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pyruvic acid and Lipid Metabolism, Inborn Error

pyruvic acid has been researched along with Lipid Metabolism, Inborn Error in 4 studies

Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Semeraro, M1
Boenzi, S1
Carrozzo, R1
Diodato, D1
Martinelli, D1
Olivieri, G1
Antonetti, G1
Sacchetti, E1
Catesini, G1
Rizzo, C1
Dionisi-Vici, C1
Behrend, AM1
Harding, CO1
Shoemaker, JD1
Matern, D1
Sahn, DJ1
Elliot, DL1
Gillingham, MB1
Platt, SR1
Chrisman, CL1
Shelton, GD1
Kolodny, EH1
Yatziv, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Fatty Acid Oxidation Disorders & Body Weight Regulation[NCT00654004]26 participants (Actual)Observational2006-04-30Completed
Effect of the Administration of L-Carnitine on Body Fat Percentage and Body Weight in Overweight Women in Crossfit Training.[NCT03436277]Phase 224 participants (Anticipated)Interventional2018-12-17Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

An Outcome of This Study is the Difference in Glucose Tolerance Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Normal Controls.

"Glucose tolerance was estimated by the Matsuda Index using glucose and insulin values from a standard oral glucose tolerance test. The Matsuda Index is calculated by the following formula: 10,000/ sq root of (fasting glucose mg/dl X fasting insulin in units/ml) X (mean glucose (mg/dl) X mean insulin (units/ml) and correlates with insulin sensitivity measured by the gold standard method of a hyperinsulinemic euglycemic clamp. Values of 2.5 or greater are considered insulin sensitive. Values of 2.4 or less are considered insulin resistance.~The Matsuda Index of Insulin Sensitivity was measured in subjects with a long-chain fatty acid oxidation disorder (n=12). Twelve age, sex and BMI matched controls and 4 heterozygotes for a long-chain fatty acid oxidation disorder were recruited who also completed an oral glucose tolerance test. The difference in Mastuda Index between subjects and age matched controls was compared by t-test." (NCT00654004)
Timeframe: Subjects will be compared to controls at one point in time.

Interventionunits on a scale (Mean)
Subjects2.8
Controls3.13

An Outcome of This Study is the Difference in Percent Body Fat (%BF) Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Normal Controls.

Body composition by DEXA was measured in subjects with a long-chain fatty acid oxidation disorder (n=13). Twelve age, sex and BMI matched controls and 4 heterozygotes for a long-chain fatty acid oxidation disorder were recruited who also completed body composition measures. The difference in body composition between subjects and age matched controls was compared by t-test. (NCT00654004)
Timeframe: Subjects will be compared to controls at one point in time.

Interventionpercentage of body fat (Mean)
Subjects31.8
Controls27.2

The Difference in Plasma Adiponectin Levels Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Matched Controls Was Compared by T-test

Fasting total adiponectin levels in ug/ml were measured in both groups (subjects with a long-chain fatty acid oxidation disorder). The differences between groups were compared with a t-test (NCT00654004)
Timeframe: Fasting total adiponectin (ug/ml)

Interventionug/ml (Mean)
Subjects17.3
Controls24.4

The Difference in Plasma Insulin Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Matched Controls Was Compared by T-test

Fasting insulin levels in uU/ml were measured in both groups. The differences between groups were compared with a t-test (NCT00654004)
Timeframe: Fasting insulin levels uUnits/ml

InterventionuU/ml (Mean)
Subjects17
Controls13

The Difference in Plasma Leptin Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Matched Controls Was Compared by T-test

Fasting leptin in ng/kg fat mass were measured in both groups (subjects with a long-chain fatty acid oxidation disorder; controls). The differences between groups were compared with a t-test (NCT00654004)
Timeframe: Fasting leptin levels ng per kg of fat mass

Interventionng/kg (Mean)
Subjects0.99
Controls0.91

Trials

1 trial available for pyruvic acid and Lipid Metabolism, Inborn Error

ArticleYear
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
    Molecular genetics and metabolism, 2012, Volume: 105, Issue:1

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo

2012
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
    Molecular genetics and metabolism, 2012, Volume: 105, Issue:1

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo

2012
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
    Molecular genetics and metabolism, 2012, Volume: 105, Issue:1

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo

2012
Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation.
    Molecular genetics and metabolism, 2012, Volume: 105, Issue:1

    Topics: Acetylcarnitine; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Adult; Child; Creatine Kinase; Demo

2012

Other Studies

3 other studies available for pyruvic acid and Lipid Metabolism, Inborn Error

ArticleYear
The urinary organic acids profile in single large-scale mitochondrial DNA deletion disorders.
    Clinica chimica acta; international journal of clinical chemistry, 2018, Volume: 481

    Topics: 3-Hydroxybutyric Acid; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Child; Child, Preschool; Cong

2018
Lipid storage myopathy in a cocker spaniel.
    The Journal of small animal practice, 1999, Volume: 40, Issue:1

    Topics: Acetoacetates; Animals; Dog Diseases; Dogs; Lactic Acid; Lipid Metabolism, Inborn Errors; Male; Musc

1999
Laboratory approaches for inherited neurometabolic diseases.
    Developmental medicine and child neurology, 1985, Volume: 27, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Galactosemias; Homocystinuria; Humans; Lactates; Lact

1985
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