pyruvic acid has been researched along with Melanoma in 12 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In addition to its anticancer property, 3BP also exhibits antimicrobial activity." | 1.51 | 3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau. ( Casal, M; Ko, YH; Niedźwiecka, K; Pedersen, PL; Ułaszewski, S, 2019) |
| "BRAFi-resistant melanomas are characterized by an increase of mitochondrial oxidative phosphorylation and are more prone to cell death induced by mitochondrial-targeting drugs." | 1.48 | Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors. ( Balayssac, S; Corazao-Rozas, P; Dekiouk, S; Gabert, PE; Garçon, G; Guerreschi, P; Joncquel Chevalier Curt, M; Khamari, R; Kluza, J; Maboudou, P; Malet-Martino, M; Marchetti, P; Mortier, L; Quesnel, B; Ravasi, L; Riveros-Cruz, S; Trinh, A, 2018) |
| "In mouse models of human melanoma and breast cancer, we were able to detect the metabolic differences among tumors of different metastatic potential and between normal and cancer tissues by optical imaging of the mitochondrial redox state of snap-frozen tissue samples." | 1.39 | In vivo metabolic evaluation of breast tumor mouse xenografts for predicting aggressiveness using the hyperpolarized (13)C-NMR technique. ( Cai, K; Hariharan, H; Kadlececk, S; Li, LZ; Profka, H; Pullinger, B; Rizi, R; Xu, HN, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Farah, C | 1 |
| Neveu, MA | 1 |
| Bouzin, C | 2 |
| Knezevic, Z | 1 |
| Gallez, B | 2 |
| Leucci, E | 1 |
| Baurain, JF | 2 |
| Mignion, L | 2 |
| Jordan, BF | 2 |
| Acciardo, S | 1 |
| Lacomblez, E | 1 |
| Schoonjans, C | 1 |
| Joudiou, N | 1 |
| Gourgue, F | 1 |
| Lees, H | 1 |
| Millan, M | 1 |
| Ahamed, F | 1 |
| Eskandari, R | 1 |
| Granlund, KL | 1 |
| Jeong, S | 1 |
| Keshari, KR | 1 |
| Khamari, R | 1 |
| Trinh, A | 1 |
| Gabert, PE | 1 |
| Corazao-Rozas, P | 1 |
| Riveros-Cruz, S | 1 |
| Balayssac, S | 1 |
| Malet-Martino, M | 1 |
| Dekiouk, S | 1 |
| Joncquel Chevalier Curt, M | 1 |
| Maboudou, P | 1 |
| Garçon, G | 1 |
| Ravasi, L | 1 |
| Guerreschi, P | 1 |
| Mortier, L | 1 |
| Quesnel, B | 1 |
| Marchetti, P | 1 |
| Kluza, J | 1 |
| Kamenisch, Y | 1 |
| Ivanova, I | 1 |
| Drexler, K | 1 |
| Berneburg, M | 1 |
| Ko, YH | 1 |
| Niedźwiecka, K | 1 |
| Casal, M | 1 |
| Pedersen, PL | 1 |
| Ułaszewski, S | 1 |
| Xu, HN | 1 |
| Kadlececk, S | 1 |
| Pullinger, B | 1 |
| Profka, H | 1 |
| Cai, K | 1 |
| Hariharan, H | 1 |
| Rizi, R | 1 |
| Li, LZ | 1 |
| Cipolleschi, MG | 1 |
| Marzi, I | 1 |
| Santini, R | 1 |
| Fredducci, D | 1 |
| Vinci, MC | 1 |
| D'Amico, M | 1 |
| Rovida, E | 1 |
| Stivarou, T | 1 |
| Torre, E | 1 |
| Dello Sbarba, P | 1 |
| Stecca, B | 1 |
| Olivotto, M | 1 |
| Delgado-Goni, T | 1 |
| Miniotis, MF | 1 |
| Wantuch, S | 1 |
| Parkes, HG | 1 |
| Marais, R | 1 |
| Workman, P | 1 |
| Leach, MO | 1 |
| Beloueche-Babari, M | 1 |
| Wallach, I | 1 |
| Jaitly, N | 1 |
| Lilien, R | 1 |
| WOODS, M | 1 |
| BURK, D | 1 |
| Kay, GF | 1 |
| Ellem, KA | 1 |
1 review available for pyruvic acid and Melanoma
| Article | Year |
|---|---|
UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis.
Topics: Animals; Cell Survival; DNA Damage; Glucose; Glycolysis; Humans; Lactic Acid; Melanoma; Mitogen-Acti | 2018 |
11 other studies available for pyruvic acid and Melanoma
| Article | Year |
|---|---|
Hyperpolarized
Topics: Carbon Isotopes; Glucose; Heterografts; Humans; Immune Checkpoint Inhibitors; Lactic Acid; Melanoma; | 2023 |
Metabolic imaging using hyperpolarized
Topics: Animals; Biomarkers, Tumor; Carbon Isotopes; Cell Line, Tumor; Drug Resistance, Neoplasm; Electron S | 2020 |
Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells.
Topics: Cell Line, Tumor; Humans; Lactic Acid; Melanoma; Metabolic Flux Analysis; Mutation; Proto-Oncogene P | 2021 |
Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors.
Topics: Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Female; | 2018 |
3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau.
Topics: Animals; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Fungi; Glycolysis; Hexokinase; Hu | 2019 |
In vivo metabolic evaluation of breast tumor mouse xenografts for predicting aggressiveness using the hyperpolarized (13)C-NMR technique.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Diagnostic Imaging; Female; Heterogr | 2013 |
Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Citric Ac | 2014 |
The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Energy Metabolism; Gene Expression Regulation, Enzymologic; | 2016 |
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways.
Topics: Breast Neoplasms; Computational Biology; Databases, Factual; Diabetes Mellitus, Type 2; Drug-Related | 2010 |
INHIBITION OF TUMOR CELL GLYCOLYSIS BY DPNH2, AND REVERSAL OF THE INHIBITION BY DPN, PYRUVATE OR METHYLENE BLUE.
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Glycolysis; Melanoma | 1963 |
Nonhaem complexes of FeIII stimulate cell attachment and growth by a mechanism different from that of serum, 2-oxocarboxylates, and haemproteins.
Topics: Blood Physiological Phenomena; Catalase; Cell Adhesion; Cell Division; Cell Line; Culture Media; Dos | 1986 |