pyruvic acid has been researched along with Metabolic Diseases in 12 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "An LP ratio >25 and glycerol >100 micromol/L, but not glutamate >12 micromol/L, were associated with significantly higher risk of imminent intracranial hypertension (odds ratio: 9." | 3.74 | Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. ( Belli, A; Kitchen, N; Petzold, A; Russo, S; Sen, J; Smith, M, 2008) |
| " Hypoxia induced an immediate and significant elevation in the intraperitoneal lactate/pyruvate ratio to 446+/-137% of the baseline values, and glycerol subsequently increased during reoxygenation to 389+/-109%." | 3.71 | Intraperitoneal microdialysis for detection of splanchnic metabolic disorders. ( Bahlmann, L; Bruch, HP; Gliemroth, J; Heringlake, M; Klaus, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 4 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Deus, CM | 1 |
| Pereira, SP | 1 |
| Cunha-Oliveira, T | 1 |
| Pereira, FB | 1 |
| Raimundo, N | 1 |
| Oliveira, PJ | 1 |
| Lee, J | 1 |
| Jin, Z | 1 |
| Lee, D | 1 |
| Yun, JH | 1 |
| Lee, W | 1 |
| Zangari, J | 1 |
| Petrelli, F | 1 |
| Maillot, B | 1 |
| Martinou, JC | 1 |
| Yin, H | 1 |
| Li, J | 1 |
| Tian, J | 1 |
| Ma, L | 1 |
| Zhang, J | 1 |
| Zhai, Q | 1 |
| Yao, S | 1 |
| Zhang, L | 1 |
| Mampilly, GT | 1 |
| Mampilly, TK | 1 |
| Christopher, R | 1 |
| Chandramohan, N | 1 |
| Janaki, V | 1 |
| Jeoung, NH | 1 |
| Harris, CR | 1 |
| Harris, RA | 1 |
| Yamane, K | 1 |
| Indalao, IL | 1 |
| Chida, J | 1 |
| Yamamoto, Y | 1 |
| Hanawa, M | 1 |
| Kido, H | 1 |
| Santos, E | 1 |
| Orakcioglu, B | 1 |
| Kentar, MM | 1 |
| Diedler, J | 1 |
| Uozumi, Y | 1 |
| Schöll, M | 1 |
| Unterberg, A | 1 |
| Sakowitz, OW | 1 |
| Klaus, S | 1 |
| Heringlake, M | 1 |
| Gliemroth, J | 1 |
| Bruch, HP | 1 |
| Bahlmann, L | 1 |
| BRUNETTI, P | 1 |
| PUXEDDU, A | 1 |
| NENCI, G | 1 |
| MIGLIORINI, E | 1 |
| Belli, A | 1 |
| Sen, J | 1 |
| Petzold, A | 1 |
| Russo, S | 1 |
| Kitchen, N | 1 |
| Smith, M | 1 |
| Artuch, R | 1 |
| Colomé, C | 1 |
| Playán, A | 1 |
| Alcaine, MJ | 1 |
| Briones, P | 1 |
| Montoya, J | 1 |
| Vilaseca, MA | 1 |
| Pineda, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects on Physical Activity on Mitochondrial Function in Skin Fibroblasts in Patients With Parkinson's Disease: a Study Protocol.[NCT05963425] | 24 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyruvic acid and Metabolic Diseases
| Article | Year |
|---|---|
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.
Topics: Animals; Gene Expression Regulation; Humans; Metabolic Diseases; Mitochondria; Mitochondrial Membran | 2020 |
Regulation of pyruvate metabolism in metabolic-related diseases.
Topics: Animals; Carbohydrate Metabolism; Glucose; Humans; Metabolic Diseases; Mitochondria; Pyruvic Acid | 2014 |
10 other studies available for pyruvic acid and Metabolic Diseases
| Article | Year |
|---|---|
Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects.
Topics: Aged; Energy Metabolism; Fibroblasts; Galactose; Glucose; Humans; Male; Metabolic Diseases; Middle A | 2020 |
Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases.
Topics: Amino Acid Sequence; Animals; Circular Dichroism; Humans; Metabolic Diseases; Mitochondrial Membrane | 2020 |
Uterine pyruvate metabolic disorder induced by silica nanoparticles act through the pentose phosphate pathway.
Topics: Animals; Metabolic Diseases; Mice; Nanoparticles; Pentose Phosphate Pathway; Pyruvic Acid; Silicon D | 2021 |
Challenges in diagnosing a metabolic disorder: error of pyruvate metabolism or drug induced?
Topics: Anticonvulsants; Female; Fructose; Humans; Infant; Metabolic Diseases; Pyruvic Acid; Topiramate; Val | 2014 |
Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza.
Topics: Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Glucose; Influenza A Virus, H | 2014 |
Pressure reactivity index correlates with metabolic dysfunction in a porcine model of intracerebral hemorrhage.
Topics: Animals; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; G | 2012 |
Intraperitoneal microdialysis for detection of splanchnic metabolic disorders.
Topics: Animals; Ascitic Fluid; Cryoprotective Agents; Disease Models, Animal; Extracellular Space; Gastroin | 2002 |
Haemolytic anaemia due to pyruvate-kinase deficiency.
Topics: Anemia; Anemia, Hemolytic; Genetics, Medical; Metabolic Diseases; Phosphotransferases; Pyruvates; Py | 1963 |
Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study.
Topics: Biomarkers; Brain; Brain Injuries; Glutamic Acid; Glycerol; Humans; Intracranial Hypertension; Lacti | 2008 |
Oxygen consumption measurement in lymphocytes for the diagnosis of pediatric patients with oxidative phosphorylation diseases.
Topics: Adolescent; Child; Child, Preschool; Digitonin; DNA, Mitochondrial; Electron Transport; Energy Metab | 2000 |