pyruvic acid has been researched along with Retinal Degeneration in 7 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grenell, A | 1 |
| Wang, Y | 1 |
| Yam, M | 1 |
| Swarup, A | 1 |
| Dilan, TL | 1 |
| Hauer, A | 1 |
| Linton, JD | 1 |
| Philp, NJ | 1 |
| Gregor, E | 1 |
| Zhu, S | 1 |
| Shi, Q | 1 |
| Murphy, J | 1 |
| Guan, T | 1 |
| Lohner, D | 1 |
| Kolandaivelu, S | 1 |
| Ramamurthy, V | 1 |
| Goldberg, AFX | 1 |
| Hurley, JB | 1 |
| Du, J | 1 |
| Adler, L | 1 |
| Chen, C | 1 |
| Koutalos, Y | 1 |
| Natoli, R | 1 |
| Rutar, M | 1 |
| Lu, YZ | 1 |
| Chu-Tan, JA | 1 |
| Chen, Y | 1 |
| Saxena, K | 1 |
| Madigan, M | 1 |
| Valter, K | 1 |
| Provis, JM | 1 |
| Sheline, CT | 2 |
| Zhou, Y | 1 |
| Bai, S | 2 |
| Ren, H | 1 |
| Liu, NY | 1 |
| Song, XF | 1 |
| Ma, YS | 1 |
| Zhai, XY | 1 |
| Yoo, MH | 1 |
| Lee, JY | 1 |
| Lee, SE | 1 |
| Koh, JY | 1 |
| Yoon, YH | 1 |
7 other studies available for pyruvic acid and Retinal Degeneration
| Article | Year |
|---|---|
Loss of MPC1 reprograms retinal metabolism to impair visual function.
Topics: Animals; Glucose; Glycolysis; Humans; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; | 2019 |
Mitochondria contribute to NADPH generation in mouse rod photoreceptors.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Glutamic Acid; Mice; Mice, Knockout; | 2014 |
The Role of Pyruvate in Protecting 661W Photoreceptor-Like Cells Against Light-Induced Cell Death.
Topics: Animals; Cell Count; Cell Death; Cell Line; Disease Models, Animal; Light; Mice; Oxidative Stress; P | 2016 |
Light-induced photoreceptor and RPE degeneration involve zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light.
Topics: Animals; Cell Death; Cell Line; Cytoprotection; Humans; Intracellular Space; Light; Niacinamide; Oxi | 2010 |
A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Erythropoietin; | 2011 |
NAD(+) maintenance attenuates light induced photoreceptor degeneration.
Topics: Animals; Antioxidants; Cell Death; Cells, Cultured; Circadian Rhythm; Cytoprotection; Disease Models | 2013 |
Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivo.
Topics: Adenosine Triphosphate; Animals; Cell Culture Techniques; Cell Survival; Chlorides; Cytoprotection; | 2004 |