pyruvic acid has been researched along with Glioblastoma in 17 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent findings show that exposure to temozolomide (TMZ), a DNA-damaging drug used to treat glioblastoma (GBM), can suppress the conversion of pyruvate to lactate." | 7.80 | Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. ( Chaumeil, MM; Gaensler, K; Ito, M; Jalbert, LE; Mukherjee, J; Nelson, SJ; Park, I; Pieper, RO; Ronen, SM, 2014) |
| "Our results indicate that TERT expression is associated with elevated NADH in multiple cancers, including glioblastoma, oligodendroglioma, melanoma, neuroblastoma, and hepatocellular carcinoma." | 4.12 | Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer. ( Barger, C; Batsios, G; Costello, JF; Gillespie, AM; Ronen, SM; Stevers, N; Taglang, C; Tran, M; Viswanath, P, 2022) |
| "Recent findings show that exposure to temozolomide (TMZ), a DNA-damaging drug used to treat glioblastoma (GBM), can suppress the conversion of pyruvate to lactate." | 3.80 | Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. ( Chaumeil, MM; Gaensler, K; Ito, M; Jalbert, LE; Mukherjee, J; Nelson, SJ; Park, I; Pieper, RO; Ronen, SM, 2014) |
| " Silencing of glutaminase (GLS), which catalyzes the first step in glutamine-dependent anaplerosis, suppressed but did not eliminate the growth of glioblastoma cells in culture and in vivo." | 3.77 | Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. ( Cheng, T; DeBerardinis, RJ; Jin, ES; Matés, JM; Mullen, AR; Sudderth, J; Yang, C, 2011) |
| "To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model." | 3.77 | Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. ( Bok, R; James, CD; Nelson, SJ; Ozawa, T; Park, I; Phillips, JJ; Ronen, SM; Vigneron, DB, 2011) |
| "Here, we show that glioblastoma are excreting large amounts of branched-chain ketoacids (BCKAs), metabolites of branched-chain amino acid (BCAA) catabolism." | 1.46 | Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype. ( Becker, HM; Gaupel, AC; Hell, R; Hiller, K; Kneisel, N; Lichter, P; Nonnenmacher, Y; Poschet, G; Radlwimmer, B; Sapcariu, S; Schlotter, M; Seiffert, M; Silva, LS; Wu, Y, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 8 (47.06) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, H | 1 |
| Hosoi, Y | 1 |
| Ishikawa, K | 1 |
| Yoshitake, J | 1 |
| Shibata, T | 1 |
| Uchida, K | 1 |
| Hashizume, H | 1 |
| Mizuno, M | 1 |
| Okazaki, Y | 1 |
| Toyokuni, S | 1 |
| Nakamura, K | 1 |
| Kajiyama, H | 1 |
| Kikkawa, F | 1 |
| Hori, M | 1 |
| Wu, S | 1 |
| Cao, R | 1 |
| Tao, B | 1 |
| Wu, P | 1 |
| Peng, C | 1 |
| Gao, H | 1 |
| Liang, J | 1 |
| Yang, W | 1 |
| Batsios, G | 1 |
| Taglang, C | 1 |
| Tran, M | 1 |
| Stevers, N | 1 |
| Barger, C | 1 |
| Gillespie, AM | 1 |
| Ronen, SM | 3 |
| Costello, JF | 1 |
| Viswanath, P | 1 |
| Zaccagna, F | 1 |
| McLean, MA | 1 |
| Grist, JT | 1 |
| Kaggie, J | 1 |
| Mair, R | 1 |
| Riemer, F | 1 |
| Woitek, R | 1 |
| Gill, AB | 1 |
| Deen, S | 1 |
| Daniels, CJ | 1 |
| Ursprung, S | 1 |
| Schulte, RF | 1 |
| Allinson, K | 1 |
| Chhabra, A | 1 |
| Laurent, MC | 1 |
| Locke, M | 1 |
| Frary, A | 1 |
| Hilborne, S | 1 |
| Patterson, I | 1 |
| Carmo, BD | 1 |
| Slough, R | 1 |
| Wilkinson, I | 1 |
| Basu, B | 1 |
| Wason, J | 1 |
| Gillard, JH | 1 |
| Matys, T | 1 |
| Watts, C | 1 |
| Price, SJ | 1 |
| Santarius, T | 1 |
| Graves, MJ | 1 |
| Jefferies, S | 1 |
| Brindle, KM | 1 |
| Gallagher, FA | 1 |
| Gondáš, E | 2 |
| Kráľová Trančíková, A | 2 |
| Dibdiaková, K | 1 |
| Galanda, T | 1 |
| Hatok, J | 1 |
| Račay, P | 1 |
| Dobrota, D | 2 |
| Murín, R | 2 |
| Mishkovsky, M | 1 |
| Gusyatiner, O | 1 |
| Lanz, B | 1 |
| Cudalbu, C | 1 |
| Vassallo, I | 1 |
| Hamou, MF | 1 |
| Bloch, J | 1 |
| Comment, A | 1 |
| Gruetter, R | 1 |
| Hegi, ME | 1 |
| Majerčíková, Z | 1 |
| Pokusa, M | 1 |
| Baranovičová, E | 1 |
| Bystrický, P | 1 |
| Kawai, T | 1 |
| Brender, JR | 1 |
| Lee, JA | 1 |
| Kramp, T | 1 |
| Kishimoto, S | 1 |
| Krishna, MC | 1 |
| Tofilon, P | 1 |
| Camphausen, KA | 1 |
| Silva, LS | 1 |
| Poschet, G | 1 |
| Nonnenmacher, Y | 1 |
| Becker, HM | 1 |
| Sapcariu, S | 1 |
| Gaupel, AC | 1 |
| Schlotter, M | 1 |
| Wu, Y | 1 |
| Kneisel, N | 1 |
| Seiffert, M | 1 |
| Hell, R | 1 |
| Hiller, K | 1 |
| Lichter, P | 1 |
| Radlwimmer, B | 1 |
| Immanuel, SRC | 1 |
| Ghanate, AD | 1 |
| Parmar, DS | 1 |
| Marriage, F | 1 |
| Panchagnula, V | 1 |
| Day, PJ | 1 |
| Raghunathan, A | 1 |
| Park, I | 3 |
| Lupo, JM | 1 |
| Nelson, SJ | 3 |
| Mukherjee, J | 1 |
| Ito, M | 1 |
| Chaumeil, MM | 1 |
| Jalbert, LE | 1 |
| Gaensler, K | 1 |
| Pieper, RO | 1 |
| Kuang, R | 1 |
| Jahangiri, A | 1 |
| Mascharak, S | 1 |
| Nguyen, A | 1 |
| Chandra, A | 1 |
| Flanigan, PM | 1 |
| Yagnik, G | 1 |
| Wagner, JR | 1 |
| De Lay, M | 1 |
| Carrera, D | 1 |
| Castro, BA | 1 |
| Hayes, J | 1 |
| Sidorov, M | 1 |
| Garcia, JLI | 1 |
| Eriksson, P | 1 |
| Ronen, S | 1 |
| Phillips, J | 1 |
| Molinaro, A | 1 |
| Koliwad, S | 1 |
| Aghi, MK | 1 |
| Cheng, T | 1 |
| Sudderth, J | 1 |
| Yang, C | 1 |
| Mullen, AR | 1 |
| Jin, ES | 1 |
| Matés, JM | 1 |
| DeBerardinis, RJ | 1 |
| Bok, R | 1 |
| Ozawa, T | 1 |
| Phillips, JJ | 1 |
| James, CD | 1 |
| Vigneron, DB | 1 |
| El Sayed, SM | 1 |
| El-Magd, RM | 1 |
| Shishido, Y | 1 |
| Chung, SP | 1 |
| Diem, TH | 1 |
| Sakai, T | 1 |
| Watanabe, H | 1 |
| Kagami, S | 1 |
| Fukui, K | 1 |
| Dalgard, CL | 1 |
| Lu, H | 1 |
| Mohyeldin, A | 1 |
| Verma, A | 1 |
17 other studies available for pyruvic acid and Glioblastoma
| Article | Year |
|---|---|
Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified.
Topics: Brain Neoplasms; Cell Death; Cell Line, Tumor; Formates; Glioblastoma; Glyoxylates; Humans; Plasma G | 2021 |
Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma.
Topics: Cell Line, Tumor; Chromatin; DNA-Binding Proteins; Glioblastoma; High Mobility Group Proteins; Histo | 2022 |
Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.
Topics: Animals; Deuterium; Glioblastoma; Lactic Acid; Mice; NAD; Pyruvic Acid; Telomerase | 2022 |
Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-
Topics: Bicarbonates; Glioblastoma; Humans; Lactate Dehydrogenase 5; Lactic Acid; Male; Middle Aged; Prospec | 2022 |
Immunodetection of Pyruvate Carboxylase Expression in Human Astrocytomas, Glioblastomas, Oligodendrogliomas, and Meningiomas.
Topics: Astrocytoma; Brain Neoplasms; Glioblastoma; Humans; Meningeal Neoplasms; Meningioma; Oligodendroglio | 2023 |
Hyperpolarized
Topics: Aerobiosis; Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Glioblastoma | 2021 |
Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells.
Topics: Astrocytoma; Glioblastoma; Humans; Neuroblastoma; Pyruvate Carboxylase; Pyruvic Acid | 2021 |
Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Glioblastoma; Humans; Lactate | 2021 |
Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype.
Topics: Amino Acids, Branched-Chain; Biological Transport; Cell Count; Cell Line, Tumor; Glioblastoma; Human | 2017 |
Integrative analysis of rewired central metabolism in temozolomide resistant cells.
Topics: Amino Acids; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dacarbazine; Dose-R | 2018 |
Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Contrast Media; Disease Models, | 2019 |
Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.
Topics: Apoptosis; Biomarkers, Tumor; Carrier Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; | 2014 |
GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance.
Topics: Angiogenesis Inhibitors; Animals; Bevacizumab; Cell Line, Tumor; Cell Survival; Drug Resistance, Neo | 2017 |
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
Topics: Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Glioblastoma; Glutaminase; Glutamine; Human | 2011 |
Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Daca | 2011 |
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Survival; Citric Acid; D-Amino-Acid Oxidase; Elec | 2012 |
Endogenous 2-oxoacids differentially regulate expression of oxygen sensors.
Topics: Cell Line, Tumor; Central Nervous System Neoplasms; Citric Acid Cycle; DNA-Binding Proteins; Gene Ex | 2004 |