Compounds > pyruvic acid
Page last updated: 2024-10-20

pyruvic acid and Disease Models, Animal

pyruvic acid has been researched along with Disease Models, Animal in 234 studies

Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
" Surprisingly, we show that replacing glucose with galactose prevented or markedly reduced the loss of ATP and any subsequent necrosis."7.88Galactose protects against cell damage in mouse models of acute pancreatitis. ( Gerasimenko, JV; Gerasimenko, OV; Gryshchenko, O; Peng, S; Petersen, OH; Samarasinghe, S; Tsugorka, TM, 2018)
"Lactic acidosis is a life-threatening complication of hemorrhagic shock."7.79Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013)
"To investigate the effects of preventive enteral administration of ornithine alpha-ketoglutarate (OKG) in an ischemia-reperfusion rat model."7.77Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats. ( Garcia, JH; Gonçalves, ES; Guimarães, SB; Prado Neto, AX; Rabelo, CM; Vasconcelos, PR, 2011)
"Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state."7.77Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011)
"We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability."7.76Reduced caloric intake during endotoxemia reduces arginine availability and metabolism. ( Bruins, MJ; Deutz, NE; Luiking, YC; Poeze, M, 2010)
"To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved."7.75[Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009)
" Striatal injection of quinolinic acid (QUIN) resulted in marked inflammation characterized by microgliosis, astrogliosis and enhanced expressions of pro-inflammatory enzymes inducible nitric oxide synthase and cyclooxygenase-2."7.73Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease. ( Choi, HB; McLarnon, JG; Ryu, JK, 2006)
" Animals, under urethane anesthesia, were exposed to high ambient temperature of 42 degrees C until mean arterial pressure and local cerebral blood flow in the striatum began to decrease, which was arbitrarily defined as the onset of heatstroke."7.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
"To compare the effects of a 12 h continuous infusion of iloprost, a stable prostacyclin analogue, on hepatic blood flow (Qliv), O2 exchange, and energy metabolism during a 24 h hyperdynamic, porcine endotoxemia with volume resuscitation alone."7.70Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost. ( Altherr, J; Brinkmann, A; Georgieff, M; Jauch, KW; Matejovic, M; Radermacher, P; Träger, K; Vlatten, A; Vogt, J; Wachter, U; Zülke, C, 2000)
"The effect of pyruvate on the progress of galactose cataract has been studied."7.68Prevention of galactose cataract by pyruvate. ( Devamanoharan, PS; Henein, M; Ramachandran, S; Varma, SD, 1992)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."5.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
"Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties."5.37Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011)
"Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation."5.29Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993)
" Ethyl pyruvate has demonstrated anti-inflammatory actions and improved hyperpermeability and bacterial translocation due to endotoxemia and is of benefit in animal models of sepsis and septic shock."4.83Is pyruvate an endogenous anti-inflammatory molecule? ( Das, UN, 2006)
" Surprisingly, we show that replacing glucose with galactose prevented or markedly reduced the loss of ATP and any subsequent necrosis."3.88Galactose protects against cell damage in mouse models of acute pancreatitis. ( Gerasimenko, JV; Gerasimenko, OV; Gryshchenko, O; Peng, S; Petersen, OH; Samarasinghe, S; Tsugorka, TM, 2018)
" Therefore, we investigated whether glycine, sodium pyruvate, and resveratrol can either support or potentially harm regeneration when applied therapeutically after reperfusion injury."3.85Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa. ( Brencher, L; Hamburger, T; Kirsch, M; Petrat, F; Stych, K, 2017)
" Characterization of overt hyperglycemia in insulin receptor mutant (Insr(P1195L/+)) mice exposed to HFD (Insr(P1195L/+)/HFD mice) revealed increased glucose-6-phosphatase (G6pc) expression in liver and increased gluconeogenesis from glycerol."3.81Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. ( Jiang, M; Lee, EY; Miki, T; Minokoshi, Y; Sakurai, K; Shirasawa, T; Tachibana, K; Tanaka, T; Toda, C; Vidal-Puig, A; Yokote, K; Zhang, X, 2015)
"Lactic acidosis is a life-threatening complication of hemorrhagic shock."3.79Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013)
" The present study was evaluated to investigate whether pyruvate attenuates the development of cardiotoxicity in isoproterenol (ISO)-induced myocardial infarction by assessing hemodynamic, biochemical and histopathological parameters."3.78Pyruvate attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity. ( Arya, DS; Goyal, S; Kumari, S; Ojha, S, 2012)
"To investigate the effects of preventive enteral administration of ornithine alpha-ketoglutarate (OKG) in an ischemia-reperfusion rat model."3.77Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats. ( Garcia, JH; Gonçalves, ES; Guimarães, SB; Prado Neto, AX; Rabelo, CM; Vasconcelos, PR, 2011)
"Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state."3.77Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011)
" Following hyperpolarized [1-(13)C]pyruvate injections, pyruvate and its metabolic products, alanine and lactate, were observed in the liver of five rats with hepatocellular carcinoma and five healthy control rats."3.76T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate. ( Butts Pauly, K; Hurd, R; King, R; Le Roux, P; Mayer, D; Pfefferbaum, A; Spielman, D; Tropp, J; Vasanawala, S; Yen, YF, 2010)
"We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability."3.76Reduced caloric intake during endotoxemia reduces arginine availability and metabolism. ( Bruins, MJ; Deutz, NE; Luiking, YC; Poeze, M, 2010)
"To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved."3.75[Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009)
"Long-term thiamine deficiency has been largely documented, whilst little is known about effects of short-term depletion/repletion periods on thiamine vitamers status."3.74Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model. ( Batifoulier, F; Besson, C; Chanliaud, E; Demigné, C; Rémésy, C; Verny, MA, 2007)
" Animals, under urethane anesthesia, were exposed to high ambient temperature of 42 degrees C until mean arterial pressure and local cerebral blood flow in the striatum began to decrease, which was arbitrarily defined as the onset of heatstroke."3.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
" Striatal injection of quinolinic acid (QUIN) resulted in marked inflammation characterized by microgliosis, astrogliosis and enhanced expressions of pro-inflammatory enzymes inducible nitric oxide synthase and cyclooxygenase-2."3.73Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease. ( Choi, HB; McLarnon, JG; Ryu, JK, 2006)
" Hypoxia induced an immediate and significant elevation in the intraperitoneal lactate/pyruvate ratio to 446+/-137% of the baseline values, and glycerol subsequently increased during reoxygenation to 389+/-109%."3.71Intraperitoneal microdialysis for detection of splanchnic metabolic disorders. ( Bahlmann, L; Bruch, HP; Gliemroth, J; Heringlake, M; Klaus, S, 2002)
"To compare the effects of a 12 h continuous infusion of iloprost, a stable prostacyclin analogue, on hepatic blood flow (Qliv), O2 exchange, and energy metabolism during a 24 h hyperdynamic, porcine endotoxemia with volume resuscitation alone."3.70Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost. ( Altherr, J; Brinkmann, A; Georgieff, M; Jauch, KW; Matejovic, M; Radermacher, P; Träger, K; Vlatten, A; Vogt, J; Wachter, U; Zülke, C, 2000)
"The effect of pyruvate on the progress of galactose cataract has been studied."3.68Prevention of galactose cataract by pyruvate. ( Devamanoharan, PS; Henein, M; Ramachandran, S; Varma, SD, 1992)
" Plasma and urinary glutathione-related metabolomes and liver function parameters were measured during the dosing period."2.52[Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity]. ( Kobayashi, A; Kondo, K; Sugai, S, 2015)
"Tamoxifen is an effective breast cancer therapy in postmenopausal women."1.72Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model. ( Bellozi, PMQ; Itinose, AM; Koerich, S; Marek, CB; Sandrini, F; Schneider, SCS; Silva, FC, 2022)
"Acute kidney injury is a major clinical challenge affecting as many as 1 percent of all hospitalized patients."1.56Metabolic reprogramming associated with progression of renal ischemia reperfusion injury assessed with hyperpolarized [1- ( Bertelsen, LB; Laustsen, C; Nielsen, PM; Qi, H, 2020)
"However, earlier animal models of type 1 diabetes are severely catabolic with very low endogenous leptin levels, unlike most patients with diabetes."1.56UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia. ( Andersen, B; Bokhari, MH; Busby, O; Cannon, B; Conde-Frieboes, KW; Fels, JJ; Nedergaard, J; Paulsson, JF; Rakipovski, G; Raun, K; Zouhar, P, 2020)
" However, siRNA dosing data suggest that it may be possible to identify a dose that limits changes in liver organic acid levels, while maintaining a desired effect of reducing glyoxylate to oxalate synthesis."1.51Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity. ( Erbe, D; Fargue, S; Holmes, RP; Knight, J; Liebow, A; Wood, KD, 2019)
"In addition to its anticancer property, 3BP also exhibits antimicrobial activity."1.513-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau. ( Casal, M; Ko, YH; Niedźwiecka, K; Pedersen, PL; Ułaszewski, S, 2019)
"The main cancer types of the 17 patients were sarcoma (n = 11), carcinoma (n = 5) and mastocytoma (n = 1)."1.48Combined hyperpolarized ( Ardenkjaer-Larsen, J; Clemmensen, AE; Gutte, H; Hansen, AE; Holst, P; Johannesen, HH; Kjaer, A; Klausen, TL; Kristensen, AT; Larsen, MME; Rahbek, S; Schøier, C, 2018)
"Hypoxic lactic acidosis was efficiently reversed in group PR, instead of group CR, (pH 7."1.48Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats. ( Li, ZY; Liu, R; Wang, SM; Yu, W; Zhang, HP; Zhou, FQ, 2018)
"BRAFi-resistant melanomas are characterized by an increase of mitochondrial oxidative phosphorylation and are more prone to cell death induced by mitochondrial-targeting drugs."1.48Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors. ( Balayssac, S; Corazao-Rozas, P; Dekiouk, S; Gabert, PE; Garçon, G; Guerreschi, P; Joncquel Chevalier Curt, M; Khamari, R; Kluza, J; Maboudou, P; Malet-Martino, M; Marchetti, P; Mortier, L; Quesnel, B; Ravasi, L; Riveros-Cruz, S; Trinh, A, 2018)
"Protection against fatty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside, a specific inhibitor of ANT."1.46Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. ( Cho, J; Choi, CS; Chun, SK; Han, C; Joseph, AM; Kalavalapalli, S; Kim, JS; Lee, HY; Lee, YJ; Mathews, CE; Morgan, D; Oh, SP; Park, HJ; Park, SY; Shiratsuchi, T; Someya, S; Sunny, NE; Terada, N; Wohlgemuth, SE; Zhang, Y, 2017)
"One of the remarkable features of cancer cells is aerobic glycolysis, a phenomenon known as the "Warburg Effect", in which cells rely preferentially on glycolysis instead of oxidative phosphorylation (OXPHOS) as the main energy source even in the presence of high oxygen tension."1.46Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells. ( Berge, V; Fan, Z; Goscinski, MA; Grigalavicius, M; Han, G; Ji, Y; Kan, Q; Li, X; Li, Y; Nesland, JM; Suo, Z; Zhang, M; Zhao, J, 2017)
"Cerebral metabolic alterations during cardiac arrest, cardiopulmonary resuscitation (CPR) and extracorporeal cardiopulmonary life support (ECLS) are poorly explored."1.43Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial. ( Ettl, F; Herkner, H; Högler, S; Hosmann, A; Janata, A; Laggner, AN; Magnet, IA; Scherer, T; Schober, A; Sterz, F; Testori, C; Warenits, AM; Weihs, W; Zeitlinger, M, 2016)
"We used a mouse model of Chuvash polycythemia (CP), a rare genetic disorder that modestly increases expression of HIF target genes in normoxia, to understand what these effects might be within the heart."1.43The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism. ( Carr, C; Clarke, K; Cole, M; Curtis, MK; Dodd, M; Giles, L; Heather, LC; Robbins, PA; Slingo, M; Tyler, D, 2016)
"Co-treatment with coenzyme Q10 induced reduction in muscle necrosis as well as in CK and myoglobin levels."1.43Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model. ( Abdallah, D; El-Ganainy, SO; El-Khatib, AS; El-Mallah, A; Khattab, MM; Mohy El-Din, MM, 2016)
"Urethane is a recognized genotoxic carcinogen in fermented foods and beverages."1.43Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016)
" Other two groups were the intravenous (IV) resuscitation (group VR) with lactated Ringer's solution with the same dosage and no fluid rehydration (group NR)."1.43Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs. ( Bai, XD; Guo, SJ; Hu, S; Hu, XH; Li, ZY; Liu, R; Wang, SM; Zhou, FQ, 2016)
"The results suggest that hypovolemic shock perturbs glucose metabolism at the level of pyruvate utilization, resulting in deranged cerebral energy stores."1.42The brain metabolic activity after resuscitation with liposome-encapsulated hemoglobin in a rat model of hypovolemic shock. ( Awasthi, V; Hedrick, AF; Hussain, A; Rao, G; Xie, J; Yadav, VR, 2015)
" In this study, we evaluated protective effects of long-term administration of pyruvate in 3xTg-AD mice, a preclinical AD model that develops amyloid-β- and tau-dependent pathology."1.42Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology. ( Bomba, M; Canzoniero, LM; Ciavardelli, D; Corona, C; Curcio, M; Granzotto, A; Isopi, E; Lattanzio, R; Navarra, R; Piantelli, M; Sensi, SL, 2015)
"Hypoxic lactic acidosis was fully corrected in group PORS in 4 h, whereas it worsened in group BORS, and the 24-h survival rate was twice higher in group PORS than in group BORS (45."1.42Pyruvate oral rehydration solution improved visceral function and survival in shock rats. ( He, ZJ; Hu, S; Lin, HY; Luo, HM; Sheng, ZY; Xie, ZY; Yu, W; Zhou, FQ, 2015)
"In an effort to mimic juvenile type 1 diabetes the experiments were conducted in one-month-old young rats that were rendered diabetic by streptozotocin (STZ, 50mg/kg, i."1.39Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats. ( Choi, BY; Kim, HJ; Kim, JH; Sohn, M; Song, HK; Suh, SW; Won, SJ; Yoo, JH, 2013)
"Excessive alcohol consumption causes alcoholic fatty liver disease (AFLD)."1.39Metabolomics of ginger essential oil against alcoholic fatty liver in mice. ( Kuo, CH; Lin, SH; Liu, CT; Raghu, R; Sheen, LY; Tseng, YJ; Wang, SY, 2013)
"Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties."1.37Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011)
"Under conditions of septic shock, an increase in lactate levels was found to be a sensitive marker of tissue metabolism disorder."1.37Microdialysis detection of lactate in subcutaneous tissue as a reliable indicator of tissue metabolic disorders in an animal sepsis model. ( Hanyu, N; Hosoyama, A; Kawasaki, N; Kobayashi, K; Komatsu, H; Ohashi, H; Ohashi, M; Taira, Y; Wada, T, 2011)
" These effects were all reversed by co-treatment with pyruvate at a well-tolerated dosage (1000 mg/kg)."1.37Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain. ( Kim, MO; Koh, PO; Lee, HY; Naseer, MI; Ullah, I; Ullah, N, 2011)
"Rats that were exposed to permanent middle cerebral artery occlusion (MCAO) and treated with intravenous 250 mg/kg pyruvate had a smaller volume of infarction and reduced brain edema, resulting in an improved neurological outcome and reduced mortality compared to control rats treated with saline."1.37Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke. ( Boyko, M; Gruenbaum, BF; Gruenbaum, SE; Kuts, R; Melamed, I; Ohayon, S; Regev, A; Shapira, Y; Teichberg, VI; Zlotnik, A, 2011)
"Heatstroke was induced by putting the animals in a folded heating pad of 42°C for 68 minutes controlled by circulating hot water."1.36Inhibition of acute lung inflammation and injury is a target of brain cooling after heatstroke injury. ( Ching-Ping, C; Hsi-Hsing, Y; Juei-Tang, C; Lin, MT, 2010)
"Neonatal pigs with asphyxia-induced cardiac arrest did not respond to a compression:ventilation ratio of 9:3 better than to 3:1."1.36Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia. ( Dannevig, I; Nakstad, B; Saugstad, OD; Solevåg, AL; Wyckoff, M, 2010)
" Reduced IC combined with intracranial volume insults leads to metabolic disturbances in a rat model."1.36Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010)
"Obesity is a risk factor for type 2 diabetes in cats."1.35The impact of obesity, sex, and diet on hepatic glucose production in cats. ( Burgess, SC; Ferguson, DC; Glushka, J; Hoenig, M; Jin, ES; Jordan, ET; Kley, S; Olson, DE; Prestegard, JH; Waldron, M; Wu, S, 2009)
"Rat models of hemorrhagic shock were built up."1.34[Protective effect of sodium pyruvate on ischemia/reperfusion injury of rats subjected to hemorrhagic shock]. ( Guan, LD; Wang, B; Wang, GY; Wang, ZL; Wei, GZ; Zhao, L; Zhou, H, 2007)
"Heatstroke is characterized by hyperthermia, vasoplegic shock, and cerebral ischemia and hypoxia."1.33Resuscitation from experimental heatstroke by hyperbaric oxygen therapy. ( Gao, CJ; Li, WX; Lin, MT; Niu, KC; Tsai, HM, 2005)
" A lower pyruvate concentration of 250 mg/kg was not protective; however, quadruple applications at this dosage was effective in reducing lesion volumes."1.32Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease. ( Kim, SU; McLarnon, JG; Ryu, JK, 2003)
"Even though cerebral vasospasm after subarachnoid hemorrhage (SAH) causes cerebral ischemia or infarction, the metabolic alterations in cerebrospinal fluids (CSF) after SAH have not been studied."1.31Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs. ( Aoki, K; Badr, A; Tibbs, R; Yin, W; Zhang, J, 2002)
"Even though cerebral vasospasm after subarachnoid hemorrhage (SAH) causes cerebral ischemia or infarction, the metabolic alterations in cerebrospinal fluids (CSF) after SAH have not been studied."1.31Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs. ( Aoki, K; Badr, A; Tibbs, R; Yin, W; Zhang, J, 2001)
"Glycerol was progressively released during prolonged ischemia."1.31Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis. ( Bäckström, T; Franco-Cereceda, A; Liska, J; Lockowandt, U; Sylven, C, 2002)
"Lactic acid was found in lower concentrations in Fe, Cu, Cu + F, Cu + Fe and F + Fe groups than in the other groups."1.29Effects of copper, iron and fluoride co-crystallized with sugar on caries development and acid formation in deslivated rats. ( Bowen, WH; Pearson, SK; Rosalen, PL, 1996)
"Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation."1.29Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993)

Research

Studies (234)

TimeframeStudies, this research(%)All Research%
pre-19902 (0.85)18.7374
1990's13 (5.56)18.2507
2000's58 (24.79)29.6817
2010's139 (59.40)24.3611
2020's22 (9.40)2.80

Authors

AuthorsStudies
Yako, H1
Niimi, N1
Kato, A1
Takaku, S1
Tatsumi, Y1
Nishito, Y1
Kato, K1
Sango, K1
Koerich, S1
Silva, FC1
Itinose, AM1
Bellozi, PMQ1
Sandrini, F1
Schneider, SCS1
Marek, CB1
Kim, YM1
Choi, SY1
Hwang, O1
Lee, JY3
Montrazi, ET1
Sasson, K1
Agemy, L1
Peters, DC1
Brenner, O1
Scherz, A1
Frydman, L2
Mu, K1
Sun, Y1
Zhao, Y1
Zhao, T1
Li, Q1
Zhang, M2
Li, H1
Zhang, R1
Hu, C1
Wang, C1
Jia, W1
Zouhar, P1
Rakipovski, G1
Bokhari, MH1
Busby, O1
Paulsson, JF1
Conde-Frieboes, KW1
Fels, JJ1
Raun, K1
Andersen, B1
Cannon, B1
Nedergaard, J1
Rossi, A1
Rigotto, G1
Valente, G1
Giorgio, V1
Basso, E1
Filadi, R1
Pizzo, P1
Hyacinthe, JN1
Buscemi, L1
Lê, TP1
Lepore, M1
Hirt, L1
Mishkovsky, M1
Yan, L1
Rust, BM1
Picklo, MJ1
Qin, H1
Zhang, V1
Bok, RA3
Santos, RD1
Cunha, JA1
Hsu, IC1
Santos Bs, JD1
Lee, JE2
Sukumar, S1
Larson, PEZ2
Vigneron, DB4
Wilson, DM1
Sriram, R1
Kurhanewicz, J2
Nielsen, PM2
Qi, H2
Bertelsen, LB3
Laustsen, C4
Kumar, VHS1
Gugino, S1
Nielsen, L1
Chandrasekharan, P1
Koenigsknecht, C1
Helman, J1
Lakshminrusimha, S1
Jin, N1
Ziyatdinova, S1
Gureviciene, I1
Tanila, H1
Pourfathi, M3
Xin, Y2
Rosalino, M1
Cereda, M2
Kadlecek, S3
Duncan, I2
Profka, H3
Hamedani, H3
Siddiqui, S3
Ruppert, K2
Chatterjee, S2
Rizi, RR2
Bertrand-Gaday, C1
Letheule, M1
Blanchet, E1
Vernus, B1
Pessemesse, L1
Bonnet-Garnier, A1
Bonnieu, A1
Casas, F1
Levitt, DG1
Levitt, JE1
Levitt, MD1
Harder, JM1
Guymer, C1
Wood, JPM1
Daskalaki, E1
Chidlow, G1
Zhang, C1
Balasubramanian, R1
Cardozo, BH1
Foxworth, NE1
Deering, KE1
Ouellette, TB1
Montgomery, C1
Wheelock, CE1
Casson, RJ1
Williams, PA1
John, SWM1
Thelen, MP1
Wirth, B1
Kye, MJ1
Alasadi, A1
Cao, B1
Guo, J1
Tao, H1
Collantes, J1
Tan, V1
Su, X1
Augeri, D1
Jin, S1
Chambers, KT1
Cooper, MA1
Swearingen, AR1
Brookheart, RT1
Schweitzer, GG1
Weinheimer, CJ1
Kovacs, A1
Koves, TR1
Muoio, DM1
McCommis, KS1
Finck, BN1
Martiñón-Gutiérrez, G1
Luna-Castro, M1
Hernández-Muñoz, R1
Ros, S1
Wright, AJ1
Bruna, A1
Caldas, C1
Brindle, KM2
Hansen, ESS1
Sadowski, T1
Ruf, S1
Scott, GF1
Nguyen, AQ1
Cherry, BH1
Hollrah, RA1
Salinas, I1
Williams, AG1
Ryou, MG2
Mallet, RT4
DeVience, SJ1
Lu, X1
Proctor, J1
Rangghran, P1
Melhem, ER1
Gullapalli, R1
Fiskum, GM1
Mayer, D2
Post, EH1
Su, F1
Hosokawa, K1
Taccone, FS1
Herpain, A1
Creteur, J1
De Backer, D1
Vincent, JL1
Li, X3
Han, G1
Kan, Q1
Fan, Z1
Li, Y1
Ji, Y1
Zhao, J2
Grigalavicius, M1
Berge, V1
Goscinski, MA1
Nesland, JM1
Suo, Z1
Brencher, L1
Petrat, F2
Stych, K1
Hamburger, T2
Kirsch, M1
Markovic, S1
Fages, A1
Roussel, T1
Hadas, R1
Brandis, A1
Neeman, M1
Gonzalez-Riano, C1
Sanz-Rodríguez, M1
Escudero-Ramirez, J1
Lorenzo, MP1
Barbas, C1
Cubelos, B1
Garcia, A1
Ehrich, J1
Khamari, R1
Trinh, A1
Gabert, PE1
Corazao-Rozas, P1
Riveros-Cruz, S1
Balayssac, S1
Malet-Martino, M1
Dekiouk, S1
Joncquel Chevalier Curt, M1
Maboudou, P1
Garçon, G1
Ravasi, L1
Guerreschi, P1
Mortier, L1
Quesnel, B1
Marchetti, P1
Kluza, J1
Munk, M1
Poulsen, FR1
Larsen, L1
Nordström, CH2
Nielsen, TH1
Hu, S6
Dai, YL1
Gao, MJ1
Wang, XN1
Wang, HB2
Dou, YQ1
Bai, XD3
Zhou, FQ6
Liu, R3
Wang, SM2
Li, ZY2
Yu, W2
Zhang, HP1
Zacharias, N1
Lee, J1
Ramachandran, S2
Shanmugavelandy, S1
McHenry, J1
Dutta, P1
Millward, S1
Gammon, S1
Efstathiou, E1
Troncoso, P1
Frigo, DE1
Piwnica-Worms, D1
Logothetis, CJ1
Maity, SN1
Titus, MA1
Bhattacharya, P1
Olivencia-Yurvati, AH2
Bünger, R1
Hansen, AE1
Gutte, H1
Holst, P1
Johannesen, HH1
Rahbek, S1
Clemmensen, AE1
Larsen, MME1
Schøier, C1
Ardenkjaer-Larsen, J1
Klausen, TL1
Kristensen, AT1
Kjaer, A1
Peng, S1
Gerasimenko, JV1
Tsugorka, TM1
Gryshchenko, O1
Samarasinghe, S1
Petersen, OH1
Gerasimenko, OV1
Madiraju, AK1
Qiu, Y1
Perry, RJ1
Rahimi, Y1
Zhang, XM1
Zhang, D1
Camporez, JG1
Cline, GW1
Butrico, GM1
Kemp, BE1
Casals, G1
Steinberg, GR1
Vatner, DF1
Petersen, KF1
Shulman, GI1
Allen, J1
Zhang, J3
Quickel, MD1
Kennett, M1
Patterson, AD1
Hankey-Giblin, PA1
Park, I1
Lupo, JM1
Nelson, SJ2
Sahenk, Z1
Yalvac, ME1
Amornvit, J1
Arnold, WD1
Chen, L1
Shontz, KM1
Lewis, S1
Tang, S1
Milshteyn, E1
Reed, G1
Gordon, J1
Bok, R1
Zhu, X1
Zhu, Z1
Ko, YH1
Niedźwiecka, K1
Casal, M1
Pedersen, PL1
Ułaszewski, S1
Choi, YS1
Kang, S1
Ko, SY1
Lee, S1
Kim, JY1
Lee, H2
Song, JE1
Kim, DH1
Kim, E2
Kim, CH1
Saksida, L1
Song, HT1
Kettunen, MI2
Elia, I1
Rossi, M1
Stegen, S1
Broekaert, D1
Doglioni, G1
van Gorsel, M1
Boon, R1
Escalona-Noguero, C1
Torrekens, S1
Verfaillie, C1
Verbeken, E1
Carmeliet, G1
Fendt, SM1
Goodwine, J1
Gil, J1
Doiron, A1
Valdes, J1
Solis, M1
Higa, A1
Davis, S1
Sauer, K1
Saheki, T3
Moriyama, M1
Kuroda, E2
Funahashi, A1
Yasuda, I1
Setogawa, Y1
Gao, Q1
Ushikai, M2
Furuie, S2
Yamamura, KI1
Takano, K1
Nakamura, Y1
Eto, K3
Kadowaki, T3
Sinasac, DS3
Furukawa, T1
Horiuchi, M1
Tai, YH1
Wood, KD1
Holmes, RP1
Erbe, D1
Liebow, A1
Fargue, S1
Knight, J1
Manzo, E1
Lorenzini, I1
Barrameda, D1
O'Conner, AG1
Barrows, JM1
Starr, A1
Kovalik, T1
Rabichow, BE1
Lehmkuhl, EM1
Shreiner, DD1
Joardar, A1
Liévens, JC1
Bowser, R1
Sattler, R1
Zarnescu, DC1
Bader, DA1
Hartig, SM1
Putluri, V1
Foley, C1
Hamilton, MP1
Smith, EA1
Saha, PK1
Panigrahi, A1
Walker, C1
Zong, L1
Martini-Stoica, H1
Chen, R1
Rajapakshe, K1
Coarfa, C1
Sreekumar, A1
Mitsiades, N1
Bankson, JA2
Ittmann, MM1
O'Malley, BW1
Putluri, N1
McGuire, SE1
Turer, A1
Altamirano, F1
Schiattarella, GG1
May, H1
Gillette, TG1
Malloy, CR1
Merritt, ME1
Bortoluzzi, VT1
Brust, L1
Preissler, T1
de Franceschi, ID1
Wannmacher, CMD1
Michel, KA1
Zieliński, R1
Walker, CM1
Le Roux, L1
Priebe, W1
Schellingerhout, D1
Broecker-Preuss, M1
Hartmann, M1
Schade, FU1
de Groot, H1
Aquaro, GD1
Frijia, F1
Positano, V1
Menichetti, L1
Santarelli, MF1
Ardenkjaer-Larsen, JH3
Wiesinger, F1
Lionetti, V1
Romano, SL1
Bianchi, G1
Neglia, D1
Giovannetti, G1
Schulte, RF1
Recchia, FA1
Landini, L1
Lombardi, M1
Ball, DR1
Cruickshank, R1
Carr, CA1
Stuckey, DJ1
Lee, P2
Clarke, K4
Tyler, DJ2
Liu, XQ1
Zhong, YX1
Fang, T1
Liu, CT1
Raghu, R1
Lin, SH1
Wang, SY1
Kuo, CH1
Tseng, YJ1
Sheen, LY1
Simeone, KA1
Matthews, SA1
Samson, KK1
Simeone, TA1
Choi, BY1
Kim, JH1
Kim, HJ2
Yoo, JH1
Song, HK1
Sohn, M1
Won, SJ1
Suh, SW2
Gouarné, C1
Tardif, G1
Tracz, J1
Latyszenok, V1
Michaud, M1
Clemens, LE1
Yu-Taeger, L1
Nguyen, HP1
Bordet, T1
Pruss, RM1
Bard-Chapeau, EA1
Nguyen, AT1
Rust, AG1
Sayadi, A1
Chua, BQ1
New, LS1
de Jong, J1
Ward, JM1
Chin, CK1
Chew, V1
Toh, HC1
Abastado, JP1
Benoukraf, T1
Soong, R1
Bard, FA1
Dupuy, AJ1
Johnson, RL1
Radda, GK1
Chan, EC1
Wessels, LF1
Adams, DJ1
Jenkins, NA1
Copeland, NG1
Baxter, P1
Chen, Y2
Xu, Y1
Swanson, RA3
Lycke, S1
Palm, F1
Østergaard, JA1
Bibby, BM1
Nørregaard, R2
Flyvbjerg, A1
Pedersen, M1
Jeong, KJ1
Kim, DY1
Quan, HY1
Jo, HK1
Kim, GW2
Chung, SH1
Shibata, K1
Inomoto, K1
Nakata, C1
Fukuwatari, T1
Hörer, TM2
Skoog, P2
Nilsson, KF2
Oikonomakis, I1
Larzon, T2
Norgren, L3
Jansson, K2
Nilsen, LH1
Witter, MP1
Sonnewald, U1
Shaghaghi, H1
Deshpande, C1
Martinez, D1
Ishii, M1
Rizi, R1
Bacelo, KL1
Hartwig, DD1
Seixas, FK1
Schuch, R1
Moreira, Ada S1
Amaral, M1
Collares, T1
Vendrusculo, CT1
McBride, AJ1
Dellagostin, OA1
Jung, YS1
Kim, H1
Kim, JS2
Park, M1
Jeong, J1
Lee, SK1
Yoon, HG1
Hwang, GS1
Namkoong, K1
Lu, XG1
Kang, X1
Wang, XZ1
Guo, S1
Fan, ZW1
Liang, ZK1
Yu, J1
Xie, ZY1
He, ZJ1
Luo, HM1
Lin, HY1
Sheng, ZY1
Filiou, MD1
Asara, JM1
Nussbaumer, M1
Teplytska, L1
Landgraf, R1
Turck, CW1
Cui, YL1
Wang, L1
Tian, ZT1
Lin, ZF1
Chen, DC1
Gaspar, P1
Al-Bayati, FA1
Andrew, PW1
Neves, AR1
Yesilkaya, H1
Isopi, E1
Granzotto, A1
Corona, C2
Bomba, M1
Ciavardelli, D1
Curcio, M1
Canzoniero, LM1
Navarra, R1
Lattanzio, R1
Piantelli, M2
Sensi, SL2
Detka, J1
Kurek, A1
Kucharczyk, M1
Głombik, K1
Basta-Kaim, A1
Kubera, M1
Lasoń, W1
Budziszewska, B1
Bluff, JE1
Reynolds, S1
Metcalf, S1
Alizadeh, T1
Kazan, SM1
Bucur, A1
Wholey, EG1
Bibby, BA1
Williams, L1
Paley, MN1
Tozer, GM1
Pant, M1
Sopariwala, DH1
Bal, NC1
Lowe, J1
Delfín, DA1
Rafael-Fortney, J1
Periasamy, M1
Fonouni, H2
Golriz, M2
Majlesara, A1
Faridar, A2
Esmaeilzadeh, M2
Jarahian, P2
Rad, MT1
Hafezi, M2
Garoussi, C1
Macher-Goeppinger, S2
Longerich, T2
Orakcioglu, B3
Sakowitz, OW4
Mehrabi, A2
Rao, G2
Hedrick, AF1
Yadav, VR1
Xie, J2
Hussain, A1
Awasthi, V2
Kobayashi, A1
Kondo, K1
Sugai, S1
Netzahualcoyotzi, C1
Tapia, R2
Wang, X1
Hu, X2
Yang, Y1
Takata, T1
Sakurai, T2
Hedrick, A1
Manjeri, GR1
Rodenburg, RJ1
Blanchet, L1
Roelofs, S1
Nijtmans, LG1
Smeitink, JA1
Driessen, JJ1
Koopman, WJ1
Willems, PH1
Bielarczyk, H1
Jankowska-Kulawy, A1
Höfling, C1
Ronowska, A1
Gul-Hinc, S1
Roßner, S1
Schliebs, R1
Pawelczyk, T1
Szutowicz, A1
Ma, X1
Deng, J1
Cao, N1
Guo, Z1
Zheng, Y1
Geng, S1
Meng, M1
Lin, H1
Duan, Y1
Du, G1
Yin, Y2
Choi, SC1
Xu, Z1
Zeumer, L1
Kanda, N1
Croker, BP1
Morel, L1
Lee, EY1
Sakurai, K1
Zhang, X1
Toda, C1
Tanaka, T1
Jiang, M1
Shirasawa, T1
Tachibana, K1
Yokote, K1
Vidal-Puig, A1
Minokoshi, Y1
Miki, T1
Kemppainen, E1
George, J1
Garipler, G1
Tuomela, T1
Kiviranta, E1
Soga, T1
Dunn, CD1
Jacobs, HT1
Kayser, EB1
Sedensky, MM1
Morgan, PG1
Moro, N2
Ghavim, SS3
Harris, NG2
Hovda, DA2
Sutton, RL3
Santa-Cruz, LD1
Guerrero-Castillo, S1
Uribe-Carvajal, S1
Hu, XH1
Guo, SJ1
Schober, A1
Warenits, AM1
Testori, C1
Weihs, W1
Hosmann, A1
Högler, S1
Sterz, F1
Janata, A1
Scherer, T1
Magnet, IA1
Ettl, F1
Laggner, AN1
Herkner, H1
Zeitlinger, M1
Natoli, R1
Rutar, M1
Lu, YZ1
Chu-Tan, JA1
Saxena, K1
Madigan, M1
Valter, K1
Provis, JM1
Maidens, J1
Gordon, JW1
Arcak, M1
Larson, PE3
El-Ganainy, SO1
El-Mallah, A1
Abdallah, D1
Khattab, MM1
Mohy El-Din, MM1
El-Khatib, AS1
Ahn, KY1
Kim, YH2
Jeong, GW1
Slingo, M1
Cole, M1
Carr, C1
Curtis, MK1
Dodd, M1
Giles, L1
Heather, LC2
Tyler, D1
Robbins, PA1
Mikkelsen, E1
Kristensen, ML1
Stødkilde-Jørgensen, H1
Xia, S1
Chen, G1
Wang, B2
Sun, Z1
Li, P1
Zhao, L2
Zhou, H2
Leung, LY1
Deng-Bryant, Y1
Cardiff, K1
Winter, M1
Tortella, F1
Shear, D1
Shijo, K1
Bartnik-Olson, BL1
Ghosh, A1
Tyson, T1
George, S1
Hildebrandt, EN1
Steiner, JA1
Madaj, Z1
Schulz, E1
Machiela, E1
McDonald, WG1
Escobar Galvis, ML1
Kordower, JH1
Van Raamsdonk, JM1
Colca, JR1
Brundin, P1
Chan, LN1
Chen, Z1
Braas, D1
Lee, JW1
Xiao, G1
Geng, H1
Cosgun, KN1
Hurtz, C1
Shojaee, S1
Cazzaniga, V1
Schjerven, H1
Ernst, T1
Hochhaus, A1
Kornblau, SM1
Konopleva, M1
Pufall, MA1
Cazzaniga, G1
Liu, GJ1
Milne, TA1
Koeffler, HP1
Ross, TS1
Sánchez-García, I1
Borkhardt, A1
Yamamoto, KR1
Dickins, RA1
Graeber, TG1
Müschen, M1
Cho, J1
Zhang, Y1
Park, SY1
Joseph, AM1
Han, C1
Park, HJ1
Kalavalapalli, S1
Chun, SK1
Morgan, D1
Someya, S1
Mathews, CE1
Lee, YJ1
Wohlgemuth, SE1
Sunny, NE1
Lee, HY2
Choi, CS1
Shiratsuchi, T1
Oh, SP1
Terada, N1
Arikan, F1
Martínez-Valverde, T1
Sánchez-Guerrero, Á1
Campos, M1
Esteves, M1
Gandara, D1
Torné, R1
Castro, L1
Dalmau, A1
Tibau, J1
Sahuquillo, J1
Tang, K1
Xie, B1
Li, S1
Rozanski, GJ1
Hartley, CE1
Varma, M1
Fischer, JP1
Riccardi, R1
Strauss, JA1
Shah, S1
Zhang, S1
Yang, ZJ1
Kley, S1
Hoenig, M1
Glushka, J1
Jin, ES1
Burgess, SC1
Waldron, M1
Jordan, ET1
Prestegard, JH1
Ferguson, DC1
Wu, S1
Olson, DE1
Nordmark, J1
Enblad, P3
Rubertsson, S1
Martín, A1
Rojas, S1
Pérez-Asensio, F1
Planas, AM1
Yan, EB1
Baburamani, AA1
Walker, AM1
Walker, DW1
Wang, Q1
van Hoecke, M1
Tang, XN1
Zheng, Z1
Yenari, MA1
Deng, ZH1
Ti, DD1
Xue, H1
Lin, J1
Wang, LH1
Yan, GT1
Kim, SH1
Yang, SO1
Kim, HS1
Kim, Y1
Park, T1
Choi, HK1
Kim, K1
Jo, YH1
Rhee, JE1
Kim, TY1
Lee, JH2
Kwon, WY1
Suh, GJ1
Lee, CC1
Singer, AJ1
Ramoz, N1
Barreto, M1
Gazdoiu, M1
Takahashi, N1
Gertner, M1
Dorr, N1
Gama Sosa, MA1
De Gasperi, R1
Perez, G1
Schmeidler, J1
Mitropoulou, V1
Le, HC1
Lupu, M1
Hof, PR1
Elder, GA1
Buxbaum, JD1
Amer-Wåhlin, I1
Nord, A1
Bottalico, B1
Hansson, SR1
Ley, D1
Marsál, K1
Ungerstedt, U3
Poeze, M1
Bruins, MJ1
Luiking, YC1
Deutz, NE1
Yen, YF1
Le Roux, P1
King, R1
Spielman, D1
Tropp, J1
Butts Pauly, K1
Pfefferbaum, A1
Vasanawala, S1
Hurd, R1
Flaherty, DC1
Hoxha, B1
Sun, J2
Gurji, H1
Simecka, JW1
Hsi-Hsing, Y1
Ching-Ping, C1
Juei-Tang, C1
Lin, MT3
Liu, A1
Zhang, Z1
Li, A1
Xue, J1
Solevåg, AL1
Dannevig, I1
Wyckoff, M1
Saugstad, OD2
Nakstad, B1
Tovedal, T1
Jonsson, O1
Zemgulis, V2
Myrdal, G1
Thelin, S2
Lennmyr, F1
Kannerup, AS1
Grønbæk, H1
Funch-Jensen, P1
Karlsen, S1
Mortensen, FV1
Salci, K1
Goiny, M1
Contant, CF1
Piper, I1
Nilsson, P1
Ojha, S1
Goyal, S1
Kumari, S1
Arya, DS1
Abrahamsson, P2
Aberg, AM2
Johansson, G2
Winsö, O2
Waldenström, A3
Haney, M2
Guan, LD1
Wang, ZL1
Wang, GY1
Wei, GZ1
Carvalho, AS1
Torres, LB1
Persike, DS1
Fernandes, MJ1
Amado, D1
Naffah-Mazzacoratti, Mda G1
Cavalheiro, EA1
da Silva, AV1
Rossignol, DA1
Frye, RE1
Gowda, K1
Zinnanti, WJ1
LaNoue, KF1
Dabos, KJ1
Whalen, HR1
Newsome, PN1
Parkinson, JA1
Henderson, NC1
Sadler, IH1
Hayes, PC1
Plevris, JN1
Zweckberger, K2
Simunovic, F1
Kiening, KL2
Unterberg, AW2
Gallagher, FA1
Day, SE1
Hu, DE1
Karlsson, M1
Gisselsson, A1
Lerche, MH1
Tahmasbi Rad, M1
Jafarieh, S1
Sakowitz, O1
Schmidt, J1
Balakrishnan, A1
Anderton, B1
Goga, A2
Ohashi, H1
Kawasaki, N1
Komatsu, H1
Wada, T1
Hosoyama, A1
Hanyu, N1
Kobayashi, K4
Ohashi, M1
Taira, Y1
Rendon, DA1
Alvarez-Bustamante, JA1
Ullah, N1
Naseer, MI1
Ullah, I1
Koh, PO1
Kim, MO1
Inoue, K2
Ono, H2
Tushima, A1
Katsura, N2
Yokogawa, M2
Yoshidumi, Y2
Kuhara, T1
Ohse, M1
Boyko, M2
Zlotnik, A2
Gruenbaum, BF2
Gruenbaum, SE2
Ohayon, S2
Kuts, R1
Melamed, I2
Regev, A1
Shapira, Y2
Teichberg, VI1
Gonçalves, ES1
Rabelo, CM1
Prado Neto, AX1
Garcia, JH1
Guimarães, SB1
Vasconcelos, PR1
Hackenberg, K1
Jung, CS1
Hertle, DN1
Hong, S1
Quintero-Monzon, O1
Ostaszewski, BL1
Podlisny, DR1
Cavanaugh, WT1
Yang, T1
Holtzman, DM1
Cirrito, JR1
Selkoe, DJ1
Schuh, RA1
Jackson, KC1
Khairallah, RJ1
Ward, CW1
Spangenburg, EE1
von Morze, C1
Yoshihara, HA1
Hua, R1
Li, C1
Gong, P1
Tang, Z1
Mei, X1
Zhao, H1
Ren, M1
Yang, SH1
Blind, PJ1
Purins, K1
Wiklund, L1
Lewén, A1
Liu, YY1
Wang, SJ1
Han, BB1
Santos, E1
Kentar, MM1
Diedler, J1
Uozumi, Y1
Schöll, M1
Unterberg, A1
Cole, MA1
Tan, JJ1
Ambrose, LJ1
Pope, S1
Abd-Jamil, AH1
Carter, EE1
Dodd, MS1
Yeoh, KK1
Schofield, CJ1
Sheline, CT2
Zhu, J1
Zhang, W1
Shi, C1
Cai, AL1
Benninger, E1
Laschke, MW1
Cardell, M1
Holstein, JH1
Lustenberger, T1
Keel, M1
Trentz, O1
Menger, MD1
Meier, C1
Leibowitz, A1
Brotfain, E1
Asakawa, A1
Inui, A1
Yamamura, K1
Schroeder, MA1
Lau, AZ1
Chen, AP1
Gu, Y1
Nagendran, J1
Barry, J1
Dyck, JR1
Connelly, KA1
Wright, GA1
Cunningham, CH1
Bai, S1
Westenbrink, BD1
Dorn, GW1
Yin, W2
Tibbs, R2
Aoki, K2
Badr, A2
Klaus, S1
Heringlake, M1
Gliemroth, J1
Bruch, HP1
Bahlmann, L1
Vincent, G1
Khairallah, M1
Bouchard, B1
Des Rosiers, C1
Romsi, P2
Kaakinen, T2
Kiviluoma, K2
Vainionpää, V1
Hirvonen, J1
Pokela, M1
Ohtonen, P1
Biancari, F2
Nuutinen, M2
Juvonen, T2
Ren, J2
Ungerstedt, J1
Nowak, G1
Ericzon, BG1
Ryu, JK3
Kim, SU2
McLarnon, JG3
Alessandri, B1
Heimann, A1
Filippi, R1
Kopacz, L1
Kempski, O1
Nemoto, M2
Yoo, MH1
Lee, SE1
Koh, JY2
Yoon, YH1
Solas, AB1
Munkeby, BH1
Contaldo, C1
Plock, J1
Sakai, H1
Takeoka, S1
Tsuchida, E1
Leunig, M1
Banic, A1
Erni, D1
Tsai, HM1
Gao, CJ1
Li, WX1
Niu, KC1
Aoyama, K1
Matsumori, Y1
Liu, J1
Peltz, M1
He, TT1
Adams, GA1
Chao, RY1
Meyer, DM1
Jessen, ME1
Chang, CP1
Chen, SH1
Varma, SD3
Hegde, KR2
Kovtun, S1
Audonnet-Blaise, S1
Krafft, MP1
Smani, Y1
Mertes, PM1
Marie, PY1
Labrude, P1
Longrois, D1
Menu, P1
Homola, A2
Zoremba, N3
Slais, K1
Kuhlen, R2
Syková, E2
Choi, HB1
Das, UN1
Heikkinen, J1
Dahlbacka, S1
Alaoja, H1
Laurila, P1
Salomäki, T1
Tuominen, H1
Lepola, P1
Rossaint, R2
Park, JH1
Hong, YH1
Kim, SM1
Kim, MJ1
Park, KS1
Sung, JJ1
Lee, KW1
Gasior, M1
French, A1
Joy, MT1
Tang, RS1
Hartman, AL1
Rogawski, MA1
Sitina, M1
Cerny, V1
Batifoulier, F1
Verny, MA1
Besson, C1
Chanliaud, E1
Rémésy, C1
Demigné, C1
Esposito, E1
Capasso, M1
di Tomasso, N1
Pellegrini, F1
Uncini, A1
Vitaglione, P1
Fogliano, V1
Schnoor, J1
Berens, M1
Wallington, J1
Ning, J1
Titheradge, MA1
Geeraerts, T1
Friggeri, A1
Mazoit, JX1
Benhamou, D1
Duranteau, J1
Vigué, B1
Pan, XD1
Sun, LZ1
Ma, WG1
Tian, LX1
Liu, NN1
Li, M1
Feng, ZY1
Long, C1
Zheng, J1
Chew, MS1
Johansson, A1
Anderson, C1
Ersson, A1
Tønnesen, E1
Hamat, RB1
Wolman, SL1
Fields, AL1
Sonnenberg, KL1
Cheema-Dhadli, S1
Halperin, ML1
Wikström, BG1
Ronquist, G2
Babin-Ebell, J1
Silber, RE1
Kobelt, F1
Amrhein, P1
Thees, SO1
Elert, O1
Geller, ER1
Higgins, LD1
Drourr, N1
Maitra, SR1
de Groot, MJ1
Coumans, WA1
Willemsen, PH1
van der Vusse, GJ1
Romand, JA1
Gorcsan, J1
Stanko, RT1
Rosalen, PL1
Pearson, SK1
Bowen, WH1
Sezai, A1
Shiono, M1
Orime, Y1
Nakata, K1
Hata, M1
Yamada, H1
Iida, M1
Kashiwazaki, S1
Kinishita, J1
Koujima, T1
Sezai, Y1
Saitoh, T1
de Jaeger, A1
Proulx, F1
Yandza, T1
Dugas, MA1
Boeuf, B1
Manika, A1
Lacroix, J1
Lambert, M1
Yamamura, H1
Hiraide, A1
Matsuoka, T1
Takaoka, M1
Shimazu, T1
Sugimoto, H1
Saether, OD1
Bäckström, T2
Aadahl, P1
Myhre, HO1
Träger, K3
Matejovic, M3
Zülke, C2
Vlatten, A2
Vogt, J2
Wachter, U2
Altherr, J2
Brinkmann, A2
Jauch, KW2
Georgieff, M3
Radermacher, P3
Phillis, JW1
O'Regan, MH1
Xu, GP1
Dave, KR1
Moraes, CT1
Busto, R1
Sick, TJ1
Bradley, WG1
Pérez-Pinzón, MA1
Möller, AD1
Grände, PO1
Bjerner, T1
Henze, A1
Wikström, G1
Brückner, UB1
Tugtekin, IF1
Theisen, M1
Stehr, A1
Ploner, F1
Matura, K1
Ince, C1
Slovin, PN1
Huang, CJ1
Cade, JR1
Wood, CE1
Nasiroglu, O1
Privette, M1
Orbach, P1
Skimming, JW1
Lockowandt, U1
Liska, J1
Sylven, C1
Franco-Cereceda, A1
Arias, C1
Montiel, T1
Quiroz-Báez, R1
Massieu, L1
Henein, M1
Devamanoharan, PS1
Kazama, M1
Tahara, C1
Miyajima, Y1
Endo, Y1
Tanaka, H1
Nakatani, T1
Tajimi, K1
Roth, KS1
Carter, BE1
Higgins, ES1
Szczepaniak, S1
Nowiński, H1
Jeleniewicz, K1
Maciejewska-Kozak, H1
Sadoshima, S1
Nakatomi, Y1
Ooboshi, H1
Fujii, K1
Ishitsuka, T1
Fujishima, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
SURV1VE-Trial - Sustained Inflation and Chest Compression Versus 3:1 Chest Compression to Ventilation Ratio During Cardiopulmonary Resuscitation of Asphyxiated Newborns: A Randomized Controlled Trial[NCT02858583]25 participants (Actual)Interventional2017-10-19Completed
Hyperpolarized MRSI in Ischemic Heart Disease: Metabolic Profiling of the Myocardium[NCT06054516]15 participants (Anticipated)Observational2023-10-13Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for pyruvic acid and Disease Models, Animal

ArticleYear
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
    BioMed research international, 2020, Volume: 2020

    Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models

2020
Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke.
    Translational stroke research, 2014, Volume: 5, Issue:1

    Topics: Animals; Apoptosis; Disease Models, Animal; Humans; Mice; Mitochondria; Neuroprotective Agents; Poly

2014
[Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2015, Volume: 135, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induc

2015
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.
    Molecular psychiatry, 2012, Volume: 17, Issue:3

    Topics: Adenosine Triphosphate; Adolescent; Animals; Biomarkers; Brain; Child; Child Development Disorders,

2012
Is pyruvate an endogenous anti-inflammatory molecule?
    Nutrition (Burbank, Los Angeles County, Calif.), 2006, Volume: 22, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Critical Illness; Cytokines; Disease

2006

Other Studies

229 other studies available for pyruvic acid and Disease Models, Animal

ArticleYear
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions.
    Scientific reports, 2021, 09-23, Volume: 11, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Survival; Citric Acid Cycle; Diabetic Nephropathies

2021
Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model.
    Toxicology and applied pharmacology, 2022, 05-01, Volume: 442

    Topics: Animals; Disease Models, Animal; Female; Glucose; Hippocampus; Humans; Hyperglycemia; Lactic Acid; P

2022
Pyruvate Prevents Dopaminergic Neurodegeneration and Motor Deficits in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease.
    Molecular neurobiology, 2022, Volume: 59, Issue:11

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Disease Models, Ani

2022
High-sensitivity deuterium metabolic MRI differentiates acute pancreatitis from pancreatic cancers in murine models.
    Scientific reports, 2023, Nov-15, Volume: 13, Issue:1

    Topics: Acute Disease; Animals; Deuterium; Disease Models, Animal; Humans; Lactic Acid; Magnetic Resonance I

2023
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.
    EBioMedicine, 2019, Volume: 47

    Topics: Adaptor Proteins, Signal Transducing; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; En

2019
UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia.
    American journal of physiology. Endocrinology and metabolism, 2020, 01-01, Volume: 318, Issue:1

    Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; Corticosterone; Diabetes Melli

2020
Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models.
    Cell reports, 2020, 02-18, Volume: 30, Issue:7

    Topics: Alzheimer Disease; Animals; Disease Models, Animal; Energy Metabolism; Humans; Mitochondria; Pyruvic

2020
Evaluating the potential of hyperpolarised [1-
    Scientific reports, 2020, 03-26, Volume: 10, Issue:1

    Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis

2020
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma.
    Anticancer research, 2020, Volume: 40, Issue:4

    Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease

2020
Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized
    International journal of radiation oncology, biology, physics, 2020, 08-01, Volume: 107, Issue:5

    Topics: Animals; Carbon Isotopes; Disease Models, Animal; Dose-Response Relationship, Radiation; Magnetic Re

2020
Metabolic reprogramming associated with progression of renal ischemia reperfusion injury assessed with hyperpolarized [1-
    Scientific reports, 2020, 06-02, Volume: 10, Issue:1

    Topics: Acute Kidney Injury; Animals; Biomarkers; Creatinine; Disease Models, Animal; Disease Progression; K

2020
Protection from systemic pyruvate at resuscitation in newborn lambs with asphyxial cardiac arrest.
    Physiological reports, 2020, Volume: 8, Issue:12

    Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Disease Models, Animal; Heart Arrest; Hypoxia-I

2020
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
    Scientific reports, 2020, 07-16, Volume: 10, Issue:1

    Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Dis

2020
Pulmonary pyruvate metabolism as an index of inflammation and injury in a rat model of acute respiratory distress syndrome.
    NMR in biomedicine, 2020, Volume: 33, Issue:11

    Topics: Animals; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Adhesion M

2020
Transient Changes of Metabolism at the Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood.
    International journal of molecular sciences, 2020, Sep-29, Volume: 21, Issue:19

    Topics: Acetylation; Animals; Carbohydrate Metabolism; Cytokines; Disease Models, Animal; Embryo, Mammalian;

2020
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-29, Volume: 117, Issue:52

    Topics: Animals; Disease Models, Animal; Glaucoma; Glucose; Intraocular Pressure; Mice, Inbred C57BL; Mice,

2020
Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons.
    Acta neuropathologica communications, 2020, 12-22, Volume: 8, Issue:1

    Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Electron Transport Complex I; Mice; Mice, K

2020
Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models.
    Oncogene, 2021, Volume: 40, Issue:12

    Topics: Adenocarcinoma; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Car

2021
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
    JCI insight, 2021, 05-10, Volume: 6, Issue:9

    Topics: Animals; Cardiolipins; Cardiomegaly; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Digly

2021
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats.
    Scientific reports, 2021, 06-03, Volume: 11, Issue:1

    Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Electromagnetic Fields; Energy

2021
Metabolic imaging with hyperpolarized [1-
    STAR protocols, 2021, 09-17, Volume: 2, Issue:3

    Topics: Animals; Breast Neoplasms; Carbon Isotopes; Disease Models, Animal; Female; Heterografts; Humans; Ma

2021
Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
    NMR in biomedicine, 2021, Volume: 34, Issue:11

    Topics: Alanine; Animals; Bicarbonates; Disease Models, Animal; Enzyme Activation; Glucose; Glycolysis; Hema

2021
Featured Article: Pyruvate preserves antiglycation defenses in porcine brain after cardiac arrest.
    Experimental biology and medicine (Maywood, N.J.), 2017, Volume: 242, Issue:10

    Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Glutathione Reductase; Glyceraldehyde-3-Pho

2017
Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-
    Scientific reports, 2017, 05-15, Volume: 7, Issue:1

    Topics: Animals; Brain Injuries, Traumatic; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; Imag

2017
The effects of acute renal denervation on kidney perfusion and metabolism in experimental septic shock.
    BMC nephrology, 2017, May-31, Volume: 18, Issue:1

    Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Female; Kidney Cortex; Lactic Acid

2017
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells.
    Oncotarget, 2017, Jul-11, Volume: 8, Issue:28

    Topics: Animals; Anion Transport Proteins; Biomarkers; Cell Line, Tumor; Citric Acid Cycle; Disease Models,

2017
Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa.
    BioMed research international, 2017, Volume: 2017

    Topics: Animals; beta-Fructofuranosidase; Cell Proliferation; Disease Models, Animal; Glycine; Injections, I

2017
Placental physiology monitored by hyperpolarized dynamic
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 03-06, Volume: 115, Issue:10

    Topics: Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Female; Humans; Lactic Acid; Magneti

2018
Target and untargeted GC-MS based metabolomic study of mouse optic nerve and its potential in the study of neurological visual diseases.
    Journal of pharmaceutical and biomedical analysis, 2018, May-10, Volume: 153

    Topics: Animals; Biomarkers; Disease Models, Animal; Eye; Female; Gas Chromatography-Mass Spectrometry; Lact

2018
Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach.
    Scientific reports, 2018, 02-23, Volume: 8, Issue:1

    Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Isotopes; Disease Models, Animal; Gene Expression; Hu

2018
Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors.
    Cell death & disease, 2018, 02-27, Volume: 9, Issue:3

    Topics: Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Female;

2018
Cerebral Metabolic Changes Related to Oxidative Metabolism in a Model of Bacterial Meningitis Induced by Lipopolysaccharide.
    Neurocritical care, 2018, Volume: 29, Issue:3

    Topics: Animals; Cerebrum; Disease Models, Animal; Female; Lactic Acid; Lipopolysaccharides; Meningitis, Bac

2018
Pyruvate as a novel carrier of hydroxyethyl starch 130/0.4 may protect kidney in rats subjected to severe burns.
    The Journal of surgical research, 2018, Volume: 225

    Topics: Acute Kidney Injury; Animals; Burns; Critical Illness; Disease Models, Animal; Drug Carriers; Fluid

2018
Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats.
    The Journal of surgical research, 2018, Volume: 226

    Topics: Acidosis, Lactic; Administration, Oral; Animals; Bicarbonates; Burns; Citric Acid; Disease Models, A

2018
Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.
    Molecular imaging and biology, 2019, Volume: 21, Issue:1

    Topics: Animals; Disease Models, Animal; Disease Progression; Heterografts; Humans; Image Enhancement; Lacti

2019
Pyruvate-enriched resuscitation for shock.
    Experimental biology and medicine (Maywood, N.J.), 2018, Volume: 243, Issue:8

    Topics: Administration, Intravenous; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Humans;

2018
Combined hyperpolarized
    European journal of radiology, 2018, Volume: 103

    Topics: Animals; Carbon Isotopes; Cross-Sectional Studies; Disease Models, Animal; Dogs; Female; Fluorodeoxy

2018
Galactose protects against cell damage in mouse models of acute pancreatitis.
    The Journal of clinical investigation, 2018, 08-31, Volume: 128, Issue:9

    Topics: Acinar Cells; Adenosine Triphosphate; Animals; Asparaginase; Disease Models, Animal; Ethanol; Galact

2018
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
    Nature medicine, 2018, Volume: 24, Issue:9

    Topics: Acetyl-CoA Carboxylase; Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dihydro

2018
Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model.
    Journal of proteome research, 2018, 09-07, Volume: 17, Issue:9

    Topics: Animals; Apolipoproteins E; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Collagen; Cytokines; D

2018
Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.
    Molecular imaging and biology, 2019, Volume: 21, Issue:4

    Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Contrast Media; Disease Models,

2019
Efficacy of exogenous pyruvate in Trembler
    Brain and behavior, 2018, Volume: 8, Issue:10

    Topics: Animals; Axons; Charcot-Marie-Tooth Disease; Disease Models, Animal; Mice; Myelin Proteins; Myelin S

2018
A regional bolus tracking and real-time B
    Magnetic resonance in medicine, 2019, Volume: 81, Issue:2

    Topics: Adult; Algorithms; Animals; Brain Mapping; Calibration; Carbon Isotopes; Disease Models, Animal; Hea

2019
3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau.
    Yeast (Chichester, England), 2019, Volume: 36, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Fungi; Glycolysis; Hexokinase; Hu

2019
Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet.
    Molecular brain, 2018, 12-18, Volume: 11, Issue:1

    Topics: Animals; Blood-Brain Barrier; Brain; Carbon Isotopes; Cognitive Dysfunction; Diet, High-Fat; Disease

2018
Hyperpolarized MRI for Studying Tumor Metabolism.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1928

    Topics: Animals; Biomarkers; Data Analysis; Disease Models, Animal; Energy Metabolism; Humans; Kinetics; Lac

2019
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.
    Nature, 2019, Volume: 568, Issue:7750

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Collagen; Disease Models, Animal; Enzyme Activation; Ex

2019
Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo.
    Scientific reports, 2019, 03-06, Volume: 9, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Burns; Culture Media; Disease Models, Animal; Fermentation

2019
Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model.
    Scientific reports, 2019, 03-12, Volume: 9, Issue:1

    Topics: Amino Acids; Ammonia; Ammonium Chloride; Animals; Aspartic Acid; Citrulline; Citrullinemia; Disease

2019
Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity.
    Biochimica et biophysica acta. Molecular basis of disease, 2019, 09-01, Volume: 1865, Issue:9

    Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Hyperoxaluria, Primary; Lactate Dehy

2019
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS.
    eLife, 2019, 06-10, Volume: 8

    Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; DNA-Binding Proteins; Drosophila mel

2019
Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.
    Nature metabolism, 2019, Volume: 1, Issue:1

    Topics: Animals; Biological Transport; Cell Line, Tumor; Disease Models, Animal; Gene Expression Regulation,

2019
Remodeling of substrate consumption in the murine sTAC model of heart failure.
    Journal of molecular and cellular cardiology, 2019, Volume: 134

    Topics: Acetyl Coenzyme A; Animals; Aorta; Citric Acid Cycle; Constriction; Disease Models, Animal; Energy M

2019
Creatine plus pyruvate supplementation prevents oxidative stress and phosphotransfer network disturbances in the brain of rats subjected to chemically-induced phenylketonuria.
    Metabolic brain disease, 2019, Volume: 34, Issue:6

    Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain; Creatine; Disease Models, Animal; Energy Metaboli

2019
Hyperpolarized Pyruvate MR Spectroscopy Depicts Glycolytic Inhibition in a Mouse Model of Glioma.
    Radiology, 2019, Volume: 293, Issue:1

    Topics: Animals; Brain; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal;

2019
Effects of glycine, pyruvate, resveratrol, and nitrite on tissue injury and cytokine response in endotoxemic rats.
    The Journal of surgical research, 2013, Volume: 183, Issue:1

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Cytokines; Disease Models, Animal; Drug Therapy, Combin

2013
3D CMR mapping of metabolism by hyperpolarized 13C-pyruvate in ischemia-reperfusion.
    JACC. Cardiovascular imaging, 2013, Volume: 6, Issue:6

    Topics: Animals; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; Feasibility Studies; Image Inte

2013
Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate.
    NMR in biomedicine, 2013, Volume: 26, Issue:11

    Topics: Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; Heart; In Vitro T

2013
Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats.
    The Journal of emergency medicine, 2013, Volume: 45, Issue:6

    Topics: Acidosis, Lactic; Analysis of Variance; Animals; Arterial Pressure; Carbon Dioxide; Disease Models,

2013
Metabolomics of ginger essential oil against alcoholic fatty liver in mice.
    Journal of agricultural and food chemistry, 2013, Nov-20, Volume: 61, Issue:46

    Topics: Animals; Disease Models, Animal; Fatty Liver, Alcoholic; Humans; Hydroxybenzoates; Liver; Male; Meta

2013
Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
    Experimental neurology, 2014, Volume: 251

    Topics: Adenosine Triphosphate; alpha-Tocopherol; Animals; Ascorbic Acid; Disease Models, Animal; Electric S

2014
Pyruvate administration reduces recurrent/moderate hypoglycemia-induced cortical neuron death in diabetic rats.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Cell Death; Cerebral Cortex; Dendrites; Diabetes Mellitus, Experimental; Diabetes Mellitus,

2013
Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Cell Respiration; Corpus Striatum; Disease Models, Animal; Extracellular Space; Glucose; Gl

2013
Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.
    Nature genetics, 2014, Volume: 46, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; DNA Transposable Elements; Gene Expressi

2014
High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging.
    Kidney international, 2014, Volume: 86, Issue:1

    Topics: Alanine; Altitude; Altitude Sickness; Animals; Atmospheric Pressure; Bicarbonates; Blood Glucose; Di

2014
Effects of eugenol on hepatic glucose production and AMPK signaling pathway in hepatocytes and C57BL/6J mice.
    Fitoterapia, 2014, Volume: 93

    Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Calcium-Calmodulin-Dependent Protein Kinase K

2014
Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats.
    Journal of nutritional science and vitaminology, 2013, Volume: 59, Issue:6

    Topics: Adipates; Animals; Disease Models, Animal; Ketoglutaric Acids; Male; Niacinamide; Oxaloacetic Acid;

2013
Intraperitoneal metabolic consequences of supraceliac aortic balloon occlusion in an experimental animal study using microdialysis.
    Annals of vascular surgery, 2014, Volume: 28, Issue:5

    Topics: Animals; Biomarkers; Disease Models, Animal; Female; Follow-Up Studies; Glucose; Hemodynamics; Lacti

2014
Abdominal hypertension and decompression: the effect on peritoneal metabolism in an experimental porcine study.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2014, Volume: 47, Issue:4

    Topics: Animals; Blood Pressure; Decompression, Surgical; Disease Models, Animal; Female; Glucose; Hemodynam

2014
Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, Volume: 34, Issue:5

    Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Citric Acid Cycle; Disease Models, Animal; Female; ga

2014
Metabolic spectroscopy of inflammation in a bleomycin-induced lung injury model using hyperpolarized 1-(13) C pyruvate.
    NMR in biomedicine, 2014, Volume: 27, Issue:8

    Topics: Analysis of Variance; Animals; Bleomycin; Carbon Isotopes; Disease Models, Animal; Inflammation; Lac

2014
Xanthan gum as an adjuvant in a subunit vaccine preparation against leptospirosis.
    BioMed research international, 2014, Volume: 2014

    Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antigens, Bacterial; Bacterial Vaccines; Cell D

2014
Metabolomic signatures in peripheral blood associated with Alzheimer's disease amyloid-β-induced neuroinflammation.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 42, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Disease Models, Animal; Encephalitis;

2014
Effects of pyruvate-enriched peritoneal dialysis solution on intestinal barrier in peritoneal resuscitation from hemorrhagic shock in rats.
    The Journal of surgical research, 2015, Volume: 193, Issue:1

    Topics: Animals; Blood Pressure; Cell Adhesion Molecules; Dialysis Solutions; Disease Models, Animal; Intest

2015
Pyruvate oral rehydration solution improved visceral function and survival in shock rats.
    The Journal of surgical research, 2015, Volume: 193, Issue:1

    Topics: Acidosis, Lactic; Animals; Bicarbonates; Disease Models, Animal; Fluid Therapy; Glucose; Lipid Perox

2015
Behavioral extremes of trait anxiety in mice are characterized by distinct metabolic profiles.
    Journal of psychiatric research, 2014, Volume: 58

    Topics: Amino Acids; Animals; Anxiety; Behavior, Animal; Computer Simulation; Disease Models, Animal; Gyrus

2014
Effect of rhubarb pre-treatment on intestinal microcirculation in septic rats.
    The American journal of Chinese medicine, 2014, Volume: 42, Issue:5

    Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dobutamine; Endothelial Cells;

2014
Lactate dehydrogenase is the key enzyme for pneumococcal pyruvate metabolism and pneumococcal survival in blood.
    Infection and immunity, 2014, Volume: 82, Issue:12

    Topics: Animals; Bacteremia; Blood; Disease Models, Animal; Female; Fermentation; Gene Deletion; L-Lactate D

2014
Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology.
    Neurobiology of disease, 2015, Volume: 81

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Cerebral Cortex;

2015
Brain glucose metabolism in an animal model of depression.
    Neuroscience, 2015, Jun-04, Volume: 295

    Topics: Administration, Oral; Animals; Brain; Depression; Disease Models, Animal; Female; Glucose; Glucoseph

2015
Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015, Volume: 116, Issue:3

    Topics: Animals; Carbon Isotopes; Disease Models, Animal; Fibrosarcoma; Hypoxia; Lactic Acid; Magnetic Reson

2015
Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Animals; Disease Models, Animal; Dynamins; Dystrophin; Energy Metabolism; Glucose; GTP Phosphohydrol

2015
Is microdialysis useful for early detection of acute rejection after kidney transplantation?
    International journal of surgery (London, England), 2015, Volume: 18

    Topics: Acute Disease; Animals; Biomarkers; Disease Models, Animal; Early Diagnosis; Glucose; Glycerol; Graf

2015
The brain metabolic activity after resuscitation with liposome-encapsulated hemoglobin in a rat model of hypovolemic shock.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:9

    Topics: Adenosine Triphosphate; Animals; Blood Substitutes; Brain; Citrate (si)-Synthase; Disease Models, An

2015
Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.
    Acta neuropathologica communications, 2015, May-14, Volume: 3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Ascorbic Acid; Cell

2015
Systemic pyruvate administration markedly reduces neuronal death and cognitive impairment in a rat model of Alzheimer's disease.
    Experimental neurology, 2015, Volume: 271

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cognition Disorders; Disease Models,

2015
Hemorrhagic shock-induced cerebral bioenergetic imbalance is corrected by pharmacologic treatment with EF24 in a rat model.
    Neuropharmacology, 2015, Volume: 99

    Topics: Adenosine Triphosphate; Animals; Benzylidene Compounds; Brain; Brain-Derived Neurotrophic Factor; Di

2015
Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia.
    Journal of inherited metabolic disease, 2016, Volume: 39, Issue:1

    Topics: Adenosine Triphosphate; Anesthesia; Animals; Brain; Disease Models, Animal; Electron Transport Compl

2016
AβPP-Transgenic 2576 Mice Mimic Cell Type-Specific Aspects of Acetyl-CoA-Linked Metabolic Deficits in Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2015, Volume: 48, Issue:4

    Topics: Acetyl Coenzyme A; Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Pre

2015
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
    Toxicology letters, 2016, Jan-05, Volume: 240, Issue:1

    Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas

2016
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
    Journal of immunology (Baltimore, Md. : 1950), 2016, Jan-01, Volume: 196, Issue:1

    Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Aci

2016
Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.
    Scientific reports, 2015, Nov-30, Volume: 5

    Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Bile Acids and Salts; Blood Gluco

2015
Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Diet; Dietary Sucrose; Disease Models, Animal; Drosophila; Female; Lactic Acid; Male; Mitoc

2016
Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Brain Stem; Cell Respiration; Cerebellum; Disease Models, Animal; Electron Transport Comple

2016
Pyruvate treatment attenuates cerebral metabolic depression and neuronal loss after experimental traumatic brain injury.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: Animals; Brain Injuries, Traumatic; Cell Survival; Cerebral Cortex; Disease Models, Animal; Glucose;

2016
Mitochondrial Dysfunction during the Early Stages of Excitotoxic Spinal Motor Neuron Degeneration in Vivo.
    ACS chemical neuroscience, 2016, 07-20, Volume: 7, Issue:7

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Excitator

2016
Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs.
    Burns : journal of the International Society for Burn Injuries, 2016, Volume: 42, Issue:4

    Topics: Animals; Bicarbonates; Burns; Capillary Permeability; Disease Models, Animal; Dogs; Fluid Therapy; F

2016
Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial.
    PloS one, 2016, Volume: 11, Issue:5

    Topics: Animals; Biomarkers; Blood Pressure; CA1 Region, Hippocampal; Cardiopulmonary Resuscitation; Cerebra

2016
The Role of Pyruvate in Protecting 661W Photoreceptor-Like Cells Against Light-Induced Cell Death.
    Current eye research, 2016, Volume: 41, Issue:11

    Topics: Animals; Cell Count; Cell Death; Cell Line; Disease Models, Animal; Light; Mice; Oxidative Stress; P

2016
Optimizing Flip Angles for Metabolic Rate Estimation in Hyperpolarized Carbon-13 MRI.
    IEEE transactions on medical imaging, 2016, Volume: 35, Issue:11

    Topics: Algorithms; Animals; Carbon Isotopes; Computer Simulation; Disease Models, Animal; Image Processing,

2016
Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model.
    Toxicology, 2016, 06-01, Volume: 359-360

    Topics: Adenosine Triphosphate; Animals; Atorvastatin; Creatine Kinase; Disease Models, Animal; Hydroxymethy

2016
Time-course metabolic changes in high-fat diet-induced obesity rats: A pilot study using hyperpolarized (13)C dynamic MRS.
    Magnetic resonance imaging, 2016, Volume: 34, Issue:8

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Body Weight; Diet, High-Fat;

2016
The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.
    American journal of physiology. Heart and circulatory physiology, 2016, 09-01, Volume: 311, Issue:3

    Topics: Adenosine Triphosphate; Animals; Apoptosis Regulatory Proteins; Aryl Hydrocarbon Receptor Nuclear Tr

2016
In situ lactate dehydrogenase activity: a novel renal cortical imaging biomarker of tubular injury?
    American journal of physiology. Renal physiology, 2017, 03-01, Volume: 312, Issue:3

    Topics: Acute Kidney Injury; Alanine; Animals; Bicarbonates; Biomarkers; Carbon Isotopes; Disease Models, An

2017
Addition of Sodium Pyruvate to Stored Red Blood Cells Attenuates Liver Injury in a Murine Transfusion Model.
    Mediators of inflammation, 2016, Volume: 2016

    Topics: Animals; Blood Preservation; Blood Transfusion; Disease Models, Animal; Erythrocytes; Hemoglobins; H

2016
Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study.
    The journal of trauma and acute care surgery, 2016, Volume: 81, Issue:5

    Topics: Animals; Brain; Disease Models, Animal; Glucose; Head Injuries, Penetrating; Hypoxia; Lactic Acid; M

2016
Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study.
    Neurochemistry international, 2017, Volume: 102

    Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Glucose; Glutamic Acid; Glutamine

2017
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.
    Science translational medicine, 2016, 12-07, Volume: 8, Issue:368

    Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Autophagy; Behavior, Animal; Brain; Caenorhab

2016
Metabolic gatekeeper function of B-lymphoid transcription factors.
    Nature, 2017, 02-23, Volume: 542, Issue:7642

    Topics: Adenosine Triphosphate; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals

2017
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
    Nature communications, 2017, 02-16, Volume: 8

    Topics: Adenine Nucleotide Translocator 2; Adenosine Triphosphate; Animals; Atractyloside; Diet, High-Fat; D

2017
Malignant infarction of the middle cerebral artery in a porcine model. A pilot study.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Animals; Brain; Disease Models, Animal; Female; Gene Expression; Glucose; Glycerol; Immunohistochemi

2017
Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:1

    Topics: Animals; Auranofin; Blotting, Western; Disease Models, Animal; Heart Failure; Isotretinoin; Kv Chann

2008
Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma.
    Journal of neurosurgery, 2008, Volume: 109, Issue:4

    Topics: Acute Disease; Animals; Brain Injuries; Disease Models, Animal; Energy Metabolism; Erythropoietin; G

2008
The impact of obesity, sex, and diet on hepatic glucose production in cats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:4

    Topics: Animals; Blood Glucose; Body Mass Index; Body Weight; Carbon Isotopes; Cats; Citrate (si)-Synthase;

2009
Cerebral energy failure following experimental cardiac arrest Hypothermia treatment reduces secondary lactate/pyruvate-ratio increase.
    Resuscitation, 2009, Volume: 80, Issue:5

    Topics: Animals; Brain; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Disease

2009
Transient benefits but lack of protection by sodium pyruvate after 2-hour middle cerebral artery occlusion in the rat.
    Brain research, 2009, May-26, Volume: 1272

    Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Brain Infarction; Disease Models, Animal; Inf

2009
Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:1

    Topics: Animals; Asphyxia; Biomarkers; Blood Flow Velocity; Blood Pressure; Brain; Carbon Dioxide; Cerebrova

2009
Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.
    Neurobiology of disease, 2009, Volume: 36, Issue:1

    Topics: Animals; Body Weight; Cell Count; Disease Models, Animal; Ectodysplasins; Encephalitis; Infarction,

2009
[Effects of ethyl pyruvate on injuries of sepsis in mice].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2009, Volume: 21, Issue:8

    Topics: Alkaline Phosphatase; Animals; Disease Models, Animal; Intestines; Lactic Acid; Lung; Male; Mice; Py

2009
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.
    Analytical and bioanalytical chemistry, 2009, Volume: 395, Issue:4

    Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine

2009
Effect of speed of rewarming and administration of anti-inflammatory or anti-oxidant agents on acute lung injury in an intestinal ischemia model treated with therapeutic hypothermia.
    Resuscitation, 2010, Volume: 81, Issue:1

    Topics: Acetylcysteine; Acute Lung Injury; Animals; Dexamethasone; Disease Models, Animal; Hypothermia, Indu

2010
Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders.
    Biological psychiatry, 2010, May-01, Volume: 67, Issue:9

    Topics: Aggrecans; Animals; Animals, Newborn; Brain; Calbindins; Cells, Cultured; Cerebellum; Developmental

2010
Fetal cerebral energy metabolism and electrocardiogram during experimental umbilical cord occlusion and resuscitation.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2010, Volume: 23, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Cardiopulmonary Resuscitation; Disease Models, Animal; Electrocardi

2010
Reduced caloric intake during endotoxemia reduces arginine availability and metabolism.
    The American journal of clinical nutrition, 2010, Volume: 91, Issue:4

    Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Endotoxins; Energy Intake; Escherichia coli;

2010
T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate.
    NMR in biomedicine, 2010, Volume: 23, Issue:4

    Topics: Alanine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Disease Models, Animal; Liver Neoplasm

2010
Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock.
    Military medicine, 2010, Volume: 175, Issue:3

    Topics: Animals; Disease Models, Animal; Drug Combinations; Fluid Therapy; Goats; Hemodynamics; Inflammation

2010
Inhibition of acute lung inflammation and injury is a target of brain cooling after heatstroke injury.
    The Journal of trauma, 2010, Volume: 69, Issue:4

    Topics: Acute Lung Injury; Animals; Body Temperature Regulation; Brain; Bronchoalveolar Lavage Fluid; Cytoki

2010
Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain.
    Brain research, 2010, Aug-06, Volume: 1347

    Topics: Analysis of Variance; Animals; Brain; Cold Temperature; Disease Models, Animal; Energy Metabolism; G

2010
Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia.
    Resuscitation, 2010, Volume: 81, Issue:11

    Topics: Analysis of Variance; Animals; Animals, Newborn; Asphyxia; Bronchoalveolar Lavage Fluid; Disease Mod

2010
Venous obstruction and cerebral perfusion during experimental cardiopulmonary bypass.
    Interactive cardiovascular and thoracic surgery, 2010, Volume: 11, Issue:5

    Topics: Animals; Biomarkers; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Cardiopulmonary Bypass; Cent

2010
Partial liver ischemia is followed by metabolic changes in the normally perfused part of the liver during reperfusion.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2010, Volume: 45, Issue:2

    Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Glucose; Glycerol; Humans; Ischemia;

2010
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
    Upsala journal of medical sciences, 2010, Volume: 115, Issue:4

    Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant

2010
Pyruvate attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Disease Models, Animal; Heart; Hemodynamics;

2012
Detection of myocardial ischaemia using surface microdialysis on the beating heart.
    Clinical physiology and functional imaging, 2011, Volume: 31, Issue:3

    Topics: Animals; Biomarkers; Disease Models, Animal; Energy Metabolism; Female; Glucose; Glycerol; Lactic Ac

2011
[Protective effect of sodium pyruvate on ischemia/reperfusion injury of rats subjected to hemorrhagic shock].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2007, Volume: 23, Issue:3

    Topics: Animals; Aspartate Aminotransferases; Disease Models, Animal; Kidney; L-Lactate Dehydrogenase; Liver

2007
Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats.
    Neurochemistry international, 2011, Volume: 58, Issue:3

    Topics: Animals; Disease Models, Animal; Male; Nerve Degeneration; Neuroprotective Agents; Oxaloacetic Acid;

2011
Delayed sodium pyruvate treatment improves working memory following experimental traumatic brain injury.
    Neuroscience letters, 2011, Mar-17, Volume: 491, Issue:2

    Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Male; Maze Learning; Memory, Short

2011
The influence of diabetes on glutamate metabolism in retinas.
    Journal of neurochemistry, 2011, Volume: 117, Issue:2

    Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Disease Models, Animal; Glutamic Acid; In

2011
Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.
    World journal of gastroenterology, 2011, Mar-21, Volume: 17, Issue:11

    Topics: Acetaminophen; Amino Acids; Animals; Biomarkers; Citric Acid Cycle; Disease Models, Animal; Gluconeo

2011
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
    Neuroscience letters, 2011, Jul-25, Volume: 499, Issue:3

    Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio

2011
Detection of tumor glutamate metabolism in vivo using (13)C magnetic resonance spectroscopy and hyperpolarized [1-(13)C]glutamate.
    Magnetic resonance in medicine, 2011, Volume: 66, Issue:1

    Topics: Alanine Transaminase; Animals; Carbon Isotopes; Cell Survival; Disease Models, Animal; Glutamic Acid

2011
Using microdialysis for early detection of vascular thrombosis after kidney transplantation in an experimental porcine model.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:2

    Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Blood Glucose; Disease Models, Animal; Ea

2012
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
    Cell metabolism, 2011, Jul-06, Volume: 14, Issue:1

    Topics: Alanine; Animals; Carbon Isotopes; Citric Acid Cycle; Disease Models, Animal; Gene Expression Profil

2011
Microdialysis detection of lactate in subcutaneous tissue as a reliable indicator of tissue metabolic disorders in an animal sepsis model.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2011, Volume: 47, Issue:1

    Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Lactic Acid; Lipopolysaccharides; Male; Microdi

2011
Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes?
    Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:7

    Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease

2011
Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain.
    Neuropharmacology, 2011, Volume: 61, Issue:8

    Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Brain; Caspa

2011
Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency.
    Molecular genetics and metabolism, 2011, Volume: 104, Issue:4

    Topics: Ammonia; Animals; Calcium-Binding Proteins; Citric Acid Cycle; Disease Models, Animal; Electrophores

2011
Pyruvate's blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke.
    The European journal of neuroscience, 2011, Volume: 34, Issue:9

    Topics: Animals; Aspartate Aminotransferases; Brain Edema; Brain Infarction; Disease Models, Animal; Dose-Re

2011
Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats.
    Acta cirurgica brasileira, 2011, Volume: 26 Suppl 1

    Topics: Animals; Calcium Carbonate; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Ischemia;

2011
Cerebral metabolism after early decompression craniotomy following controlled cortical impact injury in rats.
    Neurological research, 2011, Volume: 33, Issue:8

    Topics: Animals; Brain Injuries; Cerebral Cortex; Craniotomy; Decompression, Surgical; Disease Models, Anima

2011
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-02, Volume: 31, Issue:44

    Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analys

2011
Measuring mitochondrial respiration in intact single muscle fibers.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Mar-15, Volume: 302, Issue:6

    Topics: Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration; Cells, Cultured; Dise

2012
Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.
    Magnetic resonance imaging, 2012, Volume: 30, Issue:3

    Topics: Animals; Carbon Isotopes; Contrast Media; Cyclopropanes; Disease Models, Animal; Imaging, Three-Dime

2012
Cerebrospinal fluid biochemistry reflects effects of therapeutic hypothermia after cardiac arrest in a porcine model.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:8

    Topics: Animals; Body Temperature; Disease Models, Animal; Glucose; Glutamic Acid; Glycerol; Heart Arrest; H

2012
Pyruvate protects the brain against ischemia-reperfusion injury by activating the erythropoietin signaling pathway.
    Stroke, 2012, Volume: 43, Issue:4

    Topics: Animals; Brain; Cell Line, Tumor; Disease Models, Animal; Erythropoietin; Gene Expression Regulation

2012
Surface microdialysis sampling: a new approach described in a liver ischaemia model.
    Clinical physiology and functional imaging, 2012, Volume: 32, Issue:2

    Topics: Animals; Disease Models, Animal; Energy Metabolism; Female; Glucose; Glycerol; Ischemia; Lactic Acid

2012
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
    Neurocritical care, 2012, Volume: 16, Issue:3

    Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr

2012
[Effects of acetoacetate extract of Radix Aconite on hepatic contents of LA, LDH, PA, Gn and ATPase activities in deficient cold model rats].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2011, Volume: 31, Issue:11

    Topics: Acetoacetates; Adenosine Triphosphatases; Animals; Disease Models, Animal; Diterpenes; Drugs, Chines

2011
Pressure reactivity index correlates with metabolic dysfunction in a porcine model of intracerebral hemorrhage.
    Acta neurochirurgica. Supplement, 2012, Volume: 114

    Topics: Animals; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; G

2012
Metabolic adaptation to chronic hypoxia in cardiac mitochondria.
    Basic research in cardiology, 2012, Volume: 107, Issue:3

    Topics: Aconitate Hydratase; Adaptation, Physiological; Animals; Cell Respiration; Chronic Disease; Disease

2012
Mitochondrial inhibitor models of Huntington's disease and Parkinson's disease induce zinc accumulation and are attenuated by inhibition of zinc neurotoxicity in vitro or in vivo.
    Neuro-degenerative diseases, 2013, Volume: 11, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carrier Proteins; Cation Transport Proteins;

2013
Early detection of subclinical organ dysfunction by microdialysis of the rectus abdominis muscle in a porcine model of critical intra-abdominal hypertension.
    Shock (Augusta, Ga.), 2012, Volume: 38, Issue:4

    Topics: Animals; Disease Models, Animal; Intra-Abdominal Hypertension; Lactic Acid; Male; Microdialysis; Pyr

2012
The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2012, Volume: 9, Issue:3

    Topics: Animals; Antioxidants; Blood-Brain Barrier; Disease Models, Animal; Glutamic Acid; Male; Nervous Sys

2012
Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
    Molecular genetics and metabolism, 2012, Volume: 107, Issue:3

    Topics: Alanine; Animals; Body Weight; Cholestasis, Intrahepatic; Citrullinemia; Dietary Proteins; Disease M

2012
Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.
    European journal of heart failure, 2013, Volume: 15, Issue:2

    Topics: Adenosine Triphosphate; Animals; Bicarbonates; Carbon Isotopes; Cardiac Pacing, Artificial; Cardiac

2013
NAD(+) maintenance attenuates light induced photoreceptor degeneration.
    Experimental eye research, 2013, Volume: 108

    Topics: Animals; Antioxidants; Cell Death; Cells, Cultured; Circadian Rhythm; Cytoprotection; Disease Models

2013
Imaging the cardiac diet.
    European journal of heart failure, 2013, Volume: 15, Issue:2

    Topics: Animals; Cardiomyopathy, Dilated; Disease Models, Animal; Energy Metabolism; Glycolysis; Heart Failu

2013
Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs.
    Acta neurochirurgica. Supplement, 2002, Volume: 81

    Topics: Analysis of Variance; Animals; Caspase Inhibitors; Cerebral Hemorrhage; Disease Models, Animal; Dogs

2002
Intraperitoneal microdialysis for detection of splanchnic metabolic disorders.
    Langenbeck's archives of surgery, 2002, Volume: 387, Issue:7-8

    Topics: Animals; Ascitic Fluid; Cryoprotective Agents; Disease Models, Animal; Extracellular Space; Gastroin

2002
Metabolic phenotyping of the diseased rat heart using 13C-substrates and ex vivo perfusion in the working mode.
    Molecular and cellular biochemistry, 2003, Volume: 242, Issue:1-2

    Topics: Animals; Carbon Isotopes; Citric Acid; Disease Models, Animal; Energy Metabolism; In Vitro Technique

2003
Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs.
    The Journal of thoracic and cardiovascular surgery, 2003, Volume: 125, Issue:3

    Topics: Animals; Brain Chemistry; Brain Ischemia; Calcium; Creatine Kinase; Creatine Kinase, MB Form; Diseas

2003
Paradoxical effects of pyruvate on cardiac contractile function under normal and high glucose in ventricular myocytes.
    Pharmacological research, 2003, Volume: 48, Issue:1

    Topics: Analysis of Variance; Animals; Cells, Cultured; Diabetes Mellitus; Disease Models, Animal; Glucose;

2003
Intraperitoneal microdialysis (IPM): a new technique for monitoring intestinal ischemia studied in a porcine model.
    Shock (Augusta, Ga.), 2003, Volume: 20, Issue:1

    Topics: Animals; Catheterization; Disease Models, Animal; Female; Glucose; Glycerol; Intestinal Mucosa; Inte

2003
Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease.
    Experimental neurology, 2003, Volume: 183, Issue:2

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrat

2003
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
    Journal of neurotrauma, 2003, Volume: 20, Issue:12

    Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac

2003
Experimental evaluation of the influence of complete artificial circulation on renal circulation and tissue metabolism -comparative study of pulsatile vs nonpulsatile circulation.
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2003, Volume: 9, Issue:6

    Topics: Analysis of Variance; Animals; beta 2-Microglobulin; Blood Urea Nitrogen; Creatinine; Disease Models

2003
Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease.
    Experimental neurology, 2004, Volume: 187, Issue:1

    Topics: Animals; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Guanidines; Huntingt

2004
Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivo.
    Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:5

    Topics: Adenosine Triphosphate; Animals; Cell Culture Techniques; Cell Survival; Chlorides; Cytoprotection;

2004
Comparison of short- and long-duration oxygen treatment after cerebral asphyxia in newborn piglets.
    Pediatric research, 2004, Volume: 56, Issue:1

    Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascula

2004
New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue.
    Critical care medicine, 2005, Volume: 33, Issue:4

    Topics: Animals; Blood Substitutes; Carbohydrate Metabolism; Cattle; Cricetinae; Critical Illness; Disease M

2005
Resuscitation from experimental heatstroke by hyperbaric oxygen therapy.
    Critical care medicine, 2005, Volume: 33, Issue:4

    Topics: Animals; Biomarkers; Brain Diseases; Disease Models, Animal; Glutamic Acid; Glycerol; Heat Stroke; H

2005
Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment.
    Diabetes, 2005, Volume: 54, Issue:5

    Topics: Animals; Cell Death; Cognition Disorders; Disease Models, Animal; Hypoglycemia; Insulin; Ketoglutari

2005
Characterizing lung metabolism with carbon-13 magnetic resonance spectroscopy in a small-animal model: evidence of gluconeogenesis during hypothermic storage.
    Transplantation, 2005, Aug-15, Volume: 80, Issue:3

    Topics: Animals; Carbon Isotopes; Dextrans; Disease Models, Animal; Gluconeogenesis; Glucose; Glycogen; Hypo

2005
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:4

    Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid;

2005
Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2006, Volume: 220, Issue:1

    Topics: Animals; Cataract; Culture Media; Disease Models, Animal; Lens, Crystalline; Mice; Oxidative Stress;

2006
Resuscitation of severe but brief haemorrhagic shock with PFC in rabbits restores skeletal muscle oxygen delivery and does not alter skeletal muscle metabolism.
    Resuscitation, 2006, Volume: 70, Issue:1

    Topics: Animals; Blood Pressure; Blood Substitutes; Disease Models, Animal; Fluorocarbons; Hyperoxia; Lactic

2006
Changes in diffusion parameters, energy-related metabolites and glutamate in the rat cortex after transient hypoxia/ischemia.
    Neuroscience letters, 2006, Aug-14, Volume: 404, Issue:1-2

    Topics: Animals; Cerebral Cortex; Disease Models, Animal; Energy Metabolism; Extracellular Space; Glucose; G

2006
Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease.
    Neuroscience, 2006, Sep-15, Volume: 141, Issue:4

    Topics: Analysis of Variance; Animals; Blotting, Western; Cell Death; Cyclooxygenase 2; Disease Models, Anim

2006
Fructose-1,6-bisphosphate supports cerebral energy metabolism in pigs after ischemic brain injury caused by experimental particle embolization.
    The heart surgery forum, 2006, Volume: 9, Issue:6

    Topics: Animals; Brain; Brain Ischemia; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal

2006
Brain metabolism and extracellular space diffusion parameters during and after transient global hypoxia in the rat cortex.
    Experimental neurology, 2007, Volume: 203, Issue:1

    Topics: Animals; Cerebral Cortex; Diffusion; Disease Models, Animal; Down-Regulation; Energy Metabolism; Ext

2007
Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model.
    Neuroscience letters, 2007, Feb-21, Volume: 413, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Disease Models, Animal; Disease Progre

2007
The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid.
    Epilepsia, 2007, Volume: 48, Issue:4

    Topics: Acetone; Animals; Anticonvulsants; Diet Therapy; Disease Models, Animal; Epilepsy; Ketone Bodies; Ma

2007
Evaluating tissue perfusion using labelled water indicator microdialysis in a rat model of haemorrhagic shock.
    Physiological measurement, 2007, Volume: 28, Issue:6

    Topics: Animals; Blood Pressure; Disease Models, Animal; Lactic Acid; Liver; Male; Microdialysis; Muscle, Sk

2007
Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2007, Volume: 77, Issue:1

    Topics: Animals; Body Weight; Bread; Cerebellum; Diet; Disease Models, Animal; Glucose; Glutamic Acid; Kidne

2007
Antioxidant strategies based on tomato-enriched food or pyruvate do not affect disease onset and survival in an animal model of amyotrophic lateral sclerosis.
    Brain research, 2007, Sep-07, Volume: 1168

    Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Carotenoids; Disease Models, Ani

2007
Brain metabolism during a decrease in cerebral perfusion pressure caused by an elevated intracranial pressure in the porcine neocortex.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:3

    Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Glutamic Acid

2007
The control of hepatic glycogen metabolism in an in vitro model of sepsis.
    Molecular and cellular biochemistry, 2008, Volume: 308, Issue:1-2

    Topics: Adenylate Kinase; Animals; Cytokines; Disease Models, Animal; Glucose; Glucose-6-Phosphate; Glycogen

2008
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
    Intensive care medicine, 2008, Volume: 34, Issue:3

    Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl

2008
Neuroprotective effect of deep hypothermic circulatory arrest with low priming volume: study in a rabbit model.
    The Thoracic and cardiovascular surgeon, 2008, Volume: 56, Issue:3

    Topics: Animals; Blood Volume; Brain Ischemia; Chromatography, High Pressure Liquid; Circulatory Arrest, Dee

2008
Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:7

    Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Endotoxemia; Glucose; Lactic Acid; M

2008
Prevention of oxidative stress to the retina by pyruvate. A preliminary report.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2008, Volume: 222, Issue:3

    Topics: Animals; Biomarkers; Disease Models, Animal; Malondialdehyde; Mice; Oxidative Stress; Pyruvic Acid;

2008
Evaluation of sodium acetate as a source of alkali therapy in an experimental aerobic model of lactic acidosis due to decreased pyruvate oxidation.
    Metabolism: clinical and experimental, 1982, Volume: 31, Issue:6

    Topics: Acetates; Acidosis; Aminooxyacetic Acid; Animals; Coumaric Acids; Disease Models, Animal; Glucose; L

1982
Dynamics of myocardial metabolism in the preconditioned porcine heart studied using continuous microdialysis.
    European heart journal, 1995, Volume: 16, Issue:4

    Topics: Adenine Nucleotides; Animals; Cardiac Output; Chromatography, High Pressure Liquid; Disease Models,

1995
Concentrations of catecholamines in transplanted hearts after extracorporeal perfusion and cold storage.
    Heart and vessels, 1995, Volume: 10, Issue:3

    Topics: Animals; Cold Temperature; Disease Models, Animal; Heart Transplantation; Lactates; Lactic Acid; Mal

1995
Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock.
    The Journal of trauma, 1993, Volume: 35, Issue:5

    Topics: Animals; Diltiazem; Disease Models, Animal; Gluconeogenesis; Glucose; Isotonic Solutions; Lactates;

1993
Substrate-induced changes in the lipid content of ischemic and reperfused myocardium. Its relation to hemodynamic recovery.
    Circulation research, 1993, Volume: 72, Issue:1

    Topics: Animals; Disease Models, Animal; Fatty Acids; Glucose; Glycerol; Heart; Lactates; Lactic Acid; Male;

1993
Hemodynamic effects of pyruvate infusion in dogs.
    Journal of critical care, 1995, Volume: 10, Issue:4

    Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Dogs; Dose-Response Relationship, D

1995
Effects of copper, iron and fluoride co-crystallized with sugar on caries development and acid formation in deslivated rats.
    Archives of oral biology, 1996, Volume: 41, Issue:11

    Topics: Acetates; Acids; Animals; Butyrates; Cariogenic Agents; Cariostatic Agents; Colony Count, Microbial;

1996
Renal circulation and cellular metabolism during left ventricular assisted circulation: comparison study of pulsatile and nonpulsatile assists.
    Artificial organs, 1997, Volume: 21, Issue:7

    Topics: Animals; beta 2-Microglobulin; Blood Pressure; Blood Urea Nitrogen; Creatinine; Disease Models, Anim

1997
Markers of cellular dysoxia during orthotopic liver transplantation in pigs.
    Intensive care medicine, 1998, Volume: 24, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biomarkers; Carnitine; Cell Hypoxia; Cytosol; Disease

1998
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
    The Journal of trauma, 1999, Volume: 46, Issue:2

    Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An

1999
Microdialysis of the spinal cord during thoracic aortic cross-clamping in a porcine model.
    Spinal cord, 2000, Volume: 38, Issue:3

    Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Glucose; Glutamic Acid; Lactic Acid; Microdialysis

2000
Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost.
    Intensive care medicine, 2000, Volume: 26, Issue:10

    Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Ener

2000
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
    Journal of neurochemistry, 2001, Volume: 76, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease

2001
Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs.
    Neurological research, 2001, Volume: 23, Issue:1

    Topics: Animals; Basilar Artery; Caspase Inhibitors; Caspases; Cerebrospinal Fluid; Disease Models, Animal;

2001
Dysfunctional mitochondrial respiration in the wobbler mouse brain.
    Neuroscience letters, 2001, Mar-16, Volume: 300, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Animals; Ascorbic Acid; Brain; Cell Respiration; Disease Models, Anim

2001
Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables.
    Critical care medicine, 2001, Volume: 29, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Gas Analysis; Cats; Constriction, Pathologic; Disease Models

2001
Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation.
    Acta physiologica Scandinavica, 2001, Volume: 171, Issue:2

    Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Dialysis Solutions; Disease Models, Animal

2001
Hepatic oxygen exchange and energy metabolism in hyperdynamic porcine endotoxemia: effects of the combined thromboxane receptor antagonist and synthase inhibitor DTTX30.
    Intensive care medicine, 2001, Volume: 27, Issue:2

    Topics: Animals; Blood Gas Analysis; Blood Glucose; Chlorobenzenes; Disease Models, Animal; Drug Evaluation,

2001
Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs.
    Intensive care medicine, 2001, Volume: 27, Issue:4

    Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Escherichia coli I

2001
Protection by pyruvate against transient forebrain ischemia in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-15, Volume: 21, Issue:20

    Topics: Animals; Astrocytes; Calcium; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; In

2001
Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock.
    Resuscitation, 2001, Volume: 50, Issue:1

    Topics: Animals; Blood Glucose; Cardiotonic Agents; Disease Models, Animal; Lactic Acid; Male; Pyruvic Acid;

2001
Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis.
    Scandinavian cardiovascular journal : SCJ, 2002, Volume: 36, Issue:1

    Topics: Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Female; Glutamic Acid; Glycerol; Hemodyn

2002
beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease.
    Experimental neurology, 2002, Volume: 176, Issue:1

    Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; D

2002
Prevention of galactose cataract by pyruvate.
    Lens and eye toxicity research, 1992, Volume: 9, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cataract; Crystallins; Diet; Disease Models, Animal; Galactitol; Ga

1992
[Improving effect of the synthetic protease inhibitor E-3123 on experimental DIC in dogs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1992, Volume: 100, Issue:1

    Topics: Animals; Blood Coagulation Tests; Disease Models, Animal; Disseminated Intravascular Coagulation; Do

1992
Succinylacetone effects on renal tubular phosphate metabolism: a model for experimental renal Fanconi syndrome.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1991, Volume: 196, Issue:4

    Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Disease Models, Animal; Fanconi Syndrome; Glutamat

1991
[Pyruvic acid in the rat liver and myocardium after acute chlorfenvinphos poisoning].
    Roczniki Panstwowego Zakladu Higieny, 1991, Volume: 42, Issue:2

    Topics: Acute Disease; Animals; Chlorfenvinphos; Disease Models, Animal; Heart; Liver; Male; Myocardium; Pyr

1991
Effect of recirculation on the recovery of cerebral metabolism after experimental cerebral ischemia in male and female spontaneously hypertensive rats.
    Gerontology, 1988, Volume: 34, Issue:4

    Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Cerebral Arteries; Cerebrov

1988