pyruvic acid has been researched along with Elevated ICP (Intracranial Pressure) in 16 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "In contrast, all vehicle-treated heatstroke animals had lower levels of MAP, cerebral perfusion pressure, cerebral blood flow, and brain partial pressure of oxygen." | 5.35 | L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke. ( Chen, YC; Huang, CI; Lee, CH; Lin, MT; Liu, YC; Wang, LM; Yen, DH, 2008) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "An LP ratio >25 and glycerol >100 micromol/L, but not glutamate >12 micromol/L, were associated with significantly higher risk of imminent intracranial hypertension (odds ratio: 9." | 3.74 | Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. ( Belli, A; Kitchen, N; Petzold, A; Russo, S; Sen, J; Smith, M, 2008) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "Patients with acute liver failure have a disturbed amino acid metabolism and a compromised oxidative metabolism in the brain." | 1.38 | The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| "In contrast, all vehicle-treated heatstroke animals had lower levels of MAP, cerebral perfusion pressure, cerebral blood flow, and brain partial pressure of oxygen." | 1.35 | L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke. ( Chen, YC; Huang, CI; Lee, CH; Lin, MT; Liu, YC; Wang, LM; Yen, DH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (68.75) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cesak, T | 1 |
| Adamkov, J | 1 |
| Habalova, J | 1 |
| Poczos, P | 1 |
| Kanta, M | 1 |
| Bartos, M | 1 |
| Hosszu, T | 1 |
| Prazak, J | 1 |
| Laszikova, E | 1 |
| Pantoflicek, T | 1 |
| Ryska, O | 1 |
| Koblihova, E | 1 |
| Ryska, M | 1 |
| Brody, DL | 1 |
| Magnoni, S | 1 |
| Schwetye, KE | 1 |
| Spinner, ML | 1 |
| Esparza, TJ | 1 |
| Stocchetti, N | 1 |
| Zipfel, GJ | 1 |
| Holtzman, DM | 1 |
| Nagel, A | 1 |
| Graetz, D | 1 |
| Schink, T | 1 |
| Frieler, K | 1 |
| Sakowitz, O | 1 |
| Vajkoczy, P | 1 |
| Sarrafzadeh, A | 1 |
| Timofeev, I | 1 |
| Dahyot-Fizelier, C | 1 |
| Keong, N | 1 |
| Nortje, J | 1 |
| Al-Rawi, PG | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Kirkpatrick, PJ | 1 |
| Gupta, AK | 1 |
| Hutchinson, PJ | 1 |
| Bjerring, PN | 3 |
| Hauerberg, J | 3 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 3 |
| Tofteng, F | 2 |
| Hansen, BA | 2 |
| Larsen, FS | 3 |
| Reinstrup, P | 1 |
| Nordström, CH | 1 |
| Nielsen, HB | 1 |
| Clemmesen, JO | 1 |
| Tolias, CM | 1 |
| Reinert, M | 1 |
| Seiler, R | 1 |
| Gilman, C | 1 |
| Scharf, A | 1 |
| Bullock, MR | 1 |
| Chang, CP | 1 |
| Chen, SH | 1 |
| Lin, MT | 2 |
| Chen, YC | 1 |
| Liu, YC | 1 |
| Yen, DH | 1 |
| Wang, LM | 1 |
| Huang, CI | 1 |
| Lee, CH | 1 |
| Zoremba, N | 1 |
| Schnoor, J | 1 |
| Berens, M | 1 |
| Kuhlen, R | 1 |
| Rossaint, R | 1 |
| Vespa, PM | 1 |
| Miller, C | 1 |
| McArthur, D | 1 |
| Eliseo, M | 1 |
| Etchepare, M | 1 |
| Hirt, D | 1 |
| Glenn, TC | 1 |
| Martin, N | 1 |
| Hovda, D | 1 |
| Jorgensen, L | 1 |
| Belli, A | 1 |
| Sen, J | 1 |
| Petzold, A | 1 |
| Russo, S | 1 |
| Kitchen, N | 1 |
| Smith, M | 1 |
| Schneweis, S | 1 |
| Grond, M | 1 |
| Staub, F | 1 |
| Brinker, G | 1 |
| Neveling, M | 1 |
| Dohmen, C | 1 |
| Graf, R | 1 |
| Heiss, WD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Uncovering the 'ORIGINS' of Diabetes[NCT02226640] | 80 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| Conservative vs Conventional Oxygen Administration in Critically Ill Patients: Effects on ICU Mortality. A Multicentre Randomized Open Label Clinical Trial[NCT04198077] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2019-12-04 | Recruiting | ||
| Impact of Intermediate Normal Compared to High Normal Oxygen Levels on Outcomes of Patients Presenting in the Emergency Department With Severe Traumatic Brain Injury (INACHOS): a Pilot Randomized Controlled Trial[NCT05464277] | 50 participants (Anticipated) | Interventional | 2022-08-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for pyruvic acid and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
Ventriculostomy for control of raised ICP in acute traumatic brain injury.
Topics: Adult; Blood Pressure; Brain Injuries; Cerebrospinal Fluid; Female; Glasgow Coma Scale; Humans; Intr | 2008 |
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal | 2001 |
14 other studies available for pyruvic acid and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
The relationship between intracranial pressure and lactate/pyruvate ratio in patients with subarachnoid haemorrhage.
Topics: Aneurysm, Ruptured; Brain; Humans; Intracranial Aneurysm; Intracranial Hypertension; Intracranial Pr | 2018 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
Topics: Amyloid beta-Peptides; Brain; Brain Injuries; Extracellular Fluid; Glasgow Coma Scale; Glucose; Huma | 2008 |
Relevance of intracranial hypertension for cerebral metabolism in aneurysmal subarachnoid hemorrhage. Clinical article.
Topics: Adult; Brain; Brain Diseases; Craniotomy; Decompression, Surgical; Energy Metabolism; Female; Glutam | 2009 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep | 2012 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study.
Topics: Adolescent; Adult; Aged; Blood Glucose; Brain; Brain Injuries; Cohort Studies; Critical Care; Energy | 2004 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke.
Topics: Animals; Arginine; Cerebrovascular Circulation; Cerebrovascular Disorders; Cytokines; Encephalitis; | 2008 |
Brain metabolism during a decrease in cerebral perfusion pressure caused by an elevated intracranial pressure in the porcine neocortex.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Glutamic Acid | 2007 |
Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis.
Topics: Case-Control Studies; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2007 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study.
Topics: Biomarkers; Brain; Brain Injuries; Glutamic Acid; Glycerol; Humans; Intracranial Hypertension; Lacti | 2008 |