pyruvic acid has been researched along with Glial Cell Tumors in 25 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study's objective was to utilise microdialysis to monitor levels of glucose, lactate, pyruvate, glutamate and glycerol in patients following surgery for intrinsic brain tumours, and to assess the concentration of growth factors, cytokines and other proteins involved in the pathogenesis of high-grade gliomas in vivo." | 3.76 | In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines. ( Carpenter, KL; Hutchinson, PJ; Marcus, HJ; Price, SJ, 2010) |
| "Metabolic imaging of brain tumors using (13)C Magnetic Resonance Spectroscopy (MRS) of hyperpolarized [1-(13)C] pyruvate is a promising neuroimaging strategy which, after a decade of preclinical success in glioblastoma (GBM) models, is now entering clinical trials in multiple centers." | 1.43 | Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. ( Blough, MD; Cairncross, JG; Chaumeil, MM; Chesnelong, C; Eriksson, P; Luchman, HA; Najac, C; Radoul, M; Ronen, SM; Viswanath, P, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vaziri, S | 1 |
| Autry, AW | 1 |
| Lafontaine, M | 1 |
| Kim, Y | 1 |
| Gordon, JW | 1 |
| Chen, HY | 1 |
| Hu, JY | 1 |
| Lupo, JM | 1 |
| Chang, SM | 1 |
| Clarke, JL | 1 |
| Villanueva-Meyer, JE | 1 |
| Bush, NAO | 1 |
| Xu, D | 1 |
| Larson, PEZ | 2 |
| Vigneron, DB | 1 |
| Li, Y | 1 |
| Viswanath, P | 2 |
| Batsios, G | 1 |
| Mukherjee, J | 1 |
| Gillespie, AM | 1 |
| Luchman, HA | 2 |
| Phillips, JJ | 1 |
| Costello, JF | 1 |
| Pieper, RO | 1 |
| Ronen, SM | 2 |
| Qi, Q | 1 |
| Fox, MS | 1 |
| Lim, H | 2 |
| Bartha, R | 1 |
| Scholl, TJ | 2 |
| Hoffman, L | 1 |
| Lee, TY | 1 |
| Thiessen, JD | 1 |
| Jane, EP | 1 |
| Premkumar, DR | 1 |
| Rajasundaram, D | 1 |
| Thambireddy, S | 1 |
| Reslink, MC | 1 |
| Agnihotri, S | 1 |
| Pollack, IF | 1 |
| Michel, KA | 1 |
| Zieliński, R | 1 |
| Walker, CM | 1 |
| Le Roux, L | 1 |
| Priebe, W | 1 |
| Bankson, JA | 1 |
| Schellingerhout, D | 1 |
| Thind, K | 1 |
| Martinez-Santiesteban, FM | 1 |
| Park, JM | 2 |
| Josan, S | 2 |
| Jang, T | 2 |
| Merchant, M | 2 |
| Watkins, R | 1 |
| Hurd, RE | 2 |
| Recht, LD | 1 |
| Mayer, D | 2 |
| Spielman, DM | 2 |
| Chaumeil, MM | 1 |
| Radoul, M | 1 |
| Najac, C | 1 |
| Eriksson, P | 1 |
| Blough, MD | 1 |
| Chesnelong, C | 1 |
| Cairncross, JG | 1 |
| Joe, E | 1 |
| Lee, H | 1 |
| Lee, J | 1 |
| Yang, S | 1 |
| Choi, YS | 1 |
| Wang, E | 1 |
| Song, HT | 1 |
| Kim, DH | 1 |
| Lindvall, P | 1 |
| Roslin, M | 1 |
| Bergenheim, AT | 1 |
| Rodrigues, TB | 1 |
| López-Larrubia, P | 1 |
| Cerdán, S | 1 |
| Marcus, HJ | 1 |
| Carpenter, KL | 1 |
| Price, SJ | 1 |
| Hutchinson, PJ | 1 |
| Sikka, P | 1 |
| Walker, R | 1 |
| Cockayne, R | 1 |
| Wood, MJ | 1 |
| Harrison, PJ | 1 |
| Burnet, PW | 1 |
| Day, SE | 1 |
| Kettunen, MI | 1 |
| Cherukuri, MK | 1 |
| Mitchell, JB | 1 |
| Lizak, MJ | 1 |
| Morris, HD | 1 |
| Matsumoto, S | 1 |
| Koretsky, AP | 1 |
| Brindle, KM | 1 |
| El Sayed, SM | 1 |
| El-Magd, RM | 1 |
| Shishido, Y | 1 |
| Chung, SP | 1 |
| Diem, TH | 1 |
| Sakai, T | 1 |
| Watanabe, H | 1 |
| Kagami, S | 1 |
| Fukui, K | 1 |
| Yen, YF | 1 |
| Recht, L | 1 |
| Perrin, A | 1 |
| Roudier, E | 1 |
| Duborjal, H | 1 |
| Bachelet, C | 1 |
| Riva-Lavieille, C | 1 |
| Leverve, X | 1 |
| Massarelli, R | 1 |
| Griguer, CE | 1 |
| Oliva, CR | 1 |
| Gillespie, GY | 1 |
| Dringen, R | 1 |
| Peters, H | 1 |
| Wiesinger, H | 1 |
| Hamprecht, B | 1 |
| Portais, JC | 1 |
| Schuster, R | 1 |
| Merle, M | 1 |
| Canioni, P | 1 |
| Oudard, S | 1 |
| Arvelo, F | 1 |
| Miccoli, L | 1 |
| Apiou, F | 1 |
| Dutrillaux, AM | 1 |
| Poisson, M | 1 |
| Dutrillaux, B | 1 |
| Poupon, MF | 1 |
| Zhong, W | 1 |
| Oberley, LW | 2 |
| Oberley, TD | 1 |
| Yan, T | 1 |
| Domann, FE | 1 |
| St Clair, DK | 1 |
| Lim, R | 1 |
| Zaheer, A | 1 |
| Yorek, MA | 1 |
| Darby, CJ | 1 |
| Darbin, O | 1 |
| Lonjon, M | 1 |
| Quentien, MH | 1 |
| Michiels, JF | 1 |
| Grellier, P | 1 |
| Negrin, J | 1 |
| Rostain, JC | 1 |
| Risso, JJ | 1 |
| Galarraga, J | 1 |
| Loreck, DJ | 1 |
| Graham, JF | 1 |
| DeLaPaz, RL | 1 |
| Smith, BH | 1 |
| Hallgren, D | 1 |
| Cummins, CJ | 1 |
25 other studies available for pyruvic acid and Glial Cell Tumors
| Article | Year |
|---|---|
Assessment of higher-order singular value decomposition denoising methods on dynamic hyperpolarized [1-
Topics: Bicarbonates; Glioma; Humans; Lactic Acid; Magnetic Resonance Imaging; Pyruvic Acid | 2022 |
Non-invasive assessment of telomere maintenance mechanisms in brain tumors.
Topics: Alanine; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Genetic Eng | 2021 |
Multimodality In Vivo Imaging of Perfusion and Glycolysis in a Rat Model of C6 Glioma.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Fluorodeoxyglucose F18; Glioma; Glucose; Gl | 2021 |
Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases.
Topics: Aurora Kinases; Child; Glioma; Humans; Isoenzymes; Oxidoreductases; Piperazines; Protein Serine-Thre | 2022 |
Hyperpolarized Pyruvate MR Spectroscopy Depicts Glycolytic Inhibition in a Mouse Model of Glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; | 2019 |
Construction and evaluation of a switch-tuned (13) C - (1) H birdcage radiofrequency coil for imaging the metabolism of hyperpolarized (13) C-enriched compounds.
Topics: Animals; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Equipment Design; Glioma; Magne | 2014 |
Volumetric spiral chemical shift imaging of hyperpolarized [2-(13) c]pyruvate in a rat c6 glioma model.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Glioma; Image Processing, Computer-Assisted; Magne | 2016 |
Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.
Topics: Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Glioma; Humans; Isoci | 2016 |
An indirect method for in vivo T
Topics: Algorithms; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; | 2017 |
Cerebral metabolism during air transport of patients after surgery for malignant glioma.
Topics: Air Ambulances; Brain; Brain Neoplasms; Glioma; Glucose; Glutamic Acid; Glycerol; Humans; Lactic Aci | 2008 |
Redox dependence and compartmentation of [13C]pyruvate in the brain of deuterated rats bearing implanted C6 gliomas.
Topics: Animals; Astrocytes; Brain Chemistry; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Cerebral C | 2009 |
In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Cytokines; Dexamethasone; Energy Metabolism; Female; G | 2010 |
D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).
Topics: Amino Acid Transport System ASC; Animals; Cell Line, Tumor; D-Amino-Acid Oxidase; Dose-Response Rela | 2010 |
Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Contrast Media; Glioma; Lactic Acid; Ma | 2011 |
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Survival; Citric Acid; D-Amino-Acid Oxidase; Elec | 2012 |
Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Female; Glioma; Kinetics; Magnetic Reso | 2012 |
Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Glioma; Glucose; Humans; Hypoxia | 2002 |
Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines.
Topics: Amino Acid Sequence; Animals; Cell Hypoxia; Cell Survival; Electron Transport; Glioma; Glucose; Glyc | 2005 |
Lactate transport in cultured glial cells.
Topics: Animals; Astrocytes; Cells, Cultured; Female; Glioma; Hydrogen-Ion Concentration; Kinetics; Lactates | 1995 |
Metabolic flux determination in C6 glioma cells using carbon-13 distribution upon [1-13C]glucose incubation.
Topics: Alanine; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glioma; Gluconeogenesis; Glucose; Glutam | 1993 |
High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.
Topics: Adenosine Triphosphate; Chromosome Deletion; Chromosomes, Human, Pair 10; Glioma; Glycolysis; Hexoki | 1996 |
Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Buthionine Sulfoximine; Carmustine; Catalase; Cell Divis | 1996 |
Activation of nuclear factor-kappaB in C6 rat glioma cells after transfection with glia maturation factor.
Topics: Animals; Catalase; Glia Maturation Factor; Glioma; Humans; NF-kappa B; Pyruvic Acid; Rats; RNA, Mess | 2000 |
In vivo study of tumor metabolism: an application of new multi-probe microdialysis system in the striatum of freely moving rats grafted with C6 cells.
Topics: Animals; Brain Neoplasms; Corpus Striatum; Glioma; Glucose; Lactic Acid; Male; Microdialysis; Pyruvi | 2000 |
Glucose metabolism in human gliomas: correspondence of in situ and in vitro metabolic rates and altered energy metabolism.
Topics: Adenosine Triphosphate; Energy Metabolism; Glioma; Glucose; Humans; Phosphocreatine; Pyruvates; Pyru | 1986 |