pyruvic acid has been researched along with Neuroblastoma in 21 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyruvic acid has a critical role in energy metabolism and a capability to nonenzymatically decarboxylate H2O2 into H2O." | 5.32 | Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. ( Mazzio, EA; Soliman, KF, 2003) |
| " We investigated the toxic effects of excess extracellular copper on motor neuronal cells expressing human mutant SOD1 (G93A), and evaluated the neuroprotective effects of energy metabolism intermediates or cofactors." | 1.33 | Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity. ( Kim, HJ; Kim, JM; Kim, M; Lee, KW; Park, JH; Sung, JJ, 2005) |
| "Pyruvic acid is a neuronal metabolic energy fuel that can also rapidly undergo decarboxylation to diffuse H(2)0(2) into H(2)0." | 1.32 | Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro. ( Mazzio, E; Soliman, KF, 2003) |
| "Pyruvic acid has a critical role in energy metabolism and a capability to nonenzymatically decarboxylate H2O2 into H2O." | 1.32 | Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. ( Mazzio, EA; Soliman, KF, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, Y | 1 |
| Sakamoto, K | 1 |
| Zhang, S | 1 |
| Zhang, X | 1 |
| Wang, X | 2 |
| Li, C | 1 |
| He, C | 1 |
| Luo, T | 1 |
| Ge, P | 1 |
| Gondáš, E | 1 |
| Kráľová Trančíková, A | 1 |
| Majerčíková, Z | 1 |
| Pokusa, M | 1 |
| Baranovičová, E | 1 |
| Bystrický, P | 1 |
| Dobrota, D | 1 |
| Murín, R | 1 |
| Sweet, RL | 1 |
| Zastre, JA | 1 |
| Cocco, S | 1 |
| Secondo, A | 1 |
| Del Viscovo, A | 1 |
| Procaccini, C | 1 |
| Formisano, L | 1 |
| Franco, C | 1 |
| Esposito, A | 1 |
| Scorziello, A | 1 |
| Matarese, G | 1 |
| Di Renzo, G | 1 |
| Canzoniero, LM | 1 |
| Wilkins, HM | 1 |
| Koppel, S | 1 |
| Carl, SM | 1 |
| Ramanujan, S | 1 |
| Weidling, I | 1 |
| Michaelis, ML | 1 |
| Michaelis, EK | 1 |
| Swerdlow, RH | 1 |
| Lee, JY | 1 |
| Ishida, Y | 1 |
| Takahashi, T | 1 |
| Naganuma, A | 1 |
| Hwang, GW | 1 |
| Nciri, R | 1 |
| Desmoulin, F | 1 |
| Allagui, MS | 1 |
| Murat, JC | 1 |
| Feki, AE | 1 |
| Vincent, C | 1 |
| Croute, F | 1 |
| Niewisch, MR | 1 |
| Kuçi, Z | 1 |
| Wolburg, H | 1 |
| Sautter, M | 1 |
| Krampen, L | 1 |
| Deubzer, B | 1 |
| Handgretinger, R | 1 |
| Bruchelt, G | 1 |
| Fukuyama, R | 1 |
| Nakayama, A | 1 |
| Nakase, T | 1 |
| Toba, H | 1 |
| Mukainaka, T | 1 |
| Sakaguchi, H | 1 |
| Saiwaki, T | 1 |
| Sakurai, H | 1 |
| Wada, M | 1 |
| Fushiki, S | 1 |
| Mazzio, E | 1 |
| Soliman, KF | 2 |
| Mazzio, EA | 1 |
| GJESSING, LR | 1 |
| BORUD, O | 1 |
| Jagtap, JC | 1 |
| Chandele, A | 1 |
| Chopde, BA | 1 |
| Shastry, P | 1 |
| Moussa, CE | 1 |
| Wersinger, C | 1 |
| Tomita, Y | 1 |
| Sidhu, A | 1 |
| Kim, HJ | 1 |
| Kim, JM | 1 |
| Park, JH | 1 |
| Sung, JJ | 1 |
| Kim, M | 1 |
| Lee, KW | 1 |
| Fonseca, CP | 1 |
| Jones, JG | 1 |
| Carvalho, RA | 1 |
| Jeffrey, FM | 1 |
| Montezinho, LP | 1 |
| Geraldes, CF | 1 |
| Castro, MM | 1 |
| Perez, E | 1 |
| Liu, R | 1 |
| Yan, LJ | 1 |
| Mallet, RT | 1 |
| Yang, SH | 1 |
| Kuo, F | 1 |
| Kotyla, T | 1 |
| Wilson, T | 1 |
| Kifle, L | 1 |
| Panagiotou, T | 1 |
| Gruverman, I | 1 |
| Tagne, JB | 1 |
| Shea, T | 1 |
| Nicolosi, R | 1 |
| Loske, C | 1 |
| Neumann, A | 1 |
| Cunningham, AM | 1 |
| Nichol, K | 1 |
| Schinzel, R | 1 |
| Riederer, P | 1 |
| Münch, G | 1 |
| Stokes, AH | 1 |
| Lewis, DY | 1 |
| Lash, LH | 1 |
| Jerome, WG | 1 |
| Grant, KW | 1 |
| Aschner, M | 1 |
| Vrana, KE | 1 |
21 other studies available for pyruvic acid and Neuroblastoma
| Article | Year |
|---|---|
Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Neuroblastoma; Neuroprotective Agents; Neurotoxicity | 2023 |
Maltol inhibits oxygen glucose deprivation‑induced chromatinolysis in SH‑SY5Y cells by maintaining pyruvate level.
Topics: Catalase; Glucose; Humans; Neuroblastoma; Oxygen; Pyruvic Acid; Reactive Oxygen Species; TOR Serine- | 2023 |
Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells.
Topics: Astrocytoma; Glioblastoma; Humans; Neuroblastoma; Pyruvate Carboxylase; Pyruvic Acid | 2021 |
HIF1-α-mediated gene expression induced by vitamin B1 deficiency.
Topics: Cell Hypoxia; Cell Nucleus; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; | 2013 |
Polychlorinated Biphenyls Induce Mitochondrial Dysfunction in SH-SY5Y Neuroblastoma Cells.
Topics: Adenosine Triphosphate; Cell Line, Tumor; Chlorodiphenyl (54% Chlorine); Glycolysis; Humans; Membran | 2015 |
Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure.
Topics: Adenosine Triphosphate; Cell Line; Cell Line, Tumor; Cytosol; Energy Metabolism; Glucose; Glycolysis | 2016 |
Transport of pyruvate into mitochondria is involved in methylmercury toxicity.
Topics: Acetyl Coenzyme A; Acetylcysteine; Antioxidants; Cytoplasm; Humans; Lactate Dehydrogenases; Methylme | 2016 |
Neuroprotective effects of chronic exposure of SH-SY5Y to low lithium concentration involve glycolysis stimulation, extracellular pyruvate accumulation and resistance to oxidative stress.
Topics: Analysis of Variance; Cell Line, Tumor; Dose-Response Relationship, Drug; Extracellular Fluid; Gluta | 2013 |
Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?
Topics: Acetyl Coenzyme A; Apoptosis; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Culture Media | 2012 |
A newly established neuronal rho-0 cell line highly susceptible to oxidative stress accumulates iron and other metals. Relevance to the origin of metal ion deposits in brains with neurodegenerative disorders.
Topics: Brain; Cell Respiration; Copper; Glycolysis; Humans; Hydrogen Peroxide; Iron; Membrane Potentials; M | 2002 |
Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Hydrogen Peroxide; Hydroxydopamines; Neuroblastoma; Neuroprote | 2003 |
Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells.
Topics: Animals; Antioxidants; Brain Neoplasms; Cell Survival; Glycolysis; Hydrogen Peroxide; Kinetics; Mice | 2003 |
STUDIES OF FUNCTIONAL NEURAL TUMORS. VII. URINARY EXCRETION OF PHENOLIC PYRUVIC ACIDS.
Topics: Alkylation; Child; Chromatography; Dihydroxyphenylalanine; Humans; Metabolism; Neoplasm Metastasis; | 1965 |
Sodium pyruvate protects against H(2)O(2) mediated apoptosis in human neuroblastoma cell line-SK-N-MC.
Topics: Antioxidants; Apoptosis; Blotting, Western; Brain Neoplasms; Caspase 3; Caspases; Cell Line, Tumor; | 2003 |
Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Carbon Isotopes; Cations, Monovalent; Cell Death; | 2004 |
Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity.
Topics: Amyotrophic Lateral Sclerosis; Cell Death; Cell Line, Tumor; Copper; Energy Metabolism; Free Radical | 2005 |
Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: a 13C NMR isotopomer analysis.
Topics: Acetyl Coenzyme A; Antimanic Agents; Bipolar Disorder; Brain; Brain Chemistry; Carbon Isotopes; Cell | 2005 |
Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells.
Topics: Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Hyd | 2007 |
A nanoemulsion of an anti-oxidant synergy formulation reduces tumor growth rate in neuroblastoma-bearing nude mice.
Topics: Animals; Antioxidants; Chemistry, Pharmaceutical; Drug Synergism; Emulsions; Mice; Nanostructures; N | 2007 |
Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress.
Topics: Animals; Antioxidants; Cell Death; Cell Line; Cricetinae; Enzyme Inhibitors; Fibroblasts; Glycation | 1998 |
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis.
Topics: Apoptosis; Ascorbic Acid; Biological Assay; Buthionine Sulfoximine; Cell Membrane; Chromatography, H | 2000 |