pyruvic acid has been researched along with Disease Exacerbation in 16 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute kidney injury is a major clinical challenge affecting as many as 1 percent of all hospitalized patients." | 1.56 | Metabolic reprogramming associated with progression of renal ischemia reperfusion injury assessed with hyperpolarized [1- ( Bertelsen, LB; Laustsen, C; Nielsen, PM; Qi, H, 2020) |
| "We hypothesized that the progression of bladder cancer could be accompanied by changes in cells glycolytic profile." | 1.42 | The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism. ( Alves, MG; Conde, VR; Nunes, AR; Oliveira, PF; Pereira, JA; Ramalhosa, E; Rocha, CS; Silva, BM, 2015) |
| "Although evidence that type 2 diabetes mellitus (T2DM) is accompanied by mitochondrial dysfunction in skeletal muscle has been accumulating, a causal link between mitochondrial dysfunction and the pathogenesis of the disease remains unclear." | 1.40 | Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. ( Affolter, A; Clanachan, AS; Hersberger, M; Lemieux, H; Lou, PH; Lucchinetti, E; Warren, BE; Zaugg, M; Zhang, L, 2014) |
| "Progressive graded hypoxemia was induced by decreasing fractional inspiratory oxygen concentration (FIO2) from 1." | 1.30 | Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets. ( Blanco, CE; Maertzdorf, WJ; van der Hoeven, MA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, J | 1 |
| Quan, M | 1 |
| Xie, D | 1 |
| Gao, Y | 1 |
| Guha, S | 1 |
| Fallon, MB | 1 |
| Chen, J | 1 |
| Xie, K | 1 |
| Nielsen, PM | 1 |
| Qi, H | 1 |
| Bertelsen, LB | 1 |
| Laustsen, C | 1 |
| Zacharias, N | 1 |
| Lee, J | 1 |
| Ramachandran, S | 1 |
| Shanmugavelandy, S | 1 |
| McHenry, J | 1 |
| Dutta, P | 1 |
| Millward, S | 1 |
| Gammon, S | 1 |
| Efstathiou, E | 1 |
| Troncoso, P | 1 |
| Frigo, DE | 1 |
| Piwnica-Worms, D | 1 |
| Logothetis, CJ | 1 |
| Maity, SN | 1 |
| Titus, MA | 1 |
| Bhattacharya, P | 1 |
| Cox, BL | 1 |
| Erickson-Bhatt, S | 1 |
| Szulczewski, JM | 1 |
| Squirrell, JM | 1 |
| Ludwig, KD | 1 |
| Macdonald, EB | 1 |
| Swader, R | 1 |
| Ponik, SM | 1 |
| Eliceiri, KW | 1 |
| Fain, SB | 1 |
| Warren, BE | 1 |
| Lou, PH | 1 |
| Lucchinetti, E | 1 |
| Zhang, L | 1 |
| Clanachan, AS | 1 |
| Affolter, A | 1 |
| Hersberger, M | 1 |
| Zaugg, M | 1 |
| Lemieux, H | 1 |
| Asghar Butt, S | 1 |
| Søgaard, LV | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| Lauritzen, MH | 1 |
| Engelholm, LH | 1 |
| Paulson, OB | 1 |
| Mirza, O | 1 |
| Holck, S | 1 |
| Magnusson, P | 1 |
| Åkeson, P | 1 |
| Woitzik, J | 1 |
| Pinczolits, A | 1 |
| Hecht, N | 1 |
| Sandow, N | 1 |
| Scheel, M | 1 |
| Drenckhahn, C | 1 |
| Dreier, JP | 1 |
| Vajkoczy, P | 1 |
| Xie, H | 1 |
| Hanai, J | 1 |
| Ren, JG | 1 |
| Kats, L | 1 |
| Burgess, K | 1 |
| Bhargava, P | 1 |
| Signoretti, S | 1 |
| Billiard, J | 1 |
| Duffy, KJ | 1 |
| Grant, A | 1 |
| Wang, X | 1 |
| Lorkiewicz, PK | 1 |
| Schatzman, S | 1 |
| Bousamra, M | 1 |
| Lane, AN | 1 |
| Higashi, RM | 1 |
| Fan, TW | 1 |
| Pandolfi, PP | 1 |
| Sukhatme, VP | 1 |
| Seth, P | 1 |
| Chavarria, L | 1 |
| Romero-Giménez, J | 1 |
| Monteagudo, E | 1 |
| Lope-Piedrafita, S | 1 |
| Cordoba, J | 1 |
| Conde, VR | 1 |
| Oliveira, PF | 1 |
| Nunes, AR | 1 |
| Rocha, CS | 1 |
| Ramalhosa, E | 1 |
| Pereira, JA | 1 |
| Alves, MG | 1 |
| Silva, BM | 1 |
| Serrao, EM | 1 |
| Kettunen, MI | 1 |
| Rodrigues, TB | 1 |
| Dzien, P | 1 |
| Wright, AJ | 1 |
| Gopinathan, A | 1 |
| Gallagher, FA | 1 |
| Lewis, DY | 1 |
| Frese, KK | 1 |
| Almeida, J | 1 |
| Howat, WJ | 1 |
| Tuveson, DA | 1 |
| Brindle, KM | 1 |
| Pourfathi, M | 1 |
| Xin, Y | 1 |
| Kadlecek, SJ | 1 |
| Cereda, MF | 1 |
| Profka, H | 1 |
| Hamedani, H | 1 |
| Siddiqui, SM | 1 |
| Ruppert, K | 1 |
| Drachman, NA | 1 |
| Rajaei, JN | 1 |
| Rizi, RR | 1 |
| Grüning, NM | 1 |
| Ralser, M | 1 |
| Dohmen, C | 1 |
| Bosche, B | 1 |
| Graf, R | 1 |
| Reithmeier, T | 1 |
| Ernestus, RI | 1 |
| Brinker, G | 1 |
| Sobesky, J | 1 |
| Heiss, WD | 1 |
| Park, JH | 1 |
| Hong, YH | 1 |
| Kim, HJ | 1 |
| Kim, SM | 1 |
| Kim, MJ | 1 |
| Park, KS | 1 |
| Sung, JJ | 1 |
| Lee, KW | 1 |
| van der Hoeven, MA | 1 |
| Maertzdorf, WJ | 1 |
| Blanco, CE | 1 |
16 other studies available for pyruvic acid and Disease Exacerbation
| Article | Year |
|---|---|
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Female; Gene Expres | 2020 |
Metabolic reprogramming associated with progression of renal ischemia reperfusion injury assessed with hyperpolarized [1-
Topics: Acute Kidney Injury; Animals; Biomarkers; Creatinine; Disease Models, Animal; Disease Progression; K | 2020 |
Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.
Topics: Animals; Disease Models, Animal; Disease Progression; Heterografts; Humans; Image Enhancement; Lacti | 2019 |
A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures.
Topics: Animals; Bioreactors; Cell Line, Tumor; Cell Survival; Collagen; Contrast Media; Diffusion; Disease | 2019 |
Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat.
Topics: Aconitate Hydratase; Animals; Carnitine; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Disease P | 2014 |
Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-13C]pyruvate.
Topics: Animals; Antineoplastic Agents, Hormonal; Carbon-13 Magnetic Resonance Spectroscopy; Disease Progres | 2015 |
Excitotoxicity and metabolic changes in association with infarct progression.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Infarction; Disease Progression; Female; Glucose; Gl | 2014 |
Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
Topics: Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell | 2014 |
Real-time assessment of ¹³C metabolism reveals an early lactate increase in the brain of rats with acute liver failure.
Topics: Alanine; Animals; Brain; Carbon; Carbon Isotopes; Computer Systems; Disease Progression; Lactic Acid | 2015 |
The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism.
Topics: Alanine; Alanine Transaminase; Cell Line, Tumor; Disease Progression; Glucose; Glucose Transporter T | 2015 |
MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.
Topics: Animals; Biomarkers; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Pancreatic Ductal; Diseas | 2016 |
In vivo imaging of the progression of acute lung injury using hyperpolarized [1-
Topics: Acute Lung Injury; Animals; Carbon Isotopes; Disease Progression; Hydrochloric Acid; Image Processin | 2017 |
Cancer: Sacrifice for survival.
Topics: Anaerobiosis; Cell Respiration; Cell Survival; Disease Progression; Glycolysis; Humans; Lactic Acid; | 2011 |
Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction.
Topics: Blood Pressure; Brain; Brain Edema; Cerebrovascular Circulation; Disease Progression; Energy Metabol | 2007 |
Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Disease Models, Animal; Disease Progre | 2007 |
Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets.
Topics: Animals; Disease Progression; Hypoxia; Lactic Acid; Linear Models; Oxygen; Pyruvic Acid; Swine; Vein | 1997 |