pyruvic acid has been researched along with Pancreatic Neoplasms in 16 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Resected pancreatic cancer (n = 21) and normal pancreas were laser-capture micro-dissected, and transcripts were quantified by RNAseq." | 1.48 | Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms. ( Bamlet, WR; Carlson, SK; Couch, FJ; Damgard, SE; Deelchand, DK; Kittelson, E; Marjańska, M; Murphy, SJ; O'Brien, DR; Passow, MR; Penheiter, AR; Port, JD; Smyrk, TC; Vasmatzis, G, 2018) |
| "IP glycerol was only moderately indicative for ischemia after 91-120 minutes with 0,791 ROC AUCs (threshold 122 μmol/l)." | 1.39 | Validation of intraluminal and intraperitoneal microdialysis in ischemic small intestine. ( Minkkinen, M; Nordback, I; Perner, A; Pynnönen, L; Räty, S; Sand, J; Tenhunen, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 6 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kerk, SA | 1 |
| Lin, L | 1 |
| Myers, AL | 1 |
| Sutton, DJ | 1 |
| Andren, A | 1 |
| Sajjakulnukit, P | 1 |
| Zhang, L | 1 |
| Zhang, Y | 1 |
| Jiménez, JA | 1 |
| Nelson, BS | 1 |
| Chen, B | 1 |
| Robinson, A | 1 |
| Thurston, G | 1 |
| Kemp, SB | 1 |
| Steele, NG | 1 |
| Hoffman, MT | 1 |
| Wen, HJ | 1 |
| Long, D | 1 |
| Ackenhusen, SE | 1 |
| Ramos, J | 1 |
| Gao, X | 1 |
| Nwosu, ZC | 1 |
| Galban, S | 1 |
| Halbrook, CJ | 1 |
| Lombard, DB | 1 |
| Piwnica-Worms, DR | 1 |
| Ying, H | 1 |
| Pasca di Magliano, M | 1 |
| Crawford, HC | 1 |
| Shah, YM | 1 |
| Lyssiotis, CA | 1 |
| Li, X | 1 |
| Du, Y | 1 |
| Jiang, W | 1 |
| Dong, S | 1 |
| Li, W | 1 |
| Tang, H | 1 |
| Yi, J | 1 |
| Zhou, W | 1 |
| Zhang, H | 1 |
| Montrazi, ET | 1 |
| Sasson, K | 1 |
| Agemy, L | 1 |
| Peters, DC | 1 |
| Brenner, O | 1 |
| Scherz, A | 1 |
| Frydman, L | 1 |
| Cui, J | 1 |
| Quan, M | 1 |
| Xie, D | 1 |
| Gao, Y | 1 |
| Guha, S | 1 |
| Fallon, MB | 1 |
| Chen, J | 1 |
| Xie, K | 1 |
| Song, X | 1 |
| Liu, J | 1 |
| Kuang, F | 1 |
| Chen, X | 1 |
| Zeh, HJ | 1 |
| Kang, R | 1 |
| Kroemer, G | 1 |
| Xie, Y | 1 |
| Tang, D | 1 |
| Penheiter, AR | 1 |
| Deelchand, DK | 1 |
| Kittelson, E | 1 |
| Damgard, SE | 1 |
| Murphy, SJ | 1 |
| O'Brien, DR | 1 |
| Bamlet, WR | 1 |
| Passow, MR | 1 |
| Smyrk, TC | 1 |
| Couch, FJ | 1 |
| Vasmatzis, G | 1 |
| Port, JD | 1 |
| Marjańska, M | 1 |
| Carlson, SK | 1 |
| Dutta, P | 2 |
| Perez, MR | 1 |
| Lee, J | 1 |
| Kang, Y | 1 |
| Pratt, M | 1 |
| Salzillo, TC | 1 |
| Weygand, J | 1 |
| Zacharias, NM | 1 |
| Gammon, ST | 1 |
| Koay, EJ | 1 |
| Kim, M | 1 |
| McAllister, F | 1 |
| Sen, S | 1 |
| Maitra, A | 2 |
| Piwnica-Worms, D | 1 |
| Fleming, JB | 1 |
| Bhattacharya, PK | 1 |
| Stødkilde-Jørgensen, H | 1 |
| Laustsen, C | 1 |
| Hansen, ESS | 1 |
| Schulte, R | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| Comment, A | 1 |
| Frøkiaer, J | 1 |
| Ringgaard, S | 1 |
| Bertelsen, LB | 1 |
| Ladekarl, M | 1 |
| Weber, B | 1 |
| Pynnönen, L | 1 |
| Minkkinen, M | 1 |
| Perner, A | 1 |
| Räty, S | 1 |
| Nordback, I | 1 |
| Sand, J | 1 |
| Tenhunen, J | 1 |
| Rajeshkumar, NV | 1 |
| Yabuuchi, S | 1 |
| de Wilde, RF | 1 |
| Martinez, GV | 1 |
| Le, A | 1 |
| Kamphorst, JJ | 1 |
| Rabinowitz, JD | 1 |
| Jain, SK | 1 |
| Hidalgo, M | 1 |
| Dang, CV | 1 |
| Gillies, RJ | 1 |
| Serrao, EM | 1 |
| Kettunen, MI | 1 |
| Rodrigues, TB | 1 |
| Dzien, P | 1 |
| Wright, AJ | 1 |
| Gopinathan, A | 1 |
| Gallagher, FA | 1 |
| Lewis, DY | 1 |
| Frese, KK | 1 |
| Almeida, J | 1 |
| Howat, WJ | 1 |
| Tuveson, DA | 1 |
| Brindle, KM | 1 |
| Sheline, CT | 1 |
| Shi, C | 1 |
| Takata, T | 1 |
| Zhu, J | 1 |
| Zhang, W | 1 |
| Sheline, PJ | 1 |
| Cai, AL | 1 |
| Li, L | 1 |
| Chang, I | 1 |
| Cho, N | 1 |
| Koh, JY | 1 |
| Lee, MS | 1 |
| MacDonald, MJ | 1 |
| Fahien, LA | 1 |
| Buss, JD | 1 |
| Hasan, NM | 1 |
| Fallon, MJ | 1 |
| Kendrick, MA | 1 |
| Joseph, JW | 1 |
| Odegaard, ML | 1 |
| Ronnebaum, SM | 1 |
| Burgess, SC | 1 |
| Muehlbauer, J | 1 |
| Sherry, AD | 1 |
| Newgard, CB | 1 |
| Hale, PJ | 1 |
| Nattrass, M | 1 |
16 other studies available for pyruvic acid and Pancreatic Neoplasms
| Article | Year |
|---|---|
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
Topics: Animals; Aspartate Aminotransferase, Mitochondrial; Carcinoma, Pancreatic Ductal; Fatty Acid-Binding | 2022 |
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
Topics: Animals; Aspartate Aminotransferase, Mitochondrial; Carcinoma, Pancreatic Ductal; Fatty Acid-Binding | 2022 |
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
Topics: Animals; Aspartate Aminotransferase, Mitochondrial; Carcinoma, Pancreatic Ductal; Fatty Acid-Binding | 2022 |
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
Topics: Animals; Aspartate Aminotransferase, Mitochondrial; Carcinoma, Pancreatic Ductal; Fatty Acid-Binding | 2022 |
Integrated transcriptomics, proteomics and metabolomics-based analysis uncover TAM2-associated glycolysis and pyruvate metabolic remodeling in pancreatic cancer.
Topics: Carcinoma, Pancreatic Ductal; Glycolysis; Humans; Metabolomics; Pancreatic Neoplasms; Proteomics; Py | 2023 |
Integrated transcriptomics, proteomics and metabolomics-based analysis uncover TAM2-associated glycolysis and pyruvate metabolic remodeling in pancreatic cancer.
Topics: Carcinoma, Pancreatic Ductal; Glycolysis; Humans; Metabolomics; Pancreatic Neoplasms; Proteomics; Py | 2023 |
Integrated transcriptomics, proteomics and metabolomics-based analysis uncover TAM2-associated glycolysis and pyruvate metabolic remodeling in pancreatic cancer.
Topics: Carcinoma, Pancreatic Ductal; Glycolysis; Humans; Metabolomics; Pancreatic Neoplasms; Proteomics; Py | 2023 |
Integrated transcriptomics, proteomics and metabolomics-based analysis uncover TAM2-associated glycolysis and pyruvate metabolic remodeling in pancreatic cancer.
Topics: Carcinoma, Pancreatic Ductal; Glycolysis; Humans; Metabolomics; Pancreatic Neoplasms; Proteomics; Py | 2023 |
High-sensitivity deuterium metabolic MRI differentiates acute pancreatitis from pancreatic cancers in murine models.
Topics: Acute Disease; Animals; Deuterium; Disease Models, Animal; Humans; Lactic Acid; Magnetic Resonance I | 2023 |
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Female; Gene Expres | 2020 |
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis.
Topics: Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Diet, High-Fat; Drug | 2021 |
Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms.
Topics: Adenocarcinoma, Mucinous; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Carcinoma, Papillary; Gen | 2018 |
Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Glycolysis; Heterografts; Humans; Hypoxia- | 2019 |
Pilot Study Experiences With Hyperpolarized [1-
Topics: Carbon Isotopes; Humans; Magnetic Resonance Imaging; Pancreatic Neoplasms; Pilot Projects; Pyruvic A | 2020 |
Validation of intraluminal and intraperitoneal microdialysis in ischemic small intestine.
Topics: Aged; Carcinoma; Female; Glucose; Glycerol; Humans; Intestine, Small; Ischemia; Lactic Acid; Male; M | 2013 |
Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbon-13 Magnetic Resonance Spectroscopy; Cell P | 2015 |
MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.
Topics: Animals; Biomarkers; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Pancreatic Ductal; Diseas | 2016 |
Dietary zinc reduction, pyruvate supplementation, or zinc transporter 5 knockout attenuates β-cell death in nonobese diabetic mice, islets, and insulinoma cells.
Topics: Animals; Benzamides; Calcium Channel Blockers; Carrier Proteins; Cell Line, Tumor; Diabetes Mellitus | 2012 |
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.
Topics: Adenosine Triphosphate; Animals; Antigens, Polyomavirus Transforming; Antioxidants; Cell Death; Cell | 2003 |
Citrate oscillates in liver and pancreatic beta cell mitochondria and in INS-1 insulinoma cells.
Topics: Animals; Biological Clocks; Cell Line, Tumor; Citric Acid; Glucose; Hepatocytes; Insulinoma; Islets | 2003 |
Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.
Topics: Adenoviridae; Animals; ATP Citrate (pro-S)-Lyase; Carbon Isotopes; Cell Line, Tumor; Fatty Acid Synt | 2007 |
Metabolic profiles in patients with insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Alanine; Blood Glucose; Fatty Acids, Nonesterified; Female; Glycer | 1989 |