pyruvic acid has been researched along with Hyperoxaluria, Primary in 4 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Hyperoxaluria, Primary: A genetic disorder characterized by excretion of large amounts of OXALATES in urine; NEPHROLITHIASIS; NEPHROCALCINOSIS; early onset of RENAL FAILURE; and often a generalized deposit of CALCIUM OXALATE. There are subtypes classified by the enzyme defects in glyoxylate metabolism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Its loss of function in humans causes primary hyperoxaluria type 3 (PH3), a rare condition characterised by excessive production of oxalate." | 1.51 | Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3. ( Baker, EN; Bunker, RD; Burke, J; Griffin, MD; Huang, A; Loomes, KM; Mok, YF, 2019) |
| " However, siRNA dosing data suggest that it may be possible to identify a dose that limits changes in liver organic acid levels, while maintaining a desired effect of reducing glyoxylate to oxalate synthesis." | 1.51 | Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity. ( Erbe, D; Fargue, S; Holmes, RP; Knight, J; Liebow, A; Wood, KD, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, A | 1 |
| Burke, J | 1 |
| Bunker, RD | 1 |
| Mok, YF | 1 |
| Griffin, MD | 1 |
| Baker, EN | 1 |
| Loomes, KM | 1 |
| Wood, KD | 1 |
| Holmes, RP | 2 |
| Erbe, D | 1 |
| Liebow, A | 1 |
| Fargue, S | 1 |
| Knight, J | 2 |
| Riedel, TJ | 1 |
| Johnson, LC | 1 |
| Hantgan, RR | 1 |
| Lowther, WT | 1 |
| Horváth, VA | 1 |
| Wanders, RJ | 1 |
4 other studies available for pyruvic acid and Hyperoxaluria, Primary
| Article | Year |
|---|---|
Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3.
Topics: Catalytic Domain; Enzyme Inhibitors; Humans; Hyperoxaluria, Primary; Ketoglutaric Acids; Kinetics; O | 2019 |
Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Hyperoxaluria, Primary; Lactate Dehy | 2019 |
Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
Topics: Amino Acid Sequence; Animals; Apoenzymes; Bacteria; Catalytic Domain; Cattle; Crystallography, X-Ray | 2011 |
Rapid identification of primary hyperoxaluria type I patients using a novel, fully automated method for measurement of hepatic alanine: glyoxylate aminotransferase.
Topics: Alanine Transaminase; Autoanalysis; Centrifugation; Humans; Hyperoxaluria, Primary; L-Lactate Dehydr | 1994 |