pyruvic acid has been researched along with Myocardial Infarction in 24 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ethyl pyruvate has demonstrated anti-inflammatory actions and improved hyperpermeability and bacterial translocation due to endotoxemia and is of benefit in animal models of sepsis and septic shock." | 4.83 | Is pyruvate an endogenous anti-inflammatory molecule? ( Das, UN, 2006) |
| " The present study was evaluated to investigate whether pyruvate attenuates the development of cardiotoxicity in isoproterenol (ISO)-induced myocardial infarction by assessing hemodynamic, biochemical and histopathological parameters." | 3.78 | Pyruvate attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity. ( Arya, DS; Goyal, S; Kumari, S; Ojha, S, 2012) |
| "Cardiac hypertrophy was also evident by a 49% increase in whole cell capacitance of isolated left ventricular myocytes (P < 0." | 1.30 | Altered K+ current of ventricular myocytes in rats with chronic myocardial infarction. ( Patel, KP; Rozanski, GJ; Xu, Z; Zhang, K, 1998) |
| "Adenosine appeared to be a more sensitive marker of early ischaemia than lactate, although interestingly, adenosine levels had decreased already after 15 min, most probably due to intracellular accumulation of protons and Pi." | 1.29 | Continuous monitoring of energy metabolites using microdialysis during myocardial ischaemia in the pig. ( Maripu, E; Nilsson, S; Ronquist, G; Waldenström, A; Wikström, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zabielska, MA | 1 |
| Adamus, J | 1 |
| Kowalski, R | 1 |
| Gebicki, J | 1 |
| Slominska, EM | 1 |
| Khalpey, Z | 1 |
| Smolenski, RT | 1 |
| Zheng, MQ | 1 |
| Li, X | 2 |
| Tang, K | 2 |
| Sharma, NM | 1 |
| Wyatt, TA | 1 |
| Patel, KP | 2 |
| Gao, L | 1 |
| Bidasee, KR | 1 |
| Rozanski, GJ | 3 |
| Ball, DR | 1 |
| Cruickshank, R | 1 |
| Carr, CA | 1 |
| Stuckey, DJ | 1 |
| Lee, P | 1 |
| Clarke, K | 1 |
| Tyler, DJ | 1 |
| Xie, B | 1 |
| Li, S | 1 |
| Ojha, S | 1 |
| Goyal, S | 1 |
| Kumari, S | 1 |
| Arya, DS | 1 |
| Kavianipour, M | 1 |
| Ehlers, MR | 1 |
| Malmberg, K | 1 |
| Ronquist, G | 4 |
| Ryden, L | 1 |
| Wikström, G | 4 |
| Gutniak, M | 1 |
| Stanley, WC | 1 |
| Kivilo, KM | 1 |
| Panchal, AR | 1 |
| Hallowell, PH | 1 |
| Bomont, C | 1 |
| Kasumov, T | 1 |
| Brunengraber, H | 1 |
| Bäckström, T | 1 |
| Franco-Cereceda, A | 1 |
| Das, UN | 1 |
| Mori, H | 1 |
| Nagata, M | 2 |
| Miyazaki, T | 1 |
| Sakurai, K | 1 |
| Ogawa, S | 1 |
| Hattori, S | 1 |
| Takahashi, M | 1 |
| Nakamura, Y | 1 |
| Furkalo, NK | 1 |
| Rishko, NV | 1 |
| Regitz, V | 1 |
| Azumi, T | 1 |
| Stephan, H | 1 |
| Naujocks, S | 1 |
| Schaper, W | 1 |
| Armstrong, S | 1 |
| Ganote, CE | 1 |
| Nilsson, S | 1 |
| Maripu, E | 1 |
| Waldenström, A | 3 |
| Zhang, J | 1 |
| Wilke, N | 1 |
| Wang, Y | 1 |
| Zhang, Y | 1 |
| Wang, C | 1 |
| Eijgelshoven, MH | 1 |
| Cho, YK | 1 |
| Murakami, Y | 1 |
| Ugurbil, K | 1 |
| Bache, RJ | 1 |
| From, AH | 1 |
| Alekseeva, OP | 1 |
| Komarova, LG | 1 |
| Xu, Z | 1 |
| Zhang, K | 1 |
| Sezai, A | 1 |
| Shiono, M | 1 |
| Orime, Y | 1 |
| Nakata, K | 1 |
| Hata, M | 1 |
| Iida, M | 1 |
| Kashiwazaki, S | 1 |
| Kinoshita, J | 1 |
| Nemoto, M | 1 |
| Koujima, T | 1 |
| Furuichi, M | 1 |
| Eda, K | 1 |
| Hirose, H | 1 |
| Yoshino, T | 1 |
| Saitoh, A | 1 |
| Taniguchi, Y | 1 |
| Sezai, Y | 1 |
| Zemgulis, V | 2 |
| Bjerner, T | 2 |
| Henze, A | 2 |
| Thelin, S | 2 |
| Jonassen, AK | 1 |
| Sack, MN | 1 |
| Mjøs, OD | 1 |
| Yellon, DM | 1 |
| Lahtinen, M | 1 |
| Zhang, YL | 1 |
| Yao, LY | 1 |
| Long, YD | 1 |
| Luo, W | 1 |
| Ding, XL | 1 |
| Xiao, LM | 1 |
| Ishikura, Y | 1 |
| Odagiri, S | 1 |
| Nagano, T | 1 |
| Yoshimatu, H | 1 |
| Bernstein, LH | 1 |
| Scinto, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus[NCT02962921] | Phase 4 | 6 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvic acid and Myocardial Infarction
| Article | Year |
|---|---|
Is pyruvate an endogenous anti-inflammatory molecule?
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Critical Illness; Cytokines; Disease | 2006 |
23 other studies available for pyruvic acid and Myocardial Infarction
| Article | Year |
|---|---|
Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia.
Topics: Animals; Apolipoproteins E; Cardiotonic Agents; Creatine Kinase; Electrocardiography; Heart; Hypoxia | 2018 |
Pyruvate restores β-adrenergic sensitivity of L-type Ca(2+) channels in failing rat heart: role of protein phosphatase.
Topics: Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Cyclic AMP-Dependent Protein Kinases; H | 2013 |
Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate.
Topics: Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; Heart; In Vitro T | 2013 |
Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system.
Topics: Animals; Auranofin; Blotting, Western; Disease Models, Animal; Heart Failure; Isotretinoin; Kv Chann | 2008 |
Pyruvate attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity.
Topics: Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Disease Models, Animal; Heart; Hemodynamics; | 2012 |
Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium.
Topics: Animals; Area Under Curve; Blood Glucose; Cardiovascular System; Glucagon; Glucagon-Like Peptide 1; | 2003 |
Post-ischemic treatment with dipyruvyl-acetyl-glycerol decreases myocardial infarct size in the pig.
Topics: Animals; Blood Pressure; Citric Acid Cycle; Dose-Response Relationship, Drug; Glycerol; Injections, | 2003 |
Intravasal microdialysis is superior to intramyocardial microdialysis in detecting local ischaemia in experimental porcine myocardial infarction.
Topics: Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Coronary Vessels; Female; Glucose; Gly | 2004 |
Protection of hypoxic myocardium by intracoronary administration of verapamil in open-chest dogs.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Dogs; Energy Metabo | 1984 |
[Oxygen and hemodynamic provisions for measured physical exertion in ischemic heart disease patients with intact and atherosclerotic coronary arteries].
Topics: Adult; Coronary Disease; Exercise Test; Hemodynamics; Humans; Lactates; Lactic Acid; Middle Aged; My | 1984 |
Biochemical mechanism of infarct size reduction by pyruvate.
Topics: Adenosine Triphosphate; Animals; Dogs; Heart; Myocardial Infarction; Myocardium; NAD; Pyruvates; Pyr | 1981 |
Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: evidence of A3 receptor involvement.
Topics: Adenosine; Animals; Antihypertensive Agents; Cells, Cultured; Glucose; Myocardial Infarction; Myocar | 1994 |
Continuous monitoring of energy metabolites using microdialysis during myocardial ischaemia in the pig.
Topics: Adenosine; Animals; Energy Metabolism; Female; Guanosine; Hemodynamics; Hypoxanthine; Hypoxanthines; | 1995 |
Functional and bioenergetic consequences of postinfarction left ventricular remodeling in a new porcine model. MRI and 31 P-MRS study.
Topics: Adenosine Triphosphate; Animals; Biopsy; Coronary Circulation; Energy Metabolism; Hemodynamics; Hydr | 1996 |
[Heart failure and its relationship with the type of hemodynamic shifts and function of the blood-saliva barrier in patients with acute myocardial infarct].
Topics: Female; Heart Failure; Hemodynamics; Humans; Male; Myocardial Infarction; Pyruvates; Pyruvic Acid; S | 1995 |
Altered K+ current of ventricular myocytes in rats with chronic myocardial infarction.
Topics: Animals; Cardiomegaly; Cells, Cultured; Coronary Vessels; Dichloroacetic Acid; Evoked Potentials; He | 1998 |
Major organ function under mechanical support: comparative studies of pulsatile and nonpulsatile circulation.
Topics: Animals; Blood Circulation; Cerebrovascular Circulation; Heart-Assist Devices; Hemodynamics; Ketone | 1999 |
Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Dialysis Solutions; Disease Models, Animal | 2001 |
Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling.
Topics: Animals; bcl-Associated Death Protein; Carrier Proteins; Cell Survival; Enzyme Inhibitors; Glucose; | 2001 |
Discrepant outcome between myocardial energy-related metabolites and infarct size limitation during retroperfusion of the coronary sinus.
Topics: Animals; Coronary Circulation; Energy Metabolism; Guanosine; Jugular Veins; Lactic Acid; Microdialys | 2001 |
[Protective action of sophoridine on acute myocardial infarction in anesthetized dogs].
Topics: 6-Ketoprostaglandin F1 alpha; Alkaloids; Animals; Creatine Kinase; Dogs; Female; Lactates; Lactic Ac | 1991 |
[Effects of coenzyme Q10 on ischemic myocardium during coronary artery occlusion--evaluation of the time needed to change irreversible myocardium].
Topics: Alanine Transaminase; Animals; Coenzymes; Dogs; Hemodynamics; Mitochondria, Heart; Myocardial Infarc | 1986 |
Two methods compared for measuring LD-1/total LD activity in serum.
Topics: Adult; Aged; Creatine Kinase; Humans; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; L-Lactate De | 1986 |