pyruvic acid has been researched along with Degenerative Diseases, Central Nervous System in 13 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Accordingly, recent studies on cancer and diabetes have identified protein-protein interactions, post-translational processes, and transcriptional factors that modulate MPC function." | 2.66 | Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan. ( Buchanan, JL; Taylor, EB, 2020) |
| "Neurodegenerative disorders have been considered as a growing health concern for decades." | 2.61 | Mitochondrial metabolism: a common link between neuroinflammation and neurodegeneration. ( Agrawal, N; Garabadu, D; Sharma, A; Sharma, S, 2019) |
| " These effects were all reversed by co-treatment with pyruvate at a well-tolerated dosage (1000 mg/kg)." | 1.37 | Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain. ( Kim, MO; Koh, PO; Lee, HY; Naseer, MI; Ullah, I; Ullah, N, 2011) |
| "L-kynurenine (L-KYN) serves as a substrate for the synthesis of neurotoxic 3-OH-kynurenine (3-OH-KYN) and neuroprotective kynurenic acid (KYNA)." | 1.30 | Kynurenine metabolism in Alzheimer's disease. ( Baran, H; Deecke, L; Jellinger, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Bøgh, N | 1 |
| Laustsen, C | 1 |
| Hansen, ESS | 1 |
| Tankisi, H | 1 |
| Bertelsen, LB | 1 |
| Blicher, JU | 1 |
| Garabadu, D | 1 |
| Agrawal, N | 1 |
| Sharma, A | 1 |
| Sharma, S | 1 |
| Zangari, J | 1 |
| Petrelli, F | 1 |
| Maillot, B | 1 |
| Martinou, JC | 1 |
| Buchanan, JL | 1 |
| Taylor, EB | 2 |
| Gray, LR | 1 |
| Tompkins, SC | 1 |
| Ghosh, A | 1 |
| Tyson, T | 1 |
| George, S | 1 |
| Hildebrandt, EN | 1 |
| Steiner, JA | 1 |
| Madaj, Z | 1 |
| Schulz, E | 1 |
| Machiela, E | 1 |
| McDonald, WG | 1 |
| Escobar Galvis, ML | 1 |
| Kordower, JH | 1 |
| Van Raamsdonk, JM | 1 |
| Colca, JR | 1 |
| Brundin, P | 1 |
| Divakaruni, AS | 1 |
| Wallace, M | 1 |
| Buren, C | 1 |
| Martyniuk, K | 1 |
| Andreyev, AY | 1 |
| Li, E | 1 |
| Fields, JA | 1 |
| Cordes, T | 1 |
| Reynolds, IJ | 1 |
| Bloodgood, BL | 1 |
| Raymond, LA | 1 |
| Metallo, CM | 1 |
| Murphy, AN | 1 |
| Ullah, N | 1 |
| Naseer, MI | 1 |
| Ullah, I | 1 |
| Lee, HY | 1 |
| Koh, PO | 1 |
| Kim, MO | 1 |
| Fukuyama, R | 1 |
| Nakayama, A | 1 |
| Nakase, T | 1 |
| Toba, H | 1 |
| Mukainaka, T | 1 |
| Sakaguchi, H | 1 |
| Saiwaki, T | 1 |
| Sakurai, H | 1 |
| Wada, M | 1 |
| Fushiki, S | 1 |
| Wang, X | 1 |
| Perez, E | 1 |
| Liu, R | 1 |
| Yan, LJ | 1 |
| Mallet, RT | 1 |
| Yang, SH | 1 |
| Baran, H | 1 |
| Jellinger, K | 1 |
| Deecke, L | 1 |
| Verwer, RW | 1 |
| Hermens, WT | 1 |
| Dijkhuizen, P | 1 |
| ter Brake, O | 1 |
| Baker, RE | 1 |
| Salehi, A | 1 |
| Sluiter, AA | 1 |
| Kok, MJ | 1 |
| Muller, LJ | 1 |
| Verhaagen, J | 1 |
| Swaab, DF | 1 |
| Shin, CY | 1 |
| Choi, JW | 1 |
| Ryu, JR | 1 |
| Ko, KH | 1 |
| Choi, JJ | 1 |
| Kim, HS | 2 |
| Lee, JC | 1 |
| Lee, SJ | 1 |
| Kim, HC | 1 |
| Kim, WK | 1 |
4 reviews available for pyruvic acid and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Mitochondrial metabolism: a common link between neuroinflammation and neurodegeneration.
Topics: Alzheimer Disease; Animals; Citric Acid Cycle; Humans; Mitochondria; Neurodegenerative Diseases; Neu | 2019 |
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier.
Topics: Animals; Gene Expression Regulation; Humans; Metabolic Diseases; Mitochondria; Mitochondrial Membran | 2020 |
Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan.
Topics: Aging; Animals; Diabetes Mellitus; Humans; Mitochondrial Membrane Transport Proteins; Monocarboxylic | 2020 |
Regulation of pyruvate metabolism and human disease.
Topics: Citric Acid Cycle; Cytosol; Heart Diseases; Humans; Mitochondria; Models, Biological; Neoplasms; Neu | 2014 |
9 other studies available for pyruvic acid and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-
Topics: Amyotrophic Lateral Sclerosis; Bicarbonates; Humans; Lactic Acid; Magnetic Resonance Imaging; Neurod | 2022 |
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Autophagy; Behavior, Animal; Brain; Caenorhab | 2016 |
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.
Topics: Animals; Cell Death; Energy Metabolism; Glutamic Acid; Membrane Transport Proteins; Mitochondria; Mi | 2017 |
Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain.
Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Brain; Caspa | 2011 |
A newly established neuronal rho-0 cell line highly susceptible to oxidative stress accumulates iron and other metals. Relevance to the origin of metal ion deposits in brains with neurodegenerative disorders.
Topics: Brain; Cell Respiration; Copper; Glycolysis; Humans; Hydrogen Peroxide; Iron; Membrane Potentials; M | 2002 |
Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells.
Topics: Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Hyd | 2007 |
Kynurenine metabolism in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Caudate Nucleus; Female; Humans; Kinetics; Kynure | 1999 |
Cells in human postmortem brain tissue slices remain alive for several weeks in culture.
Topics: Aged; beta-Galactosidase; Brain; Cell Count; Cell Survival; Cells, Cultured; Culture Techniques; Dep | 2002 |
Glucose deprivation decreases nitric oxide production via NADPH depletion in immunostimulated rat primary astrocytes.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Astrocytes; Biopterins; Cell Death; Cells, Cultur | 2002 |