pyruvic acid has been researched along with Hemorrhagic Shock in 39 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 7.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| "Hypertonic sodium pyruvate (HSP), as well as ethyl pyruvate solutions, has been proposed as resuscitative fluids in the treatment of hemorrhagic shock (HS) because of their anti-inflammatory and antioxidant properties." | 7.76 | Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock. ( Mongan, PD; Sharma, P, 2010) |
| "The influence of hemorrhagic shock on hepatic energy metabolism was investigated in carbon tetrachloride (CCl4)-induced cirrhotic rat." | 7.67 | Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats. ( Ikai, I; Morimoto, T; Ozaki, N; Ozawa, K; Shimahara, Y; Tanaka, A; Tokunaga, Y; Wakashiro, S, 1988) |
| "Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation." | 5.29 | Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993) |
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 3.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| "Hypertonic sodium pyruvate (HSP), as well as ethyl pyruvate solutions, has been proposed as resuscitative fluids in the treatment of hemorrhagic shock (HS) because of their anti-inflammatory and antioxidant properties." | 3.76 | Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock. ( Mongan, PD; Sharma, P, 2010) |
| "The influence of hemorrhagic shock on hepatic energy metabolism was investigated in carbon tetrachloride (CCl4)-induced cirrhotic rat." | 3.67 | Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats. ( Ikai, I; Morimoto, T; Ozaki, N; Ozawa, K; Shimahara, Y; Tanaka, A; Tokunaga, Y; Wakashiro, S, 1988) |
| "Hypoxic lactic acidosis was fully corrected in group PORS in 4 h, whereas it worsened in group BORS, and the 24-h survival rate was twice higher in group PORS than in group BORS (45." | 1.42 | Pyruvate oral rehydration solution improved visceral function and survival in shock rats. ( He, ZJ; Hu, S; Lin, HY; Luo, HM; Sheng, ZY; Xie, ZY; Yu, W; Zhou, FQ, 2015) |
| "Six rats died due to hemorrhagic shock by 350 min (Group D) while six rats had survived for the 350 min period after exsanguination (Group A)." | 1.35 | Utility of microdialysis to detect the lactate/pyruvate ratio in subcutaneous tissue for the reliable monitoring of hemorrhagic shock. ( Fujitani, S; Hosoyama, A; Kawasaki, N; Kobayashi, K; Ohashi, H; Ohashi, M; Taira, Y; Wada, T, 2009) |
| "Rat models of hemorrhagic shock were built up." | 1.34 | [Protective effect of sodium pyruvate on ischemia/reperfusion injury of rats subjected to hemorrhagic shock]. ( Guan, LD; Wang, B; Wang, GY; Wang, ZL; Wei, GZ; Zhao, L; Zhou, H, 2007) |
| "Initial fluid resuscitation of hemorrhagic shock might be enhanced by the infusion of monocarboxylate-energy substrates." | 1.34 | Hypertonic 15% sodium pyruvate offers no initial resuscitation advantage compared with 8% hypertonic NACl in sheep with multiple hemorrhages. ( do Nascimento, P; Espana, JM; Hoskins, SL; Kinsky, MP; Kramer, GC; Vaid, SU, 2007) |
| "Cardiac function decreased during hemorrhagic shock but improved significantly in the UTI group after transfusion compared with the control group." | 1.32 | Protective effect of urinary trypsin inhibitor on myocardial mitochondria during hemorrhagic shock and reperfusion. ( Ikeda, KM; Izumi, T; Masuda, T; Matsunaga, A; Matsuyama, N; Nagasawa, H; Noda, C; Ogura, MN; Sato, K; Shimizu, K, 2003) |
| "Thirty minutes after the onset of hemorrhagic shock, sodium PYR (n = 8) was infused (0." | 1.31 | Pyruvate improves cerebral metabolism during hemorrhagic shock. ( Bünger, R; Capacchione, J; Fontana, JL; Mongan, PD; West, S, 2001) |
| "Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation." | 1.29 | Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993) |
| "This hypoglycemia is not affected by treatment with adrenaline, glucagon, nicotinadenine dinucleotide (NAD), adenosine triphosphate (ATP) alanine (A), or pyruvate (P), while fructose (F) and dihydroxyacetone (DHA) slightly increase the plasma glucose concentration." | 1.27 | Studies on the site of the block in gluconeogenesis causing severe hypoglycemia in intestinal ischemia shock in rats. ( Snijders, PM; Valkenburg, PW; van der Meer, C, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.69) | 18.7374 |
| 1990's | 5 (12.82) | 18.2507 |
| 2000's | 15 (38.46) | 29.6817 |
| 2010's | 13 (33.33) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, JJ | 4 |
| Deng, JT | 2 |
| Shen, HQ | 2 |
| Jiang, LL | 3 |
| He, QW | 1 |
| Zhan, J | 2 |
| Zhang, ZZ | 4 |
| Wang, YL | 4 |
| Zhang, QY | 1 |
| Xiong, Y | 1 |
| Levitt, DG | 1 |
| Levitt, JE | 1 |
| Levitt, MD | 1 |
| Mallet, RT | 2 |
| Olivencia-Yurvati, AH | 2 |
| Bünger, R | 2 |
| Hu, S | 4 |
| Bai, XD | 2 |
| Liu, XQ | 2 |
| Wang, HB | 2 |
| Zhong, YX | 1 |
| Fang, T | 1 |
| Zhou, FQ | 6 |
| Ma, L | 1 |
| Luo, HM | 2 |
| Lin, ZL | 1 |
| Wang, XQ | 1 |
| Jia, YH | 1 |
| Sheng, ZY | 3 |
| Ke, JJ | 1 |
| He, XH | 2 |
| Chen, DL | 2 |
| Wang, YP | 1 |
| Lu, XG | 1 |
| Kang, X | 1 |
| Wang, XZ | 1 |
| Guo, S | 1 |
| Fan, ZW | 1 |
| Liang, ZK | 1 |
| Yu, J | 2 |
| Yu, W | 1 |
| Xie, ZY | 1 |
| He, ZJ | 1 |
| Lin, HY | 1 |
| Burša, F | 1 |
| Pleva, L | 1 |
| Máca, J | 1 |
| Sklienka, P | 1 |
| Ševčík, P | 1 |
| Rao, G | 1 |
| Xie, J | 1 |
| Hedrick, A | 1 |
| Awasthi, V | 1 |
| Liu, R | 1 |
| Wang, SM | 1 |
| Guo, SJ | 1 |
| Leung, LY | 1 |
| Deng-Bryant, Y | 1 |
| Cardiff, K | 1 |
| Winter, M | 1 |
| Tortella, F | 1 |
| Shear, D | 1 |
| Sharma, P | 4 |
| Mongan, PD | 5 |
| Ohashi, H | 1 |
| Kawasaki, N | 1 |
| Fujitani, S | 1 |
| Kobayashi, K | 1 |
| Ohashi, M | 1 |
| Hosoyama, A | 1 |
| Wada, T | 1 |
| Taira, Y | 1 |
| Flaherty, DC | 1 |
| Hoxha, B | 1 |
| Sun, J | 1 |
| Gurji, H | 1 |
| Simecka, JW | 1 |
| Guan, LD | 1 |
| Wang, ZL | 1 |
| Zhao, L | 1 |
| Wang, B | 1 |
| Wang, GY | 1 |
| Wei, GZ | 1 |
| Zhou, H | 1 |
| Capacchione, J | 2 |
| West, S | 2 |
| Karaian, J | 2 |
| Dubois, D | 1 |
| Keneally, R | 1 |
| Masuda, T | 1 |
| Sato, K | 1 |
| Noda, C | 1 |
| Ikeda, KM | 1 |
| Matsunaga, A | 1 |
| Ogura, MN | 1 |
| Shimizu, K | 1 |
| Nagasawa, H | 1 |
| Matsuyama, N | 1 |
| Izumi, T | 1 |
| Van Der Schuur, BM | 1 |
| Via, DK | 1 |
| Koustova, E | 1 |
| Rhee, P | 1 |
| Hancock, T | 1 |
| Chen, H | 1 |
| Inocencio, R | 1 |
| Jaskille, A | 1 |
| Hanes, W | 1 |
| Valeri, CR | 1 |
| Alam, HB | 1 |
| Bäckström, T | 1 |
| Liska, J | 1 |
| Oldner, A | 1 |
| Lockowandt, U | 1 |
| Franco-Cereceda, A | 1 |
| Tenhunen, J | 1 |
| Walsh, KT | 1 |
| Kerr-Knott, KA | 1 |
| Karaian, JE | 1 |
| Audonnet-Blaise, S | 1 |
| Krafft, MP | 1 |
| Smani, Y | 1 |
| Mertes, PM | 1 |
| Marie, PY | 1 |
| Labrude, P | 1 |
| Longrois, D | 1 |
| Menu, P | 1 |
| do Nascimento, P | 1 |
| Vaid, SU | 1 |
| Hoskins, SL | 1 |
| Espana, JM | 1 |
| Kinsky, MP | 1 |
| Kramer, GC | 1 |
| Sitina, M | 1 |
| Cerny, V | 1 |
| Haglund, U | 1 |
| Haljamäe, H | 1 |
| Hellman, A | 1 |
| Häggendal, E | 1 |
| Jennische, E | 1 |
| Lundberg, D | 1 |
| Geller, ER | 1 |
| Higgins, LD | 1 |
| Drourr, N | 1 |
| Maitra, SR | 1 |
| Yuan, XQ | 1 |
| Wade, CE | 1 |
| Kline, JA | 1 |
| Maiorano, PC | 1 |
| Schroeder, JD | 1 |
| Grattan, RM | 1 |
| Vary, TC | 1 |
| Watts, JA | 1 |
| Fontana, JL | 1 |
| Slovin, PN | 1 |
| Huang, CJ | 1 |
| Cade, JR | 1 |
| Wood, CE | 1 |
| Nasiroglu, O | 1 |
| Privette, M | 1 |
| Orbach, P | 1 |
| Skimming, JW | 1 |
| Dolgikh, VT | 1 |
| Meerson, PZ | 1 |
| Merginsky, EM | 1 |
| Rusakov, VV | 1 |
| Korpacheva, OV | 1 |
| Cryer, HG | 1 |
| Mavroudis, C | 1 |
| Roberts, AM | 1 |
| Cué, JI | 1 |
| Richardson, JD | 1 |
| Polk, HC | 1 |
| Ikai, I | 1 |
| Shimahara, Y | 1 |
| Wakashiro, S | 1 |
| Ozaki, N | 1 |
| Tokunaga, Y | 1 |
| Tanaka, A | 1 |
| Morimoto, T | 1 |
| Ozawa, K | 1 |
| van der Meer, C | 1 |
| Valkenburg, PW | 1 |
| Snijders, PM | 1 |
1 review available for pyruvic acid and Hemorrhagic Shock
| Article | Year |
|---|---|
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models | 2020 |
38 other studies available for pyruvic acid and Hemorrhagic Shock
| Article | Year |
|---|---|
Pyruvate Protects Against Intestinal Injury by Inhibiting the JAK/STAT Signaling Pathway in Rats With Hemorrhagic Shock.
Topics: Animals; Dialysis Solutions; Drug Evaluation, Preclinical; Intestinal Diseases; Janus Kinases; Male; | 2020 |
Effect of peritoneal dialysis solution with different pyruvate concentrations on intestinal injury.
Topics: Animals; Claudin-1; Dialysis Solutions; Hemodynamics; Intercellular Adhesion Molecule-1; Interleukin | 2020 |
Pyruvate-enriched resuscitation for shock.
Topics: Administration, Intravenous; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; | 2018 |
Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Arterial Pressure; Carbon Dioxide; Disease Models, | 2013 |
Pyruvate is superior to reverse visceral hypoperfusion in peritoneal resuscitation from hemorrhagic shock in rats.
Topics: Animals; Biomarkers; Blood Pressure; Body Water; Fluid Therapy; Infusions, Parenteral; Intestinal Mu | 2014 |
Protection against intestinal injury from hemorrhagic shock by direct peritoneal resuscitation with pyruvate in rats.
Topics: Animals; Dialysis Solutions; Drug Evaluation, Preclinical; Fluid Therapy; Inflammation Mediators; In | 2014 |
Effects of pyruvate-enriched peritoneal dialysis solution on intestinal barrier in peritoneal resuscitation from hemorrhagic shock in rats.
Topics: Animals; Blood Pressure; Cell Adhesion Molecules; Dialysis Solutions; Disease Models, Animal; Intest | 2015 |
Pyruvate oral rehydration solution improved visceral function and survival in shock rats.
Topics: Acidosis, Lactic; Animals; Bicarbonates; Disease Models, Animal; Fluid Therapy; Glucose; Lipid Perox | 2015 |
Tissue ischemia microdialysis assessments following severe traumatic haemorrhagic shock: lactate/pyruvate ratio as a new resuscitation end point?
Topics: Adult; Cardiac Output; Female; Hemoglobins; Humans; Lactic Acid; Male; Microdialysis; Middle Aged; O | 2014 |
Hemorrhagic shock-induced cerebral bioenergetic imbalance is corrected by pharmacologic treatment with EF24 in a rat model.
Topics: Adenosine Triphosphate; Animals; Benzylidene Compounds; Brain; Brain-Derived Neurotrophic Factor; Di | 2015 |
EFFECT OF INTRAPERITONEAL RESUSCITATION WITH DIFFERENT CONCENTRATIONS OF SODIUM PYRUVATE ON INTESTINAL ISCHEMIA REPERFUSION INJURY IN HEMORRHAGIC SHOCK RAT.
Topics: Animals; Dose-Response Relationship, Drug; Infusions, Parenteral; Intestines; Male; Pyruvic Acid; Ra | 2016 |
Pyruvate alleviates lipid peroxidation and multiple-organ dysfunction in rats with hemorrhagic shock.
Topics: Animals; Isotonic Solutions; Lipid Peroxidation; Male; Multiple Organ Failure; Oxidative Stress; Pyr | 2016 |
Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Head Injuries, Penetrating; Hypoxia; Lactic Acid; M | 2016 |
Pyruvate is superior to chloride in hypertonic saline in resuscitation.
Topics: Animals; Chlorides; Fluid Therapy; Pyruvic Acid; Resuscitation; Saline Solution, Hypertonic; Shock, | 2008 |
Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Cytokines; Fluid Therapy; Hepatitis; Hyperton | 2010 |
Utility of microdialysis to detect the lactate/pyruvate ratio in subcutaneous tissue for the reliable monitoring of hemorrhagic shock.
Topics: Animals; Blood Pressure; Early Diagnosis; Hypotension; Lactic Acid; Male; Microdialysis; Monitoring, | 2009 |
Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Drug Combinations; Fluid Therapy; Goats; Hemodynamics; Inflammation | 2010 |
[Protective effect of sodium pyruvate on ischemia/reperfusion injury of rats subjected to hemorrhagic shock].
Topics: Animals; Aspartate Aminotransferases; Disease Models, Animal; Kidney; L-Lactate Dehydrogenase; Liver | 2007 |
Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine.
Topics: Acid-Base Equilibrium; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blood Pressure | 2002 |
Protective effect of urinary trypsin inhibitor on myocardial mitochondria during hemorrhagic shock and reperfusion.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Blood Transfusion, Autologous; Energy Metabolism; G | 2003 |
Pyruvate prevents poly-ADP ribose polymerase (PARP) activation, oxidative damage, and pyruvate dehydrogenase deactivation during hemorrhagic shock in swine.
Topics: Animals; Brain; Ketone Oxidoreductases; Liver; Models, Animal; Oxidative Stress; Poly(ADP-ribose) Po | 2003 |
Ketone and pyruvate Ringer's solutions decrease pulmonary apoptosis in a rat model of severe hemorrhagic shock and resuscitation.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Apoptosis; Energy Metabolism; Isotonic Solut | 2003 |
Splanchnic metabolism during gut ischemia and short-term endotoxin and hemorrhagic shock as evaluated by intravasal microdialysis.
Topics: Abdomen; Animals; Endotoxemia; Endotoxins; Glucose; Glycerol; Hemodynamics; Ileum; Ischemia; Lactic | 2004 |
Can we distinguish between different types of local perfusion/metabolic derangement by regional venous concentrations of intermediary energy substrates?
Topics: Animals; Endotoxins; Glucose; Glycerol; Lactic Acid; Microdialysis; Perfusion; Pyruvic Acid; Reperfu | 2004 |
Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in rats.
Topics: Animals; Apoptosis; Male; Mitochondria, Liver; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Shock, Hemo | 2005 |
Resuscitation of severe but brief haemorrhagic shock with PFC in rabbits restores skeletal muscle oxygen delivery and does not alter skeletal muscle metabolism.
Topics: Animals; Blood Pressure; Blood Substitutes; Disease Models, Animal; Fluorocarbons; Hyperoxia; Lactic | 2006 |
Hypertonic 15% sodium pyruvate offers no initial resuscitation advantage compared with 8% hypertonic NACl in sheep with multiple hemorrhages.
Topics: Animals; Blood Pressure; Female; Fluid Therapy; Hypertonic Solutions; Lactic Acid; Plasma Volume; Py | 2007 |
Evaluating tissue perfusion using labelled water indicator microdialysis in a rat model of haemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Lactic Acid; Liver; Male; Microdialysis; Muscle, Sk | 2007 |
Vascular and metabolic effects of methylprednisolone and phenoxybenzamine during controlled hypotension in the dog.
Topics: Animals; Dogs; Hydrogen-Ion Concentration; Hypotension, Controlled; Lactates; Lactic Acid; Male; Met | 1981 |
Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock.
Topics: Animals; Diltiazem; Disease Models, Animal; Gluconeogenesis; Glucose; Isotonic Solutions; Lactates; | 1993 |
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C | 1993 |
Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Arteries; Blood Chemical Analysis; Blood Pressure; Dichloroacetic A | 1997 |
Pyruvate improves cerebral metabolism during hemorrhagic shock.
Topics: Animals; Brain; Brain Ischemia; Energy Metabolism; Oxidation-Reduction; Pyruvic Acid; Shock, Hemorrh | 2001 |
Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock.
Topics: Animals; Blood Glucose; Cardiotonic Agents; Disease Models, Animal; Lactic Acid; Male; Pyruvic Acid; | 2001 |
Functional metabolic heart impairment after acute lethal hemorrhage followed by resuscitation.
Topics: Animals; Glucose; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Pyruvates | 1991 |
Shock, transfusion, and pneumonectomy. Death is due to right heart failure and increased pulmonary vascular resistance.
Topics: Animals; Blood Pressure; Blood Transfusion; Cardiac Output; Cardiac Output, Low; Heart; Lactates; La | 1990 |
Influence of hemorrhagic shock on hepatic energy metabolism in carbon tetrachloride-induced cirrhotic rats.
Topics: Adenine Nucleotides; Animals; Carbon Tetrachloride; Energy Metabolism; Kinetics; Lactates; Lactic Ac | 1988 |
Studies on the site of the block in gluconeogenesis causing severe hypoglycemia in intestinal ischemia shock in rats.
Topics: Adenosine Triphosphate; Alanine; Animals; Epinephrine; Female; Glucagon; Gluconeogenesis; Hypoglycem | 1985 |