fluxes in Escherichia coli.
Topics: Acetyltransferases; Allosteric Site; Binding, Competitive; Carbon; Cell Culture Techniques; Escheric | 2001 |
Measurement of pyruvate in blood by high-performance liquid chromatography with fluorescence detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Fluorescence; Fluorescent Dyes; Freezing; Humans; | 2001 |
Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores.
Topics: Acetic Acid; Animals; Butyric Acid; Carboxylic Acids; Citric Acid; Dairy Products; Electrophoresis, | 2002 |
Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis.
Topics: Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Female; Glutamic Acid; Glycerol; Hemodyn | 2002 |