pyruvic acid has been researched along with Endotoxin Shock in 27 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared the effects of vasopressin alone and in combination with dobutamine on systemic and splanchnic circulation and metabolism in porcine endotoxin shock." | 7.72 | Dobutamine compensates deleterious hemodynamic and metabolic effects of vasopressin in the splanchnic region in endotoxin shock. ( Martikainen, TJ; Ruokonen, E; Tenhunen, JJ; Uusaro, A, 2004) |
| "In 70 mechanically-ventilated patients with septic shock, we examined: a) S' and E' mitral annular velocities using tissue Doppler imaging (TDI), b) CFR of the left anterior descending artery after adenosine infusion using transesophageal Doppler echocardiography and c) lactate, pyruvate and glycerol in tissue by means of a microdialysis (MD) catheter inserted into the subcutaneous adipose tissue as markers of tissue ischemia and acidosis." | 3.80 | Coronary flow reserve is associated with tissue ischemia and is an additive predictor of intensive care unit mortality to traditional risk scores in septic shock. ( Armaganidis, A; Diamantakis, A; Dimopoulou, I; Ikonomidis, I; Kopterides, P; Lekakis, J; Makavos, G; Nikitas, N; Paraskevaidis, I; Parissis, J; Theodorakopoulou, M, 2014) |
| " We compared the effects of vasopressin alone and in combination with dobutamine on systemic and splanchnic circulation and metabolism in porcine endotoxin shock." | 3.72 | Dobutamine compensates deleterious hemodynamic and metabolic effects of vasopressin in the splanchnic region in endotoxin shock. ( Martikainen, TJ; Ruokonen, E; Tenhunen, JJ; Uusaro, A, 2004) |
| "Sixty consecutive adult patients who developed septic shock and lactic acidosis requiring the administration of vasopressors." | 3.70 | Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. ( Bollaert, PE; Gelot, AM; Larcan, A; Levy, B; Nabet, P; Sadoune, LO, 2000) |
| "Hyperoxia was associated with a higher sublingual microcirculatory flow over time, with higher cerebral perfusion and brain tissue oxygen pressure and with a lower cerebral lactate-to-pyruvate ratio than in control animals." | 1.46 | Should Hyperoxia Be Avoided During Sepsis? An Experimental Study in Ovine Peritonitis. ( Donadello, K; He, X; Su, F; Taccone, FS; Vincent, JL; Xie, K, 2017) |
| "Septic shock was associated with reduced renal perfusion and decreased cortical and medullary blood flow, followed by signs of anaerobic metabolism in the cortex when flow reductions became critical." | 1.46 | Changes in kidney perfusion and renal cortex metabolism in septic shock: an experimental study. ( Creteur, J; De Backer, D; Herpain, A; Hosokawa, K; Post, EH; Su, F; Taccone, FS; Vincent, JL, 2017) |
| "We enrolled 105 patients with septic shock hospitalized in the mixed intensive care unit of a tertiary hospital." | 1.39 | Elevated adipose tissue lactate to pyruvate (L/P) ratio predicts poor outcome in critically ill patients with septic shock: a microdialysis study. ( Armaganidis, A; Dimopoulou, I; Ilias, I; Kopterides, P; Nikitas, N; Theodorakopoulou, M; Vassiliadi, DA, 2013) |
| "Only 65% of patients with septic shock had hyperlactataemia at the onset of shock and 76% of these also had a high lactate/pyruvate ratio." | 1.38 | Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock. ( Bruzzi de Carvahlo, F; Cotton, F; De Backer, D; Orellano-Jimenez, C; Rimachi, R; Vincent, JL, 2012) |
| "Under conditions of septic shock, an increase in lactate levels was found to be a sensitive marker of tissue metabolism disorder." | 1.37 | Microdialysis detection of lactate in subcutaneous tissue as a reliable indicator of tissue metabolic disorders in an animal sepsis model. ( Hanyu, N; Hosoyama, A; Kawasaki, N; Kobayashi, K; Komatsu, H; Ohashi, H; Ohashi, M; Taira, Y; Wada, T, 2011) |
| "We report a case of fatal septic shock, with hyperlactatemia and blood cultures positive for Streptococcus pneumoniae, in a 70-year-old patient." | 1.30 | Increased lactate/pyruvate ratio with normal beta-hydroxybutyrate/acetoacetate ratio and lack of oxygen supply dependency in a patient with fatal septic shock. ( Annat, G; Gallet, D; Goudable, J; Vedrinne, JM; Viale, JP, 1997) |
| "During endotoxic shock increased cardiac output achieved by colloid infusion maintained elevated liver blood flow and thereby macro- and microcirculatory O2 supply." | 1.30 | Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during longterm endotoxin-induced shock in pigs. ( Adler, J; Georgieff, M; Iber, T; Radermacher, P; Rieger, KM; Santak, B; Träger, K; Vogt, J; Wachter, U, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 12 (44.44) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Levitt, DG | 1 |
| Levitt, JE | 1 |
| Levitt, MD | 1 |
| Post, EH | 2 |
| Su, F | 4 |
| Hosokawa, K | 2 |
| Taccone, FS | 4 |
| Herpain, A | 2 |
| Creteur, J | 3 |
| De Backer, D | 4 |
| Vincent, JL | 5 |
| He, X | 1 |
| Xie, K | 2 |
| Donadello, K | 1 |
| Orbegozo, D | 1 |
| Rahmania, L | 1 |
| Mallet, RT | 1 |
| Olivencia-Yurvati, AH | 1 |
| Bünger, R | 1 |
| Effenberger-Neidnicht, K | 1 |
| Brauckmann, S | 1 |
| Jägers, J | 1 |
| Patyk, V | 1 |
| Waack, IN | 1 |
| Kirsch, M | 1 |
| Nikitas, N | 3 |
| Kopterides, P | 3 |
| Ilias, I | 2 |
| Theodorakopoulou, M | 3 |
| Vassiliadi, DA | 2 |
| Armaganidis, A | 3 |
| Dimopoulou, I | 3 |
| Protti, A | 1 |
| Ikonomidis, I | 1 |
| Makavos, G | 1 |
| Paraskevaidis, I | 1 |
| Diamantakis, A | 1 |
| Parissis, J | 1 |
| Lekakis, J | 1 |
| Ohashi, H | 1 |
| Kawasaki, N | 1 |
| Komatsu, H | 1 |
| Wada, T | 1 |
| Hosoyama, A | 1 |
| Hanyu, N | 1 |
| Kobayashi, K | 1 |
| Ohashi, M | 1 |
| Taira, Y | 1 |
| Rimachi, R | 1 |
| Bruzzi de Carvahlo, F | 1 |
| Orellano-Jimenez, C | 1 |
| Cotton, F | 1 |
| Orfanos, SE | 1 |
| Tsangaris, I | 1 |
| Maniatis, NA | 1 |
| Tsantes, AE | 1 |
| Travlou, A | 1 |
| Dimitriadis, G | 1 |
| Ungerstedt, U | 1 |
| NEMETH, S | 1 |
| VIGAS, M | 1 |
| BLAIR, E | 1 |
| COWLEY, RA | 1 |
| TAIT, MK | 1 |
| Levy, B | 3 |
| Vallée, C | 1 |
| Lauzier, F | 1 |
| Plante, GE | 1 |
| Mansart, A | 1 |
| Mallie, JP | 1 |
| Lesur, O | 1 |
| Martikainen, TJ | 2 |
| Uusaro, A | 2 |
| Tenhunen, JJ | 2 |
| Ruokonen, E | 2 |
| Giovannini, I | 1 |
| Titheradge, MA | 1 |
| Knowles, RG | 1 |
| Smith, FS | 1 |
| Horton, RA | 1 |
| Ceppi, ED | 1 |
| James, JH | 1 |
| Fang, CH | 1 |
| Schrantz, SJ | 1 |
| Hasselgren, PO | 1 |
| Paul, RJ | 1 |
| Fischer, JE | 1 |
| Gallet, D | 1 |
| Goudable, J | 1 |
| Vedrinne, JM | 1 |
| Viale, JP | 1 |
| Annat, G | 1 |
| Bollaert, PE | 2 |
| Charpentier, C | 1 |
| Nace, L | 1 |
| Audibert, G | 1 |
| Bauer, P | 1 |
| Nabet, P | 2 |
| Larcan, A | 2 |
| Santak, B | 1 |
| Radermacher, P | 1 |
| Adler, J | 1 |
| Iber, T | 1 |
| Rieger, KM | 1 |
| Wachter, U | 1 |
| Vogt, J | 1 |
| Georgieff, M | 1 |
| Träger, K | 1 |
| Sadoune, LO | 1 |
| Gelot, AM | 1 |
| Mizock, BA | 1 |
| Mela-Riker, L | 1 |
| Bartos, D | 1 |
| Vlessis, AA | 1 |
| Widener, L | 1 |
| Muller, P | 1 |
| Trunkey, DD | 1 |
| Sadchikov, DV | 1 |
| Kutyreva, NV | 1 |
| Lugovskaia, TB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock: ANDROMEDA-SHOCK PHYSIOLOGY STUDY[NCT03762005] | 46 participants (Anticipated) | Interventional | 2018-06-01 | Recruiting | |||
| "Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (Double Blind Prospective Randomised Study)"[NCT04046861] | 200 participants (Anticipated) | Interventional | 2023-02-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvic acid and Endotoxin Shock
| Article | Year |
|---|---|
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models | 2020 |
1 trial available for pyruvic acid and Endotoxin Shock
| Article | Year |
|---|---|
Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Blood Gas Analysis; Dobutamine; Epin | 1997 |
25 other studies available for pyruvic acid and Endotoxin Shock
| Article | Year |
|---|---|
The effects of acute renal denervation on kidney perfusion and metabolism in experimental septic shock.
Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Female; Kidney Cortex; Lactic Acid | 2017 |
Should Hyperoxia Be Avoided During Sepsis? An Experimental Study in Ovine Peritonitis.
Topics: Animals; Brain; Cerebrovascular Circulation; Female; Hyperoxia; Lactic Acid; Microcirculation; Model | 2017 |
Peripheral Muscle Near-Infrared Spectroscopy Variables are Altered Early in Septic Shock.
Topics: Animals; Female; Lactates; Microcirculation; Muscle, Skeletal; Oxygen Consumption; Pyruvic Acid; She | 2018 |
Pyruvate-enriched resuscitation for shock.
Topics: Administration, Intravenous; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; | 2018 |
Protective Effects of Sodium Pyruvate during Systemic Inflammation Limited to the Correction of Metabolic Acidosis.
Topics: Acidosis; Animals; Blood Chemical Analysis; Blood Pressure; Endotoxemia; Inflammation; Lipopolysacch | 2019 |
Elevated adipose tissue lactate to pyruvate (L/P) ratio predicts poor outcome in critically ill patients with septic shock: a microdialysis study.
Topics: Adipose Tissue; Aged; Critical Illness; Female; Humans; Intensive Care Units; Lactic Acid; Male; Mic | 2013 |
Cellular energetic crisis during human septic shock.
Topics: Adipose Tissue; Female; Humans; Lactic Acid; Male; Pyruvic Acid; Shock, Septic | 2013 |
Coronary flow reserve is associated with tissue ischemia and is an additive predictor of intensive care unit mortality to traditional risk scores in septic shock.
Topics: Acidosis; Aged; APACHE; Blood Glucose; Coronary Circulation; Echocardiography, Doppler; Echocardiogr | 2014 |
Changes in kidney perfusion and renal cortex metabolism in septic shock: an experimental study.
Topics: Animals; Biomarkers; Female; Glucose; Hypotension; Kidney; Lactic Acid; Laser-Doppler Flowmetry; Pyr | 2017 |
Microdialysis detection of lactate in subcutaneous tissue as a reliable indicator of tissue metabolic disorders in an animal sepsis model.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Lactic Acid; Lipopolysaccharides; Male; Microdi | 2011 |
Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock.
Topics: Aerobiosis; Aged; APACHE; Biomarkers; Female; Humans; Hypoxia; Lactic Acid; Male; Middle Aged; Pyruv | 2012 |
Red blood cell transfusion affects microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis.
Topics: Adipose Tissue; Aged; Blood Specimen Collection; Erythrocyte Transfusion; Extracellular Fluid; Femal | 2012 |
CHANGES IN THE LEVELS OF GLUCOSE, PYRUVATE AND PHOSPHATE IN THE BLOOD OF RABBITS UNDER THE INFLUENCE OF VARIOUS DOSES OF ENDOTOXIN.
Topics: Animals; Blood; Blood Glucose; Endotoxins; Glucose; Lagomorpha; Pharmacology; Phosphates; Pyruvates; | 1964 |
REFRACTORY SEPTIC SHOCK IN MAN. ROLE OF LACTATE AND PYRUVATE METABOLISM AND ACID-BASE BALANCE IN PROGNOSIS.
Topics: Acid-Base Equilibrium; Acidosis; Humans; Lactates; Lactic Acid; Male; Metabolism; Prognosis; Pyruvat | 1965 |
Comparative effects of vasopressin, norepinephrine, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in endotoxic shock.
Topics: Acid-Base Equilibrium; Adenosine Triphosphate; Animals; Canavanine; Energy Metabolism; Enzyme Inhibi | 2004 |
Dobutamine compensates deleterious hemodynamic and metabolic effects of vasopressin in the splanchnic region in endotoxin shock.
Topics: Adrenergic beta-Agonists; Animals; Blood Gas Analysis; Cardiac Output; Dobutamine; Female; Fluid The | 2004 |
Epinephrine induces tissue perfusion deficit in porcine endotoxin shock: evaluation by regional CO(2) content gradients and lactate-to-pyruvate ratios.
Topics: Adrenergic Agonists; Animals; Bicarbonates; Carbon Dioxide; Epinephrine; Female; Hemodynamics; Intes | 2005 |
Mechanism of inhibition of hepatic gluconeogenesis by bacterial endotoxin: a role for nitric oxide?
Topics: Animals; Cells, Cultured; Cytokines; Gluconeogenesis; Lactates; Lactic Acid; Lipopolysaccharides; Li | 1995 |
Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis.
Topics: Aerobiosis; Alanine; Amino Acids; Animals; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; | 1996 |
Increased lactate/pyruvate ratio with normal beta-hydroxybutyrate/acetoacetate ratio and lack of oxygen supply dependency in a patient with fatal septic shock.
Topics: Acetoacetates; Aged; Fatal Outcome; Hemodynamics; Humans; Hydroxybutyrates; Lactic Acid; Male; Oxyge | 1997 |
Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during longterm endotoxin-induced shock in pigs.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cardiac Output; Gluconeogenesis; Hemodyn | 1998 |
Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Case-Control Studies; Catecholamines; Female; Hemo | 2000 |
Redox pairs, tissue hypoxia, organ dysfunction, and mortality.
Topics: Humans; Hypoxia; Ketone Bodies; Lactic Acid; Multiple Organ Failure; Oxidation-Reduction; Predictive | 2000 |
Chronic hyperdynamic sepsis in the rat. II. Characterization of liver and muscle energy metabolism.
Topics: Adenine Nucleotides; Animals; Bacteroides fragilis; Blood Glucose; Carnitine; Cytochromes; Energy Me | 1992 |
[Gas exchange and metabolic functions of the lungs in endotoxic shock].
Topics: Acidosis, Respiratory; Animals; Dogs; Female; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lactic | 1985 |