pyruvic acid has been researched along with Liver Neoplasms in 24 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following hyperpolarized [1-(13)C]pyruvate injections, pyruvate and its metabolic products, alanine and lactate, were observed in the liver of five rats with hepatocellular carcinoma and five healthy control rats." | 3.76 | T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate. ( Butts Pauly, K; Hurd, R; King, R; Le Roux, P; Mayer, D; Pfefferbaum, A; Spielman, D; Tropp, J; Vasanawala, S; Yen, YF, 2010) |
| " In summary, the results demonstrate that pyruvate metabolism acts as novel targetable metabolic vulnerabilities for HCC treatment in combination with a glutamine-deficient diet." | 1.72 | Genome-Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment. ( Bao, MH; Chan, CY; Chen, Y; Lee, D; Tse, AP; Wei, L; Wong, BP; Wong, CC; Yang, C; Yuen, VW; Zhang, MS, 2022) |
| "Follow-up screening was performed in hepatocellular carcinoma with a focused CRISPR library targeting imaging-related genes." | 1.56 | Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. ( Ackerman, D; Gade, TPF; Johnson, O; Mercadante, M; Perkons, NR; Pilla, G; Profka, E, 2020) |
| "Human hepatocellular carcinoma cells Huh7 and alveolar epithelial cells A549 were stimulated with either interleukin (IL) IL-1β (1 ng/ml, 24 h) or tumor necrosis factor (TNF) (10 ng/ml, 4 h), and then treated with EtP (2." | 1.43 | Ethanol, ethyl and sodium pyruvate decrease the inflammatory responses of human lung epithelial cells via Akt and NF-κB in vitro but have a low impact on hepatocellular cells. ( Juengel, E; Marzi, I; Mörs, K; Omid, N; Perl, M; Relja, B; Wagner, N; Werner, I, 2016) |
| "The concentrations in diabetic II and liver cancer samples were significantly lower than those from healthy people, showing their potential as biomarkers for these diseases." | 1.42 | Determination of α-ketoglutaric and pyruvic acids in urine as potential biomarkers for diabetic II and liver cancer. ( Ben-Hander, GM; Makahleh, A; Saad, B, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 13 (54.17) | 24.3611 |
| 2020's | 7 (29.17) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, H | 1 |
| Lee, HJ | 1 |
| Sim, DY | 1 |
| Park, JE | 1 |
| Ahn, CH | 1 |
| Park, SY | 2 |
| Jang, E | 1 |
| Kim, B | 1 |
| Kim, SH | 1 |
| Gnocchi, D | 1 |
| Kurzyk, A | 1 |
| Mintrone, A | 1 |
| Lentini, G | 1 |
| Sabbà, C | 1 |
| Mazzocca, A | 1 |
| Yang, C | 1 |
| Lee, D | 1 |
| Zhang, MS | 1 |
| Tse, AP | 1 |
| Wei, L | 1 |
| Bao, MH | 1 |
| Wong, BP | 1 |
| Chan, CY | 1 |
| Yuen, VW | 1 |
| Chen, Y | 1 |
| Wong, CC | 1 |
| Shi, Q | 1 |
| Xue, C | 1 |
| Zeng, Y | 1 |
| Gu, X | 1 |
| Wang, J | 1 |
| Li, L | 1 |
| Tompkins, SC | 1 |
| Sheldon, RD | 1 |
| Rauckhorst, AJ | 1 |
| Noterman, MF | 1 |
| Solst, SR | 1 |
| Buchanan, JL | 1 |
| Mapuskar, KA | 1 |
| Pewa, AD | 1 |
| Gray, LR | 1 |
| Oonthonpan, L | 1 |
| Sharma, A | 1 |
| Scerbo, DA | 1 |
| Dupuy, AJ | 2 |
| Spitz, DR | 1 |
| Taylor, EB | 1 |
| Chen, HY | 1 |
| Aggarwal, R | 1 |
| Bok, RA | 3 |
| Ohliger, MA | 1 |
| Zhu, Z | 1 |
| Lee, P | 2 |
| Gordon, JW | 1 |
| van Criekinge, M | 1 |
| Carvajal, L | 1 |
| Slater, JB | 1 |
| Larson, PEZ | 1 |
| Small, EJ | 1 |
| Kurhanewicz, J | 3 |
| Vigneron, DB | 3 |
| Perkons, NR | 1 |
| Johnson, O | 1 |
| Pilla, G | 1 |
| Profka, E | 1 |
| Mercadante, M | 1 |
| Ackerman, D | 1 |
| Gade, TPF | 1 |
| Alasadi, A | 1 |
| Cao, B | 1 |
| Guo, J | 1 |
| Tao, H | 1 |
| Collantes, J | 1 |
| Tan, V | 1 |
| Su, X | 1 |
| Augeri, D | 1 |
| Jin, S | 1 |
| Kim, J | 1 |
| Yu, L | 1 |
| Chen, W | 1 |
| Xu, Y | 2 |
| Wu, M | 1 |
| Todorova, D | 1 |
| Tang, Q | 1 |
| Feng, B | 1 |
| Jiang, L | 1 |
| He, J | 1 |
| Chen, G | 1 |
| Fu, X | 1 |
| Green, DR | 1 |
| Swisher, CL | 1 |
| Larson, PE | 2 |
| Kruttwig, K | 1 |
| Kerr, AB | 1 |
| Hu, S | 2 |
| Goga, A | 2 |
| Pauly, JM | 1 |
| Nelson, SJ | 2 |
| Bard-Chapeau, EA | 1 |
| Nguyen, AT | 1 |
| Rust, AG | 1 |
| Sayadi, A | 1 |
| Chua, BQ | 1 |
| New, LS | 1 |
| de Jong, J | 1 |
| Ward, JM | 1 |
| Chin, CK | 1 |
| Chew, V | 1 |
| Toh, HC | 1 |
| Abastado, JP | 1 |
| Benoukraf, T | 1 |
| Soong, R | 1 |
| Bard, FA | 1 |
| Johnson, RL | 1 |
| Radda, GK | 1 |
| Chan, EC | 1 |
| Wessels, LF | 1 |
| Adams, DJ | 1 |
| Jenkins, NA | 1 |
| Copeland, NG | 1 |
| Makahleh, A | 1 |
| Ben-Hander, GM | 1 |
| Saad, B | 1 |
| Relja, B | 1 |
| Omid, N | 1 |
| Wagner, N | 1 |
| Mörs, K | 1 |
| Werner, I | 1 |
| Juengel, E | 1 |
| Perl, M | 1 |
| Marzi, I | 1 |
| Brandt, AP | 1 |
| Gozzi, GJ | 1 |
| Pires, Ado R | 1 |
| Martinez, GR | 1 |
| Dos Santos Canuto, AV | 1 |
| Echevarria, A | 1 |
| Di Pietro, A | 1 |
| Cadena, SM | 1 |
| Ho, HY | 1 |
| Cheng, ML | 1 |
| Chiu, HY | 1 |
| Weng, SF | 1 |
| Chiu, DT | 1 |
| Yen, YF | 2 |
| Le Roux, P | 1 |
| Mayer, D | 2 |
| King, R | 1 |
| Spielman, D | 1 |
| Tropp, J | 1 |
| Butts Pauly, K | 1 |
| Pfefferbaum, A | 2 |
| Vasanawala, S | 1 |
| Hurd, R | 1 |
| Kannerup, AS | 1 |
| Grønbæk, H | 1 |
| Funch-Jensen, P | 1 |
| Karlsen, S | 1 |
| Mortensen, FV | 1 |
| Jung, SY | 1 |
| Song, HS | 1 |
| Chung, SH | 1 |
| Kim, YJ | 1 |
| Darpolor, MM | 1 |
| Chua, MS | 1 |
| Xing, L | 1 |
| Clarke-Katzenberg, RH | 1 |
| Shi, W | 1 |
| Josan, S | 1 |
| Hurd, RE | 1 |
| Senadheera, L | 1 |
| So, S | 1 |
| Hofmann, LV | 1 |
| Glazer, GM | 1 |
| Spielman, DM | 1 |
| Balakrishnan, A | 1 |
| Anderton, B | 1 |
| Roudier, E | 1 |
| Bachelet, C | 1 |
| Perrin, A | 1 |
| Weiss, P | 1 |
| Ashwell, G | 1 |
| Morell, AG | 1 |
| Stockert, RJ | 1 |
| Mizobuchi, N | 1 |
| Kuwao, F | 1 |
| Takeda, I | 1 |
| Takemura, T | 1 |
| Morita, S | 1 |
| Horimi, T | 1 |
| Takahashi, I | 1 |
24 other studies available for pyruvic acid and Liver Neoplasms
| Article | Year |
|---|---|
The Antitumor Effect of Cinnamaldehyde Derivative CB-PIC in Hepatocellular Carcinoma Cells via Inhibition of Pyruvate and STAT3 Signaling.
Topics: Acrolein; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; HCT116 Cells; Humans; Liver Neopla | 2022 |
Inhibition of LPAR6 overcomes sorafenib resistance by switching glycolysis into oxidative phosphorylation in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Glycolysis; Humans; Lactic Acid; Liver Neoplasms; Oxidative Phosphorylati | 2022 |
Genome-Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment.
Topics: Animals; Carcinoma, Hepatocellular; CRISPR-Cas Systems; Early Detection of Cancer; Glutamine; Liver | 2022 |
A novel prognostic model for hepatocellular carcinoma based on pyruvate metabolism-related genes.
Topics: Carcinoma, Hepatocellular; DNA Copy Number Variations; Humans; Liver Neoplasms; Prognosis; Pyruvic A | 2023 |
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Citric Acid Cycle; | 2019 |
Hyperpolarized
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carbon Isot | 2020 |
Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Hepatocellular; CRISPR-Cas Systems; D | 2020 |
Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models.
Topics: Adenocarcinoma; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Car | 2021 |
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation.
Topics: A549 Cells; Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Cell Proliferation; G | 2019 |
Paradoxical Puma Prohibits Pyruvate Pumps to Prime Pathology.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Humans; Liver Neoplasms; Oxidative Phosphorylation; Proto- | 2019 |
Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.
Topics: Alanine; Algorithms; Animals; Biomarkers, Tumor; Carbon Isotopes; Computer Simulation; Lactic Acid; | 2014 |
Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.
Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; DNA Transposable Elements; Gene Expressi | 2014 |
Determination of α-ketoglutaric and pyruvic acids in urine as potential biomarkers for diabetic II and liver cancer.
Topics: Biomarkers, Tumor; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Humans; Ketoglut | 2015 |
Ethanol, ethyl and sodium pyruvate decrease the inflammatory responses of human lung epithelial cells via Akt and NF-κB in vitro but have a low impact on hepatocellular cells.
Topics: bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Epithelial Cells; Ethanol; | 2016 |
Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2).
Topics: Adenosine Triphosphate; Antineoplastic Agents; Carcinoma, Hepatocellular; Hep G2 Cells; Hepatocytes; | 2016 |
Dehydroepiandrosterone induces growth arrest of hepatoma cells via alteration of mitochondrial gene expression and function.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Proliferation; Dehydroepiandrosterone; DNA, | 2008 |
T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate.
Topics: Alanine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Disease Models, Animal; Liver Neoplasm | 2010 |
Partial liver ischemia is followed by metabolic changes in the normally perfused part of the liver during reperfusion.
Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Glucose; Glycerol; Humans; Ischemia; | 2010 |
Pyruvate promotes tumor angiogenesis through HIF-1-dependent PAI-1 expression.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Electrophoretic Mobility Shift Assay; | 2011 |
In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma.
Topics: Alanine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic | 2011 |
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
Topics: Alanine; Animals; Carbon Isotopes; Citric Acid Cycle; Disease Models, Animal; Gene Expression Profil | 2011 |
Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Comet Assay; DNA Damage; Glutathione; Hum | 2007 |
Modulation of the asialoglycoprotein receptor in human hepatoma cells: effect of glucose.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Binding Sites; Carcinoma, Hepatocellular; Culture | 1994 |
[Changes in ketone body ratio and levels of pyruvate and lactate in arterial blood of patients with hepatocellular carcinoma after transcatheter arterial embolization].
Topics: Carcinoma, Hepatocellular; Embolization, Therapeutic; Humans; Ketones; Lactates; Lactic Acid; Liver; | 1990 |