pyruvic acid has been researched along with Encephalopathy, Hepatic in 10 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with acute liver failure have a disturbed amino acid metabolism and a compromised oxidative metabolism in the brain." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| "However, the efficacy of CsA to protect cytotoxic brain edema in ALF is problematic because it poorly crosses the blood-brain barrier, which is relatively intact in ALF." | 1.35 | Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes. ( Norenberg, MD; Rama Rao, KV; Reddy, PV, 2009) |
| "Because hyperammonemia is thought to contribute to the pathogenesis of hepatic encephalopathy, we examined the effects of ammonia on ATP levels, neuronal morphology, and synaptic function in rat hippocampal slices." | 1.33 | Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine. ( Funatsu, M; Izumi, M; Izumi, Y; Matsukawa, M; Zorumski, CF, 2005) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hertz, L | 1 |
| Song, D | 1 |
| Peng, L | 1 |
| Chen, Y | 1 |
| Reddy, PV | 1 |
| Rama Rao, KV | 1 |
| Norenberg, MD | 1 |
| Bjerring, PN | 1 |
| Hauerberg, J | 1 |
| Frederiksen, HJ | 1 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 1 |
| Larsen, FS | 2 |
| DAWSON, AM | 1 |
| DE GROOTE, J | 1 |
| ROSENTHAL, WS | 1 |
| SHERLOCK, S | 1 |
| AMATUZIO, DS | 2 |
| NESBITT, S | 2 |
| Izumi, Y | 1 |
| Izumi, M | 1 |
| Matsukawa, M | 1 |
| Funatsu, M | 1 |
| Zorumski, CF | 1 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Yao, H | 1 |
| Sadoshima, S | 1 |
| Fujii, K | 1 |
| Kusuda, K | 1 |
| Ishitsuka, T | 1 |
| Tamaki, K | 1 |
| Fujishima, M | 1 |
1 review available for pyruvic acid and Encephalopathy, Hepatic
| Article | Year |
|---|---|
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath | 2017 |
9 other studies available for pyruvic acid and Encephalopathy, Hepatic
| Article | Year |
|---|---|
Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Cell Size; Cells, Cultured; C | 2009 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
Blood pyruvic-acid and alpha-ketoglutaric-acid levels in liver disease and hepatic coma.
Topics: Glutarates; Hepatic Encephalopathy; Ketoglutaric Acids; Liver Diseases; Pyruvates; Pyruvic Acid; Vas | 1957 |
A study of pyruvic acid in the blood and spinal fluid of patients with liver disease with and without hepatic coma.
Topics: Hepatic Encephalopathy; Liver Diseases; Pyruvic Acid | 1950 |
A study of pyruvic acid in the blood, spinal fluid and urine of patients with liver disease and without hepatic coma.
Topics: Body Fluids; Hepatic Encephalopathy; Humans; Liver; Liver Diseases; Pyruvic Acid | 1950 |
Ammonia-mediated LTP inhibition: effects of NMDA receptor antagonists and L-carnitine.
Topics: Adenosine Triphosphate; Ammonia; Animals; Carnitine; Cell Respiration; Dose-Response Relationship, D | 2005 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Cerebrospinal fluid lactate in patients with hepatic encephalopathy.
Topics: Acid-Base Equilibrium; Brain; Carbon Dioxide; Female; Glycolysis; Hepatic Encephalopathy; Humans; La | 1987 |