pyruvic acid has been researched along with Peripheral Nerve Diseases in 5 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The long-term effects of the sodium salt of dichloroacetic acid (DCA) were evaluated in four patients with mitochondrial encephalomyelopathy with lactic acidosis and stroke-like episodes (MELAS) carrying A3243G mutation." | 5.11 | Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. ( Goto, T; Momoi, MY; Mori, M; Saito, S; Yamagata, T, 2004) |
| "A strategy for preventing or delaying the peripheral neuropathy induced by 2',3'-dideoxycytidine (ddC) therapy in patients with acquired immunodeficiency syndrome was suggested by findings, in two laboratories, that cultured avian and mammalian cells devoid of mitochondrial DNA continue to replicate at virtually normal rates, provided that the medium is supplemented with uridine and pyruvate." | 3.68 | Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2',3'-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate. ( Hobbs, GA; Keilbaugh, SA; Simpson, MV, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Radu, AG | 1 |
| Torch, S | 1 |
| Fauvelle, F | 1 |
| Pernet-Gallay, K | 1 |
| Lucas, A | 1 |
| Blervaque, R | 1 |
| Delmas, V | 1 |
| Schlattner, U | 1 |
| Lafanechère, L | 1 |
| Hainaut, P | 1 |
| Tricaud, N | 1 |
| Pingault, V | 1 |
| Bondurand, N | 1 |
| Bardeesy, N | 1 |
| Larue, L | 1 |
| Thibert, C | 1 |
| Billaud, M | 1 |
| BUCKLE, RM | 1 |
| Mori, M | 1 |
| Yamagata, T | 1 |
| Goto, T | 1 |
| Saito, S | 1 |
| Momoi, MY | 1 |
| JOINER, CL | 1 |
| THOMPSON, RH | 1 |
| WATSON, D | 1 |
| Keilbaugh, SA | 1 |
| Hobbs, GA | 1 |
| Simpson, MV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV[NCT00471614] | Phase 2 | 3 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pyruvic acid and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.
Topics: Abdominal Pain; Administration, Oral; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dic | 2004 |
4 other studies available for pyruvic acid and Peripheral Nerve Diseases
| Article | Year |
|---|---|
LKB1 specifies neural crest cell fates through pyruvate-alanine cycling.
Topics: Alanine; AMP-Activated Protein Kinases; Animals; Cell Differentiation; Energy Metabolism; Enteric Ne | 2019 |
BLOOD PYRUVIC ACID IN THALIDOMIDE NEUROPATHY.
Topics: Blood Chemical Analysis; Chromatography; Geriatrics; Humans; Metabolism; Peripheral Nervous System D | 1963 |
Pyruvate tolerance in peripheral neuropathy and other conditions.
Topics: Blood; Humans; Peripheral Nerves; Peripheral Nervous System Diseases; Pyruvates; Pyruvic Acid | 1950 |
Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2',3'-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cell Survival; DNA Replication; DNA, Mitochondrial; HIV | 1993 |