Page last updated: 2024-10-20

pyruvic acid and Glaucoma

pyruvic acid has been researched along with Glaucoma in 4 studies

Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

ExcerptRelevanceReference
"Of these, 42 patients with treated open-angle glaucoma and moderate visual field loss in at least 1 eye were selected for inclusion and randomized."1.72Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial. ( Blumberg, DM; Cioffi, GA; De Moraes, CG; John, SWM; Liebmann, JM; Williams, PA, 2022)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's4 (100.00)2.80

Authors

AuthorsStudies
De Moraes, CG2
John, SWM2
Williams, PA2
Blumberg, DM1
Cioffi, GA1
Liebmann, JM2
Quah Qin Xian, N1
Wong, FYK1
Harder, JM1
Guymer, C1
Wood, JPM1
Daskalaki, E1
Chidlow, G1
Zhang, C1
Balasubramanian, R1
Cardozo, BH1
Foxworth, NE1
Deering, KE1
Ouellette, TB1
Montgomery, C1
Wheelock, CE1
Casson, RJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nicotinamide and Pyruvate for Open Angle Glaucoma: A Randomized Clinical Study[NCT05695027]Phase 2/Phase 3188 participants (Anticipated)Interventional2023-03-14Recruiting
Nutritional Supplements and Performance During Visual Field Testing[NCT03797469]32 participants (Actual)Interventional2019-04-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

4 other studies available for pyruvic acid and Glaucoma

ArticleYear
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.
    JAMA ophthalmology, 2022, Jan-01, Volume: 140, Issue:1

    Topics: Animals; Double-Blind Method; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure;

2022
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.
    JAMA ophthalmology, 2022, Jan-01, Volume: 140, Issue:1

    Topics: Animals; Double-Blind Method; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure;

2022
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.
    JAMA ophthalmology, 2022, Jan-01, Volume: 140, Issue:1

    Topics: Animals; Double-Blind Method; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure;

2022
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.
    JAMA ophthalmology, 2022, Jan-01, Volume: 140, Issue:1

    Topics: Animals; Double-Blind Method; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure;

2022
Combined Use of Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma-Reply.
    JAMA ophthalmology, 2022, 04-01, Volume: 140, Issue:4

    Topics: Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Niacinamide; Pyruvic Acid

2022
Combined Use of Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma.
    JAMA ophthalmology, 2022, 04-01, Volume: 140, Issue:4

    Topics: Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Niacinamide; Pyruvic Acid

2022
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-29, Volume: 117, Issue:52

    Topics: Animals; Disease Models, Animal; Glaucoma; Glucose; Intraocular Pressure; Mice, Inbred C57BL; Mice,

2020