pyruvic acid and Lipid Metabolism, Inborn Error
pyruvic acid has been researched along with Lipid Metabolism, Inborn Error in 4 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Research
Studies (4)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (25.00) | 18.7374 |
1990's | 1 (25.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Semeraro, M | 1 |
Boenzi, S | 1 |
Carrozzo, R | 1 |
Diodato, D | 1 |
Martinelli, D | 1 |
Olivieri, G | 1 |
Antonetti, G | 1 |
Sacchetti, E | 1 |
Catesini, G | 1 |
Rizzo, C | 1 |
Dionisi-Vici, C | 1 |
Behrend, AM | 1 |
Harding, CO | 1 |
Shoemaker, JD | 1 |
Matern, D | 1 |
Sahn, DJ | 1 |
Elliot, DL | 1 |
Gillingham, MB | 1 |
Platt, SR | 1 |
Chrisman, CL | 1 |
Shelton, GD | 1 |
Kolodny, EH | 1 |
Yatziv, S | 1 |
Clinical Trials (2)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Fatty Acid Oxidation Disorders & Body Weight Regulation[NCT00654004] | 26 participants (Actual) | Observational | 2006-04-30 | Completed | |||
Effect of the Administration of L-Carnitine on Body Fat Percentage and Body Weight in Overweight Women in Crossfit Training.[NCT03436277] | Phase 2 | 24 participants (Anticipated) | Interventional | 2018-12-17 | Not yet recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
An Outcome of This Study is the Difference in Glucose Tolerance Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Normal Controls.
"Glucose tolerance was estimated by the Matsuda Index using glucose and insulin values from a standard oral glucose tolerance test. The Matsuda Index is calculated by the following formula: 10,000/ sq root of (fasting glucose mg/dl X fasting insulin in units/ml) X (mean glucose (mg/dl) X mean insulin (units/ml) and correlates with insulin sensitivity measured by the gold standard method of a hyperinsulinemic euglycemic clamp. Values of 2.5 or greater are considered insulin sensitive. Values of 2.4 or less are considered insulin resistance.~The Matsuda Index of Insulin Sensitivity was measured in subjects with a long-chain fatty acid oxidation disorder (n=12). Twelve age, sex and BMI matched controls and 4 heterozygotes for a long-chain fatty acid oxidation disorder were recruited who also completed an oral glucose tolerance test. The difference in Mastuda Index between subjects and age matched controls was compared by t-test." (NCT00654004)
Timeframe: Subjects will be compared to controls at one point in time.
Intervention | units on a scale (Mean) |
---|---|
Subjects | 2.8 |
Controls | 3.13 |
An Outcome of This Study is the Difference in Percent Body Fat (%BF) Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Normal Controls.
Body composition by DEXA was measured in subjects with a long-chain fatty acid oxidation disorder (n=13). Twelve age, sex and BMI matched controls and 4 heterozygotes for a long-chain fatty acid oxidation disorder were recruited who also completed body composition measures. The difference in body composition between subjects and age matched controls was compared by t-test. (NCT00654004)
Timeframe: Subjects will be compared to controls at one point in time.
Intervention | percentage of body fat (Mean) |
---|---|
Subjects | 31.8 |
Controls | 27.2 |
The Difference in Plasma Adiponectin Levels Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Matched Controls Was Compared by T-test
Fasting total adiponectin levels in ug/ml were measured in both groups (subjects with a long-chain fatty acid oxidation disorder). The differences between groups were compared with a t-test (NCT00654004)
Timeframe: Fasting total adiponectin (ug/ml)
Intervention | ug/ml (Mean) |
---|---|
Subjects | 17.3 |
Controls | 24.4 |
The Difference in Plasma Insulin Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Matched Controls Was Compared by T-test
Fasting insulin levels in uU/ml were measured in both groups. The differences between groups were compared with a t-test (NCT00654004)
Timeframe: Fasting insulin levels uUnits/ml
Intervention | uU/ml (Mean) |
---|---|
Subjects | 17 |
Controls | 13 |
The Difference in Plasma Leptin Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Matched Controls Was Compared by T-test
Fasting leptin in ng/kg fat mass were measured in both groups (subjects with a long-chain fatty acid oxidation disorder; controls). The differences between groups were compared with a t-test (NCT00654004)
Timeframe: Fasting leptin levels ng per kg of fat mass
Intervention | ng/kg (Mean) |
---|---|
Subjects | 0.99 |
Controls | 0.91 |
Trials
1 trial available for pyruvic acid and Lipid Metabolism, Inborn Error
Article | Year |
---|---|
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo | 2012 |
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo | 2012 |
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo | 2012 |
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo | 2012 |
Other Studies
3 other studies available for pyruvic acid and Lipid Metabolism, Inborn Error
Article | Year |
---|---|
The urinary organic acids profile in single large-scale mitochondrial DNA deletion disorders.
Topics: 3-Hydroxybutyric Acid; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Child; Child, Preschool; Cong | 2018 |
Lipid storage myopathy in a cocker spaniel.
Topics: Acetoacetates; Animals; Dog Diseases; Dogs; Lactic Acid; Lipid Metabolism, Inborn Errors; Male; Musc | 1999 |
Laboratory approaches for inherited neurometabolic diseases.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Galactosemias; Homocystinuria; Humans; Lactates; Lact | 1985 |