pyruvic acid has been researched along with Friedreich Disease in 6 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nine patients with typical Friedreich's ataxia had normal levels of pyruvate and lactate in blood, urine, and CSF." | 1.27 | Friedreich's ataxia: intravenous pyruvate load to demonstrate a defect in pyruvate metabolism. ( Dijkstra, U; Doesburg, W; Gabreëls, F; Joosten, E; Lamers, K; Renier, W; Wevers, R, 1984) |
| "Methylene blue was used to stimulate the rate of pyruvate oxidation in two different assay systems of pyruvate dehydrogenase activity in cultured human fibroblasts to determine if such partial defects, if present, could be detected in a stimulated assay system." | 1.27 | Normal pyruvate oxidation in Friedreich ataxia and Charcot-Marie-Tooth disease fibroblasts. ( Wilson, WG, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dijkstra, U | 1 |
| Gabreëls, F | 1 |
| Joosten, E | 1 |
| Wevers, R | 1 |
| Lamers, K | 1 |
| Doesburg, W | 1 |
| Renier, W | 1 |
| Barbeau, A | 2 |
| Bertagnolio, B | 1 |
| Uziel, G | 1 |
| Bottacchi, E | 1 |
| Crenna, G | 1 |
| D'Angelo, A | 1 |
| Di Donato, S | 1 |
| Bertrand, MJ | 1 |
| Bouchard, R | 1 |
| Gauthier, GL | 1 |
| Bouchard, JP | 1 |
| Wong, A | 1 |
| Yang, J | 1 |
| Cavadini, P | 1 |
| Gellera, C | 1 |
| Lonnerdal, B | 1 |
| Taroni, F | 1 |
| Cortopassi, G | 1 |
| Wilson, WG | 1 |
6 other studies available for pyruvic acid and Friedreich Disease
| Article | Year |
|---|---|
Friedreich's ataxia: intravenous pyruvate load to demonstrate a defect in pyruvate metabolism.
Topics: Adolescent; Adult; Child; Friedreich Ataxia; Glucose; Humans; Lactates; Pyruvates; Pyruvic Acid | 1984 |
The Quebec Cooperative Study of Friedreich's Ataxia: 1974-1984--10 years of research.
Topics: Amino Acids; Biotin; Friedreich Ataxia; Glucose; Humans; Lipid Metabolism; Lipoproteins; Liver; Nerv | 1984 |
Friedreich's ataxia II. Biochemical studies in cultured cells.
Topics: Adolescent; Adult; Cells, Cultured; Child; Dihydrolipoamide Dehydrogenase; Female; Fibroblasts; Frie | 1980 |
Quantitative metabolic profiling of alpha-keto acids in Friedreich's ataxia.
Topics: Adult; Friedreich Ataxia; Humans; Keto Acids; Ketoglutaric Acids; Phenylpyruvic Acids; Pyruvates; Py | 1982 |
The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis.
Topics: Apoptosis; Base Sequence; Calcium; Case-Control Studies; Caspase 3; Caspases; Cell Line; Chelating A | 1999 |
Normal pyruvate oxidation in Friedreich ataxia and Charcot-Marie-Tooth disease fibroblasts.
Topics: Cell Line; Charcot-Marie-Tooth Disease; Female; Fibroblasts; Friedreich Ataxia; Humans; Male; Methyl | 1985 |