pyruvic acid has been researched along with Diabetes Mellitus, Adult-Onset in 53 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective was to assess glucose, lactate, glycerol, and pyruvate concentrations in the interstitial fluid of the adipose tissue as well as the glucose relative recovery coefficient in reference to capillary blood (RC) during the first two days of the standard treatment of diabetic ketoacidosis (DKA) in patients with type 1 and type 2 diabetes." | 7.79 | Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. ( Ciechanowska, A; Foltynski, P; Karnafel, W; Kawiak, J; Krzymien, J; Ladyzynski, P; Pulawska, E; Sabalinska, S; Wojcicki, JM, 2013) |
| "The objective was to assess glucose, lactate, glycerol, and pyruvate concentrations in the interstitial fluid of the adipose tissue as well as the glucose relative recovery coefficient in reference to capillary blood (RC) during the first two days of the standard treatment of diabetic ketoacidosis (DKA) in patients with type 1 and type 2 diabetes." | 3.79 | Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. ( Ciechanowska, A; Foltynski, P; Karnafel, W; Kawiak, J; Krzymien, J; Ladyzynski, P; Pulawska, E; Sabalinska, S; Wojcicki, JM, 2013) |
| "Prediabetes is a major risk factor for type 2 diabetes and cardiovascular diseases." | 3.01 | A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes. ( Abumrad, NA; Bittel, AJ; Bittel, DC; Cade, WT; Mittendorfer, B; Okunade, AL; Patterson, BW; Reeds, DN, 2021) |
| "Type 1 and type 2 diabetes are both diseases of insulin insufficiency, although they develop by distinct pathways." | 2.42 | Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. ( Burgess, S; Chen, G; Hohmeier, HE; Jensen, MV; Lu, D; Newgard, CB; Sherry, AD; Tran, VV, 2004) |
| " Chronic administration of NaSH in particular at high doses impaired carbohydrate metabolism in type 2 diabetic rats." | 1.51 | Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats. ( Ghasemi, A; Gheibi, S; Jeddi, S; Kashfi, K, 2019) |
| "The concentrations in diabetic II and liver cancer samples were significantly lower than those from healthy people, showing their potential as biomarkers for these diseases." | 1.42 | Determination of α-ketoglutaric and pyruvic acids in urine as potential biomarkers for diabetic II and liver cancer. ( Ben-Hander, GM; Makahleh, A; Saad, B, 2015) |
| "Although evidence that type 2 diabetes mellitus (T2DM) is accompanied by mitochondrial dysfunction in skeletal muscle has been accumulating, a causal link between mitochondrial dysfunction and the pathogenesis of the disease remains unclear." | 1.40 | Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. ( Affolter, A; Clanachan, AS; Hersberger, M; Lemieux, H; Lou, PH; Lucchinetti, E; Warren, BE; Zaugg, M; Zhang, L, 2014) |
| "The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP)." | 1.39 | In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. ( Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T, 2013) |
| "Obesity is a risk factor for type 2 diabetes in cats." | 1.35 | The impact of obesity, sex, and diet on hepatic glucose production in cats. ( Burgess, SC; Ferguson, DC; Glushka, J; Hoenig, M; Jin, ES; Jordan, ET; Kley, S; Olson, DE; Prestegard, JH; Waldron, M; Wu, S, 2009) |
| "Subjects with type 2 diabetes mellitus were studied before and after a 6-month behavioral intervention therapy, during fasting and during a hyperinsulinemic normoglycemic clamp." | 1.35 | Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans. ( Bugianesi, E; Hanson, RW; Kalhan, SC; Kelley, DE; McCullough, AJ, 2008) |
| "Dodecanedioic acid (C12) is an even-numbered dicarboxylic acid (DA)." | 1.30 | The metabolic effect of dodecanedioic acid infusion in non-insulin-dependent diabetic patients. ( Benedetti, G; Capristo, E; De Gaetano, A; Gasbarrini, G; Greco, AV; Mingrone, G, 1998) |
| " Insulin dose-response curves revealed similar sensitivities and responsiveness." | 1.28 | Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM. ( Gavin, JR; Karl, IE; Levy, J, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (7.55) | 18.7374 |
| 1990's | 9 (16.98) | 18.2507 |
| 2000's | 10 (18.87) | 29.6817 |
| 2010's | 18 (33.96) | 24.3611 |
| 2020's | 12 (22.64) | 2.80 |
| Authors | Studies |
|---|---|
| Tulipano, G | 1 |
| Hansen, ESS | 1 |
| Bertelsen, LB | 1 |
| Bøgh, N | 1 |
| Miller, J | 1 |
| Wohlfart, P | 1 |
| Ringgaard, S | 1 |
| Laustsen, C | 1 |
| Hodges, WT | 1 |
| Jarasvaraparn, C | 1 |
| Ferguson, D | 1 |
| Griffett, K | 1 |
| Gill, LE | 1 |
| Chen, Y | 1 |
| Ilagan, MXG | 1 |
| Hegazy, L | 1 |
| Elgendy, B | 1 |
| Cho, K | 1 |
| Patti, GJ | 1 |
| McCommis, KS | 1 |
| Finck, BN | 1 |
| Johanns, M | 1 |
| Corbet, C | 1 |
| Jacobs, R | 1 |
| Drappier, M | 1 |
| Bommer, GT | 1 |
| Herinckx, G | 1 |
| Vertommen, D | 1 |
| Tajeddine, N | 1 |
| Young, D | 1 |
| Messens, J | 1 |
| Feron, O | 1 |
| Steinberg, GR | 2 |
| Hue, L | 1 |
| Rider, MH | 1 |
| Bielczyk-Maczynska, E | 3 |
| Zhao, M | 3 |
| Zushin, PH | 3 |
| Schnurr, TM | 3 |
| Kim, HJ | 3 |
| Li, J | 3 |
| Nallagatla, P | 3 |
| Sangwung, P | 3 |
| Park, CY | 3 |
| Cornn, C | 3 |
| Stahl, A | 3 |
| Svensson, KJ | 3 |
| Knowles, JW | 3 |
| Holeček, M | 1 |
| Choi, YS | 1 |
| Song, JE | 1 |
| Kim, E | 1 |
| Kim, CH | 1 |
| Lee, JE | 1 |
| Song, HT | 1 |
| Perrier, J | 1 |
| Nawrot, M | 1 |
| Madec, AM | 1 |
| Chikh, K | 1 |
| Chauvin, MA | 1 |
| Damblon, C | 1 |
| Sabatier, J | 1 |
| Thivolet, CH | 1 |
| Rieusset, J | 1 |
| Rautureau, GJP | 1 |
| Panthu, B | 1 |
| Mu, K | 1 |
| Sun, Y | 1 |
| Zhao, Y | 1 |
| Zhao, T | 1 |
| Li, Q | 1 |
| Zhang, M | 1 |
| Li, H | 1 |
| Zhang, R | 1 |
| Hu, C | 1 |
| Wang, C | 1 |
| Jia, W | 1 |
| Rider, OJ | 1 |
| Apps, A | 1 |
| Miller, JJJJ | 1 |
| Lau, JYC | 1 |
| Lewis, AJM | 1 |
| Peterzan, MA | 1 |
| Dodd, MS | 1 |
| Lau, AZ | 1 |
| Trumper, C | 1 |
| Gallagher, FA | 1 |
| Grist, JT | 1 |
| Brindle, KM | 1 |
| Neubauer, S | 1 |
| Tyler, DJ | 1 |
| Bittel, AJ | 1 |
| Bittel, DC | 1 |
| Mittendorfer, B | 1 |
| Patterson, BW | 1 |
| Okunade, AL | 1 |
| Abumrad, NA | 1 |
| Reeds, DN | 1 |
| Cade, WT | 1 |
| Park, JM | 1 |
| Josan, S | 1 |
| Hurd, RE | 1 |
| Graham, J | 1 |
| Havel, PJ | 1 |
| Bendahan, D | 1 |
| Mayer, D | 1 |
| Chung, Y | 1 |
| Spielman, DM | 1 |
| Jue, T | 1 |
| Gonzalez-Rellan, MJ | 1 |
| Fondevila, MF | 1 |
| Fernandez, U | 1 |
| Rodríguez, A | 1 |
| Varela-Rey, M | 1 |
| Veyrat-Durebex, C | 1 |
| Seoane, S | 1 |
| Bernardo, G | 1 |
| Lopitz-Otsoa, F | 1 |
| Fernández-Ramos, D | 1 |
| Bilbao, J | 1 |
| Iglesias, C | 1 |
| Novoa, E | 1 |
| Ameneiro, C | 1 |
| Senra, A | 1 |
| Beiroa, D | 1 |
| Cuñarro, J | 1 |
| Dp Chantada-Vazquez, M | 1 |
| Garcia-Vence, M | 1 |
| Bravo, SB | 1 |
| Da Silva Lima, N | 1 |
| Porteiro, B | 1 |
| Carneiro, C | 1 |
| Vidal, A | 1 |
| Tovar, S | 1 |
| Müller, TD | 1 |
| Ferno, J | 1 |
| Guallar, D | 1 |
| Fidalgo, M | 1 |
| Sabio, G | 1 |
| Herzig, S | 1 |
| Yang, WH | 1 |
| Cho, JW | 1 |
| Martinez-Chantar, ML | 1 |
| Perez-Fernandez, R | 1 |
| López, M | 1 |
| Dieguez, C | 1 |
| Mato, JM | 1 |
| Millet, O | 1 |
| Coppari, R | 1 |
| Woodhoo, A | 1 |
| Fruhbeck, G | 1 |
| Nogueiras, R | 1 |
| Nie, L | 1 |
| Yuan, XL | 1 |
| Jiang, KT | 1 |
| Jiang, YH | 1 |
| Yuan, J | 1 |
| Luo, L | 1 |
| Cui, SW | 1 |
| Sun, C | 1 |
| Madiraju, AK | 1 |
| Qiu, Y | 1 |
| Perry, RJ | 1 |
| Rahimi, Y | 1 |
| Zhang, XM | 1 |
| Zhang, D | 1 |
| Camporez, JG | 1 |
| Cline, GW | 2 |
| Butrico, GM | 1 |
| Kemp, BE | 1 |
| Casals, G | 1 |
| Vatner, DF | 1 |
| Petersen, KF | 1 |
| Shulman, GI | 2 |
| Gheibi, S | 1 |
| Jeddi, S | 1 |
| Kashfi, K | 1 |
| Ghasemi, A | 1 |
| Haney, S | 1 |
| Zhao, J | 1 |
| Tiwari, S | 1 |
| Eng, K | 1 |
| Guey, LT | 1 |
| Tien, E | 1 |
| Constantin, RP | 2 |
| Bracht, A | 1 |
| Yamamoto, NS | 1 |
| Ishii-Iwamoto, EL | 1 |
| Constantin, J | 1 |
| Ciechanowska, A | 1 |
| Ladyzynski, P | 1 |
| Wojcicki, JM | 1 |
| Sabalinska, S | 1 |
| Krzymien, J | 1 |
| Pulawska, E | 1 |
| Karnafel, W | 1 |
| Foltynski, P | 1 |
| Kawiak, J | 1 |
| Jeong, KJ | 1 |
| Kim, DY | 1 |
| Quan, HY | 1 |
| Jo, HK | 1 |
| Kim, GW | 1 |
| Chung, SH | 1 |
| Warren, BE | 1 |
| Lou, PH | 1 |
| Lucchinetti, E | 1 |
| Zhang, L | 1 |
| Clanachan, AS | 1 |
| Affolter, A | 1 |
| Hersberger, M | 1 |
| Zaugg, M | 1 |
| Lemieux, H | 1 |
| Zhou, A | 1 |
| Ni, J | 1 |
| Xu, Z | 1 |
| Wang, Y | 1 |
| Zhang, H | 1 |
| Wu, W | 1 |
| Lu, S | 1 |
| Karakousis, PC | 1 |
| Yao, YF | 1 |
| Makahleh, A | 1 |
| Ben-Hander, GM | 1 |
| Saad, B | 1 |
| Zhou, J | 1 |
| Xu, G | 1 |
| Bai, Z | 1 |
| Li, K | 1 |
| Yan, J | 1 |
| Li, F | 1 |
| Ma, S | 1 |
| Xu, H | 1 |
| Huang, K | 1 |
| Bender, T | 1 |
| Martinou, JC | 1 |
| Kley, S | 1 |
| Hoenig, M | 1 |
| Glushka, J | 1 |
| Jin, ES | 1 |
| Burgess, SC | 1 |
| Waldron, M | 1 |
| Jordan, ET | 1 |
| Prestegard, JH | 1 |
| Ferguson, DC | 1 |
| Wu, S | 1 |
| Olson, DE | 1 |
| Pongratz, RL | 1 |
| Kibbey, RG | 1 |
| Kirkpatrick, CL | 1 |
| Zhao, X | 1 |
| Pontoglio, M | 1 |
| Yaniv, M | 1 |
| Wollheim, CB | 1 |
| Saberi, M | 1 |
| Bjelica, D | 1 |
| Schenk, S | 1 |
| Imamura, T | 1 |
| Bandyopadhyay, G | 1 |
| Li, P | 1 |
| Jadhar, V | 1 |
| Vargeese, C | 1 |
| Wang, W | 1 |
| Bowman, K | 1 |
| Zhang, Y | 1 |
| Polisky, B | 1 |
| Olefsky, JM | 1 |
| Wallach, I | 1 |
| Jaitly, N | 1 |
| Lilien, R | 1 |
| Choudhuri, S | 1 |
| Mandal, LK | 1 |
| Paine, SK | 1 |
| Sen, A | 1 |
| Dutta, D | 1 |
| Chowdhury, IH | 1 |
| Mukherjee, A | 1 |
| Saha, A | 1 |
| Bhadhuri, G | 1 |
| Bhattacharya, B | 1 |
| Jensen, RV | 1 |
| Støttrup, NB | 1 |
| Kristiansen, SB | 1 |
| Bøtker, HE | 1 |
| Lee, P | 1 |
| Leong, W | 1 |
| Tan, T | 1 |
| Lim, M | 1 |
| Han, W | 1 |
| Radda, GK | 1 |
| Corkey, BE | 1 |
| Shirihai, O | 1 |
| Newgard, CB | 1 |
| Hohmeier, HE | 1 |
| Lu, D | 1 |
| Jensen, MV | 1 |
| Tran, VV | 1 |
| Chen, G | 1 |
| Burgess, S | 1 |
| Sherry, AD | 1 |
| Wang, P | 1 |
| Lloyd, SG | 1 |
| Zeng, H | 1 |
| Bonen, A | 1 |
| Chatham, JC | 2 |
| Yao, XH | 1 |
| Chen, L | 1 |
| Nyomba, BL | 1 |
| Maechler, P | 1 |
| Carobbio, S | 1 |
| Rubi, B | 1 |
| Kalhan, SC | 1 |
| Bugianesi, E | 1 |
| McCullough, AJ | 1 |
| Hanson, RW | 1 |
| Kelley, DE | 1 |
| Zhou, YP | 1 |
| Ostenson, CG | 1 |
| Ling, ZC | 1 |
| Grill, V | 1 |
| Lao, B | 1 |
| Czyzyk, A | 1 |
| Szutowski, M | 1 |
| Szczepanik, Z | 1 |
| Giroix, MH | 1 |
| Sener, A | 1 |
| Bailbe, D | 1 |
| Leclercq-Meyer, V | 1 |
| Portha, B | 1 |
| Malaisse, WJ | 1 |
| Avogaro, A | 1 |
| Toffolo, G | 1 |
| Miola, M | 1 |
| Valerio, A | 1 |
| Tiengo, A | 1 |
| Cobelli, C | 1 |
| Del Prato, S | 1 |
| Tayek, JA | 1 |
| Katz, J | 1 |
| Diraison, F | 1 |
| Large, V | 1 |
| Brunengraber, H | 1 |
| Beylot, M | 1 |
| Greco, AV | 1 |
| Mingrone, G | 1 |
| Capristo, E | 1 |
| Benedetti, G | 1 |
| De Gaetano, A | 1 |
| Gasbarrini, G | 1 |
| Terekhina, NA | 1 |
| Nenasheva, OIu | 1 |
| Akimov, PA | 1 |
| Seymour, AM | 1 |
| Marchetti, P | 1 |
| Gregorio, F | 1 |
| Benzi, L | 1 |
| Giannarelli, R | 1 |
| Cecchetti, P | 1 |
| Villani, G | 1 |
| Di Cianni, G | 1 |
| Di Carlo, A | 1 |
| Brunetti, P | 1 |
| Navalesi, R | 1 |
| Karl, IE | 1 |
| Gavin, JR | 1 |
| Levy, J | 1 |
| Koh, H | 1 |
| Uchida, K | 1 |
| Waki, M | 1 |
| Nambu, S | 1 |
| Akanji, AO | 1 |
| Humphreys, S | 1 |
| Thursfield, V | 1 |
| Hockaday, TD | 1 |
| Monge, L | 1 |
| Mojena, M | 1 |
| Ortega, JL | 1 |
| Samper, B | 1 |
| Cabello, MA | 1 |
| Feliu, JE | 1 |
| Cheli, V | 1 |
| Buzzo, P | 1 |
| Melga, P | 1 |
| Accoto, S | 1 |
| Prando, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Controlled Trial of the Effect of Remote Ischaemic Conditioning on Coronary Endothelial Function in Patients With Angina.[NCT02666235] | Phase 2 | 60 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for pyruvic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area.
Topics: Animals; Antineoplastic Agents; Diabetes Mellitus, Type 2; Female; Gluconeogenesis; Humans; Hypoglyc | 2021 |
Role of Impaired Glycolysis in Perturbations of Amino Acid Metabolism in Diabetes Mellitus.
Topics: Amino Acids; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Glycine; Glycolysis; Humans; Py | 2023 |
The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?
Topics: Animals; Anion Transport Proteins; Diabetes Mellitus, Type 2; Drosophila Proteins; Energy Metabolism | 2016 |
Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.
Topics: Animals; Cell Survival; Cytokines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose; Hu | 2004 |
In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Type 2; Electron Transport Chain Complex Protein | 2006 |
3 trials available for pyruvic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes.
Topics: Adult; Blood Glucose; Carbohydrate Metabolism; Cross-Over Studies; Diabetes Mellitus, Type 2; Glucos | 2021 |
Alcohol tolerance in patients with non-insulin-dependent (type 2) diabetes treated with sulphonylurea derivatives.
Topics: Acetaldehyde; Adult; Aged; Blood Gas Analysis; Blood Glucose; Body Temperature Regulation; Diabetes | 1994 |
Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM.
Topics: Adult; Alanine; Blood Glucose; Carbon Isotopes; Citric Acid; Citric Acid Cycle; Diabetes Mellitus, T | 1998 |
45 other studies available for pyruvic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Concentration-dependent effects of dichloroacetate in type 2 diabetic hearts assessed by hyperpolarized [1-
Topics: Acetates; Animals; Bicarbonates; Diabetes Mellitus, Type 2; Dichloroacetic Acid; Heart; Magnetic Res | 2022 |
Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice.
Topics: Animals; Anion Transport Proteins; Diabetes Mellitus, Type 2; Diet; Glucose; Mice; Mice, Obese; Mito | 2022 |
Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Glucagon; Gluconeogenesis; Glucos | 2022 |
G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Type 2; Gluconeogenesis; Glucose; Humans; Liver; Mice; Mice, Knockout; P | 2022 |
G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Type 2; Gluconeogenesis; Glucose; Humans; Liver; Mice; Mice, Knockout; P | 2022 |
G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Type 2; Gluconeogenesis; Glucose; Humans; Liver; Mice; Mice, Knockout; P | 2022 |
G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Type 2; Gluconeogenesis; Glucose; Humans; Liver; Mice; Mice, Knockout; P | 2022 |
Hyperpolarized [1-
Topics: Agmatine; Animals; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Lactic Acid; M | 2023 |
Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate.
Topics: Animals; Citric Acid; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin-Secreting Cells; | 2023 |
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.
Topics: Adaptor Proteins, Signal Transducing; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; En | 2019 |
Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Diabetes Mellitus, Type 2; Fasting; Female; Glucose; | 2020 |
Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle.
Topics: Acetyl Coenzyme A; Animals; Diabetes Mellitus, Type 2; Fatty Acids; Glucose; Insulin Resistance; Mag | 2021 |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
Topics: Acetylglucosamine; Animals; Base Sequence; Caloric Restriction; Cell Line; Colforsin; Diabetes Melli | 2021 |
Salsalate Activates Skeletal Muscle Thermogenesis and Protects Mice from High-Fat Diet Induced Metabolic Dysfunction.
Topics: Adipose Tissue, White; Animals; Body Weight; Cell Line; Diabetes Mellitus, Type 2; Diet, High-Fat; E | 2017 |
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Topics: Acetyl-CoA Carboxylase; Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dihydro | 2018 |
Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats.
Topics: Animals; Blood Glucose; Blood Pressure; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Di | 2019 |
RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.
Topics: Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dep | 2013 |
Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis.
Topics: Animals; Biological Transport; Citrus; Diabetes Mellitus, Type 2; Flavanones; Gluconeogenesis; Gluco | 2014 |
Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis.
Topics: Adipose Tissue; Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus | 2013 |
Effects of eugenol on hepatic glucose production and AMPK signaling pathway in hepatocytes and C57BL/6J mice.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Calcium-Calmodulin-Dependent Protein Kinase K | 2014 |
Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat.
Topics: Aconitate Hydratase; Animals; Carnitine; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Disease P | 2014 |
Metabolomics specificity of tuberculosis plasma revealed by (1)H NMR spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Community-Acquired Infections; Dia | 2015 |
Determination of α-ketoglutaric and pyruvic acids in urine as potential biomarkers for diabetic II and liver cancer.
Topics: Biomarkers, Tumor; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Humans; Ketoglut | 2015 |
Selenite exacerbates hepatic insulin resistance in mouse model of type 2 diabetes through oxidative stress-mediated JNK pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fasting; Gene E | 2015 |
The impact of obesity, sex, and diet on hepatic glucose production in cats.
Topics: Animals; Blood Glucose; Body Mass Index; Body Weight; Carbon Isotopes; Cats; Citrate (si)-Synthase; | 2009 |
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
Topics: Adenosine Triphosphate; Animals; Base Sequence; Cell Line; Diabetes Mellitus, Type 2; DNA Primers; F | 2009 |
Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.
Topics: Animals; Blood Glucose; Blotting, Western; Cells, Cultured; Chemistry, Pharmaceutical; Diabetes Mell | 2009 |
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways.
Topics: Breast Neoplasms; Computational Biology; Databases, Factual; Diabetes Mellitus, Type 2; Drug-Related | 2010 |
Role of hyperglycemia-mediated erythrocyte redox state alteration in the development of diabetic retinopathy.
Topics: Blood Glucose; Blood Pressure; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopa | 2013 |
Release of a humoral circulating cardioprotective factor by remote ischemic preconditioning is dependent on preserved neural pathways in diabetic patients.
Topics: Aged; Animals; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Hemodynamics; Humans; Ische | 2012 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Metabolic master regulators: sharing information among multiple systems.
Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Insulin Resistance; Lactic A | 2012 |
Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats.
Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucose; In Vit | 2005 |
Adult rats prenatally exposed to ethanol have increased gluconeogenesis and impaired insulin response of hepatic gluconeogenic genes.
Topics: Age Factors; Animals; Blood Glucose; Central Nervous System Depressants; Diabetes Mellitus, Type 2; | 2006 |
Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans.
Topics: Adult; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Gluconeogenesis; Glucose; Gluc | 2008 |
Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats.
Topics: Acetates; Animals; Diabetes Mellitus, Type 2; Epoxy Compounds; Female; Glucose; Hypoglycemic Agents; | 1995 |
Metabolic, ionic, and secretory response to D-glucose in islets from rats with acquired or inherited non-insulin-dependent diabetes.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diabetes Mellitus, Type 2; Glucos | 1993 |
Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals.
Topics: Adult; Blood Glucose; Body Fluid Compartments; Diabetes Mellitus, Type 2; Forearm; Humans; Hyperglyc | 1996 |
Glucose production, recycling, and gluconeogenesis in normals and diabetics: a mass isotopomer [U-13C]glucose study.
Topics: Diabetes Mellitus, Type 2; Female; Gas Chromatography-Mass Spectrometry; Gluconeogenesis; Glucose; H | 1996 |
The metabolic effect of dodecanedioic acid infusion in non-insulin-dependent diabetic patients.
Topics: Blood Glucose; C-Peptide; Calorimetry, Indirect; Chromatography, High Pressure Liquid; Diabetes Mell | 1998 |
[Novel methods in diabetes mellitus diagnosis].
Topics: Cadaver; Coma; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; | 2001 |
Cardiac carbohydrate metabolism in Zucker diabetic fatty rats.
Topics: Animals; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus, Type 2; Fatty Acids; Glucose; | 2002 |
Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients.
Topics: Alanine; Blood Glucose; Butyrates; Butyric Acid; Circadian Rhythm; Diabetes Mellitus, Type 2; Glycer | 1990 |
Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 1990 |
Exercise-induced increase in glandular kallikrein activity in human plasma and its significance in peripheral glucose metabolism.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Humans; Isoenzymes; Ka | 1989 |
The relationship of plasma acetate with glucose and other blood intermediary metabolites in non-diabetic and diabetic subjects.
Topics: Acetates; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fasting; Fatty | 1989 |
Chlorpropamide raises fructose-2,6-bisphosphate concentration and inhibits gluconeogenesis in isolated rat hepatocytes.
Topics: Animals; Chlorpropamide; Cyclic AMP; Diabetes Mellitus, Type 2; Fructosediphosphates; Gluconeogenesi | 1986 |
[Circadian profiles of lactic and pyruvic acid in diabetic patients treated with biguanides and sulfonylureas].
Topics: Aged; Biguanides; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 2; Diet, Diabetic; Humans | 1986 |