pyruvic acid has been researched along with Ischemic Attack, Transient in 17 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "After induction (t0) of cardiac arrest of 4 min, cardiopulmonary resuscitation was performed for 1 min, and the induced ventricular fibrillation was terminated by electrical defibrillation." | 1.33 | Xenon attenuates cerebral damage after ischemia in pigs. ( Glöggl, E; Marx, T; Reinelt, H; Schirmer, U; Schmidt, M, 2005) |
| "A 48-year-old woman suffered subarachnoid hemorrhage grade IV according to Hunt and Hess." | 1.30 | Bedside-microdialysis for early detection of vasospasm after subarachnoid hemorrhage. Case report and review of the literature. ( Lanksch, WR; Sarrafzadeh, AS; Unterberg, AW, 1998) |
| "Once treatment with nimodipine was begun, CBF was approximately double that of an untreated group." | 1.27 | Delayed treatment with nimodipine improves cerebral blood flow after complete cerebral ischemia in the dog. ( Michenfelder, JD; Milde, JH; Milde, LN, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, R | 1 |
| Zhang, X | 1 |
| Kong, X | 1 |
| Han, J | 1 |
| Yang, Q | 1 |
| Zhang, Y | 1 |
| Chen, Y | 1 |
| Li, P | 1 |
| Liu, J | 1 |
| Shi, M | 1 |
| Xiong, L | 1 |
| Zhao, G | 1 |
| Schmidt, M | 1 |
| Marx, T | 1 |
| Glöggl, E | 1 |
| Reinelt, H | 1 |
| Schirmer, U | 1 |
| Yi, JS | 1 |
| Kim, TY | 1 |
| Kyu Kim, D | 1 |
| Koh, JY | 2 |
| Mori, K | 1 |
| Nakajima, K | 1 |
| Maeda, M | 1 |
| Valtysson, J | 1 |
| Persson, L | 1 |
| Hillered, L | 1 |
| Adach, B | 1 |
| Sarrafzadeh, AS | 1 |
| Unterberg, AW | 1 |
| Lanksch, WR | 1 |
| Anderson, MF | 1 |
| Sims, NR | 2 |
| Chen, CJ | 1 |
| Cheng, FC | 1 |
| Liao, SL | 1 |
| Chen, WY | 1 |
| Lin, NN | 1 |
| Kuo, JS | 1 |
| Krasińska-Czerlunczakiewicz, H | 1 |
| Pilarczyk, M | 1 |
| Stelmasiak, Z | 1 |
| Lee, JY | 1 |
| Kim, YH | 1 |
| Gaevyĭ, MD | 1 |
| Lavinskiĭ, NG | 1 |
| Vereshchagin, VK | 1 |
| Pchelintseva, TR | 1 |
| Ivashev, MN | 1 |
| Nagornaia, GV | 1 |
| Pyshnyĭ, VO | 1 |
| Cardell, M | 1 |
| Koide, T | 1 |
| Wieloch, T | 1 |
| Milde, LN | 1 |
| Milde, JH | 1 |
| Michenfelder, JD | 1 |
| Busto, R | 1 |
| Dietrich, WD | 1 |
| Globus, MY | 1 |
| Valdés, I | 1 |
| Scheinberg, P | 1 |
| Ginsberg, MD | 1 |
| Nowak, TS | 1 |
| Fried, RL | 1 |
| Lust, WD | 1 |
| Passonneau, JV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Bromocriptine to Reduce Body Temperature in Febrile Critically-ill Adults With Acute Neurologic Disease: an Open-label, Blinded Endpoint, Randomized Controlled Trial[NCT03496545] | Phase 1/Phase 2 | 47 participants (Actual) | Interventional | 2018-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean total body temperature burden above 37°C over 48 hours during which patient receives either control or intervention medication. (NCT03496545)
Timeframe: over 48 hours
| Intervention | Temperature in degrees Celsius (Mean) |
|---|---|
| Acetaminophen | 37.8 |
| Bromocriptine and Acetaminophen | 37.7 |
Time in minutes where the temperature is ≥ 38.3ºC during the 48 hours of control versus intervention administration. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 216 |
| Bromocriptine and Acetaminophen | 300 |
Time in minutes it took after medication administration for the temperature to reach < 37.5ºC. (NCT03496545)
Timeframe: 48 hours
| Intervention | Minutes (Mean) |
|---|---|
| Acetaminophen | 253.5 |
| Bromocriptine and Acetaminophen | 556 |
Episodes of symptomatic hypotension, including decrease in supine systolic and diastolic pressures of greater than 20mm and 10mm Hg respectively with patient reported accompanying symptoms of light headedness or dizziness and incidence of nausea and headache. (NCT03496545)
Timeframe: Nursing assessment at every shift during 48 hour study period after first drug administration
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Decrease in blood pressure | Nausea | Headache | |
| Acetaminophen | 12 | 2 | 8 |
| Bromocriptine and Acetaminophen | 17 | 3 | 12 |
2 trials available for pyruvic acid and Ischemic Attack, Transient
| Article | Year |
|---|---|
[The effect of polarizing mixture KIG (potassium + insulin + glucose) on some metabolites of glucose transformation in patients with ischemic stroke during the earliest period of illness].
Topics: Aged; Drug Therapy, Combination; Glucose; Humans; Infusions, Intravenous; Insulin; Ischemic Attack, | 1997 |
[Evaluation of pyruvic acid concentration in blood of patients with ischemic stroke in the earliest stage of the disease].
Topics: Cerebral Infarction; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Pyruvic Acid | 1999 |
15 other studies available for pyruvic acid and Ischemic Attack, Transient
| Article | Year |
|---|---|
Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia.
Topics: Aconitate Hydratase; Animals; Apoptosis; Brain; Calcium; Electron Transport; Ginsenosides; Glucose; | 2011 |
Xenon attenuates cerebral damage after ischemia in pigs.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Body Temperature; Bra | 2005 |
Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Cell Death; Cerebral Infarction; Dose-Response Rela | 2007 |
Long-term monitoring of CSF lactate levels and lactate/pyruvate ratios following subarachnoid haemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Bicarbonates; Female; Humans; Hydrogen-Ion Concentration; Intracran | 1993 |
Extracellular ischaemia markers in repeated global ischaemia and secondary hypoxaemia monitored by microdialysis in rat brain.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Electroencephalography; Energy Metabolism; Extracellular S | 1998 |
Bedside-microdialysis for early detection of vasospasm after subarachnoid hemorrhage. Case report and review of the literature.
Topics: Brain; Cerebral Angiography; Female; Glucose; Humans; Ischemic Attack, Transient; Lactates; Microdia | 1998 |
Mitochondrial respiratory function and cell death in focal cerebral ischemia.
Topics: Animals; Arterial Occlusive Diseases; Cell Death; Cerebral Arterial Diseases; Cerebral Infarction; I | 1999 |
Effects of naloxone on lactate, pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain; Catalase; Energy Metabolism; Free Radicals; Glutathione Peroxidase; Is | 2000 |
Protection by pyruvate against transient forebrain ischemia in rats.
Topics: Animals; Astrocytes; Calcium; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; In | 2001 |
[The comparative characteristics of the hemodynamic and biochemical indices of the postischemic period in relation to the regimens of brain autohemoperfusion].
Topics: Animals; Blood Glucose; Brain; Cats; Female; Hemodynamics; Hemoperfusion; Ischemic Attack, Transient | 1991 |
Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat.
Topics: Animals; Brain; Corpus Striatum; Ischemic Attack, Transient; Malates; Male; Mitochondria; Oxygen Con | 1991 |
Pyruvate dehydrogenase activity in the rat cerebral cortex following cerebral ischemia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Carotid Arteries; Cerebral Cortex; Dichloroacetic Ac | 1989 |
Delayed treatment with nimodipine improves cerebral blood flow after complete cerebral ischemia in the dog.
Topics: Adenine Nucleotides; Animals; Blood; Blood Flow Velocity; Brain; Calcium Channel Blockers; Carbon Di | 1986 |
Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury.
Topics: Adenosine Triphosphate; Animals; Body Temperature; Brain; Cerebral Cortex; Cerebrovascular Circulati | 1987 |
Changes in brain energy metabolism and protein synthesis following transient bilateral ischemia in the gerbil.
Topics: Adenine Nucleotides; Animals; Brain; Energy Metabolism; Gerbillinae; Glycogen; Guanine Nucleotides; | 1985 |