pyruvic acid has been researched along with Infarction, Middle Cerebral Artery in 21 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 7.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 3.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Both stroke and depression have independently been associated with pathologically elevated glutamate levels in the brain's extra-cerebral fluid (ECF)." | 1.51 | The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach. ( Boyko, M; Brotfain, E; Frank, D; Grinshpun, Y; Gruenbaum, BF; Kuts, R; Natanel, D; Shelef, I; Tsenter, P; Zlotnik, A; Zvenigorodsky, V, 2019) |
| "This biochemical pattern contrasts to cerebral ischemia, which is characterized by a marked decrease in cerebral pyruvate." | 1.40 | Bedside diagnosis of mitochondrial dysfunction after malignant middle cerebral artery infarction. ( Nielsen, TH; Nordström, CH; Reinstrup, P; Schalén, W; Ståhl, N; Toft, P, 2014) |
| "Rats that were exposed to permanent middle cerebral artery occlusion (MCAO) and treated with intravenous 250 mg/kg pyruvate had a smaller volume of infarction and reduced brain edema, resulting in an improved neurological outcome and reduced mortality compared to control rats treated with saline." | 1.37 | Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke. ( Boyko, M; Gruenbaum, BF; Gruenbaum, SE; Kuts, R; Melamed, I; Ohayon, S; Regev, A; Shapira, Y; Teichberg, VI; Zlotnik, A, 2011) |
| "Glycerol concentration was significantly lower in patients treated by hypothermia (111 +/- 17 micromol/l; P < 0." | 1.35 | Neurochemical monitoring of therapeutic effects in large human MCA infarction. ( Berger, C; Kiening, K; Schwab, S, 2008) |
| " In other set of experiments, pyruvate was given either before, immediately after ischemia or in a long-term administration paradigm." | 1.32 | Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats. ( Candelario-Jalil, E; García-Cabrera, M; González-Falcón, A; León, OS, 2003) |
| "Transorbital 2 hour middle cerebral artery occlusion (MCAO) was performed in eight monkeys, which were studied with continuous microdialysis for 24 hours." | 1.31 | Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J; Watanabe, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (66.67) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Li, F | 3 |
| Geng, X | 3 |
| Ilagan, R | 3 |
| Bai, S | 3 |
| Chen, Y | 4 |
| Ding, Y | 3 |
| Hyacinthe, JN | 1 |
| Buscemi, L | 1 |
| Lê, TP | 1 |
| Lepore, M | 1 |
| Hirt, L | 1 |
| Mishkovsky, M | 1 |
| Frank, D | 1 |
| Kuts, R | 2 |
| Tsenter, P | 1 |
| Gruenbaum, BF | 2 |
| Grinshpun, Y | 1 |
| Zvenigorodsky, V | 1 |
| Shelef, I | 1 |
| Natanel, D | 1 |
| Brotfain, E | 1 |
| Zlotnik, A | 2 |
| Boyko, M | 2 |
| Nielsen, TH | 1 |
| Schalén, W | 1 |
| Ståhl, N | 1 |
| Toft, P | 1 |
| Reinstrup, P | 1 |
| Nordström, CH | 1 |
| Arikan, F | 1 |
| Martínez-Valverde, T | 1 |
| Sánchez-Guerrero, Á | 1 |
| Campos, M | 1 |
| Esteves, M | 1 |
| Gandara, D | 1 |
| Torné, R | 1 |
| Castro, L | 1 |
| Dalmau, A | 1 |
| Tibau, J | 1 |
| Sahuquillo, J | 1 |
| Martín, A | 1 |
| Rojas, S | 1 |
| Pérez-Asensio, F | 1 |
| Planas, AM | 1 |
| Wang, Q | 1 |
| van Hoecke, M | 1 |
| Tang, XN | 1 |
| Lee, H | 1 |
| Zheng, Z | 1 |
| Swanson, RA | 1 |
| Yenari, MA | 1 |
| Ye, R | 1 |
| Zhang, X | 1 |
| Kong, X | 1 |
| Han, J | 1 |
| Yang, Q | 1 |
| Zhang, Y | 1 |
| Li, P | 1 |
| Liu, J | 1 |
| Shi, M | 1 |
| Xiong, L | 1 |
| Zhao, G | 1 |
| Gruenbaum, SE | 1 |
| Ohayon, S | 1 |
| Melamed, I | 1 |
| Regev, A | 1 |
| Shapira, Y | 1 |
| Teichberg, VI | 1 |
| González-Falcón, A | 1 |
| Candelario-Jalil, E | 1 |
| García-Cabrera, M | 1 |
| León, OS | 1 |
| Berger, C | 5 |
| Dohmen, C | 3 |
| Maurer, MH | 1 |
| Graf, R | 3 |
| Schwab, S | 5 |
| Sakowitz, OW | 1 |
| Kiening, KL | 1 |
| Bosche, B | 1 |
| Reithmeier, T | 1 |
| Ernestus, RI | 1 |
| Brinker, G | 2 |
| Sobesky, J | 1 |
| Heiss, WD | 2 |
| Kiening, K | 1 |
| Fatar, M | 1 |
| Stroick, M | 1 |
| Griebe, M | 1 |
| Alonso, A | 1 |
| Kreisel, S | 1 |
| Kern, R | 1 |
| Hennerici, M | 1 |
| Meairs, S | 1 |
| Enblad, P | 2 |
| Frykholm, P | 2 |
| Valtysson, J | 2 |
| Silander, HC | 1 |
| Andersson, J | 1 |
| Fasth, KJ | 1 |
| Watanabe, Y | 2 |
| Långström, B | 2 |
| Hillered, L | 2 |
| Persson, L | 2 |
| Schneweis, S | 1 |
| Grond, M | 1 |
| Staub, F | 1 |
| Neveling, M | 1 |
| Badr, AE | 1 |
| Yin, W | 1 |
| Mychaskiw, G | 1 |
| Zhang, JH | 1 |
| Schäbitz, WR | 2 |
| Schellinger, PD | 1 |
| Aschoff, A | 2 |
| Steiner, T | 2 |
| Georgiadis, D | 1 |
2 trials available for pyruvic acid and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal | 2001 |
Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study.
Topics: Adult; Aged; Brain; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction, Middl | 2002 |
19 other studies available for pyruvic acid and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Exercise postconditioning reduces ischemic injury via suppression of cerebral gluconeogenesis in rats.
Topics: Animals; Brain Injuries; Gluconeogenesis; Glucose; Infarction, Middle Cerebral Artery; Lactates; Pho | 2023 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach.
Topics: Animals; Depression; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Pyruvic Acid; Random A | 2019 |
Bedside diagnosis of mitochondrial dysfunction after malignant middle cerebral artery infarction.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Cerebrum; Decompressive Craniectomy; Female; Humans; Infarc | 2014 |
Malignant infarction of the middle cerebral artery in a porcine model. A pilot study.
Topics: Animals; Brain; Disease Models, Animal; Female; Gene Expression; Glucose; Glycerol; Immunohistochemi | 2017 |
Transient benefits but lack of protection by sodium pyruvate after 2-hour middle cerebral artery occlusion in the rat.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Brain Infarction; Disease Models, Animal; Inf | 2009 |
Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.
Topics: Animals; Body Weight; Cell Count; Disease Models, Animal; Ectodysplasins; Encephalitis; Infarction, | 2009 |
Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia.
Topics: Aconitate Hydratase; Animals; Apoptosis; Brain; Calcium; Electron Transport; Ginsenosides; Glucose; | 2011 |
Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke.
Topics: Animals; Aspartate Aminotransferases; Brain Edema; Brain Infarction; Disease Models, Animal; Dose-Re | 2011 |
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Chronic Disease; Infarction, Middle Cerebral Arter | 2003 |
[Cerebral microdialysis in stroke].
Topics: Brain Edema; Critical Care; Diagnostic Imaging; Electrolytes; Energy Metabolism; Glutamic Acid; Glyc | 2004 |
Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema.
Topics: Adult; Aged; Brain; Brain Edema; Drug Monitoring; Edema; Female; Glutamic Acid; Glycerol; Humans; In | 2005 |
Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction.
Topics: Blood Pressure; Brain; Brain Edema; Cerebrovascular Circulation; Disease Progression; Energy Metabol | 2007 |
Neurochemical monitoring of therapeutic effects in large human MCA infarction.
Topics: Craniotomy; Critical Care; Female; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; Infarction | 2008 |
Effect of combined ultrasound and microbubbles treatment in an experimental model of cerebral ischemia.
Topics: Animals; Biomarkers; Brain Ischemia; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; La | 2008 |
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Hypoxanthine; Infarction | 2001 |
Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model.
Topics: Animals; Brain Damage, Chronic; Extracellular Space; Glutamic Acid; Glycerol; Infarction, Middle Cer | 2001 |
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Energy Metabolism; Extracellular Space; Glucose; Glutamic | 2001 |
Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction.
Topics: Adult; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; I | 2001 |