pyruvic acid has been researched along with Neoplasms in 115 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactate shuttle is the core of cancer cell metabolic reprogramming between two cells such as aerobic cancer cells and hypoxic cancer cells, tumor cells and stromal cells, cancer cells and vascular endothelial cells." | 2.82 | Lactate shuttle: from substance exchange to regulatory mechanism. ( Han, X; Liu, H; Ni, Y; Shen, P; Wang, X, 2022) |
| "Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment." | 2.72 | The metabolism of cancer cells during metastasis. ( Bergers, G; Fendt, SM, 2021) |
| "Melatonin is a glycolytic which converts diseased cells to the healthier phenotype." | 2.72 | Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases. ( Reiter, RJ; Rosales-Corral, S; Sharma, R, 2021) |
| "Decreased MPC expression in several cancers limits the mitochondrial oxidation of pyruvate and contributes to lactate accumulation in the cytosol, highlighting its role as a contributing, causal mediator of the Warburg effect." | 2.72 | Heart failure-emerging roles for the mitochondrial pyruvate carrier. ( Eaton, P; Fernandez-Caggiano, M, 2021) |
| "Accordingly, recent studies on cancer and diabetes have identified protein-protein interactions, post-translational processes, and transcriptional factors that modulate MPC function." | 2.66 | Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan. ( Buchanan, JL; Taylor, EB, 2020) |
| "Moreover, colorectal cancer cells can effectively shift to FAO to survive both glucose restriction and increases in oxidative stress at the expense of decreasing anabolism." | 2.66 | The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival. ( De Oliveira, MP; Liesa, M, 2020) |
| "Indeed, hypoxia benefits cancer cells in their growth, survival, and metastasis." | 2.61 | Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer. ( Harada, H; Hayashi, Y; Huang, G; Yokota, A, 2019) |
| "Systems metabolomics analysis of these cancers identified pyruvate carboxylation as an essential metabolic hub that feeds carbon skeletons of downstream metabolites of oxaloacetate into the biosynthesis of various cellular components including membrane lipids, nucleotides, amino acids, and the redox control." | 2.58 | Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection. ( Attwood, PV; Jitrapakdee, S; Lao-On, U, 2018) |
| "Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox state and create biomass." | 2.55 | Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development. ( Curry, J; Domingo-Vidal, M; Martinez-Outschoorn, U; Philp, N; Roche, M; Tanson, K; Wilde, L, 2017) |
| "In this Review, we discuss how cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression; in particular, we highlight potential metabolic vulnerabilities that might be targeted therapeutically." | 2.55 | Cancer metabolism: a therapeutic perspective. ( Lisanti, MP; Martinez-Outschoorn, UE; Peiris-Pagés, M; Pestell, RG; Sotgia, F, 2017) |
| "This review focuses on the brain and on cancer." | 2.53 | Monocarboxylate transporters in the brain and in cancer. ( Falces, J; Payen, VL; Pellerin, L; Pérez-Escuredo, J; Sboarina, M; Sonveaux, P; Van Hée, VF, 2016) |
| "Metabolic reprogramming in cancer supports the increased biosynthesis required for unchecked proliferation." | 2.53 | Mitochondrial pyruvate carrier function and cancer metabolism. ( Rauckhorst, AJ; Taylor, EB, 2016) |
| "Although anoikis is a barrier to metastasis, cancer cells have often acquired elevated threshold for anoikis and hence heightened metastatic potential." | 2.52 | The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. ( Cai, Q; Lu, J; Tan, M, 2015) |
| "It is elevated in many types of cancers and has been linked to tumor growth, maintenance, and invasion; therefore, its inhibition may restrict the energy supply in tumors and thereby reduce the metastatic and invasive potential of cancer cells." | 2.49 | Lactate dehydrogenase A in cancer: a promising target for diagnosis and therapy. ( Huang, G; Liu, J; Miao, P; Sheng, S; Sun, X, 2013) |
| "Tumorigenesis and metastasis are associated with metabolic reprogramming, including enhanced glycolysis and glutaminolysis." | 2.46 | Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing. ( Dafni, H; Ronen, SM, 2010) |
| "In the case of cancer, both chronic and acute hypoxic areas are found in the tumor." | 2.45 | Considering the role of pyruvate in tumor cells during hypoxia. ( Perrin, A; Roudier, E, 2009) |
| "One of the main challenges of anti-cancer therapy is to specifically target these drugs to malignant cells." | 2.45 | Tumor cell energy metabolism and its common features with yeast metabolism. ( Devin, A; Diaz-Ruiz, R; Rigoulet, M; Uribe-Carvajal, S, 2009) |
| "In primary tumors, such as cervix carcinomas, head and neck squamous cell carcinomas or rectum adenocarcinomas, elevated lactate levels as a mirror of a high glycolytic activity, are correlated even at the initial diagnosis with a high level of malignancy as indicated by increased formation of metastases or an elevated radiotherapy resistance." | 2.44 | [Lactate and redox status in malignant tumors]. ( Mueller-Klieser, W; Sattler, UG; Walenta, S, 2007) |
| "Globally, cancer is the second leading cause of mortality and morbidity." | 1.72 | In-Silico Analysis of Phytocompounds of ( Alomar, SY; Hashmi, MA; Imran, MA; Qais, FA, 2022) |
| "Pyruvic acid (PA) has been demonstrated to be an important cancer biomarker." | 1.56 | An enzyme-free sensing platform based on molecularly imprinted polymer/MWCNT composite for sub-micromolar-level determination of pyruvic acid as a cancer biomarker. ( Alizadeh, T; Nayeri, S, 2020) |
| "Using tissues from cervical and lung cancer patients, we find intracellular pyruvate concentrations inversely correlate with histone protein levels." | 1.51 | Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway. ( Chen, Z; Hu, B; Li, S; Ma, R; Ma, W; Workman, JL; Wu, Y; Yang, W; Yu, Q; Yu, X; Zhai, Y, 2019) |
| "In addition to its anticancer property, 3BP also exhibits antimicrobial activity." | 1.51 | 3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau. ( Casal, M; Ko, YH; Niedźwiecka, K; Pedersen, PL; Ułaszewski, S, 2019) |
| "Many cancer cells undergo metabolic reprogramming known as the Warburg effect, which is characterized by a greater dependence on glycolysis for ATP generation, even under normoxic conditions." | 1.48 | Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells. ( Shimada, N; Takasawa, R; Tanuma, SI, 2018) |
| "The main cancer types of the 17 patients were sarcoma (n = 11), carcinoma (n = 5) and mastocytoma (n = 1)." | 1.48 | Combined hyperpolarized ( Ardenkjaer-Larsen, J; Clemmensen, AE; Gutte, H; Hansen, AE; Holst, P; Johannesen, HH; Kjaer, A; Klausen, TL; Kristensen, AT; Larsen, MME; Rahbek, S; Schøier, C, 2018) |
| "One of the remarkable features of cancer cells is aerobic glycolysis, a phenomenon known as the "Warburg Effect", in which cells rely preferentially on glycolysis instead of oxidative phosphorylation (OXPHOS) as the main energy source even in the presence of high oxygen tension." | 1.46 | Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells. ( Berge, V; Fan, Z; Goscinski, MA; Grigalavicius, M; Han, G; Ji, Y; Kan, Q; Li, X; Li, Y; Nesland, JM; Suo, Z; Zhang, M; Zhao, J, 2017) |
| "The uncontrolled proliferation of cancer cells requires functional mitochondrial metabolism, which uses Ca(2+) as a cofactor." | 1.43 | Onco-IP3Rs Feed Cancerous Cravings for Mitochondrial Ca(2.). ( Bultynck, G, 2016) |
| "However, some cancer cell lines do not require GLN for survival and the basis for this discrepancy is not well understood." | 1.43 | Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine. ( Cebeci, A; Cetinbas, NM; DeBerardinis, RJ; Harris, RC; Negri, GL; Sorensen, PH; Sudderth, J; Yılmaz, ÖH, 2016) |
| "This suggests that cancer drug sensitivity and resistance are not intrinsic properties of cancer cells, and demonstrates that the environment can dictate sensitivity to therapies that impact cell metabolism." | 1.43 | Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin. ( Bush, LN; Davidson, SM; Freinkman, E; Gitego, N; Gui, DY; Hosios, AM; Luengo, A; Sullivan, LB; Thomas, CJ; Vander Heiden, MG, 2016) |
| "Our results define a role for PCK2 in cancer cell metabolic reprogramming that promotes glucose-independent cell growth and metabolic stress resistance in human tumors." | 1.42 | Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. ( Artyomov, MN; Avizonis, D; Blagih, J; Bridon, G; Choinière, L; Coelho, PP; Elder, DJ; Flynn, BR; Gingras, MC; Griss, T; Jones, RG; Loginicheva, E; Ntimbane, T; Pause, A; Raissi, TC; Samborska, B; Sergushichev, A; Tavaré, JM; Thomas, EC; Vincent, EE, 2015) |
| "Metabolic reprogramming facilitates cancer cell growth, so quantitative metabolic flux measurements could produce useful biomarkers." | 1.40 | Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells. ( Chuang, DT; DeBerardinis, RJ; Harrison, C; Jin, ES; Malloy, CR; Merritt, ME; Sherry, AD; Yang, C, 2014) |
| "Anti-angiogenic therapies for solid tumors frequently function in two steps: the transient normalization of structurally and functionally aberrant tumor blood vessels with increased blood perfusion, followed by the pruning of tumor blood vessels and the resultant cessation of nutrients and oxygen delivery required for tumor growth." | 1.40 | In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization. ( Devasahayam, N; Krishna, MC; Lizak, MJ; Matsumoto, S; Matsuo, M; Merkle, H; Mitchell, JB; Morris, HD; Munasinghe, JP; Saito, K; Suburamanian, S; Takakusagi, Y; Yasukawa, K, 2014) |
| "The detection of tumors noninvasively, the characterization of their progression by defined markers and the monitoring of response to treatment are goals of medical imaging techniques." | 1.39 | Diffusion of hyperpolarized (13) C-metabolites in tumor cell spheroids using real-time NMR spectroscopy. ( Durst, M; Düwel, S; Glaser, SJ; Haase, A; Köllisch, U; Menzel, MI; Otto, AM; Schilling, F; Schulte, RF, 2013) |
| "A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy." | 1.37 | Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. ( Brindle, K; Chekmenev, EY; Comment, A; Cunningham, CH; Deberardinis, RJ; Green, GG; Kurhanewicz, J; Leach, MO; Malloy, CR; Rajan, SS; Rizi, RR; Ross, BD; Vigneron, DB; Warren, WS, 2011) |
| "Proliferating cells, including cancer cells, require altered metabolism to efficiently incorporate nutrients such as glucose into biomass." | 1.36 | Evidence for an alternative glycolytic pathway in rapidly proliferating cells. ( Amador-Noguez, D; Asara, JM; Cantley, LC; Christofk, HR; Heffron, GJ; Locasale, JW; Rabinowitz, JD; Sharfi, H; Swanson, KD; Vander Heiden, MG; Wagner, G, 2010) |
| "Hypoxia-induced gene expression in cancer cells has been linked to malignant transformation." | 1.31 | Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. ( Forbes, RA; Lu, H; Verma, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (23.48) | 18.7374 |
| 1990's | 2 (1.74) | 18.2507 |
| 2000's | 9 (7.83) | 29.6817 |
| 2010's | 60 (52.17) | 24.3611 |
| 2020's | 17 (14.78) | 2.80 |
| Authors | Studies |
|---|---|
| Korwar, S | 1 |
| Morris, BL | 1 |
| Parikh, HI | 1 |
| Coover, RA | 1 |
| Doughty, TW | 1 |
| Love, IM | 1 |
| Hilbert, BJ | 1 |
| Royer, WE | 1 |
| Kellogg, GE | 1 |
| Grossman, SR | 1 |
| Ellis, KC | 1 |
| Wang, X | 1 |
| Liu, H | 1 |
| Ni, Y | 1 |
| Shen, P | 1 |
| Han, X | 1 |
| Elia, I | 1 |
| Rowe, JH | 1 |
| Johnson, S | 1 |
| Joshi, S | 1 |
| Notarangelo, G | 1 |
| Kurmi, K | 1 |
| Weiss, S | 1 |
| Freeman, GJ | 1 |
| Sharpe, AH | 1 |
| Haigis, MC | 1 |
| Hune, T | 1 |
| Mamone, S | 1 |
| Schroeder, H | 1 |
| Jagtap, AP | 1 |
| Sternkopf, S | 1 |
| Stevanato, G | 1 |
| Korchak, S | 1 |
| Fokken, C | 1 |
| Müller, CA | 1 |
| Schmidt, AB | 1 |
| Becker, D | 1 |
| Glöggler, S | 1 |
| Qais, FA | 1 |
| Alomar, SY | 1 |
| Imran, MA | 1 |
| Hashmi, MA | 1 |
| Truszkiewicz, A | 1 |
| Bartusik-Aebisher, D | 1 |
| Zalejska-Fiolka, J | 1 |
| Kawczyk-Krupka, A | 1 |
| Aebisher, D | 1 |
| Ma, R | 1 |
| Wu, Y | 1 |
| Zhai, Y | 1 |
| Hu, B | 1 |
| Ma, W | 1 |
| Yang, W | 1 |
| Yu, Q | 1 |
| Chen, Z | 1 |
| Workman, JL | 1 |
| Yu, X | 1 |
| Li, S | 1 |
| Cheng, A | 1 |
| Zhang, P | 1 |
| Wang, B | 1 |
| Yang, D | 1 |
| Duan, X | 1 |
| Jiang, Y | 2 |
| Xu, T | 1 |
| Shi, J | 1 |
| Ding, C | 1 |
| Wu, G | 1 |
| Sang, Z | 1 |
| Wu, Q | 1 |
| Wang, H | 2 |
| Wu, M | 1 |
| Zhang, Z | 1 |
| Pan, X | 1 |
| Pan, YY | 1 |
| Gao, P | 1 |
| Zhang, H | 3 |
| Zhou, CZ | 1 |
| Guo, J | 1 |
| Yang, Z | 1 |
| Alizadeh, T | 1 |
| Nayeri, S | 1 |
| Ye, S | 1 |
| Xu, P | 1 |
| Huang, M | 1 |
| Chen, X | 1 |
| Zeng, S | 1 |
| Wang, Q | 1 |
| Chen, J | 1 |
| Li, K | 1 |
| Gao, W | 1 |
| Liu, R | 1 |
| Liu, J | 2 |
| Shao, Y | 1 |
| Xu, Y | 1 |
| Zhang, Q | 1 |
| Zhong, Z | 1 |
| Wei, Z | 1 |
| Wang, J | 1 |
| Hao, B | 1 |
| Huang, W | 1 |
| Liu, Q | 1 |
| Zangari, J | 1 |
| Petrelli, F | 1 |
| Maillot, B | 1 |
| Martinou, JC | 3 |
| Buchanan, JL | 1 |
| Taylor, EB | 3 |
| Muthusamy, T | 1 |
| Cordes, T | 1 |
| Handzlik, MK | 1 |
| You, L | 1 |
| Lim, EW | 1 |
| Gengatharan, J | 1 |
| Pinto, AFM | 1 |
| Badur, MG | 1 |
| Kolar, MJ | 1 |
| Wallace, M | 1 |
| Saghatelian, A | 1 |
| Metallo, CM | 1 |
| De Oliveira, MP | 1 |
| Liesa, M | 1 |
| Bergers, G | 1 |
| Fendt, SM | 1 |
| Reiter, RJ | 1 |
| Sharma, R | 1 |
| Rosales-Corral, S | 1 |
| Fernandez-Caggiano, M | 1 |
| Eaton, P | 1 |
| Brindle, KM | 5 |
| Keshari, KR | 1 |
| Prochownik, EV | 1 |
| Harlan, CJ | 1 |
| Xu, Z | 2 |
| Walker, CM | 2 |
| Michel, KA | 1 |
| Reed, GD | 1 |
| Bankson, JA | 2 |
| Li, X | 2 |
| Han, G | 1 |
| Kan, Q | 1 |
| Fan, Z | 1 |
| Li, Y | 2 |
| Ji, Y | 1 |
| Zhao, J | 1 |
| Zhang, M | 1 |
| Grigalavicius, M | 1 |
| Berge, V | 1 |
| Goscinski, MA | 1 |
| Nesland, JM | 1 |
| Suo, Z | 1 |
| Ghosh, D | 1 |
| De, RK | 1 |
| Stacpoole, PW | 1 |
| Shimada, N | 1 |
| Takasawa, R | 1 |
| Tanuma, SI | 1 |
| Wilde, L | 1 |
| Roche, M | 1 |
| Domingo-Vidal, M | 1 |
| Tanson, K | 1 |
| Philp, N | 1 |
| Curry, J | 1 |
| Martinez-Outschoorn, U | 1 |
| Lao-On, U | 1 |
| Attwood, PV | 1 |
| Jitrapakdee, S | 1 |
| Hansen, AE | 2 |
| Gutte, H | 2 |
| Holst, P | 1 |
| Johannesen, HH | 2 |
| Rahbek, S | 2 |
| Clemmensen, AE | 1 |
| Larsen, MME | 1 |
| Schøier, C | 1 |
| Ardenkjaer-Larsen, J | 2 |
| Klausen, TL | 1 |
| Kristensen, AT | 2 |
| Kjaer, A | 1 |
| Ko, YH | 1 |
| Niedźwiecka, K | 1 |
| Casal, M | 1 |
| Pedersen, PL | 1 |
| Ułaszewski, S | 1 |
| Kettunen, MI | 4 |
| Hayashi, Y | 1 |
| Yokota, A | 1 |
| Harada, H | 1 |
| Huang, G | 2 |
| Zhu, Z | 1 |
| Zhu, X | 1 |
| Ohliger, MA | 1 |
| Tang, S | 1 |
| Cao, P | 1 |
| Carvajal, L | 1 |
| Autry, AW | 1 |
| Kurhanewicz, J | 2 |
| Chang, S | 1 |
| Aggarwal, R | 1 |
| Munster, P | 1 |
| Xu, D | 1 |
| Larson, PEZ | 1 |
| Vigneron, DB | 2 |
| Gordon, JW | 1 |
| Im, DK | 1 |
| Cheong, H | 1 |
| Lee, JS | 1 |
| Oh, MK | 1 |
| Yang, KM | 1 |
| Dutta, P | 1 |
| Salzillo, TC | 1 |
| Pudakalakatti, S | 1 |
| Gammon, ST | 1 |
| Kaipparettu, BA | 1 |
| McAllister, F | 1 |
| Wagner, S | 1 |
| Frigo, DE | 1 |
| Logothetis, CJ | 1 |
| Zacharias, NM | 1 |
| Bhattacharya, PK | 2 |
| Li, LZ | 1 |
| Kadlececk, S | 1 |
| Xu, HN | 1 |
| Daye, D | 1 |
| Pullinger, B | 1 |
| Profka, H | 1 |
| Chodosh, L | 1 |
| Rizi, R | 1 |
| Vanderporten, E | 1 |
| Frick, L | 1 |
| Turincio, R | 1 |
| Thana, P | 1 |
| Lamarr, W | 1 |
| Liu, Y | 1 |
| Zhdanov, AV | 1 |
| Waters, AH | 1 |
| Golubeva, AV | 1 |
| Dmitriev, RI | 1 |
| Papkovsky, DB | 1 |
| Miao, P | 1 |
| Sheng, S | 1 |
| Sun, X | 1 |
| Gray, LR | 1 |
| Tompkins, SC | 1 |
| Yang, C | 1 |
| Harrison, C | 1 |
| Jin, ES | 1 |
| Chuang, DT | 1 |
| Sherry, AD | 2 |
| Malloy, CR | 2 |
| Merritt, ME | 2 |
| DeBerardinis, RJ | 3 |
| Schmidt, R | 1 |
| Laustsen, C | 1 |
| Dumez, JN | 1 |
| Serrao, EM | 1 |
| Marco-Rius, I | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| Frydman, L | 1 |
| Matsumoto, S | 1 |
| Saito, K | 1 |
| Takakusagi, Y | 1 |
| Matsuo, M | 1 |
| Munasinghe, JP | 1 |
| Morris, HD | 1 |
| Lizak, MJ | 1 |
| Merkle, H | 1 |
| Yasukawa, K | 1 |
| Devasahayam, N | 1 |
| Suburamanian, S | 1 |
| Mitchell, JB | 1 |
| Krishna, MC | 1 |
| Lu, J | 1 |
| Tan, M | 1 |
| Cai, Q | 1 |
| Adeva-Andany, M | 1 |
| López-Ojén, M | 1 |
| Funcasta-Calderón, R | 1 |
| Ameneiros-Rodríguez, E | 1 |
| Donapetry-García, C | 1 |
| Vila-Altesor, M | 1 |
| Rodríguez-Seijas, J | 1 |
| Ozden, O | 1 |
| Park, SH | 1 |
| Wagner, BA | 1 |
| Song, HY | 1 |
| Zhu, Y | 1 |
| Vassilopoulos, A | 1 |
| Jung, B | 1 |
| Buettner, GR | 1 |
| Gius, D | 1 |
| Vanderperre, B | 1 |
| Bender, T | 2 |
| Kunji, ER | 1 |
| Szlosarek, PW | 1 |
| Lee, S | 1 |
| Pollard, PJ | 1 |
| Ngo, DC | 1 |
| Ververis, K | 1 |
| Tortorella, SM | 1 |
| Karagiannis, TC | 1 |
| Zhou, A | 1 |
| Ni, J | 1 |
| Wang, Y | 1 |
| Wu, W | 1 |
| Lu, S | 1 |
| Karakousis, PC | 1 |
| Yao, YF | 1 |
| Lai, SY | 2 |
| Fuller, CD | 1 |
| Frank, SJ | 1 |
| Larsen, MM | 1 |
| Henriksen, ST | 1 |
| Højgaard, L | 1 |
| Kjær, A | 1 |
| Ramirez, MS | 1 |
| Stefan, W | 1 |
| Fuentes, D | 1 |
| Lee, J | 1 |
| Sandulache, VC | 1 |
| Chen, Y | 1 |
| Phan, L | 1 |
| Chou, PC | 1 |
| Rao, A | 1 |
| Yeung, SC | 1 |
| Lee, MH | 1 |
| Schellingerhout, D | 1 |
| Conrad, CA | 1 |
| Malloy, C | 1 |
| Hazle, JD | 1 |
| Vincent, EE | 1 |
| Sergushichev, A | 1 |
| Griss, T | 1 |
| Gingras, MC | 1 |
| Samborska, B | 1 |
| Ntimbane, T | 1 |
| Coelho, PP | 1 |
| Blagih, J | 1 |
| Raissi, TC | 1 |
| Choinière, L | 1 |
| Bridon, G | 1 |
| Loginicheva, E | 1 |
| Flynn, BR | 1 |
| Thomas, EC | 1 |
| Tavaré, JM | 1 |
| Avizonis, D | 1 |
| Pause, A | 1 |
| Elder, DJ | 1 |
| Artyomov, MN | 1 |
| Jones, RG | 1 |
| Giampazolias, E | 1 |
| Tait, SW | 1 |
| Olson, KA | 1 |
| Schell, JC | 1 |
| Rutter, J | 1 |
| Pérez-Escuredo, J | 1 |
| Van Hée, VF | 1 |
| Sboarina, M | 1 |
| Falces, J | 1 |
| Payen, VL | 1 |
| Pellerin, L | 1 |
| Sonveaux, P | 1 |
| Bultynck, G | 1 |
| Lu, NN | 1 |
| Weng, ZY | 1 |
| Chen, QY | 1 |
| Boison, D | 1 |
| Xiao, XX | 1 |
| Gao, J | 1 |
| Martinez-Outschoorn, UE | 1 |
| Peiris-Pagés, M | 1 |
| Pestell, RG | 1 |
| Sotgia, F | 1 |
| Lisanti, MP | 1 |
| Rauckhorst, AJ | 1 |
| Yin, C | 1 |
| He, D | 1 |
| Chen, S | 1 |
| Tan, X | 1 |
| Sang, N | 1 |
| Cetinbas, NM | 1 |
| Sudderth, J | 1 |
| Harris, RC | 1 |
| Cebeci, A | 1 |
| Negri, GL | 1 |
| Yılmaz, ÖH | 1 |
| Sorensen, PH | 1 |
| Gui, DY | 1 |
| Sullivan, LB | 1 |
| Luengo, A | 1 |
| Hosios, AM | 1 |
| Bush, LN | 1 |
| Gitego, N | 1 |
| Davidson, SM | 1 |
| Freinkman, E | 1 |
| Thomas, CJ | 1 |
| Vander Heiden, MG | 3 |
| Reynolds, S | 1 |
| Metcalf, S | 1 |
| Cochrane, EJ | 1 |
| Collins, RC | 1 |
| Jones, S | 1 |
| Paley, MNJ | 1 |
| Tozer, GM | 1 |
| Roudier, E | 1 |
| Perrin, A | 1 |
| Feron, O | 1 |
| Diaz-Ruiz, R | 1 |
| Uribe-Carvajal, S | 1 |
| Devin, A | 1 |
| Rigoulet, M | 1 |
| Smolková, K | 1 |
| Plecitá-Hlavatá, L | 1 |
| Bellance, N | 1 |
| Benard, G | 1 |
| Rossignol, R | 1 |
| Ježek, P | 1 |
| Locasale, JW | 1 |
| Swanson, KD | 1 |
| Sharfi, H | 1 |
| Heffron, GJ | 1 |
| Amador-Noguez, D | 1 |
| Christofk, HR | 2 |
| Wagner, G | 1 |
| Rabinowitz, JD | 1 |
| Asara, JM | 1 |
| Cantley, LC | 2 |
| Witney, TH | 3 |
| Bohndiek, SE | 1 |
| Hu, DE | 1 |
| Kennedy, BW | 1 |
| Gallagher, FA | 1 |
| Brindle, K | 1 |
| Chekmenev, EY | 1 |
| Comment, A | 1 |
| Cunningham, CH | 2 |
| Green, GG | 1 |
| Leach, MO | 1 |
| Rajan, SS | 1 |
| Rizi, RR | 1 |
| Ross, BD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Safety and Efficacy of Esperanza Extract (Petiveria Alliacea) in Patients With Metastatic Gastrointestinal Tumors and Acute Leukemia[NCT05587088] | Phase 1/Phase 2 | 82 participants (Anticipated) | Interventional | 2022-12-15 | Not yet recruiting | ||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| The Role of Pyruvate Kinase M2 in Growth, Invasion and Drug Resistance in Human Urothelial Carcinoma[NCT01968928] | 25 participants (Anticipated) | Observational [Patient Registry] | 2014-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
35 reviews available for pyruvic acid and Neoplasms
| Article | Year |
|---|---|
Lactate shuttle: from substance exchange to regulatory mechanism.
Topics: Endothelial Cells; Energy Metabolism; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lacta | 2022 |
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.
Topics: Animals; Gene Expression Regulation; Humans; Metabolic Diseases; Mitochondria; Mitochondrial Membran | 2020 |
Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan.
Topics: Aging; Animals; Diabetes Mellitus; Humans; Mitochondrial Membrane Transport Proteins; Monocarboxylic | 2020 |
The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival.
Topics: Adipose Tissue; Animals; Cell Proliferation; Cell Survival; Fatty Acids; Glucose; Glycolysis; Humans | 2020 |
The metabolism of cancer cells during metastasis.
Topics: Acetates; Adenosine Triphosphate; Animals; Cell Plasticity; Fatty Acids; Glutamine; Humans; Lactic A | 2021 |
Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases.
Topics: Acetyl Coenzyme A; Animals; Glucose; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; | 2021 |
Heart failure-emerging roles for the mitochondrial pyruvate carrier.
Topics: Animals; Heart Failure; Humans; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Monoc | 2021 |
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells.
Topics: Acetates; Animals; Biosynthetic Pathways; Embryonic Development; Humans; Neoplasms; Pyruvic Acid; Tu | 2021 |
In Silico Modeling of Crabtree Effect.
Topics: Adaptation, Physiological; Carbon Dioxide; Citric Acid Cycle; Computer Simulation; Ethanol; Fermenta | 2017 |
Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Biomimetics; Citric Acid Cycle; Dichloroacetic Acid; Ener | 2017 |
Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis Regulatory Proteins; Cell Proliferation; Dr | 2017 |
Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection.
Topics: Animals; Diabetes Mellitus; Humans; Infections; Neoplasms; Pyruvate Carboxylase; Pyruvic Acid | 2018 |
Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer.
Topics: Cell Hypoxia; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Hypoxia-Inducible Factor 1 | 2019 |
Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging.
Topics: Animals; Carbon Isotopes; Cell Line; Humans; Magnetic Resonance Imaging; Mice; Neoplasms; Outcome an | 2019 |
Lactate dehydrogenase A in cancer: a promising target for diagnosis and therapy.
Topics: Animals; Biomarkers, Tumor; Drug Resistance, Neoplasm; Energy Metabolism; Glycolysis; Humans; Isoenz | 2013 |
Regulation of pyruvate metabolism and human disease.
Topics: Citric Acid Cycle; Cytosol; Heart Diseases; Humans; Mitochondria; Models, Biological; Neoplasms; Neu | 2014 |
The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.
Topics: Anoikis; Cell Proliferation; Citric Acid Cycle; Glucose; Glycolysis; Humans; Hypoxia-Inducible Facto | 2015 |
Comprehensive review on lactate metabolism in human health.
Topics: Alanine; Carbon Dioxide; Diabetes Mellitus; Glucose; Humans; Lactic Acid; Metabolic Networks and Pat | 2014 |
Mitochondrial pyruvate import and its effects on homeostasis.
Topics: Animals; Glucose; Homeostasis; Humans; Membrane Transport Proteins; Mitochondria; Mitochondrial Memb | 2015 |
Introduction to the molecular basis of cancer metabolism and the Warburg effect.
Topics: Apoptosis; Genes, Neoplasm; Glycolysis; Humans; Lactic Acid; Mitochondria; Neoplasms; Pyruvic Acid; | 2015 |
Mitochondria and the hallmarks of cancer.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Death; Energy Metabolism; Gene Expression Regulatio | 2016 |
The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?
Topics: Animals; Anion Transport Proteins; Diabetes Mellitus, Type 2; Drosophila Proteins; Energy Metabolism | 2016 |
Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.
Topics: Glycolysis; Humans; Neoplasms; Oxidation-Reduction; Pyruvic Acid | 2016 |
Monocarboxylate transporters in the brain and in cancer.
Topics: Animals; Astrocytes; Biological Transport, Active; Brain; Brain Diseases; Cognition; Gene Expression | 2016 |
Cancer metabolism: a therapeutic perspective.
Topics: Acetyl Coenzyme A; Adaptation, Physiological; Amino Acids; Antineoplastic Agents; Antioxidants; Auto | 2017 |
Mitochondrial pyruvate carrier function and cancer metabolism.
Topics: Cell Proliferation; Citric Acid Cycle; Electron Transport; Humans; Membrane Transport Proteins; Mito | 2016 |
Considering the role of pyruvate in tumor cells during hypoxia.
Topics: Adaptation, Physiological; Animals; Cell Hypoxia; Drug Resistance, Neoplasm; Humans; Neoplasms; Neov | 2009 |
Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells.
Topics: Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Energy Metabolism; Glycolysis; Humans; La | 2009 |
Tumor cell energy metabolism and its common features with yeast metabolism.
Topics: Animals; Apoptosis; Citric Acid Cycle; Energy Metabolism; Fermentation; Glucose; Glycolysis; Humans; | 2009 |
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells.
Topics: Adaptation, Biological; Cell Hypoxia; Cell Proliferation; Energy Metabolism; Gene Expression Regulat | 2011 |
Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing.
Topics: Bicarbonates; Diagnostic Imaging; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neoplasm Metas | 2010 |
[Tumor pathophysiology].
Topics: Animals; Blood Glucose; Cell Hypoxia; Energy Metabolism; Humans; Lactic Acid; Neoplasm Invasiveness; | 2012 |
[Lactate . pyruvate].
Topics: Acidosis, Lactic; Biomarkers; Diabetes Mellitus; Humans; Lactic Acid; Neoplasms; Pyruvic Acid | 2002 |
[Lactate and redox status in malignant tumors].
Topics: Carbohydrate Metabolism; Free Radical Scavengers; Glycolysis; Humans; Lactates; Luminescence; Neopla | 2007 |
Membrane cholesterol, tumorigenesis, and the biochemical phenotype of neoplasia.
Topics: Acetates; Animals; Asparagine; Aspartic Acid; Biological Transport, Active; Cell Division; Cell Memb | 1981 |
80 other studies available for pyruvic acid and Neoplasms
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).
Topics: Alcohol Oxidoreductases; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA-Binding Pr | 2016 |
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8
Topics: CD8-Positive T-Lymphocytes; Humans; Immunity; Lactic Acid; Neoplasms; Pyruvate Carboxylase; Pyruvic | 2022 |
Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-
Topics: Carbon Isotopes; Humans; Hydrogen; Magnetic Resonance Imaging; Neoplasms; Pyruvic Acid | 2023 |
In-Silico Analysis of Phytocompounds of
Topics: Antineoplastic Agents; Glucosides; Humans; Luteolin; Micronutrients; Molecular Docking Simulation; N | 2022 |
Cellular Lactate Spectroscopy Using 1.5 Tesla Clinical Apparatus.
Topics: Glucose; Glycogen; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Neoplasms; Protons; Pyruvic | 2022 |
Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Down-Regulation; Gene Expression Regulation | 2019 |
Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect.
Topics: Animals; Aurora Kinase A; Azepines; Cell Line, Tumor; Glycolysis; HEK293 Cells; HeLa Cells; Humans; | 2019 |
An enzyme-free sensing platform based on molecularly imprinted polymer/MWCNT composite for sub-micromolar-level determination of pyruvic acid as a cancer biomarker.
Topics: Biomarkers, Tumor; Electrodes; Humans; Limit of Detection; Molecular Imprinting; Neoplasms; Polymers | 2020 |
The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cyclic N-Oxides; Female; Glutamine; Glycolysis; Heter | 2020 |
Serine restriction alters sphingolipid diversity to constrain tumour growth.
Topics: Alanine; Animals; Cell Adhesion; Cell Division; Diet; Female; Glycine; HCT116 Cells; Humans; Membran | 2020 |
Editorial commentary for the special issue: technological developments in hyperpolarized
Topics: Carbon Isotopes; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neoplasm | 2021 |
The effect of transmit B
Topics: Humans; Magnetic Resonance Imaging; Neoplasms; Phantoms, Imaging; Pyruvic Acid; Reproducibility of R | 2021 |
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells.
Topics: Animals; Anion Transport Proteins; Biomarkers; Cell Line, Tumor; Citric Acid Cycle; Disease Models, | 2017 |
Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.
Topics: Apoptosis; Butyrates; Carrier Proteins; Cell Line, Tumor; Citric Acid Cycle; Drug Screening Assays, | 2018 |
Combined hyperpolarized
Topics: Animals; Carbon Isotopes; Cross-Sectional Studies; Disease Models, Animal; Dogs; Female; Fluorodeoxy | 2018 |
3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau.
Topics: Animals; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Fungi; Glycolysis; Hexokinase; Hu | 2019 |
Hyperpolarized MRI for Studying Tumor Metabolism.
Topics: Animals; Biomarkers; Data Analysis; Disease Models, Animal; Energy Metabolism; Humans; Kinetics; Lac | 2019 |
Coil combination methods for multi-channel hyperpolarized
Topics: Algorithms; Breast Neoplasms; Carbon Isotopes; Computer Simulation; Electromagnetic Fields; Female; | 2019 |
Protein kinase CK2-dependent aerobic glycolysis-induced lactate dehydrogenase A enhances the migration and invasion of cancer cells.
Topics: Aerobiosis; Animals; Casein Kinase II; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferati | 2019 |
Ratiometric analysis in hyperpolarized NMR (I): test of the two-site exchange model and the quantification of reaction rate constants.
Topics: Animals; Cell Line, Tumor; Computer Simulation; Humans; Kinetics; Lactic Acid; Magnetic Resonance Sp | 2013 |
Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors.
Topics: Enzyme Assays; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; L-Lactate Dehydrogenase; | 2013 |
Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling.
Topics: Animals; Apoptosis; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration; Energy Met | 2014 |
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.
Topics: Carbon Isotopes; Cell Line, Tumor; Glucose; Glycolysis; Humans; Magnetic Resonance Spectroscopy; Neo | 2014 |
In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.
Topics: Algorithms; Animals; Echo-Planar Imaging; Kidney; Lactic Acid; Lymphoma; Magnetic Resonance Imaging; | 2014 |
In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Contrast Media; Cyclic N-Oxides; Electron Spin R | 2014 |
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.
Topics: Acetylation; Blotting, Western; Cell Proliferation; Fluorescent Antibody Technique; Glucose; Glycoly | 2014 |
Rewiring mitochondrial pyruvate metabolism: switching off the light in cancer cells?
Topics: Biological Transport; Glycolysis; Humans; Mitochondria; Molecular Targeted Therapy; Neoplasms; Pyruv | 2014 |
Metabolomics specificity of tuberculosis plasma revealed by (1)H NMR spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Community-Acquired Infections; Dia | 2015 |
Metabolic Imaging as a Biomarker of Early Radiation Response in Tumors.
Topics: Biomarkers; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasms; Pyruvic | 2015 |
Simultaneous Hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 Dogs with Cancer.
Topics: Animals; Dog Diseases; Dogs; Fluorodeoxyglucose F18; Image Processing, Computer-Assisted; Lactic Aci | 2015 |
Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.
Topics: Algorithms; Animals; Carbon Radioisotopes; Cell Line, Tumor; Humans; Image Processing, Computer-Assi | 2015 |
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Topics: Adaptation, Physiological; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera | 2015 |
Onco-IP3Rs Feed Cancerous Cravings for Mitochondrial Ca(2.).
Topics: AMP-Activated Protein Kinases; Calcium; Calcium Channels; Cell Death; Cell Proliferation; Endoplasmi | 2016 |
Evaluation on the inhibition of pyrrol-2-yl ethanone derivatives to lactate dehydrogenase and anticancer activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Hep G2 Cells; Humans | 2016 |
Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate.
Topics: Acetyl Coenzyme A; Adaptation, Physiological; Adenosine Triphosphate; Cell Proliferation; Electron T | 2016 |
Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.
Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Citric Acid Cycle; Glucose; Glutamine; Glu | 2016 |
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex I; Homeosta | 2016 |
Direct arterial injection of hyperpolarized
Topics: Animals; Arteries; Carbon Isotopes; Drug Delivery Systems; Epigastric Arteries; Female; Femoral Vein | 2017 |
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Female; Glucose; G | 2010 |
Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
Topics: Animals; Carbon Isotopes; Humans; L-Lactate Dehydrogenase; Lactic Acid; Magnetic Resonance Spectrosc | 2010 |
Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.
Topics: Angiogenesis Inhibitors; Animals; Carbon Isotopes; Contrast Media; Diffusion Magnetic Resonance Imag | 2010 |
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.
Topics: Biomarkers, Tumor; Carbon Isotopes; Fumarates; Humans; Magnetic Resonance Imaging; Metabolic Network | 2011 |
Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.
Topics: Carbon Isotopes; Cell Line, Tumor; Humans; Kinetics; Lactic Acid; Models, Biological; Neoplasms; Pyr | 2011 |
Spectral-spatial excitation for rapid imaging of DNP compounds.
Topics: Acetates; Animals; Carbon Isotopes; Magnetic Resonance Spectroscopy; Neoplasms; Pyruvic Acid; Rats; | 2011 |
Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cu | 2012 |
Cancer: Sacrifice for survival.
Topics: Anaerobiosis; Cell Respiration; Cell Survival; Disease Progression; Glycolysis; Humans; Lactic Acid; | 2011 |
Diffusion of hyperpolarized (13) C-metabolites in tumor cell spheroids using real-time NMR spectroscopy.
Topics: Carbon Isotopes; Cell Line, Tumor; Cell Membrane Permeability; Diffusion; Female; Humans; Magnetic R | 2013 |
Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Energy Metabolism; Food Deprivatio | 2013 |
The anaerobic metabolism of pyruvate in homogenates of normal and neoplastic rat tissues.
Topics: Animals; Neoplasms; Pyruvates; Pyruvic Acid; Rats | 1954 |
The metabolism of neoplastic tissues: the relative rates of acetate and pyruvate utilization by surviving tissue slices of mouse tumours.
Topics: Acetates; Animals; Mice; Neoplasms; Pyruvates; Pyruvic Acid | 1955 |
Studies on the metabolism of pyruvate-2-C14 in tumor-bearing rats.
Topics: Animals; Neoplasms; Pyruvates; Pyruvic Acid; Rats | 1955 |
Substrate effects on metabolic patterns of pyruvate-2-C14 in tissue slices.
Topics: Neoplasms; Pyruvates; Pyruvic Acid | 1956 |
[Dependence of pyruvic acid excretion on volume dosage distribution in fixed field and pendulum radiotherapy].
Topics: Biological Transport; Body Fluids; Humans; Neoplasms; Pyruvates; Pyruvic Acid; Radiotherapy; Urine | 1955 |
Enzymatic activities of tumour mitochondria as demonstrated by their inhibitory effect on the oxidative response of liver mitochondria towards fatty acids and pyruvate.
Topics: Fatty Acids; Mitochondria; Mitochondria, Liver; Neoplasms; Oxidation-Reduction; Pyruvates; Pyruvic A | 1957 |
Fatty acid oxidation in normal and neoplastic tissues; the oxidation of beta-hydroxybutyrate and pyruvate by tumour mitochondria.
Topics: 3-Hydroxybutyric Acid; Butyrates; Fatty Acids; Lipid Metabolism; Mitochondria; Neoplasms; Oxidation- | 1957 |
The metabolism of neoplastic tissues: further observations on the relative rates of acetate and pyruvate utilization by surviving tissue slices of mouse tumors.
Topics: Acetates; Animals; Biochemical Phenomena; Mice; Neoplasms; Pyruvates; Pyruvic Acid | 1957 |
Blood pyruvic acid concentration in carcinoma during radiotherapy: with especial consideration of the effect of cocarboxylase and thiamine monophosphate.
Topics: Carcinoma; Genitalia; Genitalia, Female; Neoplasms; Pyruvates; Pyruvic Acid; Radiotherapy; Thiamine | 1959 |
[On pyruvic acid in blood and serum in malignant tumors in man].
Topics: Hematologic Diseases; Lymphatic Diseases; Neoplasms; Pyruvates; Pyruvic Acid | 1960 |
Pyruvate metabolism. IV. Utilization of pyruvate in the isolated mitochondria of an ascitic form of Walker rat mammary carcinoma 256.
Topics: Animals; Breast; Mitochondria; Neoplasms; Pyruvates; Pyruvic Acid; Rats | 1962 |
[Contribution to the study of serum pyruvic acid in various malignant blood diseases].
Topics: Humans; Leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma | 1962 |
[SOME DISORDERS OF CELL METABOLISM IN SYSTEMIC HISTIOCYTIC SARCOMATOSIS. III. BEHAVIOR OF THE BLOOD LEVEL OF PYRUVIC ACID AND ALPHA-KETOGLUTARIC ACID IN PATIENTS WITH SUCH MORBID FORMS].
Topics: Animals; Blood Chemical Analysis; Ketoglutaric Acids; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non | 1963 |
[SOME DISORDERS OF CELL METABOLISM IN SYSTEMIC HISTIOCYTIC SARCOMATOSIS. II. THE PYRUVATE AND ALPHA-KETOGLUTARATE CONTENT OF NORMAL AND LEUKEMIC LEUKOCYTES].
Topics: Blood Chemical Analysis; Ketoglutaric Acids; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukoc | 1963 |
STUDIES OF FUNCTIONAL NEURAL TUMORS. VII. URINARY EXCRETION OF PHENOLIC PYRUVIC ACIDS.
Topics: Alkylation; Child; Chromatography; Dihydroxyphenylalanine; Humans; Metabolism; Neoplasm Metastasis; | 1965 |
[PYRUVATE IN CEREBROPINAL FLUID].
Topics: Body Fluids; Cerebrospinal Fluid; Neoplasms; Pyruvates; Pyruvic Acid | 1965 |
Thiamine diphosphate in growing tissues. IV. Pyruvate oxidation in muscle mitochondria from young rats and in mitochondria from malignant tissues.
Topics: Animals; Mitochondria; Mitochondria, Muscle; Muscles; Neoplasms; Neoplasms, Experimental; Oxidation- | 1962 |
Pyruvate metabolism. III. Formation of citrate in ascitic nodules from a strain of Walker rat mammary carcinoma 256.
Topics: Animals; Breast; Citrates; Citric Acid; Neoplasms; Pyruvates; Pyruvic Acid; Rats | 1962 |
Activation of pyruvate oxidation in tumor mitochondria by diphosphopyridine nucleotide.
Topics: Biochemical Phenomena; Coenzymes; Mitochondria; NAD; Neoplasms; Oxidation-Reduction; Pyruvates; Pyru | 1951 |
Metabolism of pyruvate in tumor homogenates.
Topics: Neoplasms; Pyruvates; Pyruvic Acid | 1952 |
[Pyruvic acid metabolism. I. Effect of carboxylase on pyruvic acid metabolism in carcinoma and hepatitis epidemica].
Topics: Carboxy-Lyases; Hepatitis; Hepatitis A; Humans; Lyases; Neoplasms; Pyruvates; Pyruvic Acid | 1952 |
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Topics: Amines; Animals; Cell Death; Cell Division; Cell Line; Cyclization; Esters; Humans; Inhibitory Conce | 2004 |
[Role of certain products of intermediate metabolism in cancer].
Topics: Humans; Lactic Acid; Neoplasms; Pyruvic Acid | 1950 |
Energy boost: the Warburg effect returns in a new theory of cancer.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Blood Glucose; Cell Hypoxia; Cytoplasm; DNA- | 2004 |
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Topics: Alternative Splicing; Animals; Cell Line, Tumor; Cell Proliferation; Fructosediphosphates; Gene Expr | 2008 |
Control of normal and transformed cell proliferation by growth factor-nutrient interactions.
Topics: Animals; Calcium; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cul | 1984 |
Evidence that prostaglandins modulate lipogenesis in cultured lymphocytes--a comparison with its effect on macrophages and tumour cells.
Topics: Acetates; Animals; Arachidonic Acid; Carbon Radioisotopes; Cells, Cultured; Concanavalin A; DNA; DNA | 1994 |
Hydroxycitrate causes altered pyruvate metabolism by tumorigenic cells.
Topics: Animals; ATP Citrate (pro-S)-Lyase; Carbon Dioxide; Cell Line; Citrates; Citric Acid; Citric Acid Cy | 1996 |
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis.
Topics: Aerobiosis; Cells, Cultured; DNA; Gene Expression Regulation; Glucose; Glycolysis; Humans; Hypoxia-I | 2002 |
Relations between pH, oxygen partial pressure and growth in cultured cell spheroids.
Topics: Animals; Cell Division; Cell Line; Humans; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lact | 1988 |
Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cricetinae; Cricetulus; Energy Metabolism; Glucose; | 1986 |
Synthesis of pyruvate-1-11C as a radiopharmaceutical for tumor imaging.
Topics: Animals; Brain Neoplasms; Carbon Radioisotopes; Female; Humans; Isotope Labeling; Male; Middle Aged; | 1985 |