Page last updated: 2024-10-20

pyruvic acid and Neoplasm Metastasis

pyruvic acid has been researched along with Neoplasm Metastasis in 13 studies

Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.

Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Research Excerpts

ExcerptRelevanceReference
"Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment."2.72The metabolism of cancer cells during metastasis. ( Bergers, G; Fendt, SM, 2021)
"Moreover, colorectal cancer cells can effectively shift to FAO to survive both glucose restriction and increases in oxidative stress at the expense of decreasing anabolism."2.66The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival. ( De Oliveira, MP; Liesa, M, 2020)
"Although anoikis is a barrier to metastasis, cancer cells have often acquired elevated threshold for anoikis and hence heightened metastatic potential."2.52The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. ( Cai, Q; Lu, J; Tan, M, 2015)
"Tumorigenesis and metastasis are associated with metabolic reprogramming, including enhanced glycolysis and glutaminolysis."2.46Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing. ( Dafni, H; Ronen, SM, 2010)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's1 (7.69)18.2507
2000's1 (7.69)29.6817
2010's7 (53.85)24.3611
2020's3 (23.08)2.80

Authors

AuthorsStudies
Yan, L1
Rust, BM1
Picklo, MJ1
De Oliveira, MP1
Liesa, M1
Bergers, G1
Fendt, SM2
Elia, I1
Rossi, M1
Stegen, S1
Broekaert, D1
Doglioni, G1
van Gorsel, M1
Boon, R1
Escalona-Noguero, C1
Torrekens, S1
Verfaillie, C1
Verbeken, E1
Carmeliet, G1
Lu, J1
Tan, M1
Cai, Q1
Giampazolias, E1
Tait, SW1
Li, Y1
Li, X2
Kan, Q1
Zhang, M1
Xu, R1
Wang, J1
Yu, D1
Goscinski, MA1
Wen, JG1
Nesland, JM1
Suo, Z1
Reynolds, S1
Metcalf, S1
Cochrane, EJ1
Collins, RC1
Jones, S1
Paley, MNJ1
Tozer, GM1
Dafni, H1
Ronen, SM1
Keshari, KR1
Sriram, R1
Koelsch, BL1
Van Criekinge, M1
Wilson, DM1
Kurhanewicz, J1
Wang, ZJ1
GJESSING, LR1
BORUD, O1
Zhang, Q1
Wang, SY1
Nottke, AC1
Rocheleau, JV1
Piston, DW1
Goodman, RH1
Singer, S1
Souza, K1
Thilly, WG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Safety and Efficacy of Esperanza Extract (Petiveria Alliacea) in Patients With Metastatic Gastrointestinal Tumors and Acute Leukemia[NCT05587088]Phase 1/Phase 282 participants (Anticipated)Interventional2022-12-15Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for pyruvic acid and Neoplasm Metastasis

ArticleYear
The Role of Mitochondrial Fat Oxidation in Cancer Cell Proliferation and Survival.
    Cells, 2020, 12-04, Volume: 9, Issue:12

    Topics: Adipose Tissue; Animals; Cell Proliferation; Cell Survival; Fatty Acids; Glucose; Glycolysis; Humans

2020
The metabolism of cancer cells during metastasis.
    Nature reviews. Cancer, 2021, Volume: 21, Issue:3

    Topics: Acetates; Adenosine Triphosphate; Animals; Cell Plasticity; Fatty Acids; Glutamine; Humans; Lactic A

2021
The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.
    Cancer letters, 2015, Jan-28, Volume: 356, Issue:2 Pt A

    Topics: Anoikis; Cell Proliferation; Citric Acid Cycle; Glucose; Glycolysis; Humans; Hypoxia-Inducible Facto

2015
Mitochondria and the hallmarks of cancer.
    The FEBS journal, 2016, Volume: 283, Issue:5

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Death; Energy Metabolism; Gene Expression Regulatio

2016
Dynamic nuclear polarization in metabolic imaging of metastasis: common sense, hypersense and compressed sensing.
    Cancer biomarkers : section A of Disease markers, 2010, Volume: 7, Issue:4

    Topics: Bicarbonates; Diagnostic Imaging; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neoplasm Metas

2010

Other Studies

8 other studies available for pyruvic acid and Neoplasm Metastasis

ArticleYear
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma.
    Anticancer research, 2020, Volume: 40, Issue:4

    Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease

2020
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.
    Nature, 2019, Volume: 568, Issue:7750

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Collagen; Disease Models, Animal; Enzyme Activation; Ex

2019
Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas.
    Oncotarget, 2017, Jan-03, Volume: 8, Issue:1

    Topics: Adenosine Triphosphate; Biological Transport; Carcinoma, Squamous Cell; Cell Line, Tumor; Esophageal

2017
Direct arterial injection of hyperpolarized
    Magnetic resonance in medicine, 2017, Volume: 78, Issue:6

    Topics: Animals; Arteries; Carbon Isotopes; Drug Delivery Systems; Epigastric Arteries; Female; Femoral Vein

2017
Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas.
    Cancer research, 2013, Jan-15, Volume: 73, Issue:2

    Topics: Carbon Isotopes; Carcinoma, Renal Cell; Cell Line; Cell Line, Tumor; Glycolysis; Humans; Kidney Tubu

2013
STUDIES OF FUNCTIONAL NEURAL TUMORS. VII. URINARY EXCRETION OF PHENOLIC PYRUVIC ACIDS.
    Scandinavian journal of clinical and laboratory investigation, 1965, Volume: 17

    Topics: Alkylation; Child; Chromatography; Dihydroxyphenylalanine; Humans; Metabolism; Neoplasm Metastasis;

1965
Redox sensor CtBP mediates hypoxia-induced tumor cell migration.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jun-13, Volume: 103, Issue:24

    Topics: Alcohol Oxidoreductases; Biosensing Techniques; Cadherins; Cell Movement; DNA-Binding Proteins; Gene

2006
Pyruvate utilization, phosphocholine and adenosine triphosphate (ATP) are markers of human breast tumor progression: a 31P- and 13C-nuclear magnetic resonance (NMR) spectroscopy study.
    Cancer research, 1995, Nov-15, Volume: 55, Issue:22

    Topics: Adenosine Triphosphate; Biomarkers; Breast Neoplasms; Citric Acid Cycle; Female; Humans; Magnetic Re

1995