pyruvic acid has been researched along with Neoplasm Metastasis in 13 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment." | 2.72 | The metabolism of cancer cells during metastasis. ( Bergers, G; Fendt, SM, 2021) |
| "Moreover, colorectal cancer cells can effectively shift to FAO to survive both glucose restriction and increases in oxidative stress at the expense of decreasing anabolism." | 2.66 | The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival. ( De Oliveira, MP; Liesa, M, 2020) |
| "Although anoikis is a barrier to metastasis, cancer cells have often acquired elevated threshold for anoikis and hence heightened metastatic potential." | 2.52 | The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. ( Cai, Q; Lu, J; Tan, M, 2015) |
| "Tumorigenesis and metastasis are associated with metabolic reprogramming, including enhanced glycolysis and glutaminolysis." | 2.46 | Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing. ( Dafni, H; Ronen, SM, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, L | 1 |
| Rust, BM | 1 |
| Picklo, MJ | 1 |
| De Oliveira, MP | 1 |
| Liesa, M | 1 |
| Bergers, G | 1 |
| Fendt, SM | 2 |
| Elia, I | 1 |
| Rossi, M | 1 |
| Stegen, S | 1 |
| Broekaert, D | 1 |
| Doglioni, G | 1 |
| van Gorsel, M | 1 |
| Boon, R | 1 |
| Escalona-Noguero, C | 1 |
| Torrekens, S | 1 |
| Verfaillie, C | 1 |
| Verbeken, E | 1 |
| Carmeliet, G | 1 |
| Lu, J | 1 |
| Tan, M | 1 |
| Cai, Q | 1 |
| Giampazolias, E | 1 |
| Tait, SW | 1 |
| Li, Y | 1 |
| Li, X | 2 |
| Kan, Q | 1 |
| Zhang, M | 1 |
| Xu, R | 1 |
| Wang, J | 1 |
| Yu, D | 1 |
| Goscinski, MA | 1 |
| Wen, JG | 1 |
| Nesland, JM | 1 |
| Suo, Z | 1 |
| Reynolds, S | 1 |
| Metcalf, S | 1 |
| Cochrane, EJ | 1 |
| Collins, RC | 1 |
| Jones, S | 1 |
| Paley, MNJ | 1 |
| Tozer, GM | 1 |
| Dafni, H | 1 |
| Ronen, SM | 1 |
| Keshari, KR | 1 |
| Sriram, R | 1 |
| Koelsch, BL | 1 |
| Van Criekinge, M | 1 |
| Wilson, DM | 1 |
| Kurhanewicz, J | 1 |
| Wang, ZJ | 1 |
| GJESSING, LR | 1 |
| BORUD, O | 1 |
| Zhang, Q | 1 |
| Wang, SY | 1 |
| Nottke, AC | 1 |
| Rocheleau, JV | 1 |
| Piston, DW | 1 |
| Goodman, RH | 1 |
| Singer, S | 1 |
| Souza, K | 1 |
| Thilly, WG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Safety and Efficacy of Esperanza Extract (Petiveria Alliacea) in Patients With Metastatic Gastrointestinal Tumors and Acute Leukemia[NCT05587088] | Phase 1/Phase 2 | 82 participants (Anticipated) | Interventional | 2022-12-15 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for pyruvic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival.
Topics: Adipose Tissue; Animals; Cell Proliferation; Cell Survival; Fatty Acids; Glucose; Glycolysis; Humans | 2020 |
The metabolism of cancer cells during metastasis.
Topics: Acetates; Adenosine Triphosphate; Animals; Cell Plasticity; Fatty Acids; Glutamine; Humans; Lactic A | 2021 |
The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.
Topics: Anoikis; Cell Proliferation; Citric Acid Cycle; Glucose; Glycolysis; Humans; Hypoxia-Inducible Facto | 2015 |
Mitochondria and the hallmarks of cancer.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Death; Energy Metabolism; Gene Expression Regulatio | 2016 |
Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing.
Topics: Bicarbonates; Diagnostic Imaging; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neoplasm Metas | 2010 |
8 other studies available for pyruvic acid and Neoplasm Metastasis
| Article | Year |
|---|---|
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma.
Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease | 2020 |
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Collagen; Disease Models, Animal; Enzyme Activation; Ex | 2019 |
Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas.
Topics: Adenosine Triphosphate; Biological Transport; Carcinoma, Squamous Cell; Cell Line, Tumor; Esophageal | 2017 |
Direct arterial injection of hyperpolarized
Topics: Animals; Arteries; Carbon Isotopes; Drug Delivery Systems; Epigastric Arteries; Female; Femoral Vein | 2017 |
Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas.
Topics: Carbon Isotopes; Carcinoma, Renal Cell; Cell Line; Cell Line, Tumor; Glycolysis; Humans; Kidney Tubu | 2013 |
STUDIES OF FUNCTIONAL NEURAL TUMORS. VII. URINARY EXCRETION OF PHENOLIC PYRUVIC ACIDS.
Topics: Alkylation; Child; Chromatography; Dihydroxyphenylalanine; Humans; Metabolism; Neoplasm Metastasis; | 1965 |
Redox sensor CtBP mediates hypoxia-induced tumor cell migration.
Topics: Alcohol Oxidoreductases; Biosensing Techniques; Cadherins; Cell Movement; DNA-Binding Proteins; Gene | 2006 |
Pyruvate utilization, phosphocholine and adenosine triphosphate (ATP) are markers of human breast tumor progression: a 31P- and 13C-nuclear magnetic resonance (NMR) spectroscopy study.
Topics: Adenosine Triphosphate; Biomarkers; Breast Neoplasms; Citric Acid Cycle; Female; Humans; Magnetic Re | 1995 |