pyruvic acid has been researched along with Obesity in 68 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the efficacy of the 3-carbon compounds pyruvate and dihydroxyacetone (PD) in inhibiting reaccumulation of body weight and fat with refeeding after weight loss." | 5.08 | Inhibition of regain in body weight and fat with addition of 3-carbon compounds to the diet with hyperenergetic refeeding after weight reduction. ( Arch, JE; Stanko, RT, 1996) |
| " Body composition and leucine oxidation and turnover were determined before and after weight loss." | 5.07 | Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate. ( Arch, JE; Stanko, RT; Tietze, DL, 1992) |
| "Middle-age mice with pre-existing diet-induced obesity were provided with low concentration β-mercaptoethanol (BME) in drinking water for six months." | 3.80 | Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice. ( Corkey, BE; Guo, W; Hamilton, JA; Kirkland, JL; Schwanz, HA; Simmons, AL; Wong, S, 2014) |
| " Body composition and amino acid (leucine) oxidation and turnover were determined before and after weight loss." | 3.68 | Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate. ( Arch, JE; Stanko, RT; Tietze, DL, 1992) |
| "Prediabetes is a major risk factor for type 2 diabetes and cardiovascular diseases." | 3.01 | A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes. ( Abumrad, NA; Bittel, AJ; Bittel, DC; Cade, WT; Mittendorfer, B; Okunade, AL; Patterson, BW; Reeds, DN, 2021) |
| "Without adequate prevention and treatment of obesity, government agencies have suggested that the direct and indirect costs associated with obesity may overwhelm the healthcare system." | 2.42 | A perspective on the current strategies for the treatment of obesity. ( Joyal, SV, 2004) |
| " Chronic administration of NaSH in particular at high doses impaired carbohydrate metabolism in type 2 diabetic rats." | 1.51 | Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats. ( Ghasemi, A; Gheibi, S; Jeddi, S; Kashfi, K, 2019) |
| "Protection against fatty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside, a specific inhibitor of ANT." | 1.46 | Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. ( Cho, J; Choi, CS; Chun, SK; Han, C; Joseph, AM; Kalavalapalli, S; Kim, JS; Lee, HY; Lee, YJ; Mathews, CE; Morgan, D; Oh, SP; Park, HJ; Park, SY; Shiratsuchi, T; Someya, S; Sunny, NE; Terada, N; Wohlgemuth, SE; Zhang, Y, 2017) |
| "Obesity has been linked to many health problems, such as diabetes." | 1.43 | miR-378 Activates the Pyruvate-PEP Futile Cycle and Enhances Lipolysis to Ameliorate Obesity in Mice. ( Li, C; Li, H; Song, Y; Tang, H; Wang, H; Zhai, L; Zhang, Y; Zhao, Y; Zhong, R; Zhu, D, 2016) |
| "Obesity is associated with multiple diseases." | 1.42 | Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner. ( Ernst, B; Gralka, E; Luchinat, C; Schultes, B; Tenori, L; Thurnheer, M, 2015) |
| "Obesity is a risk factor for type 2 diabetes in cats." | 1.35 | The impact of obesity, sex, and diet on hepatic glucose production in cats. ( Burgess, SC; Ferguson, DC; Glushka, J; Hoenig, M; Jin, ES; Jordan, ET; Kley, S; Olson, DE; Prestegard, JH; Waldron, M; Wu, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (25.00) | 18.7374 |
| 1990's | 11 (16.18) | 18.2507 |
| 2000's | 9 (13.24) | 29.6817 |
| 2010's | 25 (36.76) | 24.3611 |
| 2020's | 6 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Hodges, WT | 1 |
| Jarasvaraparn, C | 1 |
| Ferguson, D | 1 |
| Griffett, K | 1 |
| Gill, LE | 1 |
| Chen, Y | 2 |
| Ilagan, MXG | 1 |
| Hegazy, L | 1 |
| Elgendy, B | 1 |
| Cho, K | 1 |
| Patti, GJ | 1 |
| McCommis, KS | 1 |
| Finck, BN | 1 |
| Uema, T | 1 |
| Millman, JF | 1 |
| Okamoto, S | 1 |
| Nakamura, T | 2 |
| Yamashiro, K | 1 |
| Uehara, M | 1 |
| Honma, KI | 1 |
| Miyazato, M | 1 |
| Ashikari, A | 1 |
| Saito, S | 1 |
| Maeda, S | 1 |
| Imamura, M | 1 |
| Ishida, H | 1 |
| Matsushita, M | 1 |
| Nakamura, K | 1 |
| Masuzaki, H | 1 |
| Jevtovic, F | 1 |
| Zheng, D | 1 |
| Lopez, CA | 1 |
| Kern, K | 1 |
| Tanner, CJ | 1 |
| Jones, TE | 1 |
| Pories, WJ | 1 |
| Dohm, GL | 2 |
| Houmard, JA | 1 |
| May, LE | 1 |
| Broskey, NT | 1 |
| Ronda, OAHO | 1 |
| van de Heijning, BJM | 1 |
| de Bruin, A | 1 |
| Jurdzinski, A | 1 |
| Kuipers, F | 1 |
| Verkade, HJ | 1 |
| Mu, K | 1 |
| Sun, Y | 1 |
| Zhao, Y | 2 |
| Zhao, T | 1 |
| Li, Q | 1 |
| Zhang, M | 1 |
| Li, H | 2 |
| Zhang, R | 1 |
| Hu, C | 1 |
| Wang, C | 1 |
| Jia, W | 1 |
| Bittel, AJ | 1 |
| Bittel, DC | 1 |
| Mittendorfer, B | 1 |
| Patterson, BW | 1 |
| Okunade, AL | 1 |
| Abumrad, NA | 1 |
| Reeds, DN | 1 |
| Cade, WT | 1 |
| Crovesy, L | 1 |
| El-Bacha, T | 1 |
| Rosado, EL | 1 |
| Gonzalez-Rellan, MJ | 1 |
| Fondevila, MF | 1 |
| Fernandez, U | 1 |
| Rodríguez, A | 1 |
| Varela-Rey, M | 1 |
| Veyrat-Durebex, C | 1 |
| Seoane, S | 1 |
| Bernardo, G | 1 |
| Lopitz-Otsoa, F | 1 |
| Fernández-Ramos, D | 1 |
| Bilbao, J | 1 |
| Iglesias, C | 1 |
| Novoa, E | 1 |
| Ameneiro, C | 1 |
| Senra, A | 1 |
| Beiroa, D | 1 |
| Cuñarro, J | 1 |
| Dp Chantada-Vazquez, M | 1 |
| Garcia-Vence, M | 1 |
| Bravo, SB | 1 |
| Da Silva Lima, N | 1 |
| Porteiro, B | 1 |
| Carneiro, C | 1 |
| Vidal, A | 1 |
| Tovar, S | 1 |
| Müller, TD | 1 |
| Ferno, J | 1 |
| Guallar, D | 1 |
| Fidalgo, M | 1 |
| Sabio, G | 1 |
| Herzig, S | 1 |
| Yang, WH | 1 |
| Cho, JW | 1 |
| Martinez-Chantar, ML | 1 |
| Perez-Fernandez, R | 1 |
| López, M | 1 |
| Dieguez, C | 1 |
| Mato, JM | 1 |
| Millet, O | 1 |
| Coppari, R | 1 |
| Woodhoo, A | 1 |
| Fruhbeck, G | 1 |
| Nogueiras, R | 1 |
| Patel, DP | 1 |
| Krausz, KW | 1 |
| Xie, C | 1 |
| Beyoğlu, D | 1 |
| Gonzalez, FJ | 1 |
| Idle, JR | 1 |
| Nie, L | 1 |
| Yuan, XL | 1 |
| Jiang, KT | 1 |
| Jiang, YH | 1 |
| Yuan, J | 1 |
| Luo, L | 1 |
| Cui, SW | 1 |
| Sun, C | 1 |
| Li, J | 1 |
| Diao, B | 1 |
| Guo, S | 1 |
| Huang, X | 1 |
| Yang, C | 1 |
| Feng, Z | 1 |
| Yan, W | 1 |
| Ning, Q | 1 |
| Zheng, L | 1 |
| Wu, Y | 1 |
| Soto, M | 1 |
| Orliaguet, L | 1 |
| Reyzer, ML | 1 |
| Manier, ML | 1 |
| Caprioli, RM | 1 |
| Kahn, CR | 1 |
| Wu, CY | 1 |
| Satapati, S | 1 |
| Gui, W | 1 |
| Wynn, RM | 1 |
| Sharma, G | 1 |
| Lou, M | 1 |
| Qi, X | 1 |
| Burgess, SC | 3 |
| Malloy, C | 1 |
| Khemtong, C | 1 |
| Sherry, AD | 1 |
| Chuang, DT | 1 |
| Merritt, ME | 1 |
| Alkhalidy, H | 1 |
| Moore, W | 1 |
| Wang, A | 1 |
| Luo, J | 1 |
| McMillan, RP | 1 |
| Wang, Y | 1 |
| Zhen, W | 1 |
| Hulver, MW | 1 |
| Liu, D | 1 |
| Zhang, C | 1 |
| Seo, J | 1 |
| Murakami, K | 1 |
| Salem, ESB | 1 |
| Bernhard, E | 1 |
| Borra, VJ | 1 |
| Choi, K | 1 |
| Yuan, CL | 1 |
| Chan, CC | 1 |
| Chen, X | 1 |
| Huang, T | 1 |
| Weirauch, MT | 1 |
| Divanovic, S | 1 |
| Qi, NR | 1 |
| Thomas, HE | 1 |
| Mercer, CA | 1 |
| Siomi, H | 1 |
| Maeda Júnior, AS | 1 |
| Constantin, J | 1 |
| Utsunomiya, KS | 1 |
| Gilglioni, EH | 1 |
| Gasparin, FRS | 1 |
| Carreño, FO | 1 |
| de Moraes, SMF | 1 |
| Rocha, M | 1 |
| Natali, MRM | 1 |
| Ghizoni, CVC | 1 |
| Bracht, A | 1 |
| Ishii-Iwamoto, EL | 1 |
| Constantin, RP | 1 |
| Gheibi, S | 1 |
| Jeddi, S | 1 |
| Kashfi, K | 1 |
| Ghasemi, A | 1 |
| Min, BK | 1 |
| Park, S | 1 |
| Kang, HJ | 1 |
| Kim, DW | 1 |
| Ham, HJ | 1 |
| Ha, CM | 1 |
| Choi, BJ | 1 |
| Lee, JY | 1 |
| Oh, CJ | 1 |
| Yoo, EK | 1 |
| Kim, HE | 1 |
| Kim, BG | 1 |
| Jeon, JH | 1 |
| Hyeon, DY | 1 |
| Hwang, D | 1 |
| Kim, YH | 2 |
| Lee, CH | 1 |
| Lee, T | 1 |
| Kim, JW | 1 |
| Choi, YK | 1 |
| Park, KG | 1 |
| Chawla, A | 1 |
| Lee, J | 1 |
| Harris, RA | 1 |
| Lee, IK | 1 |
| Onakpoya, I | 1 |
| Hunt, K | 1 |
| Wider, B | 1 |
| Ernst, E | 1 |
| Wong, S | 1 |
| Kirkland, JL | 1 |
| Schwanz, HA | 1 |
| Simmons, AL | 1 |
| Hamilton, JA | 1 |
| Corkey, BE | 2 |
| Guo, W | 1 |
| Gray, LR | 1 |
| Sultana, MR | 1 |
| Rauckhorst, AJ | 1 |
| Oonthonpan, L | 1 |
| Tompkins, SC | 1 |
| Sharma, A | 1 |
| Fu, X | 1 |
| Miao, R | 1 |
| Pewa, AD | 1 |
| Brown, KS | 1 |
| Lane, EE | 1 |
| Dohlman, A | 1 |
| Zepeda-Orozco, D | 1 |
| Xie, J | 1 |
| Rutter, J | 1 |
| Norris, AW | 1 |
| Cox, JE | 1 |
| Potthoff, MJ | 1 |
| Taylor, EB | 1 |
| Gralka, E | 1 |
| Luchinat, C | 1 |
| Tenori, L | 1 |
| Ernst, B | 1 |
| Thurnheer, M | 1 |
| Schultes, B | 1 |
| Arrabal, S | 1 |
| Lucena, MA | 1 |
| Canduela, MJ | 1 |
| Ramos-Uriarte, A | 1 |
| Rivera, P | 1 |
| Serrano, A | 1 |
| Pavón, FJ | 1 |
| Decara, J | 1 |
| Vargas, A | 1 |
| Baixeras, E | 1 |
| Martín-Rufián, M | 1 |
| Márquez, J | 1 |
| Fernández-Llébrez, P | 1 |
| De Roos, B | 1 |
| Grandes, P | 1 |
| Rodríguez de Fonseca, F | 1 |
| Suárez, J | 1 |
| Zhang, Y | 2 |
| Li, C | 1 |
| Song, Y | 1 |
| Zhai, L | 1 |
| Wang, H | 1 |
| Zhong, R | 1 |
| Tang, H | 1 |
| Zhu, D | 1 |
| Kim, GW | 1 |
| Ahn, KY | 1 |
| Jeong, GW | 1 |
| Cho, J | 1 |
| Park, SY | 1 |
| Joseph, AM | 1 |
| Han, C | 1 |
| Park, HJ | 1 |
| Kalavalapalli, S | 1 |
| Chun, SK | 1 |
| Morgan, D | 1 |
| Kim, JS | 1 |
| Someya, S | 1 |
| Mathews, CE | 1 |
| Lee, YJ | 1 |
| Wohlgemuth, SE | 1 |
| Sunny, NE | 1 |
| Lee, HY | 1 |
| Choi, CS | 1 |
| Shiratsuchi, T | 1 |
| Oh, SP | 1 |
| Terada, N | 1 |
| Kley, S | 1 |
| Hoenig, M | 1 |
| Glushka, J | 1 |
| Jin, ES | 1 |
| Waldron, M | 1 |
| Jordan, ET | 1 |
| Prestegard, JH | 1 |
| Ferguson, DC | 1 |
| Wu, S | 1 |
| Olson, DE | 1 |
| Kim, SH | 1 |
| Yang, SO | 1 |
| Kim, HS | 1 |
| Kim, Y | 1 |
| Park, T | 1 |
| Choi, HK | 1 |
| Hörer, T | 1 |
| Norgren, L | 1 |
| Jansson, K | 1 |
| Thyfault, JP | 1 |
| Cree, MG | 1 |
| Tapscott, EB | 1 |
| Bell, JA | 1 |
| Koves, TR | 1 |
| Ilkayeva, O | 1 |
| Wolfe, RR | 1 |
| Muoio, DM | 1 |
| Bakkman, L | 1 |
| Fernström, M | 1 |
| Loogna, P | 1 |
| Rooyackers, O | 1 |
| Brandt, L | 1 |
| Lagerros, YT | 1 |
| Shirihai, O | 1 |
| Hodson, L | 1 |
| Humphreys, SM | 2 |
| Karpe, F | 1 |
| Frayn, KN | 2 |
| GUGGENHEIM, K | 1 |
| MAYER, J | 2 |
| PENNINGTON, AW | 1 |
| ARENDT, EC | 1 |
| PATTEE, CJ | 1 |
| NYFOS, L | 2 |
| SKOUBY, AP | 2 |
| CHRISTOPHE, J | 1 |
| JEANRENAUD, B | 1 |
| RENOLD, AE | 1 |
| HAAGENSEN, NR | 1 |
| MOORHOUSE, JA | 1 |
| ISRAELS, S | 1 |
| HAWORTH, JC | 1 |
| GOURLEY, B | 1 |
| FORD, JD | 1 |
| BENTLEY, R | 1 |
| LOPRESTI, T | 1 |
| TAYLOR, RM | 1 |
| McHENRY, EW | 1 |
| Naruta, EE | 1 |
| Egorov, AI | 1 |
| Omel'ianchik, CN | 1 |
| Buko, VU | 1 |
| Joyal, SV | 1 |
| Wang, P | 1 |
| Lloyd, SG | 1 |
| Zeng, H | 1 |
| Bonen, A | 1 |
| Chatham, JC | 2 |
| Koh-Banerjee, PK | 1 |
| Ferreira, MP | 1 |
| Greenwood, M | 1 |
| Bowden, RG | 1 |
| Cowan, PN | 1 |
| Almada, AL | 1 |
| Kreider, RB | 1 |
| Gerin, I | 1 |
| Dolinsky, VW | 1 |
| Shackman, JG | 1 |
| Kennedy, RT | 1 |
| Chiang, SH | 1 |
| Burant, CF | 1 |
| Steffensen, KR | 1 |
| Gustafsson, JA | 1 |
| MacDougald, OA | 1 |
| Boschmann, M | 1 |
| Engeli, S | 1 |
| Adams, F | 1 |
| Franke, G | 1 |
| Luft, FC | 1 |
| Sharma, AM | 1 |
| Jordan, J | 1 |
| Molnár, D | 3 |
| Kardos, M | 2 |
| Soltész, G | 2 |
| Baranyai, S | 1 |
| Baranyai, Z | 1 |
| Luboshitzky, R | 1 |
| Bernardis, LL | 1 |
| Goldman, JK | 1 |
| Kodis, M | 1 |
| Domènech, M | 1 |
| López-Soriano, FJ | 1 |
| Argilés, JM | 1 |
| Ivy, JL | 2 |
| Cortez, MY | 2 |
| Chandler, RM | 1 |
| Byrne, HK | 1 |
| Miller, RH | 2 |
| Coppack, SW | 1 |
| Fisher, RM | 1 |
| Clark, ML | 1 |
| Pointon, JJ | 1 |
| Nagase, H | 2 |
| Bray, GA | 2 |
| York, DA | 2 |
| Stanko, RT | 3 |
| Arch, JE | 3 |
| Sukala, WR | 1 |
| Seymour, AM | 1 |
| Tietze, DL | 2 |
| Robertson, DA | 1 |
| Singh, BM | 1 |
| Nattrass, M | 1 |
| Torgan, CE | 1 |
| Brozinick, JT | 1 |
| Roca, P | 1 |
| Gianotti, M | 1 |
| Palou, A | 1 |
| Rösen, P | 1 |
| Herberg, L | 1 |
| Reinauer, H | 1 |
| Varga, P | 1 |
| Rubecz, I | 1 |
| Hamar, A | 1 |
| Mestyán, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Probiotic and Symbiotic in Body Weight, Blood Sugar and Lipemia of Obese Women[NCT02505854] | 32 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Metabolomic Fingerprint of Severe Obesity is Dynamically Affected by Bariatric Surgery in a Procedure-dependent Manner[NCT02480322] | 106 participants (Actual) | Observational | 2010-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for pyruvic acid and Obesity
| Article | Year |
|---|---|
Pyruvate supplementation for weight loss: a systematic review and meta-analysis of randomized clinical trials.
Topics: Dietary Supplements; Humans; Obesity; Overweight; Placebos; Pyruvic Acid; Randomized Controlled Tria | 2014 |
A perspective on the current strategies for the treatment of obesity.
Topics: Anti-Obesity Agents; Bariatrics; Chromium; Citrates; Cyclobutanes; Energy Intake; Ephedrine; Exercis | 2004 |
Pyruvate: beyond the marketing hype.
Topics: Adipose Tissue; Anticholesteremic Agents; Antioxidants; Appetite Depressants; Humans; Obesity; Physi | 1998 |
6 trials available for pyruvic acid and Obesity
| Article | Year |
|---|---|
A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes.
Topics: Adult; Blood Glucose; Carbohydrate Metabolism; Cross-Over Studies; Diabetes Mellitus, Type 2; Glucos | 2021 |
Modulation of the gut microbiota by probiotics and symbiotics is associated with changes in serum metabolite profile related to a decrease in inflammation and overall benefits to metabolic health: a double-blind randomized controlled clinical trial in wom
Topics: Adult; Amino Acids; Bifidobacterium animalis; Citric Acid; Double-Blind Method; Female; Gastrointest | 2021 |
Effects of calcium pyruvate supplementation during training on body composition, exercise capacity, and metabolic responses to exercise.
Topics: Adult; Analysis of Variance; Body Composition; Calcium; Dietary Supplements; Double-Blind Method; En | 2005 |
Influences of AT1 receptor blockade on tissue metabolism in obese men.
Topics: Adipose Tissue; Adult; Angiotensin II Type 1 Receptor Blockers; Biphenyl Compounds; Cross-Over Studi | 2006 |
Inhibition of regain in body weight and fat with addition of 3-carbon compounds to the diet with hyperenergetic refeeding after weight reduction.
Topics: Adipose Tissue; Adult; Body Composition; Diet; Dihydroxyacetone; Electric Impedance; Energy Intake; | 1996 |
Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate.
Topics: Body Composition; Diet, Reducing; Energy Intake; Energy Metabolism; Female; Humans; Leucine; Nitroge | 1992 |
59 other studies available for pyruvic acid and Obesity
| Article | Year |
|---|---|
Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice.
Topics: Animals; Anion Transport Proteins; Diabetes Mellitus, Type 2; Diet; Glucose; Mice; Mice, Obese; Mito | 2022 |
Profile of gut microbiota and serum metabolites associated with metabolic syndrome in a remote island most afflicted by obesity in Japan.
Topics: Body Mass Index; Creatine; Gastrointestinal Microbiome; Glycated Hemoglobin; Humans; Insulins; Japan | 2022 |
Greater reliance on glycolysis is associated with lower mitochondrial substrate oxidation and insulin sensitivity in infant myogenic MSCs.
Topics: Carbon Dioxide; Glucose; Glycolysis; Humans; Insulin; Insulin Resistance; Lactic Acid; Mesenchymal S | 2023 |
Programming effects of an early life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet.
Topics: Adipose Tissue; Animal Feed; Animals; Body Composition; Body Weight; Diet; Diet, High-Fat; Dietary F | 2019 |
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.
Topics: Adaptor Proteins, Signal Transducing; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; En | 2019 |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
Topics: Acetylglucosamine; Animals; Base Sequence; Caloric Restriction; Cell Line; Colforsin; Diabetes Melli | 2021 |
Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice.
Topics: Animals; Blood Chemical Analysis; Citric Acid; Diet, High-Fat; Energy Metabolism; Fatty Acids; Gas C | 2017 |
Salsalate Activates Skeletal Muscle Thermogenesis and Protects Mice from High-Fat Diet Induced Metabolic Dysfunction.
Topics: Adipose Tissue, White; Animals; Body Weight; Cell Line; Diabetes Mellitus, Type 2; Diet, High-Fat; E | 2017 |
VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Topics: Animals; Coronavirus Infections; Diet, High-Fat; HEK293 Cells; Hepatitis, Viral, Animal; Humans; Inf | 2017 |
Pyruvate induces torpor in obese mice.
Topics: Adenosine; Adipose Tissue, Brown; Animals; Brain; Insulin Resistance; Male; Mice, Inbred C57BL; Mice | 2018 |
A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.
Topics: Animals; Carbohydrates; Diet; Energy Metabolism; Heart; Male; Mice; Mice, Inbred C57BL; Mice, Obese; | 2018 |
Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice.
Topics: Animals; Blood Glucose; Body Composition; Diet, High-Fat; Eating; Gluconeogenesis; Glycogen; Hypergl | 2018 |
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.
Topics: AMP-Activated Protein Kinases; Animals; Argonaute Proteins; Diet, High-Fat; Eukaryotic Initiation Fa | 2018 |
Cafeteria Diet Feeding in Young Rats Leads to Hepatic Steatosis and Increased Gluconeogenesis under Fatty Acids and Glucagon Influence.
Topics: Animals; Diet; Energy Intake; Fatty Acids; Fatty Liver; Feeding Behavior; Glucagon; Gluconeogenesis; | 2018 |
Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats.
Topics: Animals; Blood Glucose; Blood Pressure; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Di | 2019 |
Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
Topics: Acetyl Coenzyme A; Animals; Cytosol; Diet, High-Fat; Insulin Resistance; Macrophage Activation; Macr | 2019 |
Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice.
Topics: Adipokines; Adipose Tissue; Animals; Antioxidants; Body Composition; C-Reactive Protein; Diet, High- | 2014 |
Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis.
Topics: Acrylates; Animals; Cells, Cultured; Citric Acid Cycle; Diet, High-Fat; Gluconeogenesis; Glucose; Gl | 2015 |
Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner.
Topics: Adult; Amino Acids, Aromatic; Amino Acids, Branched-Chain; Blood Banks; Body Mass Index; Citric Acid | 2015 |
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.
Topics: Animals; Body Weight; Cell Line; Diet; Dietary Carbohydrates; Dihydrolipoamide Dehydrogenase; Electr | 2015 |
miR-378 Activates the Pyruvate-PEP Futile Cycle and Enhances Lipolysis to Ameliorate Obesity in Mice.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Energy Metabolism; Glucose; Humans; Lipolysis; Mice; Mice, | 2016 |
Time-course metabolic changes in high-fat diet-induced obesity rats: A pilot study using hyperpolarized (13)C dynamic MRS.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Body Weight; Diet, High-Fat; | 2016 |
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Topics: Adenine Nucleotide Translocator 2; Adenosine Triphosphate; Animals; Atractyloside; Diet, High-Fat; D | 2017 |
The impact of obesity, sex, and diet on hepatic glucose production in cats.
Topics: Animals; Blood Glucose; Body Mass Index; Body Weight; Carbon Isotopes; Cats; Citrate (si)-Synthase; | 2009 |
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.
Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine | 2009 |
Complications but not obesity or diabetes mellitus have impact on the intraperitoneal lactate/pyruvate ratio measured by microdialysis.
Topics: Aged; Aged, 80 and over; Diabetes Complications; Female; Humans; Lactic Acid; Male; Microdialysis; M | 2010 |
Metabolic profiling of muscle contraction in lean compared with obese rodents.
Topics: Acetyl-CoA Carboxylase; Animals; Biological Transport; Carnitine; Glucose; Glycogen; Lactic Acid; Li | 2010 |
Reduced respiratory capacity in muscle mitochondria of obese subjects.
Topics: Adult; Biopsy; Body Mass Index; Case-Control Studies; Cell Respiration; Energy Metabolism; Exercise; | 2010 |
Metabolic master regulators: sharing information among multiple systems.
Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Insulin Resistance; Lactic A | 2012 |
Metabolic signatures of human adipose tissue hypoxia in obesity.
Topics: Adult; Body Mass Index; Cell Hypoxia; Fasting; Female; Forearm; Glucose; Glycolysis; Humans; Lactic | 2013 |
Studies of pyruvate and acetate metabolism in the hereditary obesity-diabetes syndrome of mice.
Topics: Acetates; Animals; Diabetes Mellitus; Mice; Obesity; Pyruvates; Pyruvic Acid; Syndrome | 1952 |
ACETATE and pyruvate metabolism in obese mice.
Topics: Acetates; Animals; Humans; Mice; Mice, Obese; Obesity; Pyruvates; Pyruvic Acid | 1953 |
Pyruvic acid metabolism in obesity.
Topics: Biochemical Phenomena; Humans; Obesity; Pyruvates; Pyruvic Acid | 1955 |
Studies on obesity. II. Blood pyruvate and lactate curves in obese and normal subjects after ingestion of glucose.
Topics: Blood; Eating; Glucose; Humans; Lactates; Lactic Acid; Obesity; Pyruvates; Pyruvic Acid | 1956 |
Blood pyruvic acid in obesity.
Topics: Humans; Obesity; Pyruvates; Pyruvic Acid | 1957 |
Blood pyruvic acid in obesity.
Topics: Humans; Obesity; Pyruvates; Pyruvic Acid | 1957 |
Blood pyruvic acid in obesity.
Topics: Humans; Obesity; Pyruvates; Pyruvic Acid | 1957 |
Blood pyruvic acid in obesity.
Topics: Humans; Obesity; Pyruvates; Pyruvic Acid | 1957 |
Metabolism in vitro of adipose tissue in obese-hyperglycemic and goldthioglucose-treated mice. II. Metabolism of pyruvate and acetate.
Topics: Acetates; Adipose Tissue; Animals; Gold; Hyperglycemia; In Vitro Techniques; Mice; Obesity; Pyruvate | 1961 |
Inorganic phosphate and pyruvate in obese patients during glucose assimilation.
Topics: Carbohydrate Metabolism; Glucose; Humans; Obesity; Phosphates; Pyruvates; Pyruvic Acid | 1960 |
PYRUVATE-TOLERANCE TESTS IN HEALTHY AND DIABETIC SUBJECTS.
Topics: Blood Chemical Analysis; Diabetes Mellitus; Fasting; Geriatrics; Humans; Hypoglycemic Agents; Inject | 1964 |
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES.
Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism | 1964 |
[METABOLISM OF PYRUVIC ACID AND ITS RELATIONS WITH INSULIN THERAPY OF VARIOUS FORMS OF DIABETES MELLITUS].
Topics: Blood; Diabetes Mellitus; Drug Therapy; Glucose Tolerance Test; Humans; Insulin; Metabolism; Obesity | 1964 |
Blood pyruvate curves of normal and obese subjects following the ingestion of carbohydrate.
Topics: Blood; Carbohydrates; Eating; Humans; Obesity; Pyruvic Acid | 1949 |
[The influence of panthotenic acid mitochondrial oxidation and oxidative phosphorylation in liver of rats with alimentary obesity].
Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Fatty Acids; Female; Mitochondria, Liver; Obes | 2004 |
Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats.
Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucose; In Vit | 2005 |
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.
Topics: Adipocytes; Adipose Tissue; Aging; Animals; Body Composition; Carbohydrate Metabolism; Cholesterol; | 2005 |
Intravenous glucose tolerance test in childhood obesity: metabolite levels and their relation to glucose utilization rate (KG).
Topics: Blood Glucose; Body Height; Child; Cholesterol; Fasting; Fatty Acids, Nonesterified; Glucose Toleran | 1982 |
Effect of glucagon infusion on some plasma metabolites and hormones in obese children.
Topics: Amino Acids; Blood Glucose; Child; Cholesterol; Fatty Acids, Nonesterified; Glucagon; Glycerol; Grow | 1982 |
Brown adipose tissue metabolism in hypothalamic-obese rats.
Topics: Adipose Tissue, Brown; Aging; Animals; Diet; Fatty Acids; Glucose; Hypothalamus; Lactates; Lactic Ac | 1983 |
Alanine as a lipogenic precursor in isolated hepatocytes from obese Zucker rats.
Topics: Acetyl Coenzyme A; Alanine; Alanine Transaminase; Animals; Cells, Cultured; Citrates; Coumaric Acids | 1993 |
Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cholesterol; Energy Metabolism; Female; G | 1994 |
Carbohydrate metabolism in insulin resistance: glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal.
Topics: Adipose Tissue; Adult; Female; Forearm; Glucose; Humans; Insulin; Insulin Resistance; Lactates; Lact | 1996 |
Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity.
Topics: Animals; Body Weight; Diet; Diet, Fat-Restricted; Dietary Fats; Eating; Lactates; Lactic Acid; Liver | 1996 |
Pyruvate and hepatic pyruvate dehydrogenase levels in rat strains sensitive and resistant to dietary obesity.
Topics: Animals; Dietary Fats; Liver; Obesity; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Rats; Rats, Inb | 1996 |
Cardiac carbohydrate metabolism in Zucker diabetic fatty rats.
Topics: Animals; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus, Type 2; Fatty Acids; Glucose; | 2002 |
Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate.
Topics: Adult; Basal Metabolism; Body Composition; Diet, Reducing; Dihydroxyacetone; Energy Metabolism; Fema | 1992 |
Effect of obesity on circulating intermediary metabolite concentrations in the absence of impaired glucose tolerance.
Topics: Adult; Alanine; Blood Glucose; Body Mass Index; C-Peptide; Fatty Acids, Nonesterified; Female; Gluco | 1991 |
Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats.
Topics: Animals; Basal Metabolism; Blood Glucose; Diet; Dihydroxyacetone; Energy Metabolism; Fatty Acids; Fe | 1991 |
Metabolic response to short term starvation in non-pregnant and late pregnant cafeteria-obese rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Female; Fetal Blood; Glycerol; Hydroxy | 1989 |
Different types of postinsulin receptor defects contribute to insulin resistance in hearts of obese Zucker rats.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Epoxy Compounds; Glucose; Insulin Resistance; Lacta | 1986 |
Food-induced thermogenesis in obese children.
Topics: Adolescent; Blood Glucose; Body Temperature Regulation; Child; Energy Metabolism; Fatty Acids, Nones | 1985 |