pyruvic acid has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 44 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 7.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| " A 48-week, prospective, single-centre, exploratory, clinical study enrolled 11 Japanese adult patients with genetically, biochemically, and clinically confirmed mitochondrial disease; they had intractable lactic acidosis and received SP (0." | 3.91 | Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease. ( Inoue, E; Koga, Y; Nashiki, K; Povalko, N; Tanaka, M, 2019) |
| "Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally." | 3.74 | Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis. ( Allard, P; Debray, FG; Hanley, JA; Lambert, M; Mitchell, GA; Robinson, BH, 2007) |
| "Since mitochondrial disorders (MDs) can represent a diagnostic challenge for clinicians, due to their clinical and genetic heterogeneity, the identification of easily measurable biomarkers becomes a high priority." | 2.58 | Biomarkers for mitochondrial energy metabolism diseases. ( Boenzi, S; Diodato, D, 2018) |
| "According to previous studies, cerebral ischemia was defined as lactate/pyruvate (LP) ratio > 30 with intracerebral pyruvate level < 70 µmol L(-1)." | 1.42 | Bedside evaluation of cerebral energy metabolism in severe community-acquired bacterial meningitis. ( Andersen, ÅB; Jacobsen, A; Larsen, L; Nielsen, TH; Nordström, CH; Poulsen, FR; Schalén, W; Schulz, M, 2015) |
| "The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be the result of respiratory chain enzyme deficiency." | 1.42 | Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders. ( Arahata, H; Fujita, Y; Fukumoto, Y; Ishii, A; Ito, M; Kakuma, T; Koga, Y; Kojima, T; Saiki, R; Tanaka, M; Yatsuga, S, 2015) |
| "This biochemical pattern contrasts to cerebral ischemia, which is characterized by a marked decrease in cerebral pyruvate." | 1.40 | Bedside diagnosis of mitochondrial dysfunction after malignant middle cerebral artery infarction. ( Nielsen, TH; Nordström, CH; Reinstrup, P; Schalén, W; Ståhl, N; Toft, P, 2014) |
| " Multivariate analysis showed that statin dosage was independently associated with MD (OR:1." | 1.36 | Mitochondrial dysfunction induced by statin contributes to endothelial dysfunction in patients with coronary artery disease. ( Chan, HT; Dai, YL; Fong, B; Lau, CP; Lee, SW; Li, SW; Luk, TH; Siu, CW; Tam, S; Tse, HF; Yiu, KH, 2010) |
| "The majority of children with autism (6 of 10) had complex I activity below control range values." | 1.36 | Mitochondrial dysfunction in autism. ( Giulivi, C; Hertz-Picciotto, I; Omanska-Klusek, A; Pessah, IN; Ross-Inta, C; Tassone, F; Wong, S; Zhang, YF, 2010) |
| "It has been suggested that the hyperphenylalaninaemia in patients with PKU reduces complex I (NADH:ubiquinone reductase) activity of the mitochondrial respiratory chain (MRC) and/or biosynthesis of coenzyme Q(10) (CoQ(10)), which acts as an electron carrier in the MRC, leading to impaired energy metabolism in the brain of patients with PKU and hence the neurological pathology." | 1.35 | Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia. ( Hargreaves, I; Kyprianou, N; Lee, P; Murphy, E, 2009) |
| "Epilepsy was present in 19 patients." | 1.33 | Mitochondrial dysfunction in autism spectrum disorders: a population-based study. ( Ataíde, A; Borges, L; Diogo, L; Garcia, P; Grazina, M; Marques, C; Miguel, T; Oliveira, CR; Oliveira, G; Vicente, AM, 2005) |
| "Diagnosis of mitochondrial disorders usually requires a muscle biopsy to examine mitochondrial function." | 1.33 | Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology. ( Janssen, AJ; Morava, E; Rodenburg, RJ; Ruitenbeek, W; Sengers, RC; Smeitink, JA; Trijbels, FJ; van den Heuvel, LP; van Engelen, BG; Wintjes, LT, 2006) |
| "Cardiac function decreased during hemorrhagic shock but improved significantly in the UTI group after transfusion compared with the control group." | 1.32 | Protective effect of urinary trypsin inhibitor on myocardial mitochondria during hemorrhagic shock and reperfusion. ( Ikeda, KM; Izumi, T; Masuda, T; Matsunaga, A; Matsuyama, N; Nagasawa, H; Noda, C; Ogura, MN; Sato, K; Shimizu, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (27.27) | 29.6817 |
| 2010's | 26 (59.09) | 24.3611 |
| 2020's | 6 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Hiraki, N | 1 |
| Tanaka, TD | 1 |
| Yoshimura, M | 1 |
| Adant, I | 1 |
| Bird, M | 1 |
| Decru, B | 1 |
| Windmolders, P | 1 |
| Wallays, M | 1 |
| de Witte, P | 1 |
| Rymen, D | 1 |
| Witters, P | 1 |
| Vermeersch, P | 1 |
| Cassiman, D | 1 |
| Ghesquière, B | 1 |
| Turton, N | 1 |
| Cufflin, N | 1 |
| Dewsbury, M | 1 |
| Fitzpatrick, O | 1 |
| Islam, R | 1 |
| Watler, LL | 1 |
| McPartland, C | 1 |
| Whitelaw, S | 1 |
| Connor, C | 1 |
| Morris, C | 1 |
| Fang, J | 1 |
| Gartland, O | 1 |
| Holt, L | 1 |
| Hargreaves, IP | 1 |
| Morava, E | 3 |
| Oglesbee, D | 1 |
| Suomalainen, A | 1 |
| Deus, CM | 1 |
| Pereira, SP | 1 |
| Cunha-Oliveira, T | 1 |
| Pereira, FB | 1 |
| Raimundo, N | 1 |
| Oliveira, PJ | 1 |
| Sasaki, K | 1 |
| Sakamoto, S | 1 |
| Uchida, H | 1 |
| Narumoto, S | 1 |
| Shigeta, T | 1 |
| Fukuda, A | 1 |
| Ito, R | 1 |
| Irie, R | 1 |
| Yoshioka, T | 1 |
| Murayama, K | 3 |
| Kasahara, M | 1 |
| Gupta, D | 1 |
| Singla, R | 1 |
| Mazzeo, AT | 1 |
| Schnieder, EB | 1 |
| Tandon, V | 1 |
| Kale, SS | 1 |
| Mahapatra, AK | 1 |
| Munk, M | 1 |
| Poulsen, FR | 2 |
| Larsen, L | 2 |
| Nordström, CH | 4 |
| Nielsen, TH | 4 |
| Semeraro, M | 1 |
| Boenzi, S | 2 |
| Carrozzo, R | 1 |
| Diodato, D | 2 |
| Martinelli, D | 1 |
| Olivieri, G | 1 |
| Antonetti, G | 1 |
| Sacchetti, E | 1 |
| Catesini, G | 1 |
| Rizzo, C | 1 |
| Dionisi-Vici, C | 1 |
| Iannetti, EF | 1 |
| Smeitink, JAM | 1 |
| Willems, PHGM | 1 |
| Beyrath, J | 1 |
| Koopman, WJH | 1 |
| Zhang, HY | 1 |
| Tan, XX | 1 |
| Kang, K | 1 |
| Wang, W | 1 |
| Lian, KQ | 1 |
| Kang, WJ | 1 |
| Koga, Y | 6 |
| Povalko, N | 1 |
| Inoue, E | 1 |
| Nashiki, K | 1 |
| Tanaka, M | 6 |
| Schalén, W | 2 |
| Ståhl, N | 1 |
| Toft, P | 2 |
| Reinstrup, P | 1 |
| Fujii, T | 2 |
| Nozaki, F | 1 |
| Saito, K | 2 |
| Hayashi, A | 1 |
| Nishigaki, Y | 2 |
| Hiejima, I | 1 |
| Kumada, T | 2 |
| Schulz, M | 1 |
| Jacobsen, A | 1 |
| Andersen, ÅB | 1 |
| Fujita, Y | 2 |
| Ito, M | 2 |
| Kojima, T | 2 |
| Yatsuga, S | 2 |
| Danhauser, K | 1 |
| Smeitink, JA | 3 |
| Freisinger, P | 1 |
| Sperl, W | 1 |
| Sabir, H | 1 |
| Hadzik, B | 1 |
| Mayatepek, E | 1 |
| Distelmaier, F | 1 |
| Komulainen, T | 1 |
| Lodge, T | 1 |
| Hinttala, R | 1 |
| Bolszak, M | 1 |
| Pietilä, M | 1 |
| Koivunen, P | 1 |
| Hakkola, J | 1 |
| Poulton, J | 1 |
| Morten, KJ | 1 |
| Uusimaa, J | 1 |
| Ishii, A | 1 |
| Fukumoto, Y | 1 |
| Arahata, H | 1 |
| Kakuma, T | 1 |
| Saiki, R | 1 |
| Inoue, T | 1 |
| Murakami, N | 1 |
| Ayabe, T | 1 |
| Oto, Y | 1 |
| Nishino, I | 1 |
| Goto, Y | 1 |
| Sakuta, R | 1 |
| Feldman, AG | 1 |
| Sokol, RJ | 1 |
| Hardison, RM | 1 |
| Alonso, EM | 1 |
| Squires, RH | 1 |
| Narkewicz, MR | 1 |
| Kyprianou, N | 1 |
| Murphy, E | 1 |
| Lee, P | 1 |
| Hargreaves, I | 1 |
| Jonckheere, AI | 1 |
| Huigsloot, M | 1 |
| Janssen, AJ | 2 |
| Kappen, AJ | 1 |
| Rodenburg, RJ | 2 |
| Dai, YL | 1 |
| Luk, TH | 1 |
| Siu, CW | 1 |
| Yiu, KH | 1 |
| Chan, HT | 1 |
| Lee, SW | 1 |
| Li, SW | 1 |
| Tam, S | 1 |
| Fong, B | 1 |
| Lau, CP | 1 |
| Tse, HF | 1 |
| Bor-Seng-Shu, E | 1 |
| de Lima Oliveira, M | 1 |
| Teixeira, MJ | 1 |
| Giulivi, C | 1 |
| Zhang, YF | 1 |
| Omanska-Klusek, A | 1 |
| Ross-Inta, C | 1 |
| Wong, S | 1 |
| Hertz-Picciotto, I | 1 |
| Tassone, F | 1 |
| Pessah, IN | 1 |
| Rossignol, DA | 1 |
| Frye, RE | 1 |
| Kimura, N | 1 |
| Oda, N | 1 |
| Shimomura, H | 1 |
| Miyajima, T | 1 |
| Yamada, K | 1 |
| Toribe, Y | 1 |
| Yanagihara, K | 1 |
| Mano, T | 1 |
| Akagi, M | 1 |
| Suzuki, Y | 1 |
| Mouadil, A | 1 |
| Debout, C | 1 |
| Read, MH | 1 |
| Morello, R | 1 |
| Allouche, S | 1 |
| Chapon, F | 1 |
| Bindslev, TT | 1 |
| Pedersen, SM | 1 |
| Olsen, NV | 1 |
| Shah, NS | 1 |
| Mitchell, WG | 1 |
| Boles, RG | 1 |
| Brivet, M | 1 |
| Garcia-Cazorla, A | 1 |
| Lyonnet, S | 1 |
| Dumez, Y | 1 |
| Nassogne, MC | 1 |
| Slama, A | 1 |
| Boutron, A | 1 |
| Touati, G | 1 |
| Legrand, A | 1 |
| Saudubray, JM | 1 |
| Masuda, T | 1 |
| Sato, K | 1 |
| Noda, C | 1 |
| Ikeda, KM | 1 |
| Matsunaga, A | 1 |
| Ogura, MN | 1 |
| Shimizu, K | 1 |
| Nagasawa, H | 1 |
| Matsuyama, N | 1 |
| Izumi, T | 1 |
| Oliveira, G | 2 |
| Diogo, L | 2 |
| Grazina, M | 2 |
| Garcia, P | 1 |
| Ataíde, A | 2 |
| Marques, C | 2 |
| Miguel, T | 2 |
| Borges, L | 2 |
| Vicente, AM | 2 |
| Oliveira, CR | 1 |
| Barnérias, C | 1 |
| Giurgea, I | 1 |
| Hertz-Pannier, L | 1 |
| Bahi-Buisson, N | 1 |
| Boddaert, N | 1 |
| Rustin, P | 1 |
| Rotig, A | 1 |
| Desguerre, I | 1 |
| Munnich, A | 1 |
| de Lonlay, P | 1 |
| Trijbels, FJ | 1 |
| Sengers, RC | 1 |
| Wintjes, LT | 1 |
| Ruitenbeek, W | 1 |
| van Engelen, BG | 1 |
| van den Heuvel, LP | 1 |
| Correia, C | 1 |
| Coutinho, AM | 1 |
| Almeida, J | 1 |
| Oliveira, C | 1 |
| Debray, FG | 1 |
| Mitchell, GA | 1 |
| Allard, P | 1 |
| Robinson, BH | 1 |
| Hanley, JA | 1 |
| Lambert, M | 1 |
| Fuku, N | 1 |
| Ibi, T | 1 |
| Sahashi, K | 1 |
| Oguro, N | 1 |
| Momoi, MY | 1 |
| Hirai, M | 1 |
| Suzuki, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects on Physical Activity on Mitochondrial Function in Skin Fibroblasts in Patients With Parkinson's Disease: a Study Protocol.[NCT05963425] | 24 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | |||
| Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779] | 12 participants (Actual) | Observational | 2017-08-28 | Completed | |||
| GDF-15 as a Biomarker for Mitochondrial Disease[NCT02745938] | 97 participants (Actual) | Observational | 2016-06-30 | Completed | |||
| A Multi-Center Group to Study Acute Liver Failure in Children[NCT00986648] | 158 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-10-18 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for pyruvic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
The Biochemical Assessment of Mitochondrial Respiratory Chain Disorders.
Topics: Electron Transport; Humans; Mitochondrial Diseases; Mitochondrial Membranes; Pyruvic Acid; Reproduci | 2022 |
Laboratory and metabolic investigations.
Topics: Amino Acids; Humans; Lactic Acid; Mitochondria; Mitochondrial Diseases; Pyruvic Acid | 2023 |
Blood biomarkers of mitochondrial disease-One for all or all for one?
Topics: Biomarkers; Humans; Mitochondria; Mitochondrial Diseases; Pyruvic Acid | 2023 |
Biomarkers for mitochondrial energy metabolism diseases.
Topics: Amino Acids; Biomarkers; Carnitine; Creatine Kinase; Energy Metabolism; Fibroblast Growth Factors; G | 2018 |
Treatment options for lactic acidosis and metabolic crisis in children with mitochondrial disease.
Topics: Acidosis, Lactic; Child; Child, Preschool; Disease Management; Humans; Hypothermia; Mitochondrial Di | 2015 |
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.
Topics: Adenosine Triphosphate; Adolescent; Animals; Biomarkers; Brain; Child; Child Development Disorders, | 2012 |
[The screening test for mitochondrial disease].
Topics: Biomarkers; Diagnosis, Differential; Glucose Tolerance Test; Humans; Lactic Acid; Mass Screening; Mi | 2002 |
[Lactic acidosis].
Topics: Acidosis, Lactic; Diagnosis, Differential; Humans; Mitochondria; Mitochondrial Diseases; Prognosis; | 2002 |
36 other studies available for pyruvic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
A Man With Left Ventricular Hypertrophy.
Topics: Adult; Atrophy; Cardiomyopathies; Cerebellar Diseases; Cognitive Dysfunction; Echocardiography; Gluc | 2022 |
Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction.
Topics: Animals; Metabolome; Mitochondrial Diseases; NAD; Oxidative Phosphorylation; Pyruvic Acid; Rotenone; | 2022 |
Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects.
Topics: Aged; Energy Metabolism; Fibroblasts; Galactose; Glucose; Humans; Male; Metabolic Diseases; Middle A | 2020 |
Liver Transplantation for Mitochondrial Respiratory Chain Disorder: A Single-Center Experience and Excellent Marker of Differential Diagnosis.
Topics: Adult; Biomarkers; Diagnosis, Differential; Female; Humans; Lactic Acid; Liver Failure, Acute; Liver | 2017 |
Detection of metabolic pattern following decompressive craniectomy in severe traumatic brain injury: A microdialysis study.
Topics: Brain Injuries, Traumatic; Cerebrovascular Circulation; Decompressive Craniectomy; Female; Glasgow O | 2017 |
Cerebral Metabolic Changes Related to Oxidative Metabolism in a Model of Bacterial Meningitis Induced by Lipopolysaccharide.
Topics: Animals; Cerebrum; Disease Models, Animal; Female; Lactic Acid; Lipopolysaccharides; Meningitis, Bac | 2018 |
The urinary organic acids profile in single large-scale mitochondrial DNA deletion disorders.
Topics: 3-Hydroxybutyric Acid; Acyl-CoA Dehydrogenase, Long-Chain; Adolescent; Child; Child, Preschool; Cong | 2018 |
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Topics: Adenosine Triphosphate; Aspartic Acid; Cell Death; Culture Media; Electron Transport Complex I; Fibr | 2018 |
Simultaneous determination of lactic acid and pyruvic acid in tissue and cell culture media by gas chromatography after in situ derivatization-ultrasound-assisted emulsification microextraction.
Topics: Animals; Cells, Cultured; Chromatography, Gas; Citric Acid Cycle; Culture Media; Emulsions; Lactic A | 2019 |
Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease.
Topics: Acidosis, Lactic; Adolescent; Adult; Biomarkers; Female; Fibroblast Growth Factors; Growth Different | 2019 |
Bedside diagnosis of mitochondrial dysfunction after malignant middle cerebral artery infarction.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Cerebrum; Decompressive Craniectomy; Female; Humans; Infarc | 2014 |
Efficacy of pyruvate therapy in patients with mitochondrial disease: a semi-quantitative clinical evaluation study.
Topics: Child; Drug Administration Schedule; Female; Glycolysis; Humans; Infant; Lactic Acid; Male; Mitochon | 2014 |
Bedside evaluation of cerebral energy metabolism in severe community-acquired bacterial meningitis.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Child; Child, Preschool; Disease Transmission, Infectious; | 2015 |
GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases.
Topics: Biomarkers; Drug Monitoring; Gene Expression Profiling; Growth Differentiation Factor 15; Humans; Mi | 2015 |
Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model.
Topics: Adenosine Triphosphate; Anticonvulsants; Cell Death; Cell Proliferation; Cell Respiration; Chemical | 2015 |
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.
Topics: Adolescent; Adult; Biomarkers; Child; Creatine Kinase; Female; Fibroblast Growth Factors; Growth Dif | 2015 |
Pyruvate Improved Insulin Secretion Status in a Mitochondrial Diabetes Mellitus Patient.
Topics: Adult; C-Peptide; Diabetes Mellitus; Humans; Insulin; Male; Mitochondrial Diseases; Mutation; Pyruvi | 2016 |
Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure.
Topics: Adolescent; Age Factors; Biomarkers; Child; Child, Preschool; Cohort Studies; Female; Humans; Lactic | 2017 |
Assessment of mitochondrial respiratory chain function in hyperphenylalaninaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cell Line, Tumor; Cells, Cultured; Culture Media; Elect | 2009 |
High-throughput assay to measure oxygen consumption in digitonin-permeabilized cells of patients with mitochondrial disorders.
Topics: Cell Membrane Permeability; Cell Respiration; Cells, Cultured; Digitonin; Fibroblasts; Fluorescence; | 2010 |
Mitochondrial dysfunction induced by statin contributes to endothelial dysfunction in patients with coronary artery disease.
Topics: Aged; Biomarkers; Brachial Artery; Coronary Artery Disease; Dose-Response Relationship, Drug; Endoth | 2010 |
Traumatic brain injury and metabolism.
Topics: Blood Flow Velocity; Blood Glucose; Brain; Brain Injuries; Craniotomy; Decompression, Surgical; Ener | 2010 |
Mitochondrial dysfunction in autism.
Topics: Autistic Disorder; Case-Control Studies; Child, Preschool; DNA Copy Number Variations; DNA, Mitochon | 2010 |
Pyruvate therapy for mitochondrial DNA depletion syndrome.
Topics: DNA, Mitochondrial; Female; Humans; Infant; Mitochondrial Diseases; Pyruvic Acid; Syndrome | 2012 |
Diagnostic accuracy of blood and CSF lactate in identifying children with mitochondrial diseases affecting the central nervous system.
Topics: Adolescent; Area Under Curve; Central Nervous System Diseases; Child; Child, Preschool; Female; Huma | 2012 |
Blood metabolite data in response to maximal exercise in healthy subjects.
Topics: Adult; Ammonia; Biomarkers; Energy Metabolism; Exercise; Exercise Test; Exercise Tolerance; Female; | 2012 |
Cerebral energy metabolism during induced mitochondrial dysfunction.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Pressure; Body T | 2013 |
Mitochondrial disorders: a potentially under-recognized etiology of infantile spasms.
Topics: Diagnosis, Differential; DNA, Mitochondrial; Energy Metabolism; Female; Humans; Infant; Infant, Newb | 2002 |
Impaired mitochondrial pyruvate importation in a patient and a fetus at risk.
Topics: Algeria; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Consanguinity; Digitonin | 2003 |
Protective effect of urinary trypsin inhibitor on myocardial mitochondria during hemorrhagic shock and reperfusion.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Blood Transfusion, Autologous; Energy Metabolism; G | 2003 |
Mitochondrial dysfunction in autism spectrum disorders: a population-based study.
Topics: Adolescent; Autistic Disorder; Child; Comorbidity; Cross-Sectional Studies; Epilepsy; Female; Humans | 2005 |
Respiratory chain deficiency in a female with Aicardi-Goutières syndrome.
Topics: Basal Ganglia; Calcinosis; Chromatography, Gas; Dementia, Vascular; Female; Humans; Interferon-alpha | 2006 |
Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology.
Topics: Adenosine Triphosphate; Adolescent; Adult; Biopsy; Carbon Radioisotopes; Carnitine; Child; Child, Pr | 2006 |
Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene.
Topics: Aspartic Acid; Autistic Disorder; Chromosome Mapping; DNA Mutational Analysis; DNA Primers; DNA, Mit | 2006 |
Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis.
Topics: Acidosis, Lactic; Child; Diagnosis, Differential; Female; Hospitals, Pediatric; Humans; Lactic Acid; | 2007 |
Therapeutic potential of pyruvate therapy for mitochondrial diseases.
Topics: Adult; Animals; Calcium-Binding Proteins; Enzyme Activation; Ethanol; Female; Glycolysis; Humans; La | 2007 |